Skip to main content
main-content

Tip

Swipe om te navigeren naar een ander artikel

19-12-2017 | Uitgave 4/2018

Quality of Life Research 4/2018

Utility of a patient-reported outcome in measuring functional impairment during autologous stem cell transplant in patients with multiple myeloma

Tijdschrift:
Quality of Life Research > Uitgave 4/2018
Auteurs:
Nina Shah, Qiuling Shi, Sergio Giralt, Loretta Williams, Qaiser Bashir, Muzaffar Qazilbash, Richard E. Champlin, Charles S. Cleeland, Xin Shelley Wang
Belangrijke opmerkingen

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s11136-017-1759-2) contains supplementary material, which is available to authorized users.

Abstract

Background

We aimed to determine the utility of a patient-reported outcome (PRO) as it relates to patient performed testing (PPT) for measuring functional status in multiple myeloma patients after autologous hematopoietic stem cell transplantation (auto-HCT).

Methods

Symptom interference on walking (a PRO) was measured by the MD Anderson Symptom Inventory (MDASI). PPT was assessed via 6-min walk test (6MWT). Mixed effects modeling was used to examine (1) the longitudinal relationship between the MDASI score and 6MWT distance and (2) the MDASI scores between patients who did or did not complete the 6WMT. Receiver operating characteristic (ROC) curve analysis was performed to quantify the construct validity of the PRO by differentiating performance status.

Results

Seventy-nine patients were included. Mean 6MWT distance significantly correlated with MDASI-walking interference score (PRO) over the first month of auto-HCT (est = 6.09, p = 0.006). There was a significantly higher completion rate for MDASI versus 6MWT at each time point (p < 0.01). Patients who completed the 6MWT reported less interference on walking during the study period (est = 1.61, p < 0.0001). Finally, the PRO demonstrated significant construct validity for measuring functioning status with MDASI-walking against ECOG-PS as the anchor (AUC = 0.77, 95% CI 0.60–0.94, p = 0.003).

Conclusion

The PRO of MDASI-walking interference is a valid physical functioning measure, correlating with an objective functional measure (6MWT) in MM patients undergoing auto-HCT. As patients with poorer functional status during therapy are less likely to complete PPT, this PRO may offer a more practical quantitative measure of functioning in patients.

Log in om toegang te krijgen

Met onderstaand(e) abonnement(en) heeft u direct toegang:

BSL Podotherapeut Totaal

Binnen de bundel kunt u gebruik maken van boeken, tijdschriften, e-learnings, web-tv's en uitlegvideo's. BSL Podotherapeut Totaal is overal toegankelijk; via uw PC, tablet of smartphone.

Extra materiaal
Supplementary Figure 1. Example of MDASI daily symptom interference on module. Question 25 (red arrow) asked patients to rate interference with “walking” on a 0-10 scale (PDF 15 KB)
11136_2017_1759_MOESM1_ESM.pdf
Supplementary Figure 2. Kaplan-Meier analysis of overall survival, comparing patients who were able to perform the 6MWT versus those who were not at 5 days after auto-HCT. There was no significant difference in median overall survival between these groups (TIF 24917 KB)
11136_2017_1759_MOESM2_ESM.tif
Literatuur
Over dit artikel

Andere artikelen Uitgave 4/2018

Quality of Life Research 4/2018Naar de uitgave