The majority of children and adolescents are found to have experienced some form of trauma in their lives (i.e. between 56 and 84%; Copeland et al.,
2007; Joseph et al.,
2000; Karatzias et al.,
2020; Landolt et al.,
2013; McLaughlin et al.,
2013). While many recover naturally from acute stress symptoms induced by trauma (Hiller et al.,
2016), around 10–15% of youth go on to develop post-traumatic stress disorder (PTSD; Alisic et al.,
2014; Bryant et al.,
2007; Copeland et al.,
2007; Costello et al.,
2002; Kassam-Adams & Winston,
2004; Ogle et al.,
2013). According to Lewis et al. (
2019) and Maercker et al. (
2022), around 8% of children and adolescents have suffered from PTSD at some point in their life. PTSD is associated with a wide range of physical, emotional, social and developmental impacts on a young person (Fairbank & Fairbank,
2009). PTSD in the context of early life not only disrupts recently acquired developmental skills, but also impedes subsequent development of areas such as cognition, emotion regulation, social skills, perception of danger, self-concept and impulse control (Caffo et al.,
2005; Davis & Siegel,
2000; Lubit et al.,
2003; Pfefferbaum,
1997). These developmental delays are associated with significant impairment in social and academic functioning (Frieze et al.,
2015; McLean et al.,
2013). PTSD also increases the risk of developing other emotional and behavioral difficulties including depression, anxiety, substance abuse, conduct disorder, aggression, adjustment disorders and externalizing disorders (Bernhard et al.,
2018; Kerig et al.,
2010; Shaw,
2000; Simmons & Suárez,
2016). If left unattended, these impacts are likely to persist into adulthood and later adulthood (Lupien et al.,
2009; Ogle et al.,
2013). Given such devastating and far-reaching consequences, it is important to understand the factors that predict the development of PTSD in order to prevent and mitigate it.
Predictors of PTSD in Children and Adolescents
A number of pre-trauma psychosocial risk factors, event-related risk factors and cognitive risk factors were found to predict PTSD symptoms in children and adolescent subsequent to trauma exposure. Psychosocial factors include prior life events, socioeconomic status, intelligence, self-esteem, social support and female gender (Allen et al.,
2021; Cox et al.,
2008; Trickey et al.,
2012), while event-related factors include interpersonal versus non-interpersonal trauma, presence of deaths, injury severity, levels of pain, peritraumatic dissociation and perceived fear responses (Cox et al.,
2008; Trickey et al.,
2012; Vogt et al.,
2007). These factors, however, tended to account for only small to medium effect sizes (Cox et al.,
2008; Memarzia et al.,
2021; Trickey et al.,
2012). Conversely, cognitive factors such as trauma appraisals, data-driven processing (i.e. processing of sensory and perceptual information of the traumatic event instead of its meaning), nature of trauma memory, rumination and thought suppression (Brewin et al.,
1996; Ehlers & Clark,
2000; Foa et al.,
1989) were consistently shown to be strong predictors of PTSD with medium to large effect sizes (Ehlers et al.,
2003; Gómez de La Cuesta et al.,
2019; Meiser-Stedman et al.,
2009; Memarzia et al.,
2021; Stallard & Smith,
2007).
Cognitive Theories of PTSD
The cognitive model of psychopathology holds that it is not the events themselves, but the interpretation of events, that causes distress (Beck,
1972; Ellis,
1977). While originally used to formulate and treat depression, the model was later extended to the treatment of various anxiety disorders (Beck & Clark,
1997). Among cognitive theories in the PTSD literature (e.g. Brewin et al.,
1996; Ehlers & Clark,
2000; Foa & Rothbaum,
2001), the Ehlers and Clark (
2000)’s model is one of the most widely researched ones. According to the model, people with PTSD tend to process the traumatic event and its consequences in a way that produces a sense of ongoing threat. Two factors are proposed to play a role: First, memory of the trauma tends to be fragmented, sensory based, lacking in context, involuntarily triggered and possessing a here-and-now quality. Such disruption of autobiographical memory evokes a strong sense of current threat to the person. Second, trauma and its sequelae (e.g. flashbacks, numbing and anger outbursts) tend to be appraised in negative, overgeneralizing or catastrophic ways. By way of illustration, one may endorse the beliefs “I attract disasters”, “the world is a dangerous place” and “the next disaster will strike soon” in relation to a traumatic event that has occurred. One may also have such beliefs as “I am going crazy”, “I am never going to recover” and “I have changed for the worst” in relation to one’s reactions to trauma. These maladaptive beliefs consequently fuel one’s sense of threat. In an attempt to contain the threat, one may engage in strategies such as safety-seeking behaviours, cognitive avoidance, rumination and thought suppression. However, despite their short-term benefits, these strategies tend to perpetuate and intensify anxiety in the long term, resulting in ongoing PTSD symptoms (Ehlers & Clark,
2000; Nolen-Hoeksema,
2004; Sibrava & Borkovec,
2006).
Anxiety Sensitivity and PTSD
A cognitive factor that may be conceptually associated with trauma appraisal is anxiety sensitivity. Anxiety sensitivity refers to the fear of anxiety and arousal-related sensations due to the belief that they have detrimental consequences for the individual (Reiss,
1985). According to the Anxiety Sensitivity Index (ASI; Reiss et al.,
1986), these perceived consequences can be classified into physical domains (e.g. “When I notice my heart beating rapidly, I worry that I might be having a heart attack”), cognitive domains (e.g. “When I cannot keep my mind on a task, I worry that I might be going crazy”) and social domains (e.g. “Other people notice when I feel shaky”). An additional domain, unsteady concerns (e.g.
“It scares me when I can’t keep my mind on my schoolwork”), was found to be present among children and young people and was hence incorporated in the child adapted version of ASI, i.e. the Childhood Anxiety Sensitivity Index (CASI; Silverman et al.,
1991).
As a cognitive construct, its association with panic disorder has been widely established (Donnell & McNally,
1990; Li & Zinbarg,
2007; McNally,
2002; Poletti et al.,
2015). This is in line with cognitive models of panic disorder (e.g. Clark,
1986) which consider catastrophic misinterpretations of anxiety-induced bodily symptoms as the core maintaining factor of the disorder. In recent decades, research has begun to explore the role of anxiety sensitivity in other anxiety disorders such as PTSD (Asmundson & Stapleton,
2008; Marshall-Berenz et al.,
2010; Olatunji & Wolitzky-Taylor,
2009; Taylor,
2003). A relationship between anxiety sensitivity and PTSD is postulated due to cognitive theories of PTSD regarding the impact of trauma appraisals (e.g. Ehlers & Clark,
2000) as well as high comorbidity rates between PTSD and panic disorder (Leskin & Sheikh,
2002). Despite its potential significance, however, anxiety sensitivity is less researched than other cognitive factors such as trauma appraisals, rumination and thought suppression. To date this line of research has mostly focused on adults; less is known about how anxiety sensitivity might affect PTSD in the context of children and adolescents. Whilst individual studies (e.g. Hensley & Varela,
2008; Kadak et al.,
2013) have reported correlated statistics around anxiety sensitivity and PTSD symptoms in this population, there are yet attempts to aggregate existing various findings around effect size. It remains unclear how strong a role anxiety sensitivity may play overall in contributing and maintaining PTSD symptoms in youths.
Current Review
The current review aimed to conduct a comprehensive search and analysis of the existing empirical studies on anxiety sensitivity and PTSD symptoms among trauma-exposed children and adolescents. To our knowledge, this constitutes the first meta-analysis in the area. Clarifying the relationship between anxiety sensitivity and post-traumatic stress symptoms (PTSS) would not only help enrich existing cognitive theories of PTSD, but also inform the prevention, management and treatment of the condition.