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23-09-2020 | Uitgave 3/2021

Quality of Life Research 3/2021

A head-to-head comparison of measurement properties of the EQ-5D-3L and EQ-5D-5L in acute myeloid leukemia patients

Tijdschrift:
Quality of Life Research > Uitgave 3/2021
Auteurs:
Hongjuan Yu, Xueyun Zeng, Mingjie Sui, Rui Liu, Rachel Lee-Yin Tan, Jinjin Yang, Weidong Huang, Nan Luo
Belangrijke opmerkingen
Hongjuan Yu, Xueyun Zeng and Mingjie Sui contributed equally to this article. They are co-first authors.

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Abstract

Purpose

This study aimed to compare the measurement properties of EQ-5D-3L(3L) and EQ-5D-5L(5L) in patients with acute myeloid leukemia (AML) in China.

Methods

We consecutively recruited 168 patients with AML from three tertiary hospitals to complete two rounds of interviews using the two versions of the EQ-5D. We compared (i) the ceiling effect using the McNemar’s test, (ii) test–retest reliability using intraclass correlation coefficient (ICC) and Cohen’s weighted Kappa, (iii) convergent validity using Spearman’s rank correlation coefficient (r) and iv) discriminatory ability using F statistic and area under the receiver operating characteristics curve (AUROC) of the 5L and the 3L.

Results

The 5L descriptive system showed significantly lower ceiling effects in comparison to the 3L descriptive system (p < 0.001). While 5L showed superior reproducibility (Cohen’s weighted Kappa = 0.56–0.67 and ICC = 0.89), both instruments exhibited good test–retest reliability. Even though both 3L and 5L showed good convergent and known-groups validity, 5L showed better convergent validity and discriminatory ability.

Conclusion

The current study found both 3L and 5L to be suitable for use in AML patients. However, 5L showed superior measurement properties compared to 3L. Thus, 5L could be the preferred instrument over 3L for use in AML patients.

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