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01-01-2008 | Original Paper

Arousal Modulation in Females with Fragile X or Turner Syndrome

Auteurs: Jane Roberts, Michèle M. M. Mazzocco, Melissa M. Murphy, Rudolf Hoehn-Saric

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 1/2008

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Abstract

The present study was carried out to examine physiological arousal modulation (heart activity and skin conductance, across baseline and cognitive tasks, in females with fragile X or Turner syndrome and a comparison group of females with neither syndrome. Relative to the comparison group, for whom a greater increase in skin conductance was associated with poor arithmetic performance and less risk taking behavior, females with fragile X displayed a minimal increase in heart activity that was nevertheless associated with poor performance on mental arithmetic. In contrast, no arousal–cognitive performance relationship emerged for the group with Turner syndrome. Taken together, our findings suggest that distinct profiles of arousal modulation might be associated with cognitive deficits in these syndrome populations.
Literatuur
go back to reference Althaus, M., Mulder, L. J., Mulder, G., Aarnoudse, C. C., & Minderaa, R. B. (1999). Cardiac adaptivity to attention-demanding tasks in children with a pervasive developmental disorder not otherwise specified (PDD-NOS). Biological Psychiatry, 46, 799–809.PubMedCrossRef Althaus, M., Mulder, L. J., Mulder, G., Aarnoudse, C. C., & Minderaa, R. B. (1999). Cardiac adaptivity to attention-demanding tasks in children with a pervasive developmental disorder not otherwise specified (PDD-NOS). Biological Psychiatry, 46, 799–809.PubMedCrossRef
go back to reference Bailey, D. B. Jr., Hatton, D. D., & Skinner, M. (1998). Early developmental trajectories of males with fragile X syndrome. American Journal on Mental Retardation, 1, 29–39.CrossRef Bailey, D. B. Jr., Hatton, D. D., & Skinner, M. (1998). Early developmental trajectories of males with fragile X syndrome. American Journal on Mental Retardation, 1, 29–39.CrossRef
go back to reference Belser, R. C., & Sudhalter, V. (1995). Arousal difficulties in males with fragile X syndrome: A preliminary report. Developmental Brain Dysfunction, 8, 270–279. Belser, R. C., & Sudhalter, V. (1995). Arousal difficulties in males with fragile X syndrome: A preliminary report. Developmental Brain Dysfunction, 8, 270–279.
go back to reference Cohen, I. L. (1995). Behavioral profiles of autistic and nonautistic fragile X males. Developmental Brain Dysfunction, 8, 252–269. Cohen, I. L. (1995). Behavioral profiles of autistic and nonautistic fragile X males. Developmental Brain Dysfunction, 8, 252–269.
go back to reference Dykens, E. M. (2000). Psychopathology in children with intellectual disability. Journal of Child Psychology & Psychiatry, 41, 407–417.CrossRef Dykens, E. M. (2000). Psychopathology in children with intellectual disability. Journal of Child Psychology & Psychiatry, 41, 407–417.CrossRef
go back to reference Fowles, D. C., Christie, M. J., Edelberg, R., Grings, W. W., Lykken, D. T., & Venables, P. H. (1981). Publication recommendations for electrodermal measurements. Psychophysiology, 18, 232–239.PubMedCrossRef Fowles, D. C., Christie, M. J., Edelberg, R., Grings, W. W., Lykken, D. T., & Venables, P. H. (1981). Publication recommendations for electrodermal measurements. Psychophysiology, 18, 232–239.PubMedCrossRef
go back to reference Hagerman, R. J. (2002). The physical and behavioral phenotype. In R. J. Hagerman & P. J. Hagerman (Eds.) Fragile X syndrome: Diagnosis, treatment, and research (3rd ed., pp. 206–248). Baltimore: Johns Hopkins University Press. Hagerman, R. J. (2002). The physical and behavioral phenotype. In R. J. Hagerman & P. J. Hagerman (Eds.) Fragile X syndrome: Diagnosis, treatment, and research (3rd ed., pp. 206–248). Baltimore: Johns Hopkins University Press.
go back to reference Hansen, A. L., Johnsen, B. H., & Thayer, J. F. (2003). Vagal influence on working memory and attention. International Journal of Psychophysiology, 48, 263–74.PubMedCrossRef Hansen, A. L., Johnsen, B. H., & Thayer, J. F. (2003). Vagal influence on working memory and attention. International Journal of Psychophysiology, 48, 263–74.PubMedCrossRef
go back to reference Hessl, D., Glaser, B., Dyer-Friedman, J., Blasey, C., Hastie, T., Gunnar, M., et al. (2002). Cortisol and behavior in fragile X syndrome. Psychoneuroendocinology, 27, 855–72.CrossRef Hessl, D., Glaser, B., Dyer-Friedman, J., Blasey, C., Hastie, T., Gunnar, M., et al. (2002). Cortisol and behavior in fragile X syndrome. Psychoneuroendocinology, 27, 855–72.CrossRef
go back to reference Hook, E. B., & Warburton, D. (1983). The distribution of chromosomal genotypes associated with Turner’s syndrome: Livebirth prevalence rates and evidence for diminished fetal mortality and severity in genotypes associated with structural X abnormalities or mosaicism. Human Genetics, 64, 24–27.PubMedCrossRef Hook, E. B., & Warburton, D. (1983). The distribution of chromosomal genotypes associated with Turner’s syndrome: Livebirth prevalence rates and evidence for diminished fetal mortality and severity in genotypes associated with structural X abnormalities or mosaicism. Human Genetics, 64, 24–27.PubMedCrossRef
go back to reference Keysor, C. S., & Mazzocco, M. M. M. (2002). A developmental approach to understanding fragile X syndrome in females. Microscopy Research and Technique, 57, 179–186.PubMedCrossRef Keysor, C. S., & Mazzocco, M. M. M. (2002). A developmental approach to understanding fragile X syndrome in females. Microscopy Research and Technique, 57, 179–186.PubMedCrossRef
go back to reference Keysor, C. S., Mazzocco, M. M., McLeod, D. R., & Hoehn-Saric, R. (2002). Physiological arousal in females with fragile X or Turner syndrome. Developmental Psychobiology, 41, 133–146.PubMedCrossRef Keysor, C. S., Mazzocco, M. M., McLeod, D. R., & Hoehn-Saric, R. (2002). Physiological arousal in females with fragile X or Turner syndrome. Developmental Psychobiology, 41, 133–146.PubMedCrossRef
go back to reference Kwon, H., Menon, V., Eliez, S., Warsofsky, I. S., White, C. D., Dyer-Friedman, J., et al. (2001). Functional neuroanatomy of visuospatial working memory in fragile X syndrome: relation to behavioral and molecular measures. American Journal of Psychiatry, 158, 1040–1051.PubMedCrossRef Kwon, H., Menon, V., Eliez, S., Warsofsky, I. S., White, C. D., Dyer-Friedman, J., et al. (2001). Functional neuroanatomy of visuospatial working memory in fragile X syndrome: relation to behavioral and molecular measures. American Journal of Psychiatry, 158, 1040–1051.PubMedCrossRef
go back to reference Mazzocco, M. M. M. (2006). The cognitive phenotype of Turner syndrome: Specific learning disabilities. International Congress Series, 1298, 83–92.CrossRef Mazzocco, M. M. M. (2006). The cognitive phenotype of Turner syndrome: Specific learning disabilities. International Congress Series, 1298, 83–92.CrossRef
go back to reference McCauley, E., Feuillan, P., Kushner, H., & Ross, J. L. (2001). Psychosocial development in adolescents with Turner syndrome. Journal of Behavioral and Developmental Pediatrics, 22, 360–365. McCauley, E., Feuillan, P., Kushner, H., & Ross, J. L. (2001). Psychosocial development in adolescents with Turner syndrome. Journal of Behavioral and Developmental Pediatrics, 22, 360–365.
go back to reference McLeod, D. R., Hoehn-Saric, R., Labib, A. S., & Greenblatt, D. J. (1988). Six weeks of diazepam treatment in normal women: Effects on psychomotor performance and psychophysiology. Journal of Clinical Psychopharmacology, 8, 83–99.PubMedCrossRef McLeod, D. R., Hoehn-Saric, R., Labib, A. S., & Greenblatt, D. J. (1988). Six weeks of diazepam treatment in normal women: Effects on psychomotor performance and psychophysiology. Journal of Clinical Psychopharmacology, 8, 83–99.PubMedCrossRef
go back to reference Miller, L. J., McIntosh, D. N., McGrath, J., Shyu, V., Lampe, M., Taylor, A. K., et al. (1999). Electrodermal responses to sensory stimuli in individuals with fragile X syndrome: a preliminary report. American Journal of Medical Genetics, 4, 268–279.CrossRef Miller, L. J., McIntosh, D. N., McGrath, J., Shyu, V., Lampe, M., Taylor, A. K., et al. (1999). Electrodermal responses to sensory stimuli in individuals with fragile X syndrome: a preliminary report. American Journal of Medical Genetics, 4, 268–279.CrossRef
go back to reference Porges, S. W. (1985, April). Method and apparatus for evaluating rhythmic oscillations in aperiodic physiological response systems. U. S. Patent 451 0944. Porges, S. W. (1985, April). Method and apparatus for evaluating rhythmic oscillations in aperiodic physiological response systems. U. S. Patent 451 0944.
go back to reference Reyes Del Paso, G. A., Gonzalez, E., & Hernandez, J. A. (2004). Baroreceptor sensitivity and effectiveness varies differentially as a function of cognitive-attentional demands. Biological Psychology, 67, 385–395.CrossRef Reyes Del Paso, G. A., Gonzalez, E., & Hernandez, J. A. (2004). Baroreceptor sensitivity and effectiveness varies differentially as a function of cognitive-attentional demands. Biological Psychology, 67, 385–395.CrossRef
go back to reference Roberts, J. E., Boccia, M. L., Bailey, D. B., Hatton, D. H., & Skinner, M. (2001). Cardiovascular indices of psychophysiological arousal in boys with fragile X syndrome. Developmental Psychobiology, 39, 107–123.PubMedCrossRef Roberts, J. E., Boccia, M. L., Bailey, D. B., Hatton, D. H., & Skinner, M. (2001). Cardiovascular indices of psychophysiological arousal in boys with fragile X syndrome. Developmental Psychobiology, 39, 107–123.PubMedCrossRef
go back to reference Rousseau, F., Heitz, D., Tarleton, J., MacPherson, J., Malmgren, H., Dahl, N., et al. (1994). A multicenter study on genotype-phenotype correlations in the fragile X syndrome, using direct diagnosis with probe StB12.3: the first 2,253 cases. American Journal of Human Genetics, 55, 225–237.PubMed Rousseau, F., Heitz, D., Tarleton, J., MacPherson, J., Malmgren, H., Dahl, N., et al. (1994). A multicenter study on genotype-phenotype correlations in the fragile X syndrome, using direct diagnosis with probe StB12.3: the first 2,253 cases. American Journal of Human Genetics, 55, 225–237.PubMed
go back to reference Rypman, B., Berger, J. S., Genova, H. M., Rebbechi, D., & D’Esposito, M. (2005). Dissociating age-related changed in cognitive strategy and neural efficiency using event-related fMRI. Cortex, 41, 582–594. Rypman, B., Berger, J. S., Genova, H. M., Rebbechi, D., & D’Esposito, M. (2005). Dissociating age-related changed in cognitive strategy and neural efficiency using event-related fMRI. Cortex, 41, 582–594.
go back to reference Skuse, D. H., Morris, J. S., & Dolan, R. J. (2005). Functional dissociation of amygdala-modulated arousal and cognitive appraisal, in Turner syndrome. Brain, 128, 2084–2096.PubMedCrossRef Skuse, D. H., Morris, J. S., & Dolan, R. J. (2005). Functional dissociation of amygdala-modulated arousal and cognitive appraisal, in Turner syndrome. Brain, 128, 2084–2096.PubMedCrossRef
go back to reference Tamm, L., Menon, V., Johnston, C. K., Hessl, D. R., & Reiss, A. L. (2002). fMRI study of cognitive interference processing in females with fragile X syndrome. Journal of Cognitive Neuroscience, 14, 160–171.PubMedCrossRef Tamm, L., Menon, V., Johnston, C. K., Hessl, D. R., & Reiss, A. L. (2002). fMRI study of cognitive interference processing in females with fragile X syndrome. Journal of Cognitive Neuroscience, 14, 160–171.PubMedCrossRef
go back to reference Turner, G., Webb, T., Wake, S., & Robinson, H. (1996). Prevalence of the fragile X syndrome. American Journal of Medical Genetics, 64, 196–197.PubMedCrossRef Turner, G., Webb, T., Wake, S., & Robinson, H. (1996). Prevalence of the fragile X syndrome. American Journal of Medical Genetics, 64, 196–197.PubMedCrossRef
Metagegevens
Titel
Arousal Modulation in Females with Fragile X or Turner Syndrome
Auteurs
Jane Roberts
Michèle M. M. Mazzocco
Melissa M. Murphy
Rudolf Hoehn-Saric
Publicatiedatum
01-01-2008
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 1/2008
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-007-0356-6