Skip to main content
main-content
Top

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in: Quality of Life Research 1/2016

14-07-2015

Anemia has a negative impact on self-rated health in kidney transplant recipients with well-functioning grafts: findings from an 8-year follow-up study

Auteurs: Maria Majernikova, Jaroslav Rosenberger, Lucia Prihodova, Daniele Marcelli, Robert Roland, Johan W. Groothoff, Jitse P. van Dijk

Gepubliceerd in: Quality of Life Research | Uitgave 1/2016

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Purpose

Anemia is a predictor of mortality and of self-rated health (SRH). However, studies on the relationship between SRH and changes in hemoglobin (Hb) value over time stratified by chronic kidney disease (CKD) stages are lacking. The aim is to explore whether a change in Hb-value over time associates with SRH at up to 8-year follow-up, stratified for CKD stages.

Methods

A prospective study with a baseline measurement between the 3rd and 12th month after KT was performed on 337 consecutive patients. Demographic and clinical data were retrieved from medical records. CKD stages were estimated using the CKD-EPI formula and divided into two groups: CKD1–2 and CKD3–5. Generalized estimating equations (GEE) were performed to identify associations of SRH at follow-up in both CKD groups.

Results

Male gender, new-onset diabetes mellitus after KT (NODAT), a decrease in estimated glomerular filtration rate (eGFR) and Hb-value over time contributed significantly to the GEE model on SRH at follow-up in CKD1–2. For SRH at follow-up in CKD3–5, older age, male gender and chronic renal allograft dysfunction (CRAD) contributed significantly to the GEE model.

Conclusions

At up to 8-year follow-up, male gender, NODAT, a decrease in eGFR and Hb-value over time are associated with poorer SRH in CKD1–2. In such patients, we suggest monitoring slight deteriorations in eGFR and Hb-values. In CKD3–5, higher age, male gender and higher presence of CRAD are associated with poorer SRH at up to 8-year follow-up. In these patients, adequate treatment would slow down CRAD progression.
Literatuur
1.
go back to reference World Health Organization. (2011). Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity (p. 6). Geneva: World Health Organization. World Health Organization. (2011). Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity (p. 6). Geneva: World Health Organization.
2.
go back to reference Eknoyan, G., Lameire, N., Eckardt, K. U., et al. (2012). KDIGO clinical practice guideline for anemia in chronic kidney disease. Kidney International Supplements, 2(4), 64. Eknoyan, G., Lameire, N., Eckardt, K. U., et al. (2012). KDIGO clinical practice guideline for anemia in chronic kidney disease. Kidney International Supplements, 2(4), 64.
3.
4.
go back to reference Kidney disease: Improving Global Outcomes (KDIGO) Transplant Work Group. (2009). KDIGO clinical practice guideline for the care of kidney transplant recipients. American Journal of Transplantation, 9(Suppl 3), S1–S157. Kidney disease: Improving Global Outcomes (KDIGO) Transplant Work Group. (2009). KDIGO clinical practice guideline for the care of kidney transplant recipients. American Journal of Transplantation, 9(Suppl 3), S1–S157.
5.
go back to reference Ponticelli, C., Morales, J., Abramowicz, D., Baboolal, K., & Vanrenterghem, Y. (2003). Prevalence and management of anemia in renal transplant recipients: A European survey. American Journal of Transplantation, 3(7), 835–845. PubMedCrossRef Ponticelli, C., Morales, J., Abramowicz, D., Baboolal, K., & Vanrenterghem, Y. (2003). Prevalence and management of anemia in renal transplant recipients: A European survey. American Journal of Transplantation, 3(7), 835–845. PubMedCrossRef
6.
go back to reference Benjamins, M. R., Hummer, R. A., Eberstein, I. W., & Nam, C. B. (2004). Self-reported health and adult mortality risk: An analysis of cause-specific mortality. Social Science and Medicine, 59, 1297–1306. (0277-9536; 6). PubMedCrossRef Benjamins, M. R., Hummer, R. A., Eberstein, I. W., & Nam, C. B. (2004). Self-reported health and adult mortality risk: An analysis of cause-specific mortality. Social Science and Medicine, 59, 1297–1306. (0277-9536; 6). PubMedCrossRef
7.
go back to reference Spiegel, B. M. R., Melmed, G., Robbins, S., & Esrailian, E. (2008). Biomarkers and health-related quality of life in end-stage renal disease: A systematic review. Clinical Journal of the American Society of Nephrology, 3(6), 1759–1768. PubMedPubMedCentralCrossRef Spiegel, B. M. R., Melmed, G., Robbins, S., & Esrailian, E. (2008). Biomarkers and health-related quality of life in end-stage renal disease: A systematic review. Clinical Journal of the American Society of Nephrology, 3(6), 1759–1768. PubMedPubMedCentralCrossRef
8.
go back to reference De Salvo, K. B., Bloser, N., Reynolds, K., He, J., & Muntner, P. (2006). Mortality prediction with a single general self-rated health question. A meta-analysis. Journal of General Internal Medicine, 21, 267–275. (1525-1497; 3). CrossRef De Salvo, K. B., Bloser, N., Reynolds, K., He, J., & Muntner, P. (2006). Mortality prediction with a single general self-rated health question. A meta-analysis. Journal of General Internal Medicine, 21, 267–275. (1525-1497; 3). CrossRef
9.
go back to reference Christian, L. M., Glaser, R., Porter, K., Malarkey, W. B., Beversdorf, D., & Kiecolt-Glaser, J. K. (2011). Poorer self-rated health is associated with elevated inflammatory markers among older adults. Psychoneuroendocrino, 36(10), 1495–1504. CrossRef Christian, L. M., Glaser, R., Porter, K., Malarkey, W. B., Beversdorf, D., & Kiecolt-Glaser, J. K. (2011). Poorer self-rated health is associated with elevated inflammatory markers among older adults. Psychoneuroendocrino, 36(10), 1495–1504. CrossRef
10.
go back to reference Rebollo, P., Ortega, F., Baltar, J. M., et al. (1998). Health-related quality of life (HRQOL) in end stage renal disease (ESRD) patients over 65 years. Geriatric Nephrology and Urology, 8, 85–94. (0924-8455; 2). PubMedCrossRef Rebollo, P., Ortega, F., Baltar, J. M., et al. (1998). Health-related quality of life (HRQOL) in end stage renal disease (ESRD) patients over 65 years. Geriatric Nephrology and Urology, 8, 85–94. (0924-8455; 2). PubMedCrossRef
11.
go back to reference Thong, M. S. Y., Kaptein, A. A., Benyamini, Y., Krediet, R. T., Boeschoten, E. W., & Dekker, F. W. (2008). Association between a self-rated health question and mortality in young and old dialysis patients: A cohort study. American Journal of Kidney Diseases, 52(1), 111–117. PubMedCrossRef Thong, M. S. Y., Kaptein, A. A., Benyamini, Y., Krediet, R. T., Boeschoten, E. W., & Dekker, F. W. (2008). Association between a self-rated health question and mortality in young and old dialysis patients: A cohort study. American Journal of Kidney Diseases, 52(1), 111–117. PubMedCrossRef
12.
go back to reference Majernikova, M., Rosenberger, J., Prihodova, L., Nagyova, I., Roland, R., Groothoff, J. W., & van Dijk, J. P. (2012). Self-rated health predicts mortality and graft loss after kidney transplantation: A 10-year follow-up study. American Journal of Nephrology, 36(5), 459–465. PubMedCrossRef Majernikova, M., Rosenberger, J., Prihodova, L., Nagyova, I., Roland, R., Groothoff, J. W., & van Dijk, J. P. (2012). Self-rated health predicts mortality and graft loss after kidney transplantation: A 10-year follow-up study. American Journal of Nephrology, 36(5), 459–465. PubMedCrossRef
13.
go back to reference Saracino, A., Gollo, I., Di Noia, I., et al. (2008). Loss of renal function is associated with deterioration of health-related quality of life in kidney transplant patients. Transplantation Proceedings, 40, 3460–3465. (0041-1345; 10). PubMedCrossRef Saracino, A., Gollo, I., Di Noia, I., et al. (2008). Loss of renal function is associated with deterioration of health-related quality of life in kidney transplant patients. Transplantation Proceedings, 40, 3460–3465. (0041-1345; 10). PubMedCrossRef
14.
go back to reference Majernikova, M., Prihodova, L., Rosenberger, J., Nagyova, I., Roland, R., Groothoff, J. W., & van Dijk, J. P. (2011). Factors associated with self-rated health after kidney transplantation: A prospective study. American Journal of Nephrology, 33(4), 364–369. PubMedCrossRef Majernikova, M., Prihodova, L., Rosenberger, J., Nagyova, I., Roland, R., Groothoff, J. W., & van Dijk, J. P. (2011). Factors associated with self-rated health after kidney transplantation: A prospective study. American Journal of Nephrology, 33(4), 364–369. PubMedCrossRef
15.
go back to reference Bolin, P., Gandra, S. R., Scarlata, D., Petersen, J., & Bloom, R. D. (2011). Impact on health-related quality of life in kidney transplant recipients with late posttransplant anemia administered darbepoetin alfa: Results from the STRATA study. Transplantation Proceedings, 43(5), 1593–1600. PubMedCrossRef Bolin, P., Gandra, S. R., Scarlata, D., Petersen, J., & Bloom, R. D. (2011). Impact on health-related quality of life in kidney transplant recipients with late posttransplant anemia administered darbepoetin alfa: Results from the STRATA study. Transplantation Proceedings, 43(5), 1593–1600. PubMedCrossRef
16.
go back to reference Iseki, K., & Kohagura, K. (2007). Anemia as a risk factor for chronic kidney disease. Kidney International, 72(1), 4–9. CrossRef Iseki, K., & Kohagura, K. (2007). Anemia as a risk factor for chronic kidney disease. Kidney International, 72(1), 4–9. CrossRef
17.
go back to reference Revicki, D. A., Brown, R. E., Feeny, D. H., et al. (1995). Health-related quality of life associated with recombinant human erythropoietin therapy for predialysis chronic renal disease patients. American Journal of Kidney Diseases, 25(4), 548–554. PubMedCrossRef Revicki, D. A., Brown, R. E., Feeny, D. H., et al. (1995). Health-related quality of life associated with recombinant human erythropoietin therapy for predialysis chronic renal disease patients. American Journal of Kidney Diseases, 25(4), 548–554. PubMedCrossRef
18.
go back to reference Choukroun, G., Kamar, N., Dussol, B., et al. (2012). Correction of postkidney transplant anemia reduces progression of allograft nephropathy. Journal of the American Society of Nephrology, 23(2), 360–368. PubMedPubMedCentralCrossRef Choukroun, G., Kamar, N., Dussol, B., et al. (2012). Correction of postkidney transplant anemia reduces progression of allograft nephropathy. Journal of the American Society of Nephrology, 23(2), 360–368. PubMedPubMedCentralCrossRef
19.
go back to reference Molnar, M. Z., Mucsi, I., Macdougall, I. C., et al. (2011). Prevalence and management of anaemia in renal transplant recipients: Data from ten European centres. Nephron Clinical Practice, 117(2), C127–C134. PubMedCrossRef Molnar, M. Z., Mucsi, I., Macdougall, I. C., et al. (2011). Prevalence and management of anaemia in renal transplant recipients: Data from ten European centres. Nephron Clinical Practice, 117(2), C127–C134. PubMedCrossRef
20.
go back to reference Wolfe, R. A., Ashby, V. B., Milford, E. L., et al. (1999). Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. New England Journal of Medicine, 341, 1725–1730. (0028-4793; 23). PubMedCrossRef Wolfe, R. A., Ashby, V. B., Milford, E. L., et al. (1999). Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. New England Journal of Medicine, 341, 1725–1730. (0028-4793; 23). PubMedCrossRef
21.
go back to reference Laupacis, A., Keown, P., Pus, N., et al. (1996). A study of the quality of life and cost-utility of renal transplantation. Kidney International, 50, 235–242. (0085-2538; 1). PubMedCrossRef Laupacis, A., Keown, P., Pus, N., et al. (1996). A study of the quality of life and cost-utility of renal transplantation. Kidney International, 50, 235–242. (0085-2538; 1). PubMedCrossRef
22.
go back to reference Drent, G., Moon, P., De Geest, S., Kleibeuker, J. H., & Haagsma, E. B. (2008). Symptom experience associated with immunosuppressive drugs after liver transplantation in adults: Possible relationship with medication non-compliance? Clinical Transplantation, 22(6), 700–709. PubMedCrossRef Drent, G., Moon, P., De Geest, S., Kleibeuker, J. H., & Haagsma, E. B. (2008). Symptom experience associated with immunosuppressive drugs after liver transplantation in adults: Possible relationship with medication non-compliance? Clinical Transplantation, 22(6), 700–709. PubMedCrossRef
23.
go back to reference Ware, J. E, Jr, & Sherbourne, C. D. (1992). The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Medical Care, 30, 473–483. (0025-7079; 6). PubMedCrossRef Ware, J. E, Jr, & Sherbourne, C. D. (1992). The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Medical Care, 30, 473–483. (0025-7079; 6). PubMedCrossRef
24.
go back to reference Mantzavinis, G. D. (2005). Multivariate models of self-reported health often neglected essential candidate determinants and methodological issues. Journal of Clinical Epidemiology, 58(5), 436–443. PubMedCrossRef Mantzavinis, G. D. (2005). Multivariate models of self-reported health often neglected essential candidate determinants and methodological issues. Journal of Clinical Epidemiology, 58(5), 436–443. PubMedCrossRef
25.
go back to reference Ware, J. (1998). Overview of the SF-36 health survey and the international quality of life assessment (IQOLA) project. Journal of Clinical Epidemiology, 51(11), 903–912. PubMedCrossRef Ware, J. (1998). Overview of the SF-36 health survey and the international quality of life assessment (IQOLA) project. Journal of Clinical Epidemiology, 51(11), 903–912. PubMedCrossRef
26.
go back to reference Nagyova, I. (2009). Measuring health and quality of life in the chronically ill (p. 267). Kosice: EQUILIBRIA. Nagyova, I. (2009). Measuring health and quality of life in the chronically ill (p. 267). Kosice: EQUILIBRIA.
27.
go back to reference Wight, J. P., Edwards, L., Brazier, J., Walters, S., Payne, J. N., & Brown, C. B. (1998). The SF36 as an outcome measure of services for end stage renal failure. Qual Health Care, 7, 209–221. (0963-8172; 4). PubMedPubMedCentralCrossRef Wight, J. P., Edwards, L., Brazier, J., Walters, S., Payne, J. N., & Brown, C. B. (1998). The SF36 as an outcome measure of services for end stage renal failure. Qual Health Care, 7, 209–221. (0963-8172; 4). PubMedPubMedCentralCrossRef
28.
go back to reference Gomez-Besteiro, M. I., Santiago-Perez, M. I., Alonso-Hernandez, A., Valdes-Canedo, F., & Rebollo-Alvarez, P. (2004). Validity and reliability of the SF-36 questionnaire in patients on the waiting list for a kidney transplant and transplant patients. American Journal of Nephrology, 24, 346–351. (0250-8095; 0250-8095; 3). PubMedCrossRef Gomez-Besteiro, M. I., Santiago-Perez, M. I., Alonso-Hernandez, A., Valdes-Canedo, F., & Rebollo-Alvarez, P. (2004). Validity and reliability of the SF-36 questionnaire in patients on the waiting list for a kidney transplant and transplant patients. American Journal of Nephrology, 24, 346–351. (0250-8095; 0250-8095; 3). PubMedCrossRef
29.
go back to reference Levey, A. S., & Stevens, L. A. (2010). Estimating GFR using the CKD epidemiology collaboration (CKD-EPI) creatinine equation: More accurate GFR estimates, lower CKD prevalence estimates, and better risk predictions. American Journal of Kidney Diseases, 55(4), 622–627. PubMedPubMedCentralCrossRef Levey, A. S., & Stevens, L. A. (2010). Estimating GFR using the CKD epidemiology collaboration (CKD-EPI) creatinine equation: More accurate GFR estimates, lower CKD prevalence estimates, and better risk predictions. American Journal of Kidney Diseases, 55(4), 622–627. PubMedPubMedCentralCrossRef
30.
go back to reference Sis, B., Mengel, M., Haas, M., et al. (2010). Banff ‘09 meeting report: Antibody mediated graft deterioration and implementation of banff working groups. American Journal of Transplantation, 10(3), 464–471. PubMedCrossRef Sis, B., Mengel, M., Haas, M., et al. (2010). Banff ‘09 meeting report: Antibody mediated graft deterioration and implementation of banff working groups. American Journal of Transplantation, 10(3), 464–471. PubMedCrossRef
31.
go back to reference Ratcliffe, S. J., & Shults, J. (2008). GEEQBOX: A MATLAB toolbox for generalized estimating equations and quasi-least squares. Journal of Statistical Software, 25(14), 1–14. CrossRef Ratcliffe, S. J., & Shults, J. (2008). GEEQBOX: A MATLAB toolbox for generalized estimating equations and quasi-least squares. Journal of Statistical Software, 25(14), 1–14. CrossRef
32.
go back to reference Hubbard, A. E., Ahern, J., Fleischer, N. L., et al. (2010). To GEE or not to GEE comparing population average and mixed models for estimating the associations between neighborhood risk factors and health. Epidemiology, 21(4), 467–474. PubMedCrossRef Hubbard, A. E., Ahern, J., Fleischer, N. L., et al. (2010). To GEE or not to GEE comparing population average and mixed models for estimating the associations between neighborhood risk factors and health. Epidemiology, 21(4), 467–474. PubMedCrossRef
33.
go back to reference Kewalramani, R., Agodoa, I., Globe, D., & Alexander, M. (2007). Association of anemia correction with health related quality of life in patients not on dialysis. Current Medical Research and Opinion, 23(12), 2997–3008. PubMedCrossRef Kewalramani, R., Agodoa, I., Globe, D., & Alexander, M. (2007). Association of anemia correction with health related quality of life in patients not on dialysis. Current Medical Research and Opinion, 23(12), 2997–3008. PubMedCrossRef
34.
go back to reference Augustine, J. J., Knauss, T. C., Schulak, J. A., Bodziak, K. A., Siegel, C., & Hricik, D. E. (2002). Comparative effect of sirolimus and mycophenolate mofetil on erythropoiesis in kidney transplant patients. American Journal of Transplantation, 4, 2001–2006. CrossRef Augustine, J. J., Knauss, T. C., Schulak, J. A., Bodziak, K. A., Siegel, C., & Hricik, D. E. (2002). Comparative effect of sirolimus and mycophenolate mofetil on erythropoiesis in kidney transplant patients. American Journal of Transplantation, 4, 2001–2006. CrossRef
35.
go back to reference Ravindran, V., Baboolal, K., & Moore, R. (2004). Post transplant diabetes mellitus after renal transplantation: The emerging clinical challenge. Yonsei Medical Journal, 45(6), 1059–1064. PubMedCrossRef Ravindran, V., Baboolal, K., & Moore, R. (2004). Post transplant diabetes mellitus after renal transplantation: The emerging clinical challenge. Yonsei Medical Journal, 45(6), 1059–1064. PubMedCrossRef
36.
go back to reference Rebollo, P., Baltar, J. M., Campistol, J. M., Ortega, T., & Ortega, F. (2004). Quality of life of patients with chronic renal allograft rejection and anemia. J Nephrology, 17, 531–536. (1121-8428; 4). Rebollo, P., Baltar, J. M., Campistol, J. M., Ortega, T., & Ortega, F. (2004). Quality of life of patients with chronic renal allograft rejection and anemia. J Nephrology, 17, 531–536. (1121-8428; 4).
Metagegevens
Titel
Anemia has a negative impact on self-rated health in kidney transplant recipients with well-functioning grafts: findings from an 8-year follow-up study
Auteurs
Maria Majernikova
Jaroslav Rosenberger
Lucia Prihodova
Daniele Marcelli
Robert Roland
Johan W. Groothoff
Jitse P. van Dijk
Publicatiedatum
14-07-2015
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 1/2016
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-015-1067-7