Skip to main content
main-content
Top

Tip

Swipe om te navigeren naar een ander artikel

30-03-2017 | Uitgave 1/2018 Open Access

Journal of Abnormal Child Psychology 1/2018

Chronic Stressors and Adolescents’ Externalizing Problems: Genetic Moderation by Dopamine Receptor D4. The TRAILS Study

Tijdschrift:
Research on Child and Adolescent Psychopathology > Uitgave 1/2018
Auteurs:
Anna Roos E. Zandstra, Johan Ormel, Pieter J. Hoekstra, Catharina A. Hartman
Belangrijke opmerkingen

Electronic supplementary material

The online version of this article (doi:10.​1007/​s10802-017-0279-4) contains supplementary material, which is available to authorized users.

Abstract

The existing literature does not provide consistent evidence that carriers of the Dopamine D4 Receptor 7-repeat allele are more sensitive to adverse environmental influences, resulting in enhanced externalizing problems, compared to noncarriers. One explanation is that the adverse influences examined in prior studies were not severe, chronic, or distressing enough to reveal individual differences in sensitivity reflected by DRD4–7R. This study examined whether the 7-repeat allele moderated the association between chronic stressors capturing multiple stressful aspects of individuals’ lives and externalizing problems in adolescence. We expected that chronic stressor levels would be associated with externalizing levels only in 7-repeat carriers. Using Linear Mixed Models, we analyzed data from 1621 Dutch adolescents (52.2% boys), obtained in three measurement waves (mean age approximately 11, 13.5, and 16 years) from the TRacking Adolescents’ Individual Lives Survey (TRAILS) population-based birth cohort and the parallel clinic-referred cohort. Across informants, we found that higher levels of chronic stressors were related to higher externalizing levels in 7-repeat carriers but not in noncarriers, as hypothesized. Although previous studies on the 7-repeat allele as a moderator of environmental influences on adolescents’ externalizing problems have not convincingly demonstrated individual differences in sensitivity to adverse environmental influences, our findings suggest that adolescent carriers of the Dopamine D4 Receptor 7-repeat allele are more sensitive to chronic, multi-context stressors than noncarriers.

Onze productaanbevelingen

BSL Psychologie Totaal

Met BSL Psychologie Totaal blijf je als professional steeds op de hoogte van de nieuwste ontwikkelingen binnen jouw vak. Met het online abonnement heb je toegang tot een groot aantal boeken, protocollen, vaktijdschriften en e-learnings op het gebied van psychologie en psychiatrie. Zo kun je op je gemak en wanneer het jou het beste uitkomt verdiepen in jouw vakgebied.

Extra materiaal
Literatuur
Over dit artikel

Andere artikelen Uitgave 1/2018

Journal of Abnormal Child Psychology 1/2018 Naar de uitgave