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07-05-2023

Post-discharge health assessment in survivors of coronavirus disease: a time-point analysis of a prospective cohort study

Auteurs: Ramin Sami, Sina Arabi, Khojasteh Ghasemi, Mahsa Akafzadeh, Sara Ebrahimi, Arash Toghyani, Razieh Mahvari, Reza Moayednia, Seyed Amir Dadkhahi, Sara Sadeghi, Hamid Reza Marateb, Peyman Adibi, Aryan Kavosh, Marjan Mansourian

Gepubliceerd in: Quality of Life Research | Uitgave 9/2023

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Abstract

Purpose

 The objective of this study was to quantitatively evaluate psychological and quality of life-related complications at three months following discharge in hospitalized coronavirus disease 2019 (COVID-19) patients during the pandemic in Iran.

Methods

In this time-point analysis of prospective cohort study data, adult patients hospitalized with symptoms suggestive of COVID-19 were enrolled. Patients were stratified in analyses based on severity. The primary outcomes consisted of psychological problems and pulmonary function tests (PFTs) in the three months following discharge, with Health-related quality of life (HRQoL) as the secondary outcome. Exploratory predictors were determined for both primary and secondary outcomes.

Results

283 out of 900 (30%) eligible patients were accessible for the follow-up assessment and included in the study. The mean age was 53.65 ± 13.43 years, with 68% experiencing a severe disease course. At the time of the final follow-up, participants still reported persistent symptoms, among which fatigue, shortness of breath, and cough were the most common. Based on the regression-adjusted analysis, lower levels of forced expiratory volume in one second (FEV1) to forced vital capacity (FVC) ratio was associated with higher levels of depression (standardized β = − 0.161 (SE = 0.042), P = 0.017) and stress levels (standardized β =− 0.110 (SE = 0.047), P = 0.015). Furthermore, higher levels of anti-SARS-CoV-2 immunoglobulin-M (IgM) were associated with significantly lower levels of depression (standardized β = − 0.139 (SE = 0.135), P = 0.031).

Conclusions

There is an association between lung damage during COVID-19 and the reduction of pulmonary function for up to three months from acute infection in hospitalized patients. Varying degrees of anxiety, depression, stress, and low HRQoL frequently occur in patients with COVID-19. More severe lung damage and lower COVID-19 antibodies were associated with lower levels of psychological health.
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Metagegevens
Titel
Post-discharge health assessment in survivors of coronavirus disease: a time-point analysis of a prospective cohort study
Auteurs
Ramin Sami
Sina Arabi
Khojasteh Ghasemi
Mahsa Akafzadeh
Sara Ebrahimi
Arash Toghyani
Razieh Mahvari
Reza Moayednia
Seyed Amir Dadkhahi
Sara Sadeghi
Hamid Reza Marateb
Peyman Adibi
Aryan Kavosh
Marjan Mansourian
Publicatiedatum
07-05-2023
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 9/2023
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-023-03415-z

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