Introduction
Methods
Study design and setting
Study population
Ethics and dissemination
Objectives of the ONCOR registry
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To register the incidence of major adverse cardiovascular events, defined as: (i) cardiac hospitalisation (categorised by heart failure, acute coronary syndrome, arrhythmia or ‘other’); (ii) cardiac death; (iii) implantation of an implantable cardiac defibrillator or cardiac resynchronization therapy devices; or (iv) (need for) cardiac mechanical support or orthotopic heart transplantation.
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To facilitate research on mechanisms of cardiovascular complications, risk factors, and diagnostic, prognostic and therapeutic strategies.
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To provide a future platform for registry-based randomised controlled trials.
Data collection and management
Data sharing
Timeline
Baseline assessment and clinical visits during follow‑up
Echocardiography and other cardiovascular investigations
Cardiovascular complications
First results
Variable | Patients (n = 1142) |
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Demographics | |
Age at treatment, years | 50.8 ± 16.8 |
Age at first consultation, years | 54.6 ± 14.2 |
Number of females | 700 (61%) |
Malignancy | |
Breast cancer | 445 (39%) |
Lymphoma | 214 (19%) |
Acute leukaemia | 177 (16%) |
Haemato-oncology (other) | 176 (15%) |
Other | 130 (11%) |
Referral reason | |
Screening during treatment | 761 (67%) |
Screening after treatment | 184 (16%) |
Cardiac complaints | 197 (17%) |
Cancer therapy-related cardiovascular complications | |
Myocardial dysfunction and heart failure | 206 |
Coronary artery disease (including coronary vasospasms) | 27 |
Valvular disease | 22 |
Arrhythmias | 74 |
Arterial hypertension | 7 |
Thrombo-embolic disease | 4 |
Peripheral vascular disease and stroke | 2 |
Pulmonary hypertension | 2 |
Pericardial disease | 34 |