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Gepubliceerd in: Neuropraxis 3/2007

01-06-2007 | Artikelen

Cholesterol: nieuw therapeutisch target bij de ziekte van Alzheimer?

Auteurs: Monique Mulder, Tim van Mierlo

Gepubliceerd in: Neuropraxis | Uitgave 3/2007

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Abstract

Op dit moment zijn er in Nederland naar schatting 250.0000 mensen met dementie, van wie 60 á 70% de ziekte van Alzheimer heeft. De prevalentie zal, gezien de vergrijzing, in de toekomst sterk toenemen. Honderd jaar na de ontdekking van de ziekte zijn de onderliggende moleculaire mechanismen die leiden tot het geleidelijke verlies van cognitieve functies, zoals het geheugen, nog voor het grootste gedeelte onbekend. Op dit moment bestaat er geen werkzame therapie.
Literatuur
go back to reference Abildayeva, K., P.J. Jansen, et al., (2006). 24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux. J Biol Chem 281(18): 12799–808. Abildayeva, K., P.J. Jansen, et al., (2006). 24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux. J Biol Chem 281(18): 12799–808.
go back to reference Bjorkhem, I., D. Lutjohann, et al., (1997). Importance of a novel oxidative mechanism for elimination of brain cholesterol. Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with 18O2 techniques in vivo and in vitro. J Biol Chem 272(48): 30178–84. Bjorkhem, I., D. Lutjohann, et al., (1997). Importance of a novel oxidative mechanism for elimination of brain cholesterol. Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with 18O2 techniques in vivo and in vitro. J Biol Chem 272(48): 30178–84.
go back to reference Bjorkhem, I. and S. Meaney (2004). Brain cholesterol: long secret life behind a barrier. Arterioscler Thromb Vasc Biol 24(5): 806–15. Bjorkhem, I. and S. Meaney (2004). Brain cholesterol: long secret life behind a barrier. Arterioscler Thromb Vasc Biol 24(5): 806–15.
go back to reference Bjorkhem, I., L. Starck, et al., (2001). Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol. J Lipid Res 42(3): 366–71. Bjorkhem, I., L. Starck, et al., (2001). Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol. J Lipid Res 42(3): 366–71.
go back to reference Bretillon, L., D. Lutjohann, et al., (2000). Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface. J Lipid Res 41(5): 840–5. Bretillon, L., D. Lutjohann, et al., (2000). Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface. J Lipid Res 41(5): 840–5.
go back to reference Brown, J., 3rd, C. Theisler, et al., (2004). Differential expression of cholesterol hydroxylases in Alzheimer's disease. J Biol Chem 279(33): 34674–81. Brown, J., 3rd, C. Theisler, et al., (2004). Differential expression of cholesterol hydroxylases in Alzheimer's disease. J Biol Chem 279(33): 34674–81.
go back to reference Burns, M.P., L. Vardanian, et al., (2006). The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo. J Neurochem 98(3): 792–800. Burns, M.P., L. Vardanian, et al., (2006). The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo. J Neurochem 98(3): 792–800.
go back to reference Corder, E.H., A.M. Saunders, et al., (1993). Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261(5123): 921–3. Corder, E.H., A.M. Saunders, et al., (1993). Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261(5123): 921–3.
go back to reference Craft, S. (2005). Insulin resistance syndrome and Alzheimer's disease: age- and obesity-related effects on memory, amyloid, and inflammation. Neurobiol Aging 26 Suppl 1: 65–9. Craft, S. (2005). Insulin resistance syndrome and Alzheimer's disease: age- and obesity-related effects on memory, amyloid, and inflammation. Neurobiol Aging 26 Suppl 1: 65–9.
go back to reference Eckert, G.P., C. Kirsch, et al., (2001). Differential effects of lovastatin treatment on brain cholesterol levels in normal and apoE-deficient mice. Neuroreport 12(5): 883–7. Eckert, G.P., C. Kirsch, et al., (2001). Differential effects of lovastatin treatment on brain cholesterol levels in normal and apoE-deficient mice. Neuroreport 12(5): 883–7.
go back to reference Edmond, J., R.A. Korsak, et al., (1991). Dietary cholesterol and the origin of cholesterol in the brain of developing rats. J Nutr 121(9): 1323–30. Edmond, J., R.A. Korsak, et al., (1991). Dietary cholesterol and the origin of cholesterol in the brain of developing rats. J Nutr 121(9): 1323–30.
go back to reference Frears, E.R., D.J. Stephens, et al., (1999). The role of cholesterol in the biosynthesis of beta-amyloid. Neuroreport 10(8): 1699–705. Frears, E.R., D.J. Stephens, et al., (1999). The role of cholesterol in the biosynthesis of beta-amyloid. Neuroreport 10(8): 1699–705.
go back to reference George, A.J., R.M. Holsinger, et al., (2004). APP intracellular domain is increased and soluble Abeta is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease. Neurobiol Dis 16(1): 124–32. George, A.J., R.M. Holsinger, et al., (2004). APP intracellular domain is increased and soluble Abeta is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease. Neurobiol Dis 16(1): 124–32.
go back to reference Grant, W.B., A. Campbell, et al., (2002). The significance of environmental factors in the etiology of Alzheimer's disease. J Alzheimers Dis 4(3): 179–89. Grant, W.B., A. Campbell, et al., (2002). The significance of environmental factors in the etiology of Alzheimer's disease. J Alzheimers Dis 4(3): 179–89.
go back to reference Hartmann, T. (2006). Role of amyloid precursor protein, amyloid-beta and gamma-secretase in cholesterol maintenance. Neurodegener Dis 3(4-5): 305–11. Hartmann, T. (2006). Role of amyloid precursor protein, amyloid-beta and gamma-secretase in cholesterol maintenance. Neurodegener Dis 3(4-5): 305–11.
go back to reference Hayashi, H., R.B. Campenot, et al., (2004). Glial lipoproteins stimulate axon growth of central nervous system neurons in compartmented cultures. J Biol Chem 279(14): 14009–15. Hayashi, H., R.B. Campenot, et al., (2004). Glial lipoproteins stimulate axon growth of central nervous system neurons in compartmented cultures. J Biol Chem 279(14): 14009–15.
go back to reference Heverin, M., N. Bogdanovic, et al., (2004). Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease. J Lipid Res 45(1): 186–93. Heverin, M., N. Bogdanovic, et al., (2004). Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease. J Lipid Res 45(1): 186–93.
go back to reference Jansen, P.J., D. Lutjohann, et al., (2006). Dietary plant sterols accumulate in the brain. Biochim Biophys Acta 1761(4): 445–53. Jansen, P.J., D. Lutjohann, et al., (2006). Dietary plant sterols accumulate in the brain. Biochim Biophys Acta 1761(4): 445–53.
go back to reference Joseph, S.B., A. Castrillo, et al., (2003). Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med 9(2): 213–9. Joseph, S.B., A. Castrillo, et al., (2003). Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med 9(2): 213–9.
go back to reference Joseph, S.B. and P. Tontonoz (2003). lxr's: new therapeutic targets in atherosclerosis? Curr Opin Pharmacol 3(2): 192–7. Joseph, S.B. and P. Tontonoz (2003). lxr's: new therapeutic targets in atherosclerosis? Curr Opin Pharmacol 3(2): 192–7.
go back to reference Koldamova, R.P., I.M. Lefterov, et al., (2005). The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease. lxr 280(6): 4079–88. Koldamova, R.P., I.M. Lefterov, et al., (2005). The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease. lxr 280(6): 4079–88.
go back to reference Kolsch, H., D. Lutjohann, et al., (2002). Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease. Mol Psychiatry 7(8): 899–902. Kolsch, H., D. Lutjohann, et al., (2002). Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease. Mol Psychiatry 7(8): 899–902.
go back to reference Kotti, T.J., D.M. Ramirez, et al., (2006). Brain cholesterol turnover required for geranylgeraniol production and learning in mice. Proc Natl Acad Sci USA 103(10): 3869–74. Kotti, T.J., D.M. Ramirez, et al., (2006). Brain cholesterol turnover required for geranylgeraniol production and learning in mice. Proc Natl Acad Sci USA 103(10): 3869–74.
go back to reference Lemaire-Ewing, S., C. Prunet, et al., (2005). Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols. Cell Biol Toxicol 21(2): 97–114. Lemaire-Ewing, S., C. Prunet, et al., (2005). Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols. Cell Biol Toxicol 21(2): 97–114.
go back to reference Levin-Allerhand, J.A., C.E. Lominska, et al., (2002). Increased amyloid- levels in appswe transgenic mice treated chronically with a physiological high-fat high-cholesterol diet. J Nutr Health Aging 6(5): 315–9. Levin-Allerhand, J.A., C.E. Lominska, et al., (2002). Increased amyloid- levels in appswe transgenic mice treated chronically with a physiological high-fat high-cholesterol diet. J Nutr Health Aging 6(5): 315–9.
go back to reference Li, L., D. Cao, et al., (2006). Simvastatin enhances learning and memory independent of amyloid load in mice. Ann Neurol 60(6): 729–39. Li, L., D. Cao, et al., (2006). Simvastatin enhances learning and memory independent of amyloid load in mice. Ann Neurol 60(6): 729–39.
go back to reference Lund, E.G., C. Xie, et al., (2003). Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover. J Biol Chem 278(25): 22980–8. Lund, E.G., C. Xie, et al., (2003). Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover. J Biol Chem 278(25): 22980–8.
go back to reference Lutjohann, D., O. Breuer, et al., (1996). Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation. Proc Natl Acad Sci USA 93(18): 9799–804. Lutjohann, D., O. Breuer, et al., (1996). Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation. Proc Natl Acad Sci USA 93(18): 9799–804.
go back to reference Mahley, R.W. (1988). Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240(4852): 622–30. Mahley, R.W. (1988). Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240(4852): 622–30.
go back to reference Marx, J. (2001). Alzheimer's disease. Bad for the heart, bad for the mind? Science 294(5542): 508–9. Marx, J. (2001). Alzheimer's disease. Bad for the heart, bad for the mind? Science 294(5542): 508–9.
go back to reference Moghadasian, M.H., G. Salen, et al., (2002). Cerebrotendinous xanthomatosis: a rare disease with diverse manifestations. Arch Neurol 59(4): 527–9. Moghadasian, M.H., G. Salen, et al., (2002). Cerebrotendinous xanthomatosis: a rare disease with diverse manifestations. Arch Neurol 59(4): 527–9.
go back to reference Mori, T., D. Paris, et al., (2001). Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic app(sw) mice. J Neuropathol Exp Neurol 60(8): 778–85. Mori, T., D. Paris, et al., (2001). Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic app(sw) mice. J Neuropathol Exp Neurol 60(8): 778–85.
go back to reference Mulder, M., A. Blokland, et al., (2001). Apolipoprotein E protects against neuropathology induced by a high-fat diet and maintains the integrity of the blood-brain barrier during aging. Lab Invest 81(7): 953–60. Mulder, M., A. Blokland, et al., (2001). Apolipoprotein E protects against neuropathology induced by a high-fat diet and maintains the integrity of the blood-brain barrier during aging. Lab Invest 81(7): 953–60.
go back to reference Mulder, M., R. Ravid, et al., (1998). Reduced levels of cholesterol, phospholipids, and fatty acids in cerebrospinal fluid of Alzheimer disease patients are not related to apolipoprotein E4. Alzheimer Dis Assoc Disord 12(3): 198–203. Mulder, M., R. Ravid, et al., (1998). Reduced levels of cholesterol, phospholipids, and fatty acids in cerebrospinal fluid of Alzheimer disease patients are not related to apolipoprotein E4. Alzheimer Dis Assoc Disord 12(3): 198–203.
go back to reference Mulder, M. and D. Terwel (1998). Possible link between lipid metabolism and cerebral amyloid angiopathy in Alzheimer's disease: A role for high-density lipoproteins? Haemostasis 28(3–4): 174–94. Mulder, M. and D. Terwel (1998). Possible link between lipid metabolism and cerebral amyloid angiopathy in Alzheimer's disease: A role for high-density lipoproteins? Haemostasis 28(3–4): 174–94.
go back to reference Murphy, E.J., H.M. Huang, et al., (2006). Phospholipid mass is increased in fibroblasts bearing the Swedish amyloid precursor mutation. Brain Res Bull 69(1): 79–85. Murphy, E.J., H.M. Huang, et al., (2006). Phospholipid mass is increased in fibroblasts bearing the Swedish amyloid precursor mutation. Brain Res Bull 69(1): 79–85.
go back to reference Oksman, M., H. Iivonen, et al., (2006). Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in app/ps transgenic mice. Neurobiol Dis 23(3): 563–72. Oksman, M., H. Iivonen, et al., (2006). Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in app/ps transgenic mice. Neurobiol Dis 23(3): 563–72.
go back to reference Papassotiropoulos, A., D. Lutjohann, et al., (2002). 24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia. J Psychiatr Res 36(1): 27–32. Papassotiropoulos, A., D. Lutjohann, et al., (2002). 24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia. J Psychiatr Res 36(1): 27–32.
go back to reference Park, I.H., E.M. Hwang, et al., (2003). Lovastatin enhances Abeta production and senile plaque deposition in female Tg2576 mice. Neurobiol Aging 24(5): 637–43. Park, I.H., E.M. Hwang, et al., (2003). Lovastatin enhances Abeta production and senile plaque deposition in female Tg2576 mice. Neurobiol Aging 24(5): 637–43.
go back to reference Pitas, R. E., J.K. Boyles, et al., (1987). Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins. Biochim Biophys Acta 917(1): 148–61. Pitas, R. E., J.K. Boyles, et al., (1987). Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins. Biochim Biophys Acta 917(1): 148–61.
go back to reference Poirier, J., A. Baccichet, et al., (1993). Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult rats. Neuroscience 55(1): 81–90. Poirier, J., A. Baccichet, et al., (1993). Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult rats. Neuroscience 55(1): 81–90.
go back to reference Poirier, J., J. Davignon, et al., (1993). Apolipoprotein E polymorphism and Alzheimer's disease. Lancet 342(8873): 697–9. Poirier, J., J. Davignon, et al., (1993). Apolipoprotein E polymorphism and Alzheimer's disease. Lancet 342(8873): 697–9.
go back to reference Puglielli, L., B.C. Ellis, et al., (2004). Role of acyl-coenzyme a: cholesterol acyltransferase activity in the processing of the amyloid precursor protein. J Mol Neurosci 24(1): 93–6. Puglielli, L., B.C. Ellis, et al., (2004). Role of acyl-coenzyme a: cholesterol acyltransferase activity in the processing of the amyloid precursor protein. J Mol Neurosci 24(1): 93–6.
go back to reference Puglielli, L., G. Konopka, et al., (2001). Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nat Cell Biol 3(10): 905–12. Puglielli, L., G. Konopka, et al., (2001). Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nat Cell Biol 3(10): 905–12.
go back to reference Rebeck, G.W. (2004). Cholesterol efflux as a critical component of Alzheimer's disease pathogenesis. J Mol Neurosci 23(3): 219–24. Rebeck, G.W. (2004). Cholesterol efflux as a critical component of Alzheimer's disease pathogenesis. J Mol Neurosci 23(3): 219–24.
go back to reference Schneider, A., W. Schulz-Schaeffer, et al., (2006). Cholesterol depletion reduces aggregation of amyloid-beta peptide in hippocampal neurons. Neurobiol Dis 23(3): 573–7. Schneider, A., W. Schulz-Schaeffer, et al., (2006). Cholesterol depletion reduces aggregation of amyloid-beta peptide in hippocampal neurons. Neurobiol Dis 23(3): 573–7.
go back to reference Schonknecht, P., D. Lutjohann, et al., (2002). Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls. Neurosci Lett 324(1): 83–5. Schonknecht, P., D. Lutjohann, et al., (2002). Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls. Neurosci Lett 324(1): 83–5.
go back to reference Simons, M., P. Keller, et al., (1998). Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc Natl Acad Sci USA 95(11): 6460–4. Simons, M., P. Keller, et al., (1998). Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc Natl Acad Sci USA 95(11): 6460–4.
go back to reference Sparks, D.L. (1997). Coronary artery disease, hypertension, ApoE, and cholesterol: a link to Alzheimer's disease? Ann N Y Acad Sci 826: 128–46. Sparks, D.L. (1997). Coronary artery disease, hypertension, ApoE, and cholesterol: a link to Alzheimer's disease? Ann N Y Acad Sci 826: 128–46.
go back to reference Sun, Y., J. Yao, et al., (2003). Expression of liver X receptor target genes decreases cellular amyloid beta peptide secretion. J Biol Chem 278(30): 27688–94. Sun, Y., J. Yao, et al., (2003). Expression of liver X receptor target genes decreases cellular amyloid beta peptide secretion. J Biol Chem 278(30): 27688–94.
go back to reference Thelen, K.M., P. Falkai, et al., (2006). Cholesterol synthesis rate in human hippocampus declines with aging. Neurosci Lett 403(1–2): 15–9. Thelen, K.M., P. Falkai, et al., (2006). Cholesterol synthesis rate in human hippocampus declines with aging. Neurosci Lett 403(1–2): 15–9.
go back to reference Thelen, K.M., K.M. Rentsch, et al., (2006). Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin. J Pharmacol Exp Ther 316(3): 1146–52. Thelen, K.M., K.M. Rentsch, et al., (2006). Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin. J Pharmacol Exp Ther 316(3): 1146–52.
go back to reference Travert, C., S. Carreau, et al., (2006). Induction of apoptosis by 25-hydroxycholesterol in adult rat Leydig cells: protective effect of 17beta-estradiol. Reprod Toxicol 22(4): 564–70. Travert, C., S. Carreau, et al., (2006). Induction of apoptosis by 25-hydroxycholesterol in adult rat Leydig cells: protective effect of 17beta-estradiol. Reprod Toxicol 22(4): 564–70.
go back to reference Wagstaff, L.R., M.W. Mitton, et al., (2003). Statin-associated memory loss: analysis of 60 case reports and review of the literature. Pharmacotherapy 23(7): 871–80. Wagstaff, L.R., M.W. Mitton, et al., (2003). Statin-associated memory loss: analysis of 60 case reports and review of the literature. Pharmacotherapy 23(7): 871–80.
go back to reference Wang, L., G.U. Schuster, et al., (2002). Liver X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration. Proc Natl Acad Sci USA 99(21): 13878–83. Wang, L., G.U. Schuster, et al., (2002). Liver X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration. Proc Natl Acad Sci USA 99(21): 13878–83.
go back to reference Whitney, K.D., M.A. Watson, et al., (2002). Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system. Mol Endocrinol 16(6): 1378–85. Whitney, K.D., M.A. Watson, et al., (2002). Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system. Mol Endocrinol 16(6): 1378–85.
go back to reference Wiegand, V., T.Y. Chang, et al., (2003). Transport of plasma membrane-derived cholesterol and the function of Niemann-Pick C1 Protein. Faseb J 17(6): 782–4. Wiegand, V., T.Y. Chang, et al., (2003). Transport of plasma membrane-derived cholesterol and the function of Niemann-Pick C1 Protein. Faseb J 17(6): 782–4.
go back to reference Wolozin, B. (2004). Cholesterol and the biology of Alzheimer's disease. Neuron 41(1): 7–10. Wolozin, B. (2004). Cholesterol and the biology of Alzheimer's disease. Neuron 41(1): 7–10.
go back to reference Xie, C., E.G. Lund, et al., (2003). Quantitation of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration. J Lipid Res 44(9): 1780–9. Xie, C., E.G. Lund, et al., (2003). Quantitation of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration. J Lipid Res 44(9): 1780–9.
go back to reference Yang, C., L. Yu, et al., (2004). Disruption of cholesterol homeostasis by plant sterols. J Clin Invest 114(6): 813–22. Yang, C., L. Yu, et al., (2004). Disruption of cholesterol homeostasis by plant sterols. J Clin Invest 114(6): 813–22.
Metagegevens
Titel
Cholesterol: nieuw therapeutisch target bij de ziekte van Alzheimer?
Auteurs
Monique Mulder
Tim van Mierlo
Publicatiedatum
01-06-2007
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Neuropraxis / Uitgave 3/2007
Print ISSN: 1387-5817
Elektronisch ISSN: 1876-5785
DOI
https://doi.org/10.1007/BF03079128

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