Skip to main content
Top

Tip

Swipe om te navigeren naar een ander hoofdstuk

Gepubliceerd in:
Omslag van het boek

2019 | OriginalPaper | Hoofdstuk

1. Neurofysiologie bij pijn

Auteurs : Dr. A. Malfliet, Prof.dr. J. Nijs

Gepubliceerd in: Handboek pijnrevalidatie

Uitgeverij: Bohn Stafleu van Loghum

share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Samenvatting

In dit eerste hoofdstuk staan twee aspecten van pijn centraal: de onderliggende pijnfysiologische en de pijnpsychologische mechanismen. Dit hoofdstuk omvat de definitie van pijn, de neurofysiologie van acute en chronische pijn, de invloed van coping, gedachten, percepties, emoties en cognities op pijn, en de invloed van stress en slaapdeprivatie op pijn. Binnen de neurofysiologie van acute pijn belichten we het perifere zenuwstelsel (neuronen, axonen en de actiepotentiaal), het centrale zenuwstelsel (het ruggenmerg, de dorsale hoorn, ascenderende en descenderende banen, en de verwerking op hersenniveau), het mechanisme achter nociceptieve inhibitie en facilitatie, en hoe en waarom perifere sensitisatie tot stand komt. Bij de neurofysiologie van chronische pijn gaan we in op de mechanismen achter chronische pijn en centrale sensitisatie, waaronder windup, disfunctionele nociceptieve inhibitie en overactieve nociceptieve facilitatie, sensitisatie op hersenniveau en de invloed van gliacellen. Dit alles zou moeten leiden tot een summiere kennis van de neurofysiologie en neuropsychologie van chronische pijn, die de basis zal vormen voor de rest van dit boek, waarin de revalidatie voor de patiënt met chronische pijn centraal staat.
Literatuur
go back to reference Bartolomucci, A., Palanza, P., Parmigiani, S., Pederzani, T., Merlot, E., Neveu, P. J., et al. (2003). Chronic psychosocial stress down-regulates central cytokines mRNA. Brain Research Bulletin, 62(3), 173–178. PubMedCrossRef Bartolomucci, A., Palanza, P., Parmigiani, S., Pederzani, T., Merlot, E., Neveu, P. J., et al. (2003). Chronic psychosocial stress down-regulates central cytokines mRNA. Brain Research Bulletin, 62(3), 173–178. PubMedCrossRef
go back to reference Bushnell, M. C., Čeko, M., & Low, L. A. (2013). Cognitive and emotional control of pain and its disruption in chronic pain. Nature Reviews Neuroscience, 14(7), 502–511. PubMedPubMedCentralCrossRef Bushnell, M. C., Čeko, M., & Low, L. A. (2013). Cognitive and emotional control of pain and its disruption in chronic pain. Nature Reviews Neuroscience, 14(7), 502–511. PubMedPubMedCentralCrossRef
go back to reference Chudler, E. H., Sugiyama, K., & Dong, W. K. (1993). Nociceptive responses in the neostriatum and globus pallidus of the anesthetized rat. Journal of Neurophysiology, 69(6), 1890–1903. PubMedCrossRef Chudler, E. H., Sugiyama, K., & Dong, W. K. (1993). Nociceptive responses in the neostriatum and globus pallidus of the anesthetized rat. Journal of Neurophysiology, 69(6), 1890–1903. PubMedCrossRef
go back to reference Cull-Candy, S., Brickley, S., & Farrant, M. (2001). NMDA receptor subunits: Diversity, development and disease. Current Opinion in Neurobiology, 11(3), 327–335. PubMedCrossRef Cull-Candy, S., Brickley, S., & Farrant, M. (2001). NMDA receptor subunits: Diversity, development and disease. Current Opinion in Neurobiology, 11(3), 327–335. PubMedCrossRef
go back to reference Daenen, L., Nijs, J., Roussel, N., Wouters, K., Loo, M. van, & Cras, P. (2013). Dysfunctional pain inhibition in patients with chronic whiplash-associated disorders: An experimental study. Clinical Rheumatology, 32(1), 23–31. PubMedCrossRef Daenen, L., Nijs, J., Roussel, N., Wouters, K., Loo, M. van, & Cras, P. (2013). Dysfunctional pain inhibition in patients with chronic whiplash-associated disorders: An experimental study. Clinical Rheumatology, 32(1), 23–31. PubMedCrossRef
go back to reference Davis, K. D., & Moayedi, M. (2013). Central mechanisms of pain revealed through functional and structural MRI. Journal of Neuroimmune Pharmacology, 8(3), 518–534. PubMedCrossRef Davis, K. D., & Moayedi, M. (2013). Central mechanisms of pain revealed through functional and structural MRI. Journal of Neuroimmune Pharmacology, 8(3), 518–534. PubMedCrossRef
go back to reference Felice, M. de, & Ossipov, M. H. (2016). Cortical and subcortical modulation of pain. Pain Management, 6(2), 111–120. PubMedCrossRef Felice, M. de, & Ossipov, M. H. (2016). Cortical and subcortical modulation of pain. Pain Management, 6(2), 111–120. PubMedCrossRef
go back to reference Haack, M., Sanchez, E., & Mullington, J. M. (2007). Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers. Sleep, 30(9), 1145–1152. PubMedPubMedCentralCrossRef Haack, M., Sanchez, E., & Mullington, J. M. (2007). Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers. Sleep, 30(9), 1145–1152. PubMedPubMedCentralCrossRef
go back to reference Jahn, A., Nee, D. E., Alexander, W. H., & Brown, J. W. (2016). Distinct regions within medial prefrontal cortex process pain and cognition. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 36(49), 12385–12392. CrossRef Jahn, A., Nee, D. E., Alexander, W. H., & Brown, J. W. (2016). Distinct regions within medial prefrontal cortex process pain and cognition. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 36(49), 12385–12392. CrossRef
go back to reference Jones, A. K., & Derbyshire, S. W. (1997). Reduced cortical responses to noxious heat in patients with rheumatoid arthritis. Annals of the Rheumatic Diseases, 56(10), 601–607. PubMedPubMedCentralCrossRef Jones, A. K., & Derbyshire, S. W. (1997). Reduced cortical responses to noxious heat in patients with rheumatoid arthritis. Annals of the Rheumatic Diseases, 56(10), 601–607. PubMedPubMedCentralCrossRef
go back to reference Julien, N., Goffaux, P., Arsenault, P., & Marchand, S. (2005). Widespread pain in fibromyalgia is related to a deficit of endogenous pain inhibition. Pain, 114(1–2), 295–302. PubMedCrossRef Julien, N., Goffaux, P., Arsenault, P., & Marchand, S. (2005). Widespread pain in fibromyalgia is related to a deficit of endogenous pain inhibition. Pain, 114(1–2), 295–302. PubMedCrossRef
go back to reference Kalinchuk, A. V., McCarley, R. W., Porkka-Heiskanen, T., & Basheer, R. (2010). Sleep deprivation triggers inducible nitric oxide-dependent nitric oxide production in wake–Active basal forebrain neurons. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 30(40), 13254–13264. CrossRef Kalinchuk, A. V., McCarley, R. W., Porkka-Heiskanen, T., & Basheer, R. (2010). Sleep deprivation triggers inducible nitric oxide-dependent nitric oxide production in wake–Active basal forebrain neurons. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 30(40), 13254–13264. CrossRef
go back to reference Kregel, J., Coppieters, I., DePauw, R., Malfliet, A., Danneels, L., Nijs, J., et al. (2017). Does conservative treatment change the brain in patients with chronic musculoskeletal pain? A systematic review. Pain Physician, 20(3), 139–154. Kregel, J., Coppieters, I., DePauw, R., Malfliet, A., Danneels, L., Nijs, J., et al. (2017). Does conservative treatment change the brain in patients with chronic musculoskeletal pain? A systematic review. Pain Physician, 20(3), 139–154.
go back to reference Latremoliere, A., & Woolf, C. J. (2009). Central sensitization: A generator of pain hypersensitivity by central neural plasticity. The Journal of Pain: Official Journal of the American Pain Society, 10(9), 895–926. CrossRef Latremoliere, A., & Woolf, C. J. (2009). Central sensitization: A generator of pain hypersensitivity by central neural plasticity. The Journal of Pain: Official Journal of the American Pain Society, 10(9), 895–926. CrossRef
go back to reference Liu, Y., & Zhang, J. (2000). Recent development in NMDA receptors. Chinese Medical Journal, 113(10), 948–956. PubMed Liu, Y., & Zhang, J. (2000). Recent development in NMDA receptors. Chinese Medical Journal, 113(10), 948–956. PubMed
go back to reference Loggia, M. L., Chonde, D. B., Akeju, O., Arabasz, G., Catana, C., Edwards, R., et al. (2015). Evidence for brain glial activation in chronic pain patients. Brain, 138(3), 604–615. PubMedPubMedCentralCrossRef Loggia, M. L., Chonde, D. B., Akeju, O., Arabasz, G., Catana, C., Edwards, R., et al. (2015). Evidence for brain glial activation in chronic pain patients. Brain, 138(3), 604–615. PubMedPubMedCentralCrossRef
go back to reference Malfliet, A., Coppieters, I., Wilgen, P. van, Kregel, J., Pauw, R. de, Dolphens M., et al. (2017). Brain changes associated with cognitive and emotional factors in chronic pain: A systematic review. European Journal of Pain, 21(5), 769–786. PubMedCrossRef Malfliet, A., Coppieters, I., Wilgen, P. van, Kregel, J., Pauw, R. de, Dolphens M., et al. (2017). Brain changes associated with cognitive and emotional factors in chronic pain: A systematic review. European Journal of Pain, 21(5), 769–786. PubMedCrossRef
go back to reference Malfliet, A., Kregel, J., Cagnie, B., Kuipers, M., Dolphens, M., Roussel, N., et al. (2015). Lack of evidence for central sensitization in idiopathic, non-traumatic neck pain: A systematic review. Pain Physician, 18(3), 223–236. PubMed Malfliet, A., Kregel, J., Cagnie, B., Kuipers, M., Dolphens, M., Roussel, N., et al. (2015). Lack of evidence for central sensitization in idiopathic, non-traumatic neck pain: A systematic review. Pain Physician, 18(3), 223–236. PubMed
go back to reference Mansour, A. R., Farmer, M. A., Baliki, M. N., & Apkarian, A. V. (2014). Chronic pain: The role of learning and brain plasticity. Restorative Neurology and Neuroscience, 32(1), 129–139. PubMedPubMedCentral Mansour, A. R., Farmer, M. A., Baliki, M. N., & Apkarian, A. V. (2014). Chronic pain: The role of learning and brain plasticity. Restorative Neurology and Neuroscience, 32(1), 129–139. PubMedPubMedCentral
go back to reference McCray, C. J., & Agarwal, S. K. (2011). Stress and autoimmunity. Immunology and Allergy Clinics of North America, 31(1), 1–18. PubMedCrossRef McCray, C. J., & Agarwal, S. K. (2011). Stress and autoimmunity. Immunology and Allergy Clinics of North America, 31(1), 1–18. PubMedCrossRef
go back to reference McCulloch, J., & Transfeldt, E. (1997). Pain. In Macnab’s backache (pp. 358–373). Baltimore: Williams & Wilkins. McCulloch, J., & Transfeldt, E. (1997). Pain. In Macnab’s backache (pp. 358–373). Baltimore: Williams & Wilkins.
go back to reference Meeus, M., Nijs, J., Wauwer, N. van de, Toeback, L., & Truijen, S. (2008). Diffuse noxious inhibitory control is delayed in chronic fatigue syndrome: An experimental study. Pain, 139(2), 439–448. PubMedCrossRef Meeus, M., Nijs, J., Wauwer, N. van de, Toeback, L., & Truijen, S. (2008). Diffuse noxious inhibitory control is delayed in chronic fatigue syndrome: An experimental study. Pain, 139(2), 439–448. PubMedCrossRef
go back to reference Naugle, K. M., Fillingim, R. B., & Riley, J. L. (2012). A meta-analytic review of the hypoalgesic effects of exercise. The Journal of Pain: Official Journal of the American Pain Society, 13(12), 1139–1150. CrossRef Naugle, K. M., Fillingim, R. B., & Riley, J. L. (2012). A meta-analytic review of the hypoalgesic effects of exercise. The Journal of Pain: Official Journal of the American Pain Society, 13(12), 1139–1150. CrossRef
go back to reference Nijs, J., Kosek, E., Oosterwijck, J. van, & Meeus, M. (2012). Dysfunctional endogenous analgesia during exercise in patients with chronic pain: To exercise or not to exercise? Pain Physician, 15(3 Suppl), ES205–ES213. Nijs, J., Kosek, E., Oosterwijck, J. van, & Meeus, M. (2012). Dysfunctional endogenous analgesia during exercise in patients with chronic pain: To exercise or not to exercise? Pain Physician, 15(3 Suppl), ES205–ES213.
go back to reference Oosterwijck, J. van, Nijs, J., Meeus, M., & Paul, L. (2013). Evidence for central sensitization in chronic whiplash: A systematic literature review. European Journal of Pain (London, England), 17(3), 299–312. CrossRef Oosterwijck, J. van, Nijs, J., Meeus, M., & Paul, L. (2013). Evidence for central sensitization in chronic whiplash: A systematic literature review. European Journal of Pain (London, England), 17(3), 299–312. CrossRef
go back to reference Ossipov, M. H., Morimura, K., & Porreca, F. (2014). Descending pain modulation and chronification of pain. Current Opinion in Supportive and Palliative Care, 8(2), 143–151. PubMedPubMedCentral Ossipov, M. H., Morimura, K., & Porreca, F. (2014). Descending pain modulation and chronification of pain. Current Opinion in Supportive and Palliative Care, 8(2), 143–151. PubMedPubMedCentral
go back to reference Paoletti, P., & Neyton, J. (2007). NMDA receptor subunits: Function and pharmacology. Current Opinion in Pharmacology, 7(1), 39–47. PubMedCrossRef Paoletti, P., & Neyton, J. (2007). NMDA receptor subunits: Function and pharmacology. Current Opinion in Pharmacology, 7(1), 39–47. PubMedCrossRef
go back to reference Petersen, G. L., Finnerup, N. B., Grosen, K., Pilegaard, H. K., Tracey, I., Benedetti, F., et al. (2014). Expectations and positive emotional feelings accompany reductions in ongoing and evoked neuropathic pain following placebo interventions. Pain, 155(12), 2687–2698. PubMedCrossRef Petersen, G. L., Finnerup, N. B., Grosen, K., Pilegaard, H. K., Tracey, I., Benedetti, F., et al. (2014). Expectations and positive emotional feelings accompany reductions in ongoing and evoked neuropathic pain following placebo interventions. Pain, 155(12), 2687–2698. PubMedCrossRef
go back to reference Ren, K., & Dubner, R. (1996). Enhanced descending modulation of nociception in rats with persistent hindpaw inflammation. Journal of Neurophysiology, 76, 3025–3037. PubMedCrossRef Ren, K., & Dubner, R. (1996). Enhanced descending modulation of nociception in rats with persistent hindpaw inflammation. Journal of Neurophysiology, 76, 3025–3037. PubMedCrossRef
go back to reference Simons, L. E., Elman, I., & Borsook, D. (2014). Psychological processing in chronic pain: A neural systems approach. Neuroscience and Biobehavioral Reviews, 39, 61–78. PubMedCrossRef Simons, L. E., Elman, I., & Borsook, D. (2014). Psychological processing in chronic pain: A neural systems approach. Neuroscience and Biobehavioral Reviews, 39, 61–78. PubMedCrossRef
go back to reference Tarrago, M. da G. L., Deitos, A., Brietzke, A. P., Vercelino, R., Torres, I. L. S., Fregni, F., et al. (2016). Descending control of nociceptive processing in knee osteoarthritis is associated with intracortical disinhibition: An exploratory study. Medicine, 95(17), e3353. PubMedCentralCrossRef Tarrago, M. da G. L., Deitos, A., Brietzke, A. P., Vercelino, R., Torres, I. L. S., Fregni, F., et al. (2016). Descending control of nociceptive processing in knee osteoarthritis is associated with intracortical disinhibition: An exploratory study. Medicine, 95(17), e3353. PubMedCentralCrossRef
go back to reference Tesarz, J., Gerhardt, A., Leisner, S., Janke, S., Treede, R. D., & Eich, W. (2015). Distinct quantitative sensory testing profiles in nonspecific chronic back pain subjects with and without psychological trauma. Pain, 156(4), 577–586. PubMedCrossRef Tesarz, J., Gerhardt, A., Leisner, S., Janke, S., Treede, R. D., & Eich, W. (2015). Distinct quantitative sensory testing profiles in nonspecific chronic back pain subjects with and without psychological trauma. Pain, 156(4), 577–586. PubMedCrossRef
go back to reference Vase, L., Nikolajsen, L., Christensen, B., Egsgaard, L. L., Arendt-Nielsen, L., Svensson, P., et al. (2011). Cognitive-emotional sensitization contributes to wind-up-like pain in phantom limb pain patients. Pain, 152(1), 157–162. PubMedCrossRef Vase, L., Nikolajsen, L., Christensen, B., Egsgaard, L. L., Arendt-Nielsen, L., Svensson, P., et al. (2011). Cognitive-emotional sensitization contributes to wind-up-like pain in phantom limb pain patients. Pain, 152(1), 157–162. PubMedCrossRef
go back to reference Vierck, C. J., Whitsel, B. L., Favorov, O. V., Brown, A. W., & Tommerdahl, M. (2013). Role of primary somatosensory cortex in the coding of pain. Pain, 154(3), 334–344. PubMedCrossRef Vierck, C. J., Whitsel, B. L., Favorov, O. V., Brown, A. W., & Tommerdahl, M. (2013). Role of primary somatosensory cortex in the coding of pain. Pain, 154(3), 334–344. PubMedCrossRef
go back to reference Walker, F. R., Nilsson, M., & Jones, K. (2013). Acute and chronic stress-induced disturbances of microglial plasticity, phenotype and function. Current Drug Targets, 14(11), 1262–1276. PubMedCrossRef Walker, F. R., Nilsson, M., & Jones, K. (2013). Acute and chronic stress-induced disturbances of microglial plasticity, phenotype and function. Current Drug Targets, 14(11), 1262–1276. PubMedCrossRef
go back to reference Williams, A. C. de C., & Craig, K. D. (2016). Updating the definition of pain. Pain, 157(11), 2420–2423. PubMedCrossRef Williams, A. C. de C., & Craig, K. D. (2016). Updating the definition of pain. Pain, 157(11), 2420–2423. PubMedCrossRef
go back to reference Wisor, J. P., Schmidt, M. A., & Clegern, W. C. (2011). Evidence for neuroinflammatory and microglial changes in the cerebral response to sleep loss. Sleep, 34(3), 261–272. PubMedPubMedCentralCrossRef Wisor, J. P., Schmidt, M. A., & Clegern, W. C. (2011). Evidence for neuroinflammatory and microglial changes in the cerebral response to sleep loss. Sleep, 34(3), 261–272. PubMedPubMedCentralCrossRef
go back to reference Woolf, C. J. (2011). Central sensitization: Implications for the diagnosis and treatment of pain. Pain, 152(3 Suppl), S2–S15. PubMedCrossRef Woolf, C. J. (2011). Central sensitization: Implications for the diagnosis and treatment of pain. Pain, 152(3 Suppl), S2–S15. PubMedCrossRef
go back to reference Woolf, C. J., & Salter, M. W. (2000). Neuronal plasticity: Increasing the gain in pain. Science (New York, N.Y.), 288(5472), 1765–1769. CrossRef Woolf, C. J., & Salter, M. W. (2000). Neuronal plasticity: Increasing the gain in pain. Science (New York, N.Y.), 288(5472), 1765–1769. CrossRef
go back to reference Yu, R., Gollub, R. L., Spaeth, R., Napadow, V., Wasan, A., & Kong, J. (2014). Disrupted functional connectivity of the periaqueductal gray in chronic low back pain. NeuroImage Clinical, 6, 100–108. PubMedPubMedCentralCrossRef Yu, R., Gollub, R. L., Spaeth, R., Napadow, V., Wasan, A., & Kong, J. (2014). Disrupted functional connectivity of the periaqueductal gray in chronic low back pain. NeuroImage Clinical, 6, 100–108. PubMedPubMedCentralCrossRef
go back to reference Zhang, H., Xie, W., & Xie, Y. (2005). Spinal cord injury triggers sensitization of wide dynamic range dorsal horn neurons in segments rostral to the injury. Brain Research, 1055(1), 103–110. PubMedCrossRef Zhang, H., Xie, W., & Xie, Y. (2005). Spinal cord injury triggers sensitization of wide dynamic range dorsal horn neurons in segments rostral to the injury. Brain Research, 1055(1), 103–110. PubMedCrossRef
go back to reference Zhou, Q., Price, D. D., Callam, C. S., Woodruff, M. A., & Verne, G. N. (2011). Effects of the N-methyl-D-aspartate receptor on temporal summation of second pain (wind-up) in irritable bowel syndrome. The Journal of Pain: Official Journal of the American Pain Society, 12(2), 297–303. CrossRef Zhou, Q., Price, D. D., Callam, C. S., Woodruff, M. A., & Verne, G. N. (2011). Effects of the N-methyl-D-aspartate receptor on temporal summation of second pain (wind-up) in irritable bowel syndrome. The Journal of Pain: Official Journal of the American Pain Society, 12(2), 297–303. CrossRef
go back to reference Zusman, M. (2002). Forebrain-mediated sensitization of central pain pathways: “Non-specific” pain and a new image for MT. Manual Therapy, 7(2), 80–88. PubMedCrossRef Zusman, M. (2002). Forebrain-mediated sensitization of central pain pathways: “Non-specific” pain and a new image for MT. Manual Therapy, 7(2), 80–88. PubMedCrossRef
Metagegevens
Titel
Neurofysiologie bij pijn
Auteurs
Dr. A. Malfliet
Prof.dr. J. Nijs
Copyright
2019
Uitgeverij
Bohn Stafleu van Loghum
DOI
https://doi.org/10.1007/978-90-368-2230-5_1