Swipe om te navigeren naar een ander artikel
Anemia is a predictor of mortality and of self-rated health (SRH). However, studies on the relationship between SRH and changes in hemoglobin (Hb) value over time stratified by chronic kidney disease (CKD) stages are lacking. The aim is to explore whether a change in Hb-value over time associates with SRH at up to 8-year follow-up, stratified for CKD stages.
A prospective study with a baseline measurement between the 3rd and 12th month after KT was performed on 337 consecutive patients. Demographic and clinical data were retrieved from medical records. CKD stages were estimated using the CKD-EPI formula and divided into two groups: CKD1–2 and CKD3–5. Generalized estimating equations (GEE) were performed to identify associations of SRH at follow-up in both CKD groups.
Male gender, new-onset diabetes mellitus after KT (NODAT), a decrease in estimated glomerular filtration rate (eGFR) and Hb-value over time contributed significantly to the GEE model on SRH at follow-up in CKD1–2. For SRH at follow-up in CKD3–5, older age, male gender and chronic renal allograft dysfunction (CRAD) contributed significantly to the GEE model.
At up to 8-year follow-up, male gender, NODAT, a decrease in eGFR and Hb-value over time are associated with poorer SRH in CKD1–2. In such patients, we suggest monitoring slight deteriorations in eGFR and Hb-values. In CKD3–5, higher age, male gender and higher presence of CRAD are associated with poorer SRH at up to 8-year follow-up. In these patients, adequate treatment would slow down CRAD progression.
Log in om toegang te krijgen
Met onderstaand(e) abonnement(en) heeft u direct toegang:
World Health Organization. (2011). Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity (p. 6). Geneva: World Health Organization.
Eknoyan, G., Lameire, N., Eckardt, K. U., et al. (2012). KDIGO clinical practice guideline for anemia in chronic kidney disease. Kidney International Supplements, 2(4), 64.
Kidney disease: Improving Global Outcomes (KDIGO) Transplant Work Group. (2009). KDIGO clinical practice guideline for the care of kidney transplant recipients. American Journal of Transplantation, 9(Suppl 3), S1–S157.
De Salvo, K. B., Bloser, N., Reynolds, K., He, J., & Muntner, P. (2006). Mortality prediction with a single general self-rated health question. A meta-analysis. Journal of General Internal Medicine, 21, 267–275. (1525-1497; 3). CrossRef
Christian, L. M., Glaser, R., Porter, K., Malarkey, W. B., Beversdorf, D., & Kiecolt-Glaser, J. K. (2011). Poorer self-rated health is associated with elevated inflammatory markers among older adults. Psychoneuroendocrino, 36(10), 1495–1504. CrossRef
Bolin, P., Gandra, S. R., Scarlata, D., Petersen, J., & Bloom, R. D. (2011). Impact on health-related quality of life in kidney transplant recipients with late posttransplant anemia administered darbepoetin alfa: Results from the STRATA study. Transplantation Proceedings, 43(5), 1593–1600. PubMedCrossRef
Iseki, K., & Kohagura, K. (2007). Anemia as a risk factor for chronic kidney disease. Kidney International, 72(1), 4–9. CrossRef
Nagyova, I. (2009). Measuring health and quality of life in the chronically ill (p. 267). Kosice: EQUILIBRIA.
Gomez-Besteiro, M. I., Santiago-Perez, M. I., Alonso-Hernandez, A., Valdes-Canedo, F., & Rebollo-Alvarez, P. (2004). Validity and reliability of the SF-36 questionnaire in patients on the waiting list for a kidney transplant and transplant patients. American Journal of Nephrology, 24, 346–351. (0250-8095; 0250-8095; 3). PubMedCrossRef
Ratcliffe, S. J., & Shults, J. (2008). GEEQBOX: A MATLAB toolbox for generalized estimating equations and quasi-least squares. Journal of Statistical Software, 25(14), 1–14. CrossRef
Augustine, J. J., Knauss, T. C., Schulak, J. A., Bodziak, K. A., Siegel, C., & Hricik, D. E. (2002). Comparative effect of sirolimus and mycophenolate mofetil on erythropoiesis in kidney transplant patients. American Journal of Transplantation, 4, 2001–2006. CrossRef
Rebollo, P., Baltar, J. M., Campistol, J. M., Ortega, T., & Ortega, F. (2004). Quality of life of patients with chronic renal allograft rejection and anemia. J Nephrology, 17, 531–536. (1121-8428; 4).
- Anemia has a negative impact on self-rated health in kidney transplant recipients with well-functioning grafts: findings from an 8-year follow-up study
Johan W. Groothoff
Jitse P. van Dijk
- Springer International Publishing