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01-11-2014 | Original Article | Uitgave 11/2014 Open Access

Netherlands Heart Journal 11/2014

Preoperative statin therapy and infectious complications in cardiac surgery

Netherlands Heart Journal > Uitgave 11/2014
N. L. Hartholt, T. C. D. Rettig, M. Schijffelen, W. J. Morshuis, E. M. W. van de Garde, P. G. Noordzij
Belangrijke opmerkingen
N. L. Hartholt and T. C. D. Rettig contributed equally to this study



To assess whether preoperative statin therapy is associated with the risk of postoperative infection in patients undergoing cardiac surgery.


520 patients undergoing cardiac surgery in 2010 were retrospectively examined. Data regarding statin and antibiotic use prior to and after surgery were available from the hospital pharmacy information system. Cultures and clinical data of patients on postoperative antibiotics other than standard prophylactic therapy were studied to identify postoperative infections up to 30 days from day of surgery.


370 (71.2 %) patients were on preoperative statin therapy. Overall, 82 patients (15.8 %) suffered from postoperative infection of which 11 were surgical site infections. In multivariable regression analysis, statin therapy was associated with a reduced risk of postoperative infection (adjusted odds ratio: 0.329, 95 %: CI 0.19–0.57; P < 0.001).


Preoperative statin use was associated with a considerable reduced risk of postoperative infections following cardiac surgery. Randomised controlled trials are required to clarify the role of statin therapy in the prevention of postoperative infections.

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Netherlands Heart Journal

Het Netherlands Heart Journal wordt uitgegeven in samenwerking met de Nederlandse Vereniging voor Cardiologie en de Nederlandse Hartstichting. Het tijdschrift is Engelstalig en wordt gratis beschikbaa ...

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