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01-12-2008 | Uitgave 10/2008

Quality of Life Research 10/2008

Changes in health-related quality of life (HRQoL) in a population-based sample of children and adolescents after 3 years of follow-up

Quality of Life Research > Uitgave 10/2008
J. A. Palacio-Vieira, E. Villalonga-Olives, J. M. Valderas, M. Espallargues, M. Herdman, S. Berra, J. Alonso, L. Rajmil



To assess changes in health-related quality of life (HRQoL) in children and adolescents over a 3-year period and to examine factors associated with change.


A representative sample of Spanish children and adolescents aged 8–18 years and their parents completed the KIDSCREEN-52 questionnaire at baseline and again after 3 years. Data were also collected on gender, pubertal development (PD), and family socio-economic status (SES). Change in HRQOL over time was evaluated using effect sizes (ES). Generalized estimating equations (GEE) were used to analyze associations among changes in KIDSCREEN scores, socio-demographic factors, and pubertal development.


Response rate at follow-up was 54% (n = 454). Overall, HRQoL worsened in eight out of the ten KIDSCREEN dimensions, with ES ranging from −0.10 (Moods and Emotions) to −0.34 (Psychological Well-being). The decrease was most marked in the intermediate age group (13–17 years of age at follow-up) and in girls. In the GEE models, pubertal development more strongly impacted changes in girls than in boys.


In this representative, population-based sample of children and adolescents, moderate decrements in HRQoL were observed after 3 years. Changes were particularly important among girls and in relation to pubertal development. These results could provide useful reference data for other longitudinal studies in population sub-groups.

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