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01-06-2009 | Interuniversity Cardiology Institute of the Netherlands

A genome wide association analysis in the GENDER study

Auteurs: M. L. Sampietro, D. Pons, P. de Knijff, P. E. Slagboom, A. H. Zwinderman, J. W. Jukema

Gepubliceerd in: Netherlands Heart Journal | Uitgave 6/2009

Abstract

Percutaneous coronary intervention (PCI) has become an effective therapy to treat coronary artery diseases. However, one of the major drawbacks of PCI is the occurrence of restenosis in 8 to 40% of all treated patients. The GENetic Determinants of Restenosis (GENDER) project was designed to study the association between genetic polymorphisims and clinical restenosis. The discovery of genetic variants associated to the occurrence of restenosis after PCI may provide a more tailored therapy and may serve as rationale for new antirestenotic therapies. So far, several candidate gene approaches had already been performed in the GENDER samples but a Genome Wide Association Scan (GWAS) was still lacking. Here, we present preliminary results from the GWAS we are currently carrying out in the GENDER population. (Neth Heart J 2009;17:262–4.)

vorige artikel The Caveats of drug-eluting stents – a critical appraisal of the safety concerns

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Titel: A genome wide association analysis in the GENDER study
Auteurs: M. L. Sampietro
D. Pons
P. de Knijff
P. E. Slagboom
A. H. Zwinderman
J. W. Jukema
Publicatiedatum: 01-06-2009
Uitgeverij: Bohn Stafleu van Loghum
Gepubliceerd in: Netherlands Heart Journal / Uitgave 6/2009
Print ISSN: 1568-5888
Elektronisch ISSN: 1876-6250
DOI: https://doi.org/10.1007/BF03086261

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