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17-10-2020 | Uitgave 3/2021 Open Access

Quality of Life Research 3/2021

Obtaining EQ-5D-5L utilities from the disease specific quality of life Alzheimer’s disease scale: development and results from a mapping study

Quality of Life Research > Uitgave 3/2021
Ines Rombach, Marvi Iftikhar, Gurleen S. Jhuti, Anders Gustavsson, Pascal Lecomte, Mark Belger, Ron Handels, Amparo Y. Castro Sanchez, Jan Kors, Louise Hopper, Marcel Olde Rikkert, Geir Selbæk, Astrid Stephan, Sietske A. M. Sikkes, Bob Woods, Manuel Gonçalves-Pereira, Orazio Zanetti, Inez H. G. B. Ramakers, Frans R. J. Verhey, John Gallacher, Actifcare Consortium, LeARN Consortium, Filipa Landeiro, Alastair M. Gray, ROADMAP Consortium
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The online version of this article (https://​doi.​org/​10.​1007/​s11136-020-02670-8) contains supplementary material, which is available to authorized users.
Ines Rombach, Marvi Iftikhar, Filipa Landeiro and Alastair M. Gray have contributed equally as joint first and joint senior authors.

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The Quality of Life Alzheimer’s Disease Scale (QoL-AD) is commonly used to assess disease specific health-related quality of life (HRQoL) as rated by patients and their carers. For cost-effectiveness analyses, utilities based on the EQ-5D are often required. We report a new mapping algorithm to obtain EQ-5D indices when only QoL-AD data are available.


Different statistical models to estimate utility directly, or responses to individual EQ-5D questions (response mapping) from QoL-AD, were trialled for patient-rated and proxy-rated questionnaires. Model performance was assessed by root mean square error and mean absolute error.


The response model using multinomial regression including age and sex, performed best in both the estimation dataset and an independent dataset.


The recommended mapping algorithm allows researchers for the first time to estimate EQ-5D values from QoL-AD data, enabling cost-utility analyses using datasets where the QoL-AD but no utility measures were collected.

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