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24-01-2022

The 5-year outcome of subjective quality of life in older schizophrenia patients

Auteurs: Sjors M. M. Lange, Paul D. Meesters, Max L. Stek, Brenda W. Penninx, Didi Rhebergen

Gepubliceerd in: Quality of Life Research | Uitgave 8/2022

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Abstract

Purpose

Subjective quality of life (SQOL) is increasingly valued as an important outcome in schizophrenia treatment. The current study aims to gain insight into changes in SQOL during 5-year follow-up in older persons with schizophrenia spectrum disorders (SSD).

Methods

The sample consisted of a catchment area-based group of 75 older Dutch patients (mean age 66.0 years) with schizophrenia or schizoaffective disorder. Factor analysis was used to identify subdomains of SQOL, measured with the Manchester Short Assessment of Quality of Life (MANSA). 5-Year course trajectories and putative predictors of changes in SQOL and subdomains were examined using multivariable regression analyses.

Results

72% was stable in either a high or a low SQOL-status over time. When outcome was defined as change score, 36%, 20%, and 44% of participants, respectively, reported a clinically relevant improvement, deterioration, or no change of SQOL during follow-up. Three SQOL subdomains were identified with different course trajectories; 33% of participants reported an improvement in the subdomains satisfaction with ‘daily life’ and ‘personal circumstances.’ The largest number of declines (28%) was reported in the subdomain satisfaction with ‘physical and mental health.’ Predictors of positive total and subdomain SQOL-change scores were limited to a higher age of onset and higher baseline SQOL scores.

Conclusion

In this cohort of older persons, it was demonstrated that SQOL might considerably change during 5-year follow-up. As course trajectories differed among subdomains, separate evaluation of these subdomains is clinically relevant. Improvement of SQOL is an attainable goal in older SSD patients despite deteriorating physical health.
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Metagegevens
Titel
The 5-year outcome of subjective quality of life in older schizophrenia patients
Auteurs
Sjors M. M. Lange
Paul D. Meesters
Max L. Stek
Brenda W. Penninx
Didi Rhebergen
Publicatiedatum
24-01-2022
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 8/2022
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-021-03062-2

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