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Netherlands Heart Journal

Gepubliceerd in:

01-09-2008 | review article

Regenerative cell therapy and pharmacotherapeutic intervention in heart failure

Part 1: Cardiovascular progenitor cells, their functions and sources

Auteurs: C. Qian, R. G. Schoemaker, W. H. van Gilst, B. Yu, A. J. M. Roks

Gepubliceerd in: Netherlands Heart Journal | Uitgave 9/2008

Abstract

It has been postulated that bone marrow derived endothelial progenitor cells (BM-EPCs) are essential for neovascularisation and endothelial repair and are involved in pharmacological treatment, and even its potential targets. There is no doubt that the ultimate success of angiogenic cell therapy will be determined by an appropriate stimulation of certain angiogenic progenitor cell subpopulations. Unfortunately, the biology of EPCs is still poorly understood. In particular, the understanding of endogenous microenvironments within the progenitor cell niches is critical, and will provide us with information about the signalling systems that supply a basis to develop rational pharmacotherapy to enhance the functional activity of endogenous or transplanted progenitor cells. The final success of clinical improvement of progenitor cell-mediated vascular repair and angiogenic therapy depends on a better understanding of EPC biology and a smart therapeutic design. In the first part of this review we first briefly discuss the possible involvement of progenitor cells in chronic heart failure. In part 2 we focus on factors that beneficially affect BMEPCs, with an emphasis on pharmacological molecular pathways involved in BM-EPC-induced neovascularisation. (Neth Heart J 2008;16:305-9.)

vorige artikel The many faces of aggressive aortic pathology: Loeys-Dietz syndrome

volgende artikel Recurrent acute pulmonary oedema after aortic and mitral valve surgery due to trachea malacia and obstructive sleep apnoea syndrome

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Titel: Regenerative cell therapy and pharmacotherapeutic intervention in heart failure
Part 1: Cardiovascular progenitor cells, their functions and sources
Auteurs: C. Qian
R. G. Schoemaker
W. H. van Gilst
B. Yu
A. J. M. Roks
Publicatiedatum: 01-09-2008
Uitgeverij: Bohn Stafleu van Loghum
Gepubliceerd in: Netherlands Heart Journal / Uitgave 9/2008
Print ISSN: 1568-5888
Elektronisch ISSN: 1876-6250
DOI: https://doi.org/10.1007/BF03086169

Bohn Stafleu van Loghum

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