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01-01-2009 | Original Paper | Uitgave 1/2009

Association of a Monoamine Oxidase-A Gene Promoter Polymorphism With ADHD and Anxiety in Boys With Autism Spectrum Disorder

Tijdschrift:: Journal of Autism and Developmental Disorders > Uitgave 1/2009

Auteurs:: Jasmin Roohi, Carla J. DeVincent, Eli Hatchwell, Kenneth D. Gadow

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Abstract

The aim of the present study was to examine the association between a variable number tandem repeat (VNTR) functional polymorphism in the promoter region of the MAO-A gene and severity of ADHD and anxiety in boys with ASD. Parents and teachers completed a DSM-IV-referenced rating scale for 5- to 14-year-old boys with ASD (n = 43). Planned comparisons indicated that children with the 4- versus 3-repeat allele had significantly (p < 05) more severe parent-rated ADHD inattention and impulsivity, and more severe teacher-rated symptoms of generalized anxiety. Our results support a growing body of research indicating that concomitant behavioral disturbances in children with ASD warrant consideration as clinical phenotypes, but replication with independent samples is necessary to confirm this preliminary finding.

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Meer informatie

Achenbach, T. M., McConaughy, S. H., & Howell, C. T. (1987). Child/adolescent behavioral and emotional problems: Implications of cross-informant correlations for situational specificity. Psychological Bulletin, 101, 213–232. doi: 10.1037/0033-2909.101.2.213. PubMedCrossRef

Aman, M. G., Lam, K. S. L., & Van Bourgondien, M. E. (2005). Medication patterns in patients with autism: Temporal, regional, and demographic influences. Journal of Child and Adolescent Psychopharmacology, 5, 16–126.

American Psychiatric Association. (1994). Diagnostic and Statistical Manual of Mental disorders (4th Ed.). Washington, DC: American Psychiatric Association.

Boomsma, D. I., van Beijsterveldt, C. E. M., & Hudziak, J. J. (2005). Genetic and environmental influences on anxious/depression during childhood: A study from the Netherlands Twin register. Genes Brain & Behavior, 4, 466–481. doi: 10.1111/j.1601-183X.2005.00141.x. CrossRef

Brookes, K., Xu, X., Chen, W., Zhou, K., Neale, B., Lowe, N., et al. (2006). The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: Association signals in DRD4, DAQT1 and 16 others. Molecular Psychiatry, 11, 934–953. doi: 10.1038/sj.mp. 4001869. PubMedCrossRef

Cardon, L. R., & Palmer, L. J. (2003). Population stratification and spurious allelic association. Lancet, 361, 598–604. doi: 10.1016/S0140-6736(03)12520-2. PubMedCrossRef

Cicchetti, D. V., Volkmar, F., Klin, A., & Showalter, D. (1995). Diagnosing autism using ICD -10 criteria: A comparison of neural networks and standard multivariate procedures. Child Neuropsychology, 1, 26–37. doi: 10.1080/09297049508401340. CrossRef

Cohen, J. (1988). Statistical Power Analysis for the Behavioral Sciences (2nd Ed.). Mahwah, NJ: Lawrence Erlbaum.

Cohen, I. L., Liu, X., Schultz, C., White, B. N., Jenkins, E. C., Brown, W. T., et al. (2003). Association of autism severity with a monoamine oxidase A functional polymorphism. Clinical Genetics, 64, 190–197. doi: 10.1034/j.1399-0004.2003.00115.x. PubMedCrossRef

Congdon, E., Lesch, K. P., & Canli, T. (2008). Analysis of DRD4 and DAT polymorphisms and behavioral inhibition in healthy adults: Implications for impulsivity. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 147B, 27–32. doi: 10.1002/ajmg.b.30557. CrossRef

Dawson, G., Webb, S. J., Wijsman, E., Schellenberg, G., Estes, A., Munson, J., et al. (2005). Neurocognitive and electrophysiological evidence of altered face processing in parents of children with autism: Implications for a model of abnormal development of social brain circuity in autism. Development and Psychopathology, 17, 679–697. PubMedCrossRef

Deckert, J., Catalano, M., Syagailo, Y. V., Bosi, M., Okladnovo, O., DiBella, D., et al. (1999). Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder. Human Molecular Genetics, 8, 621–624. doi: 10.1093/hmg/8.4.621. PubMedCrossRef

Devlin, B., Cook, E. H., Jr, Coon, H., Dawson, G., Grigorenko, E. L., McMahon, W., et al. (2005). Autism and the serotonin transporter: The long and the short of it. Molecular Psychiatry, 10, 1110–1116. doi: 10.1038/sj.mp. 4001724. PubMedCrossRef

Drabick, D. A. G., Gadow, K. D., & Loney, J. (2008). Co-occurring ODD and GAD symptom groups: Source-specific syndromes and cross-informant comorbidity. Journal of Clinical Child and Adolescent Psychology, 37, 314–326.

Evenden, J. L. (1999). Varieties of impulsivity. Psychopharmacology, 146, 348–361. doi: 10.1007/PL00005481. PubMedCrossRef

Fowler, J.S., Alia-Klein, N., Kriplani, A., Logan, J., Williams, B., Zhu, W., et al. (2007). Evidence that brain MAO A activity does not correspond to MAO A genotype in healthy male subjects. Biological Psychiatry, 62, 355–358.

Gadow, K. D., & Sprafkin, J. (1986). Stony Brook Child Psychiatric Checklist-3. Stony Brook, NY: Department of Psychiatry, State University of New York.

Gadow, K. D., & Sprafkin, J. (2002). Child Symptom Inventory-4 Screening and Norms Manual. Stony Brook, NY: Checkmate Plus.

Gadow, K.D., & Sprafkin, J. (2007). The Symptom Inventories: An Annotated Bibliography [On-line]. Checkmate Plus: Stony Brook, NY. Available: www.checkmateplus.com.

Gadow, K. D., De Vincent, C. J., Pomeroy, J., & Azizian, A. (2004a). Psychiatric symptoms in preschool children with PDD and clinic and comparison samples. Journal of Autism and Developmental Disorders, 34, 379–393. doi: 10.1023/B:JADD.0000037415.21458.93. PubMedCrossRef

Gadow, K. D., Drabick, D. A. G., Loney, J., Sprafkin, J., Salisbury, H., Azizian, A., et al. (2004b). Comparison of ADHD symptom subtypes as source-specific syndromes. Journal of Child Psychology and Psychiatry and Allied Disciplines, 45, 1135–1149. doi: 10.1111/j.1469-7610.2004.00306.x. CrossRef

Gadow, K. D., DeVincent, C. J., Pomeroy, J., & Azizian, A. (2005). Comparison of DSM-IV symptoms in elementary school-aged children with PDD versus clinic and community samples. Autism, 9, 392–415. doi: 10.1177/1362361305056079. PubMedCrossRef

Gadow, K. D., DeVincent, C. J., & Pomeroy, J. (2006). ADHD symptom subtypes in children with pervasive developmental disorder. Journal of Autism and Developmental Disorders, 36, 271–283. doi: 10.1007/s10803-005-0060-3. PubMedCrossRef

Gadow, K. D., Sverd, J., Nolan, E. E., Sprafkin, J., & Schneider, J. (2007). Immediate-release methylphenidate for ADHD in children with comorbid chronic multiple tic disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 46, 840–848. doi: 10.1097/chi.0b013e31805c0860. PubMedCrossRef

Gadow, K. D., DeVincent, C. J., & Drabick, D. A. G. (in press-a). Oppositional defiant disorder as a clinical phenotype in children with pervasive developmental disorder. Journal of Autism and Developmental Disorders.

Gadow, K. D., Roohi, J., De Vincent, C. J., & Hatchwell, E. (in press-b). Association of ADHD, tics, and anxiety with dopamine transporter (DAT1) genotype in autism spectrum disorder. Journal of Child Psychology and Psychiatry, and Allied Disciplines.

Grayson, P., & Carlson, G. A. (1991). The utility of a DSM-III-R-based checklist in screening child psychiatric patients. Journal of the American Academy of Child and Adolescent Psychiatry, 30, 669–673. doi: 10.1097/00004583-199107000-00021. PubMedCrossRef

Grice, D. E., & Buxbaum, J. D. (2006). The genetic architecture of autism and related disorders. Clinical Neuroscience Research, 6, 161–168. doi: 10.1016/j.cnr.2006.06.004. CrossRef

Herring, S., Gray, K., Taffe, J., Tonge, B., Sweeney, D., & Einfeld, S. (2006). Behaviour and emotional problems in toddlers with pervasive developmental disorders and developmental delay: Associations with parental mental health and family functioning. Journal of Intellectual Disability Research, 50, 874–882. doi: 10.1111/j.1365-2788.2006.00904.x. PubMedCrossRef

Hollingshead, A. B. (1975). Four factor index of social status. New Haven, CT: Department of Sociology, Yale University.

Hudziak, J. J., Derks, E. M., Althoff, R. R., Copeland, W., & Boomsma, D. I. (2005). The genetic and environmental contributions to oppositional defiant behavior: A multi-informant twin study. Journal of the American Academy of Child and Adolescent Psychiatry, 44, 907–914. doi: 10.1097/01.chi.0000169011.73912.27. PubMedCrossRef

Jones, M. B., Palmour, R. M., Zwaigenbaum, L., & Szatmari, P. (2004). Modifier effects in autism at the MAOA-A and DBH loci. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 126B, 58–65. doi: 10.1002/ajmg.b.20172. CrossRef

Jonsson, E. G., Norton, N., Gustavsson, J. P., Oreland, L., Owen, M. J., & Sedvall, G. C. (2000). A promoter polymorphism in monoamine oxidase A gene and its relationships to monoamine metabolite concentrations in CSF of healthy volunteers. Journal of Psychiatric Research, 34, 239–244. doi: 10.1016/S0022-3956(00)00013-3. PubMedCrossRef

Kim-Cohen, J., Caspi, A., Taylor, A., Williams, B., Newcombe, R., Craig, I. W., et al. (2006). MAOA, maltreatment, and gene-environment interaction predicting children’s mental health: New evidence and a meta-analysis. Molecular Psychiatry, 11, 903–913. doi: 10.1038/sj.mp. 4001851. PubMedCrossRef

Lawson, D. C., Turic, D., Langley, K., Pay, H. M., Govan, C. F., Norton, N., et al. (2003). Association analysis of monoamine oxidase A and attention deficit hyperactivity disorder. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 116B, 84–89. doi: 10.1002/ajmg.b.10002. CrossRef

Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Jr, Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30, 205–223. doi: 10.1023/A:1005592401947. PubMedCrossRef

Manor, I., Tyano, S., Mel, E., Eisenberg, J., Bachner-Melman, R., Kotler, M., et al. (2002). Family-based and association studies of monoamine oxidase A and attention deficit hyperactivity disorder (ADHD): Preferential transmission of the long promoter region repeat and its association with impaired performance on a continuous performance test (TOVA). Molecular Psychiatry, 7, 626–632. doi: 10.1038/sj.mp. 4001037. PubMedCrossRef

Manuck, S. B., Flory, J. D., Ferrell, R. E., Mann, J. J., & Muldoon, M. F. (2000). A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity. Psychiatry Research, 95, 9–23. doi: 10.1016/S0165-1781(00)00162-1. PubMedCrossRef

Martin, N., Scourfield, J., & McGuffin, P. (2002). Observer effects and heritability of childhood attention-deficit hyperactivity disorder symptoms. The British Journal of Psychiatry, 180, 260–265. doi: 10.1192/bjp. 180.3.260. PubMedCrossRef

Offord, D. R., Boyle, M. H., Racine, Y., Szatmari, P., Fleming, J. E., Sanford, M., et al. (1996). Integrating assessment data from multiple informants. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 1078–1085. doi: 10.1097/00004583-199608000-00019. PubMedCrossRef

Passamonti, L., Fera, F., Margariello, A., Cerasa, A., Gioia, M. C., Muglia, M., et al. (2006). Monoamine oxidase-A genetic variations influence brain activity associated with inhibitory control: New insight into the neural correlates of impulsivity. Biological Psychiatry, 59, 334–340. doi: 10.1016/j.biopsych.2005.07.027. PubMedCrossRef

Rothman, K. (1990). No adjustments are needed for multiple comparisons. Epidemiology (Cambridge, Mass.), 1, 43–46.

Rutter, M., Couteur, A., & Lord, C. (2003). Autism Diagnostic Interview-Revised. Los Angeles, CA: Western Psychological Services.

Rutter, M., Greenfield, D., & Lockyer, L. (1967). A five to fifteen year follow-up study of infantile psychosis II: Social and behavioral outcome. The British Journal of Psychiatry, 113, 1183–1190. PubMedCrossRef

Sabol, S. Z., Hu, S., & Hamer, D. (1998). A functional polymorphism in the monoamine oxidase A gene promoter. Human Genetics, 103, 273–279. doi: 10.1007/s004390050816. PubMedCrossRef

Samochowiec, J., Hajduk, A., Samochowiec, A., Horodnicki, J., Stepien, G., Grzywacz, A., et al. (2004). Association studies of MAO-A, COMT, and 5-HTT genes polymorphisms in patients with anxiety disorders of the phobic spectrum. Psychiatry Research, 128, 21–26. doi: 10.1016/j.psychres.2004.05.012. PubMedCrossRef

Sherman, D. K., McGue, M. K., & Iacono, W. G. (1997). Twin concordance for attention deficit hyperactivity disorder: A comparison of teachers’ and mothers’ reports. The American Journal of Psychiatry, 154, 532–535. PubMed

Soubrie, P. (1986). Reconciling the role of central serotonin neurons in human and animal behavior. The Behavioral and Brain Sciences, 9, 319–364. CrossRef

Sprafkin, J., Gadow, K. D., Salisbury, H., Schneider, J., & Loney, J. (2002). Further evidence of reliability and validity of the Child Symptom Inventory-4: Parent Checklist in clinically referred boys. Journal of Clinical Child and Adolescent Psychology, 31, 513–524. PubMed

Sukhodolsky, D. G., Scahill, L., Gadow, K. D., Eugene, A. L., Aman, M. G., McDougle, C. J., et al. (2008). Parent-rated anxiety symptoms in children with pervasive developmental disorders: Frequency and association with core autism symptoms and cognitive functioning. Journal of Abnormal Child Psychology, 36, 117–128. doi: 10.1007/s10802-007-9165-9. PubMedCrossRef

Szatmari, P., Maziade, M., Zwaigenbaum, L., Merette, C., Roy, M.-A., Joober, R., et al. (2007). Informative phenotypes for genetic studies of psychiatric disorders. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 144B, 581–588. doi: 10.1002/ajmg.b.30426. CrossRef

Weisbrot, D. M., Gadow, K. D., DeVincent, C. J., & Pomeroy, J. (2005). The presentation of anxiety in children with pervasive developmental disorders. Journal of Child and Adolescent Psychopharmacology, 15, 477–496. doi: 10.1089/cap.2005.15.477. PubMedCrossRef

Williams, R. B., Marchuk, D. A., Gadde, K. M., Barefoot, J. C., Grichnik, K., Helms, M. J., et al. (2003). Serotonin related gene polymorphisms and central nervous system serotonin function. Neuropsychopharmacology, 28, 533–541. doi: 10.1038/sj.npp. 1300054. PubMedCrossRef

Yirmiya, N., Pilowsky, T., Tidhar, S., Nemanov, L., Altmark, L., & Ebstein, R. P. (2002). Family-based and population study of a functional promoter-region monoamine oxidase A polymorphism in autism: Possible association with IQ. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 114B, 284–287.

Titel: Association of a Monoamine Oxidase-A Gene Promoter Polymorphism With ADHD and Anxiety in Boys With Autism Spectrum Disorder
Auteurs:: Jasmin Roohi
Carla J. DeVincent
Eli Hatchwell
Kenneth D. Gadow
Publicatiedatum: 01-01-2009
DOI: https://doi.org/10.1007/s10803-008-0600-8
Uitgeverij: Springer US
Tijdschrift: Journal of Autism and Developmental Disorders
Uitgave 1/2009
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432

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