Skip to main content
main-content
Top

Tip

Swipe om te navigeren naar een ander artikel

01-03-2014 | Uitgave 2/2014

Quality of Life Research 2/2014

Quality of life in female cancer survivors: is it related to ovarian reserve?

Tijdschrift:
Quality of Life Research > Uitgave 2/2014
Auteurs:
Laxmi A. Kondapalli, Katherine E. Dillon, Mary D. Sammel, Anushree Ray, Maureen Prewitt, Jill P. Ginsberg, Clarisa R. Gracia
Belangrijke opmerkingen
Presented at the 65th Annual Meeting of the American Society of Reproductive Medicine, Atlanta, Georgia, October 17–21, 2009.

Abstract

Purpose

The purpose of the study is to assess the quality-of-life scores and possible association with measures of ovarian reserve in female cancer survivors compared to healthy controls of similar age.

Methods

In this prospective cohort study, fifty-nine cancer survivors aged 16–39 years and 66 healthy, similarly aged unexposed women were recruited at the University of Pennsylvania. The primary outcome measures are the generic and cancer-specific domain scores on the Quality of Life in Adult Cancer Survivors (QLACS) instrument, early follicular phase serum hormones, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), inhibin B (INH), anti-Mullerian hormone (AMH), and ovarian ultrasound measurements [ovarian volume and antral follicle count (AFC)].

Results

Cancer survivors had significantly higher total and cancer-specific domain scores compared to unexposed participants. Serum AMH, INH, ovarian volume, and AFC were lower while serum FSH was higher in cancer survivors. Although survivors exhibited diminished ovarian reserve, these markers were not independently associated with total QLACS score. Cancer survivors with irregular menstrual function were found to have lower quality-of-life (QOL) scores than those with regular cycles.

Conclusions

We found that QOL appears to be significantly impaired in cancer survivors compared to controls, even when remote from initial cancer diagnosis. In addition, our study suggests that reproductive aging contributes to QOL in the setting of irregular menses and likely profound impairment of ovarian function.

Log in om toegang te krijgen

Met onderstaand(e) abonnement(en) heeft u direct toegang:

BSL Podotherapeut Totaal

Binnen de bundel kunt u gebruik maken van boeken, tijdschriften, e-learnings, web-tv's en uitlegvideo's. BSL Podotherapeut Totaal is overal toegankelijk; via uw PC, tablet of smartphone.

Literatuur
Over dit artikel

Andere artikelen Uitgave 2/2014

Quality of Life Research 2/2014 Naar de uitgave