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01-03-2014

Quality of life in female cancer survivors: is it related to ovarian reserve?

Auteurs: Laxmi A. Kondapalli, Katherine E. Dillon, Mary D. Sammel, Anushree Ray, Maureen Prewitt, Jill P. Ginsberg, Clarisa R. Gracia

Gepubliceerd in: Quality of Life Research | Uitgave 2/2014

Abstract

Purpose

The purpose of the study is to assess the quality-of-life scores and possible association with measures of ovarian reserve in female cancer survivors compared to healthy controls of similar age.

Methods

In this prospective cohort study, fifty-nine cancer survivors aged 16–39 years and 66 healthy, similarly aged unexposed women were recruited at the University of Pennsylvania. The primary outcome measures are the generic and cancer-specific domain scores on the Quality of Life in Adult Cancer Survivors (QLACS) instrument, early follicular phase serum hormones, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), inhibin B (INH), anti-Mullerian hormone (AMH), and ovarian ultrasound measurements [ovarian volume and antral follicle count (AFC)].

Results

Cancer survivors had significantly higher total and cancer-specific domain scores compared to unexposed participants. Serum AMH, INH, ovarian volume, and AFC were lower while serum FSH was higher in cancer survivors. Although survivors exhibited diminished ovarian reserve, these markers were not independently associated with total QLACS score. Cancer survivors with irregular menstrual function were found to have lower quality-of-life (QOL) scores than those with regular cycles.

Conclusions

We found that QOL appears to be significantly impaired in cancer survivors compared to controls, even when remote from initial cancer diagnosis. In addition, our study suggests that reproductive aging contributes to QOL in the setting of irregular menses and likely profound impairment of ovarian function.

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Titel: Quality of life in female cancer survivors: is it related to ovarian reserve?
Auteurs: Laxmi A. Kondapalli
Katherine E. Dillon
Mary D. Sammel
Anushree Ray
Maureen Prewitt
Jill P. Ginsberg
Clarisa R. Gracia
Publicatiedatum: 01-03-2014
Uitgeverij: Springer International Publishing
Gepubliceerd in: Quality of Life Research / Uitgave 2/2014
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-013-0473-y

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Abstract

Purpose

Methods

Results

Conclusions

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