Top

Gepubliceerd in:

2019 | OriginalPaper | Hoofdstuk

29. Ovarian cancer

Auteurs : Professor Marian J. E. Mourits, Dr Florine A. Eggink, Dr Mathilde Jalving, Dr Marco de Bruyn, Dr Joost Bart, Professor Hans W. Nijman

Gepubliceerd in: Textbook of Obstetrics and Gynaecology

Uitgeverij: Bohn Stafleu van Loghum

Summary

Ovarian cancer is a relatively uncommon type of cancer. Factors that increase the risk of developing epithelial ovarian cancer are early menarche, nulliparity, late menopause, increasing age and inherited predisposition. Around 90 % of malignant tumours in the ovaries are epithelial in origin; other types include non-epithelial and metastatic tumours. The epithelial ovarian cancers form a heterogeneous group with high-grade serous carcinoma as the most common subtype. This subtype most likely originates from the epithelium of the distal fallopian tube. Due to a lack of specific symptoms the majority of patients with ovarian cancer are diagnosed with advanced stage of the disease. In most European countries, therapy for patients with ovarian cancer has been centralized to specialized hospitals ensuring higher case volumes and concentration of expertise. Standard therapy for ovarian cancer comprises a combination of surgery and chemotherapy. Despite an initial response, patients frequently develop resistance to chemotherapy. The prognosis of patients with ovarian cancer is therefore unfavourable. Innovative therapeutic strategies, for example based on molecular subtyping, are required to improve treatment outcome.

vorige hoofdstuk Uterine cancer and premalignant lesions

volgende hoofdstuk Vulvar cancer and vulvar premalignancies

Alleen toegankelijk voor geautoriseerde gebruikers

Sex cord-stromal tumours

Tumours composed of pure stromal cells, pure sex cord cells or a combination

Adjuvant chemotherapy

Therapy that is given after the primary surgery to decrease the risk of recurrence

Neo-adjuvant chemotherapy

Therapy that is given before the primary surgery to reduce tumour volume

Cytoreduction

Reducing the number of macroscopic tumour cells

Exfoliation

Process of spontaneous or induced complete detachment of single epithelial (tumour) cells

Cytotoxic

Any agent or process that kills cells

Neo-antigens

Newly exposed antigen

Burger RA, Brady MF, Bookman MA, Fleming GF, Monk BJ, Huang H, Mannel RS, Homesley HD, Fowler J, Greer BE, Boente M, Birrer MJ, Liang SX; Gynecologic Oncology Group. Incorporation of bevacizumab in the primary treatment of ovarian cancer. N Engl J Med. 2011 Dec 29;365(26):2473–83.CrossRef

Buys SS, Partridge E, Black A, Johnson CC, Lamerato L, Isaacs C, Reding DJ, Greenlee RT, Yokochi LA, Kessel B, Crawford ED, Church TR, Andriole GL, Weissfeld JL, Fouad MN, Chia D, O’Brien B, Ragard LR, Clapp JD, Rathmell JM, Riley TL, Hartge P, Pinsky PF, Zhu CS, Izmirlian G, Kramer BS, Miller AB, Xu JL, Prorok PC, Gohagan JK, Berg CD; PLCO Project Team. Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening randomized controlled trial. JAMA 2011 Jun 8;305(22):2295–303.

Collinson F, Qian W, Fossati R, Lissoni A, Williams C, Parmar M, Ledermann J, Colombo N, Swart A; ICON1 collaborators. Optimal treatment of early-stage ovarian cancer. Ann Oncol. 2014;25(6):1165–71.CrossRef

Jacobs IJ, Menon U, Ryan A, Gentry-Maharaj A, Burnell M, Kalsi JK, Amso NN, Apostolidou S, Benjamin E, Cruickshank D, Crump DN, Davies SK, Dawnay A, Dobbs S, Fletcher G, Ford J, Godfrey K, Gunu R, Habib M, Hallett R, Herod J, Jenkins H, Karpinskyj C, Leeson S, Lewis SJ, Liston WR, Lopes A, Mould T, Murdoch J, Oram D, Rabideau DJ, Reynolds K, Scott I, Seif MW, Sharma A, Singh N, Taylor J, Warburton F, Widschwendter M, Williamson K, Woolas R, Fallowfield L, McGuire AJ, Campbell S, Parmar M, Skates SJ. Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial. Lancet 2016 Mar 5;387(10022):945–56.CrossRef

Kurman RJ, Shih IeM. The dualistic model of ovarian carcinogenesis: revisited, revised, and expanded. Am J Pathol. 2016;186(4):733–47.CrossRef

Oza AM, Cook AD, Pfisterer J, Embleton A, Ledermann JA, Pujade-Lauraine E, Kristensen G, Carey MS, Beale P, Cervantes A, Park-Simon TW, Rustin G, Joly F, Mirza MR, Plante M, Quinn M, Poveda A, Jayson GC, Stark D, Swart AM, Farrelly L, Kaplan R, Parmar MK, Perren TJ; ICON7 trial investigators. Standard chemotherapy with or without bevacizumab for women with newly diagnosed ovarian cancer (ICON7): overall survival results of a phase 3 randomised trial. Lancet Oncol. 2015;16(8):928–36.CrossRef

Piek JM, Diest PJ van, Zweemer RP, Jansen JW, Poort-Keesom RJ, Menko FH, Gille JJ, Jongsma AP, Pals G, Kenemans P, Verheijen RH. Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer. J Pathol. 2001;195(4):451–6.

Rebbeck TR, Kauff ND, Domchek SM. Meta-analysis of risk reduction estimates associated with risk-reducing salpingo-oophorectomy in BRCA1 or BRCA2 mutation carriers. J Natl Cancer Inst. 2009 Jan 21;101(2):80–7.CrossRef

Rustin GJ, Vergote I, Eisenhauer E, Pujade-Lauraine E, Quinn M, Thigpen T, Bois A du, Kristensen G, Jakobsen A, Sagae S, Greven K, Parmar M, Friedlander M, Cervantes A, Vermorken J; Gynecological Cancer Intergroup. Definitions for response and progression in ovarian cancer clinical trials incorporating RECIST 1.1 and CA 125 agreed by the Gynecological Cancer Intergroup (GCIG). Int J Gynecol Cancer 2011;21(2):419–23.CrossRef

10.

Wright AA, Bohlke K, Armstrong DK, Bookman MA, Cliby WA, Coleman RL, Dizon DS, Kash JJ, Meyer LA, Moore KN, Olawaiye AB, Oldham J, Salani R, Sparacio D, Tew WP, Vergote I, Edelson MI. Neoadjuvant chemotherapy for newly diagnosed, advanced ovarian cancer: society of gynecologic oncology and American society of clinical oncology clinical practice guideline. J Clin Oncol. 2016 Oct 1;34(28):3460–73.

Titel: Ovarian cancer
Auteurs: Professor Marian J. E. Mourits
Dr Florine A. Eggink
Dr Mathilde Jalving
Dr Marco de Bruyn
Dr Joost Bart
Professor Hans W. Nijman
Uitgeverij: Bohn Stafleu van Loghum
Boek: Textbook of Obstetrics and Gynaecology
Print ISBN: 978-90-368-2130-8

Elektronisch ISBN: 978-90-368-2131-5

Copyright: 2019
DOI: https://doi.org/10.1007/978-90-368-2131-5_29

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Summary

Log in om toegang te krijgen