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Journal of Autism and Developmental Disorders

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01-01-2008 | Brief Communication

Brief Report: Plasma Leptin Levels are Elevated in Autism: Association with Early Onset Phenotype?

Auteurs: Paul Ashwood, Christina Kwong, Robin Hansen, Irva Hertz-Picciotto, Lisa Croen, Paula Krakowiak, Wynn Walker, Isaac N. Pessah, Judy Van de Water

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 1/2008

Abstract

There is evidence of both immune dysregulation and autoimmune phenomena in children with autism spectrum disorders (ASD). We examined the hormone/cytokine leptin in 70 children diagnosed with autism (including 37 with regression) compared with 99 age-matched controls including 50 typically developing (TD) controls, 26 siblings without autism, and 23 children with developmental disabilities (DD). Children with autism had significantly higher plasma leptin levels compared with TD controls (p < .006). When further sub-classified into regression or early onset autism, children with early onset autism had significantly higher plasma leptin levels compared with children with regressive autism (p < .042), TD controls (p < .0015), and DD controls (p < .004). We demonstrated an increase in leptin levels in autism, a finding driven by the early onset group.

vorige artikel Narrative Role-Taking in Autism

volgende artikel Brief Report: Adults with Mild Autism Spectrum Disorders (ASD): Scores on the Autism Spectrum Quotient (AQ) and Comorbid Psychopathology

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Titel: Brief Report: Plasma Leptin Levels are Elevated in Autism: Association with Early Onset Phenotype?
Auteurs: Paul Ashwood
Christina Kwong
Robin Hansen
Irva Hertz-Picciotto
Lisa Croen
Paula Krakowiak
Wynn Walker
Isaac N. Pessah
Judy Van de Water
Publicatiedatum: 01-01-2008
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 1/2008
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-006-0353-1

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