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Quality of Life Research

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17-08-2022 | Review

Therapeutic massage/Tuina for treatment of functional dyspepsia: a systematic review and meta-analysis of randomized controlled trials

Auteurs: Ning Dai, Qingyun He, Xuehan Liu, Min Fang, Min Xiong, Xun Li, Duoduo Li, Jianping Liu

Gepubliceerd in: Quality of Life Research | Uitgave 3/2023

Abstract

Purpose

A systematic review of randomized controlled trials (RCTs) was conducted to assess the potential effect of therapeutic massage/Tuina on functional dyspepsia (FD) patients.

Method

Twelve databases and three clinical trial registries were searched until December 2021, for RCTs that compared Tuina combined with or without conventional therapy versus conventional therapy in FD. We assessed the methodological quality of included trials by the Cochrane Risk of Bias tool, and graded the quality of the evidence. The data were presented as risk ratio (RR) or mean difference (MD) respectively with their 95% confidence interval (CI).

Results

In total, 14 RCTs with 1128 FD participants were included. Compared with conventional therapy, Tuina showed significant beneficial effects on improving overall symptom (RR = 1.12, 95% CI 1.06 to 1.19, low certainty evidence), and early satiation (MD −0.44 scores, 95% CI −0.72 to −0.16, very low certainty evidence). Compared with conventional therapy, Tuina plus conventional therapy also significantly improved overall symptom (RR = 1.14, 95% CI 1.06–1.23, low certainty evidence), quality of life (MD 10.44 scores, 95% CI 7.65–13.23, low certainty evidence), and epigastric pain (MD −0.76 scores, 95% CI −1.11 to −0.41, low certainty evidence). No adverse events related to Tuina and cost-effectiveness were reported.

Conclusion

Low certainty evidence showed that Tuina significantly improved overall symptom of FD participants compared with conventional therapy. Low certainty evidence showed that Tuina plus conventional therapy obviously improved overall symptom and quality of life of FD participants compared with conventional therapy.

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Mahadeva, S., & Goh, K. L. (2006). Epidemiology of functional dyspepsia: A global perspective. World Gastroenterology, 17, 2661–2666. https://doi.org/10.3748/wjg.v12.i17.2661CrossRef

Yasser, S., & Hashem, B. E. S. (2004). the prevalence and risk factors of functional dyspepsia in a multiethnic population in the United States. The American journal of gastroenterology, 11, 2210–2216. https://doi.org/10.1111/j.1572-0241.2004.40052.xCrossRef

Lacy, B. E., Weiser, K. T., Kennedy, A. T., Crowell, M. D., & Talley, N. J. (2013). Functional dyspepsia: The economic impact to patients. Alimentary Pharmacology and Therapeutics, 38, 170–177. https://doi.org/10.1111/apt.12355CrossRefPubMed

El-Serag, H. B., & Talley, N. J. (2003). Health-related quality of life in functional dyspepsia. Alimentary Pharmacology & Therapeutics, 18(4), 387–393. https://doi.org/10.1046/j.0269-2813.2003.01706.xÓ2003CrossRef

Levy, R. L., Olden, K. W., Naliboff, B. D., Bradley, L. A., Francisconi, C., Drossman, D. A., & Creed, F. (2006). Psychosocial aspects of the functional gastrointestinal disorders. Gastroenterology, 130(5), 1447–1458. https://doi.org/10.1053/j.gastro.2005.11.057CrossRefPubMed

Talley, N. J., Locke, G. R., 3rd., Lahr, B. D., Zinsmeister, A. R., Tougas, G., Ligozio, G., Rojavin, M. A., & Tack, J. (2006). Functional dyspepsia, delayed gastric emptying, and impaired quality of life. Gut, 55(7), 933–939. https://doi.org/10.1136/gut.2005.078634CrossRefPubMedPubMedCentral

Talley, N. J. (1996). Quality of life in functional dyspepsia. Scandinavian Journal of Gastroenterology. Supplement, 221, 21–22. https://doi.org/10.3109/00365529609095547CrossRefPubMed

Welén, K., Faresjö, A., & Faresjö, T. (2008). Functional dyspepsia affects women more than men in daily life: A case-control study in primary care. Gender medicine, 5(1), 62–73. https://doi.org/10.1016/s1550-8579(08)80009-5CrossRefPubMed

Haag, S., Senf, W., Häuser, W., Tagay, S., Grandt, D., Heuft, G., Gerken, G., Talley, N. J., & Holtmann, G. (2008). Impairment of health-related quality of life in functional dyspepsia and chronic liver disease: The influence of depression and anxiety. Alimentary Pharmacology & Therapeutics, 27(7), 561–571. https://doi.org/10.1111/j.1365-2036.2008.03619.xCrossRef

10.

Haag, S., Senf, W., Tagay, S., Heuft, G., Gerken, G., Talley, N. J., & Holtmann, G. (2010). Is there any association between disturbed gastrointestinal visceromotor and sensory function and impaired quality of life in functional dyspepsia? Neurogastroenterology and Motility : The Official Journal of the European Gastrointestinal Motility Society, 22(3), 262-e79. https://doi.org/10.1111/j.1365-2982.2009.01415.xCrossRefPubMed

11.

Gutiérrez, A., Rodrigo, L., Riestra, S., Fernández, E., Cadahia, V., Tojo, R., Fuentes, D., Niño, P., & Olcoz, J. L. (2003). Quality of life in patients with functional dyspepsia: A prospective 1-year follow-up study in Spanish patients. European Journal of Gastroenterology & Hepatology, 15(11), 1175–1181. https://doi.org/10.1097/00042737-200311000-00005CrossRef

12.

Aro, P., Talley, N. J., Agréus, L., Johansson, S. E., Bolling-Sternevald, E., Storskrubb, T., & Ronkainen, J. (2011). Functional dyspepsia impairs quality of life in the adult population. Alimentary Pharmacology & Therapeutics, 33(11), 1215–1224. https://doi.org/10.1111/j.1365-2036.2011.04640.xCrossRef

13.

Liu, J. P., Yang, M., Liu, Y. X., Wei, M. L., & Grimsgaard, S. (2006). Herbal medicines for treatment of irritable bowel syndrome. Cochrane Database Syst Rev, 1, Cd004116. https://doi.org/10.1002/14651858.CD004116.pub2CrossRef

14.

Michael, H. K. C., Irene, X. Y. W., Robin, S. T. H., Charlene, H. L. W., Anthony, L. Z., Yan, Z., Justin, C. Y. W., & Vincent, C. H. C. (2018). Chinese herbal medicine for functional dyspepsia: Systematic review of systematic reviews. Ther Adv Gastroent, 11, 1–24. https://doi.org/10.1177/1756284818785573CrossRef

15.

Goats, G. C. (1994). Massage–the scientific basis of an ancient art: Part 1 The Techniques. British Journal of Sports Medicine, 28, 149–152. https://doi.org/10.1136/bjsm.28.3.149CrossRefPubMedPubMedCentral

16.

Shao, M. X. (1998). Practice of Tuina (1st ed.). Beijing: People’s Military Medical Press. [Chinese].

17.

Goats, G. C. (1994). Massage–the scientific basis of an ancient art: Part 2: Physiological and therapeutic effects. British Journal of Sports Medicine, 28, 153–156. https://doi.org/10.1136/bjsm.28.3.153CrossRefPubMedPubMedCentral

18.

State Council of the People’s Republic of China. (2000, September 14). Law of the People’s Republic of China on Medical Practitioners. Retrieved from http://www.gov.cn/zhengce/2020-12/26/content_5574369.htm. [Chinese]

19.

National Administration of Traditional Chinese Medicine. (2005, September 5). Notice on issues related to the management of TCM massage and other activities (Ministry of Health, State Administration of Traditional Chinese Medicine). Retrieved from http://fjs.satcm.gov.cn/zhengcewenjian/2018-03-24/2600.html. [Chinese]

20.

Yang, X., Zhao, H., & Wang, J. (2014). Chinese Massage (Tuina) for the treatment of essential hypertension: A systematic review and meta-analysis. Complement Ther Med, 22, 541–548. https://doi.org/10.1016/j.ctim.2014.03.008CrossRefPubMed

21.

Wang, J., Liu, Y., Tan, Z. D., Yu, S. T., & Yin, H. (2011). A summary of the literature research on the disease spectrum of modern Tuina in China. Inform Traditional Chinese Medicine, 04, 151–153.

22.

Talley, N. J., Stanghellini, V., Heading, R. C., Koch, K. L., Malagelada, J. R., & Tytgat, G. N. J. (1999). Functional gastroduodenal disorders. Gut, 45(Suppl 2), 37–42. https://doi.org/10.1136/gut.45.2008.ii37CrossRef

23.

Stanghellini, V., Tosetti, C., Giorgio, R. D., Barbara, G., & Corinaldesi, R. (2002). Dyspepsia and dyspepsia subgroups: Not all roads lead to Rome. Digestive and Liver Disease, 34(5), 316–318. https://doi.org/10.1016/s1590-8658(02)80122-0CrossRefPubMed

24.

Tack, J., & Talley, N. J. (2013). Functional dyspepsia—symptoms, definitions and validity of the Rome III criteria. Nature Reviews Gastroenterology & Hepatology, 10(3), 134–141. https://doi.org/10.1038/nrgastro.2013.14CrossRef

25.

Drossman, D. A., Chang, L., Chey, W. D., Kellow, J., Tack, J., Whitehead, W. E., Ke, M. Y., Fang, X. C., & Hou, X. H. (2016). Rome IV: Functional gastrointestinal disorders/disorders of gut-brain interaction. Science Press.CrossRef

26.

Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., Stewart, L. A., & PRISMA-P Group. (2015). Preferred reporting items for systematic review and metaanalysis protocols (PRISMA-P) 2015 statement. Syst Rev, 2015(4), 1–9. https://doi.org/10.1186/2046-4053-4-1CrossRef

27.

Food and Drug Administration, HHS. (2012). International Conference on Harmonisation; Final Recommendation for the Revision of the Permitted Daily Exposure for the Solvent Cumene According to the Maintenance Procedures for the Guidance Q3c Impurities: Residual Solvents; Availability. Federal Register, 77, 10754–10755.

28.

Higgins, J. P. T., Altman, D. G., Gotzsche, P. C., Moher, D., Oxman, A. D., Savovic, J., Schulz, K. F., Weeks, L., Sterne, J. A. C., Cochrane Bias Methods Group, & Cochrane Statistical Methods Group. (2011). The Cochrane collaboration’s tool for assessing risk of bias in randomised trials. BMJ, 343, d5928. https://doi.org/10.1136/bmj.d5928CrossRef

29.

Higgins, J. P. T., & Thompson, S. G. (2002). Quantifying heterogeneity in a meta-analysis. Stat Med, 21(11), 1539–1558. https://doi.org/10.1002/sim.1186CrossRefPubMed

30.

Sterne, J. A., & Egger, M. (2001). Funnel plots for detecting bias in meta-analysis: Guidelines on choice of axis. J Clin Epidemiol, 54(10), 1046–1055. https://doi.org/10.1016/s0895-4356(01)00377-8CrossRefPubMed

31.

Guyatt, G. H., Oxman, A. D., Kunz, R., Vist, G. E., Kunz, R., Ytter, Y. F., Coello, P. A., Schünemann, H. J. & GRADE Working Group. (2008). GRADE working group. Rating quality of evidence and strength of recommendations: What is “quality of evidence” and why is it important to clinicians? BMJ, 7651, 995–998. https://doi.org/10.1136/bmj.39489.470347.ADCrossRef

32.

Chen, Y. Y., Bao, A., Wang, H. T., Li, J. L., Fan, Q., & Wang, J. G. (2021). Clinical effect of abdominal Tuina on functional dyspepsia of liver stagnation and spleen deficiency based on the theory of ‘middle burner.’ Tianjin Journal of Traditional Chinese Medicine, 10, 1268–1272.

33.

Guo, J. J. (2016). Observation on the effect of mosapril combined with chiropractic in the treatment of functional dyspepsia. China Health Care & Nutrition, 4, 235–236.

34.

Li, S., & Tian, G. (2019). Study on the value of pediatric Tuina in treating functional dyspepsia. China Health Vision, 18, 140–141.

35.

Luo, G. L., Yang, S. W., Liu, H. Y., Liu, X. J., & Zhen, H. L. (2019). Effects of abdominal exercise on plasma somatostatin and motilin in patients with functional dyspepsia. China Medicine and Pharmacy, 5, 54–56.

36.

Ning, J. J., Yu, J., Li, W., & Li, J. S. (2018). Observation on clinical effect of Tuina plus western medication for functional dyspepsia due to liver Qi stagnation and spleen deficiency. Journal of Acupuncture Tuina Science, 16(2), 109–114. https://doi.org/10.1007/s11726-018-1033-3CrossRef

37.

Ning, X. (2010). Clinical study on the treatment of functional dyspepsia by meridian point Tuina combined with cisapride. Modern Journal of Integrated Traditional Chinese and Western Medicine, 19(23), 2895–2896.

38.

Qu, Y. J. (2020). Clinical observation and analysis of abdominal Tuina in the treatment of functional dyspepsia. Electronic Journal of Clinical Medical Literature, 7(59), 33.

39.

Sun, Y., & Gai, Y. H. (2009). Clinical study of omeprazole combined with Tuina in the treatment of functional dyspepsia. China Practical Medicine, 29, 124–125.

40.

Tang, L., Xiang, Q., Li, S. L., Weng, W. W., & Wang, L. N. (2015). Effect of chiropractic combined with external washing of traditional Chinese medicine on functional dyspepsia in children. Guangzhou Medical Journal, 46(5), 58–60.

41.

Wang, C. Y., Zhang, Y. Q., Zhang, Z. Y., Xu, J. Y., Dou, Y. B., Fan, S., & Han, X. X. (2016). Efficacy evaluation of massaging Jiaji Acupoint treating functional dyspepsia of postprandial distress syndrome. Chinese Manipulation and Rehabilitation Medicine, 7(3), 41–42.

42.

Yang, S. W., Luo, G. L., Liu, X. J., Qiu, J. X., Zhen, H. L., & Yang, N. K. (2020). Clinical effect of Mofu Yunqi Dirigation on patients with functional dyspepsia. China Medicine and Pharmacy, 10(20), 89–91.

43.

Zhang, D. S., Xue, W. G., & Li, J. H. (2010). Clinical observation of abdominal Tuina for functional dyspepsia. Beijing Journal of Traditional Chinese Medicine, 29(8), 619–621.

44.

Zhang, J. F., Lin, Q., Liu, H. B., & Zhou, P. (2007). Clinical comparative study on massage therapy and Cisapride in treating functional dyspepsia. Journal of Acupuncture Tuina Science, 3, 166–168. https://doi.org/10.1007/sll726-007-0166-6CrossRef

45.

Zhou, H. Y., & Xu, X. M. (2021). Clinical effect of Tuina on functional dyspepsia children and appetite regulation factor. Hunan Journal of Traditional Chinese Medicine, 37(6), 106–107.

46.

Bu, F. L., Han, M., Lu, C. L., Wang, W. G., Lai, J. L. M., Qiu, X. H., He, B. X., Zhang, H., Robinson, N., Fei, Y. T., & Liu, J. P. (2020). Systematic review of Tuina for irritable bowel syndrome: Recommendations for future trials. Complement Ther Med, 52, 102504. https://doi.org/10.1016/j.ctim.2020.102504CrossRefPubMed

47.

Fang, Y. P., Huang, Y. T., Chen, D., Kan, Y., Wang, J. W., Kang, X. L., Wang, D. Y., Liao, J., & Jing, X. H. (2021). Systematic review and meta analysis on the effectiveness and safety of Tuina in treatment of functional constipation. Zhongguo Zhen Jiu, 41(6), 691–698. https://doi.org/10.13703/j.0255-2930.20200411-0004CrossRefPubMed

48.

World Health Organization. (2020). WHO benchmarks for the practice of tuina. Licence: CC BY-NC-SA 3.0 IGO. Retrieved from https://www.who.int/publications/i/item/9789240016903.

49.

Zhao, Y., & Ji, Y. (2016). Manipulation of Tuina. China Press of Traditional Chinese Medicine.

50.

Fang, M., & Song, B. L. (2016). Science of Tuina. China Press of Traditional Chinese Medicine.

51.

Liu, F. B., Jin, Y. X., Wu, Y. H., Hou, Z. K., & Chen, X. L. (2014). Translation and psychometric evaluation of the Chinese version of functional digestive disorders quality of life questionnaire. Digestive Diseases and Sciences, 59(2), 390–420. https://doi.org/10.1007/s10620-013-2897-1CrossRef

52.

Brun, R., & Kuo, B. (2010). Functional dyspepsia. Therapeutic Advances in Gastroenterology, 3(3), 145–164. https://doi.org/10.1177/1756283X10362639CrossRefPubMedPubMedCentral

53.

Agréus, L., & Borgquist, L. (2002). The cost of gastro-oesophageal reflux disease, dyspepsia and peptic ulcer disease in Sweden. PharmacoEconomics, 20(5), 347–355. https://doi.org/10.2165/00019053-200220050-00006CrossRefPubMed

54.

Miwa, H., Nagahara, A., Asakawa, A., Arai, M., Oshima, T., Kasugai, K., Kamada, K., Suzuki, H., Tanaka, F., Tominaga, K., Futagami, S., Hojo, M., Mihara, H., Higuchi, K., Kusano, M., Arisawa, T., Kato, M., Joh, T., Mochida, S., Enomoto, N., et al. (2022). Evidence-based clinical practice guidelines for functional dyspepsia 2021. Journal of Gastroenterology, 57(2), 47–61. https://doi.org/10.1007/s00535-021-01843-7CrossRefPubMedPubMedCentral

55.

Veldhuyzen van Zanten, S. J., Cleary, C., Talley, N. J., Peterson, T. C., Nyrén, O., Bradley, L. A., Verlinden, M., & Tytgat, G. N. (1996). Drug treatment of functional dyspepsia: A systematic analysis of trial methodology with recommendations for design of future trials. The American Journal of Gastroenterology, 91(4), 660–673.PubMed

56.

Talley, N. J. (1994). A critique of therapeutic trials in Helicobacter pylori-positive functional dyspepsia. Gastroenterology, 106(5), 1174–1183. https://doi.org/10.1016/0016-5085(94)90007-8CrossRefPubMed

57.

Talley, N. J., Verlinden, M., & Jones, M. (2001). Quality of life in functional dyspepsia: Responsiveness of the Nepean Dyspepsia Index and development of a new 10-item short form. Alimentary Pharmacology & Therapeutics, 15(2), 207–216. https://doi.org/10.1046/j.1365-2036.2001.00900.xCrossRef

58.

Chang, L. (2004). Review article: Epidemiology and quality of life in functional gastrointestinal disorders. Alimentary Pharmacology & Therapeutics, 20(Suppl 7), 31–39. https://doi.org/10.1111/j.1365-2036.2004.02183.xCrossRef

59.

Kutner, J. S., Smith, M. C., Corbin, L., Hemphill, L., Benton, K., Mellis, B. K., Beaty, B., Felton, S., Yamashita, T. E., Bryant, L. L., & Fairclough, D. L. (2008). Massage therapy versus simple touch to improve pain and mood in patients with advanced cancer: A randomized trial. Annals of Internal Medicine, 149(6), 369–379. https://doi.org/10.7326/0003-4819-149-6-200809160-00003CrossRefPubMedPubMedCentral

60.

Ford, A. C., Mahadeva, S., Carbone, M. F., Lacy, B., & Tally, N. J. (2020). Functional dyspepsia. Lancet, 396(10263), 1689–1702. https://doi.org/10.1016/S0140-6736(20)30469-4CrossRefPubMed

61.

Reid, A. M. A., & Dunn, I. C. (2018). Gastrointestinal distribution of chicken gastrin-cholecystokinin family transcript expression and response to short-term nutritive state. General and Comparative Endocrinology, 255, 64–70. https://doi.org/10.1016/j.ygcen.2017.10.009CrossRefPubMedPubMedCentral

62.

Zatorski, H., Mosinska, P., Storr, M., & Fichna, J. (2017). Relamorelin and other ghrelin receptor agonists-future options for gastroparesis, functional dyspepsia and proton pump inhibitors-resistant non-erosive reflux disease. Journal of Physiology and Pharmacology, 68(6), 797–805.PubMed

63.

Chen, C. Y., & Tsai, C. Y. (2012). Ghrelin and motilin in the gastrointestinal system. Current Pharmaceutical Design, 18(31), 4755–4765. https://doi.org/10.2174/138161212803216915CrossRefPubMed

64.

Mariana, G., Jersy, C., & Cristina, Á. (2020). Somatostatin analogs in clinical practice: A review. Int J Mol Sci, 21(5), 1682. https://doi.org/10.3390/ijms21051682CrossRef

65.

Sobhani, I., Bado, A., Vissuzaine, C., Buyse, M., Kermorgant, S., Laigneau, J. P., Attoub, S., Lehy, T., Henin, D., Mignon, M., & Lewin, M. J. (2020). Leptin secretion and leptin receptor in the human stomach. Gut, 47(2), 178–183. https://doi.org/10.1136/gut.47.2.178CrossRef

66.

Lankarani, K. B., Moghadami, M., Masoumpoor, M., Geramizadeh, B., & Omrani, G. R. (2004). Serum leptin level in patients with functional dyspepsia. Dig Liver Dis, 36(11), 717–721. https://doi.org/10.1016/j.dld.2004.07.001CrossRefPubMed

67.

Jonsson, B. H., & Hellström, P. M. (2001). Motilin-and neuropeptide Y-like immunoreactivity in a psychophysiological stress experiment on patients with functional dyspepsia. Integr Physiol Behav Sci, 35(4), 256–265. https://doi.org/10.1007/BF02688788CrossRef

68.

Liu, S., Peng, S., Hou, X., Ke, M., & Chen, D. Z. (2008). Transcutaneous electroacupuncture improves dyspeptic symptoms and increases high frequency heart rate variability in patients with functional dyspepsia. Neurogastroenterol Motil, 20(11), 1204–1211. https://doi.org/10.1111/j.1365-2982.2008.01164.xCrossRefPubMed

69.

Han, X., Gao, Y., Yin, X., Zhang, Z., Lao, L., Chen, Q., & Xu, S. (2021). The mechanism of electroacupuncture for depression on basic research: A systematic review. Chin Med, 16(1), 10. https://doi.org/10.1186/s13020-020-00421-yCrossRefPubMedPubMedCentral

70.

Forbes, S. C., & Cox, H. M. (2014). Peptide YY, neuropeptide y and corticotrophin-releasing factor modulate gastrointestinal motility and food intake during acute stress. Neurogastroenterology & Motility, 26(11), 1605–1614. https://doi.org/10.1111/nmo.12428CrossRef

71.

Rao, J. Q., Bu, X. L., Chen, H., & Sha, W. H. (2015). Peripheral blood motilin, neuropeptide y and leptin levels in patients with functional dyspepsia. Chinese Journal of Gastroenterology, 20(8), 486–488.

72.

Egger, M., Juni, P., Bartlett, C., Holenstein, F., & Sterne, J. (2003). How important are comprehensive literature searches and the assessment of trial quality in systematic reviews? Empirical study. Health Technology Assessment, 7(1), 1–76.CrossRefPubMed

73.

Isabelle, B., David, M., Douglas, G. A., Kenneth, F. S., & Philippe, R. (2008). Methods and processes of the consort group: Example of an extension for trials assessing nonpharmacologic treatments. Annals of Internal Medicine, 148(4), W60-66. https://doi.org/10.7326/0003-4819-148-4-200802190-00008-w1CrossRef

Titel: Therapeutic massage/Tuina for treatment of functional dyspepsia: a systematic review and meta-analysis of randomized controlled trials
Auteurs: Ning Dai
Qingyun He
Xuehan Liu
Min Fang
Min Xiong
Xun Li
Duoduo Li
Jianping Liu
Publicatiedatum: 17-08-2022
Uitgeverij: Springer International Publishing
Gepubliceerd in: Quality of Life Research / Uitgave 3/2023
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-022-03228-6

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