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01-01-2009 | Original Paper | Uitgave 1/2009

Association of a Monoamine Oxidase-A Gene Promoter Polymorphism With ADHD and Anxiety in Boys With Autism Spectrum Disorder

Tijdschrift:: Journal of Autism and Developmental Disorders > Uitgave 1/2009

Auteurs:: Jasmin Roohi, Carla J. DeVincent, Eli Hatchwell, Kenneth D. Gadow

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Abstract

The aim of the present study was to examine the association between a variable number tandem repeat (VNTR) functional polymorphism in the promoter region of the MAO-A gene and severity of ADHD and anxiety in boys with ASD. Parents and teachers completed a DSM-IV-referenced rating scale for 5- to 14-year-old boys with ASD (n = 43). Planned comparisons indicated that children with the 4- versus 3-repeat allele had significantly (p < 05) more severe parent-rated ADHD inattention and impulsivity, and more severe teacher-rated symptoms of generalized anxiety. Our results support a growing body of research indicating that concomitant behavioral disturbances in children with ASD warrant consideration as clinical phenotypes, but replication with independent samples is necessary to confirm this preliminary finding.

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Titel: Association of a Monoamine Oxidase-A Gene Promoter Polymorphism With ADHD and Anxiety in Boys With Autism Spectrum Disorder
Auteurs:: Jasmin Roohi
Carla J. DeVincent
Eli Hatchwell
Kenneth D. Gadow
Publicatiedatum: 01-01-2009
DOI: https://doi.org/10.1007/s10803-008-0600-8
Uitgeverij: Springer US
Tijdschrift: Journal of Autism and Developmental Disorders
Uitgave 1/2009
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432

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