Swipe om te navigeren naar een ander artikel
The online version of this article (https://doi.org/10.1007/s11136-017-1779-y) contains supplementary material, which is available to authorized users.
Acute respiratory infections (ARIs), and associated symptoms such as cough, are frequently experienced among children and impose a burden on families (e.g., use of medical resources and time off work/school). However, there are little data on changes in, and predictors of, quality of life (QoL) over the duration of an ARI with cough (ARIwC) episode. We therefore aimed to determine cough-specific QoL and identify its influencing factors among children with ARIwC, at the time of presentation to a pediatric emergency department (ED), and over the following 4 weeks.
Data from 283 children aged < 15 years were included in our analyses. We used the validated parent-proxy children’s acute cough-specific QoL questionnaire (PAC-QoL) at each time-point. Linear regression and mixed effect modeling were used to identify factors influencing QoL at baseline and over the follow-up period.
Median PAC-QoL at baseline was 2.7 (IQR 2.1–3.6) and significantly improved by Day-7 (4.9, IQR 3.8–6.1) and Day-14 (6.59, IQR 5.1–7.0), both p < 0.001. The improvements in median PAC-QoL between Days-14, -21, and -28 were not significant. Regression modeling identified that day-cough severity, night-cough severity, and financial concerns had the highest impact on both baseline, and follow-up, PAC-QoL scores. There were five additional independent significant factors at baseline and six at follow-up.
Quality of life is considerably impaired at presentation to ED, but improves significantly by Days-7 and -14. As cough severity and financial concerns had the highest impact on QoL, effectively managing cough to reduce the clinical and financial burden on children and families is important.
Log in om toegang te krijgen
Met onderstaand(e) abonnement(en) heeft u direct toegang:
Supplementary material 1 (DOCX 14 KB)11136_2017_1779_MOESM1_ESM.docx
Chang, A. B., Landau, L. I., Van Asperen, P. P., Glasgow, N. J., Robertson, C. F., Marchant, J. M., et al. (2006). Cough in children: Definitions and clinical evaluation. The Medical Journal of Australia, 184(8), 398–403. PubMed
Pandee, U., Vallipakorn, S. A., & Plitponkarnpim, A. (2015). The profile of pediatric patients visit emergency department at urban University Hospital in Thailand. Journal of the Medical Association of Thailand, 98(8), 761–767. PubMed
Moore, H. C., De Klerk, N., Jacoby, P., Richmond, P., & Lehmann, D. (2012). Can linked emergency department data help assess the out-of-hospital burden of acute lower respiratory infections? A population-based cohort study. BMC Public Health, 12(1), 703–711. https://doi.org/10.1186/1471-2458-12-703. PubMed
O’Grady, K. F., Grimwood, K., Sloots, T. P., Whiley, D. M., Acworth, J. P., Phillips, N., et al. (2016). Prevalence, codetection and seasonal distribution of upper airway viruses and bacteria in children with acute respiratory illnesses with cough as a symptom. Clinical Microbiology and Infection, 22(6), 527–534. https://doi.org/10.1016/j.cmi.2016.02.004. PubMed
Angoulvant, F., Jumel, S., Prot-Labarthe, S., Bellettre, X., Kahil, M., Smail, A., et al. (2013). Multiple health care visits related to a pediatric emergency visit for young children with common illnesses. European Journal of Pediatrics, 172(6), 797–802. https://doi.org/10.1007/s00431-013-1968-9. PubMed
Britt, H., Miller, G. C., Henderson, J., Bayram, C., Harrison, C., Valenti, L., Wong, C., Gordon, J., Pollack, A. J., Pan, Y., Charles, J. (2015). General practice activity in Australia 2014–15. General practice series no. 38. Sydney: Sydney University Press. Retrieved from http://hdl.handle.net/2123/13765.
Petsios, K. T., Priftis, K. N., Tsoumakas, C., Perperoglou, A., Hatziagorou, E., Tsanakas, J. N., et al. (2009). Cough affects quality of life in asthmatic children aged 8–14 more than other asthma symptoms. Allergologia et Immunopathologia, 37(2), 80–88. https://doi.org/10.1016/s0301-0546(09)71109-7. PubMed
Anderson-James, S., Newcombe, P. A., Marchant, J. M., O’Grady, K. A. F., Acworth, J. P., Stone, D. G., et al. (2015). An acute cough-specific quality-of-life questionnaire for children: Development and validation. The Journal of Allergy and Clinical Immunology, 135(5), 1179–1185.e4. https://doi.org/10.1016/j.jaci.2014.08.036. PubMed
Newcombe, P. A., Sheffield, J. K., & Chang, A. B. (2013). Parent cough-specific quality of life: Development and validation of a short form. The Journal of Allergy and Clinical Immunology, 131(4), 1069–1074. https://doi.org/10.1016/j.jaci.2012.10.004. PubMed
Shoham, Y., Dagan, R., Givon-Lavi, N., Liss, Z., Shagan, T., Zamir, O., et al. (2005). Community-acquired pneumonia in children: Quantifying the burden on patients and their families including decrease in quality of life. Pediatrics, 115(5), 1213–1219. https://doi.org/10.1542/peds.2004-1285. PubMed
Jiang, X., Sun, L., Wang, B., Yang, X., Shang, L., & Zhang, Y. (2013). Health-related quality of life among children with recurrent respiratory tract infections in Xi’an, China. PLoS ONE, 8(2), e56945. doi. https://doi.org/10.1371/journal.pone.0056945. PubMed
Jensen, M. E., Mendelson, M. J., Desplats, E., Zhang, X., Platt, R., & Ducharme, F. M. (2016). Caregiver’s functional status during a young child’s asthma exacerbation: A validated instrument. The Journal of Allergy and Clinical Immunology, 137(3), 782–788.e6. https://doi.org/10.1016/j.jaci.2015.08.031. PubMed
Drescher, B. J., Chang, A. B., Phillips, N., Acworth, J., Marchant, J., Sloots, T. P., et al. (2013). The development of chronic cough in children following presentation to a tertiary paediatric emergency department with acute respiratory illness: Study protocol for a prospective cohort study. BMC Pediatrics, 13(1), 125–133. https://doi.org/10.1186/1471-2431-13-125. PubMed
Chang, A. B., Newman, R. G., Carlin, J. B., Phelan, P. D., & Robertson, C. F. (1998). Subjective scoring of cough in children: Parent-completed vs child-completed diary cards vs an objective method. European Respiratory Journal, 11(2), 462–466. https://doi.org/10.1183/09031936.98.11020462. PubMed
Galecki, A. T., West, B. T., & Welch, K. B. (2006). Linear mixed models: A practical guide using statistical software. Philadelphia, PA: Chapman and Hall.
Zuur, A., Ieno, E. N., & Walker, N. (2009). Statistics for biology and health: Mixed effects models and extensions in ecology with R. New York: Springer. CrossRef
Australian Bureau of Statistics. (2016). Census of population and housing, quick stats Queensland—Level of highest educational attainment. 2017. Retrieved from http://www.censusdata.abs.gov.au/census_services/getproduct/census/2016/quickstat/3?opendocument.
Australian Institute of Family Studies. (2013). Parents working out work (Australian Family Trends No. 1). Retrieved from http://www.aifs.gov.au/publications/parents-working-out-work.
Australian Bureau of Statistics. (2016). Census of population and housing, general community profile: Queensland, Table G28 total family income (weekly) by family composition—Couple family with children. 2017. Excel spreadsheet, cat. no. 2001.0. Retrieved from http://www.censusdata.abs.gov.au/CensusOutput/copsub2016.NSF/All%20docs%20by%20catNo/2016~Community%20Profile~3/$File/GCP_3.zip?OpenElement.
Australian Bureau of Statistics. (2016). Census of population and housing, general community profile: Queensland, G01 selected person characteristics by sex (1 of 2)—Males and females 0–14 years. 2017. Excel spreadsheet, cat. no. 2001.0. Retrieved from http://www.censusdata.abs.gov.au/CensusOutput/copsub2016.NSF/All%20docs%20by%20catNo/2016~Community%20Profile~3/$File/GCP_3.zip?OpenElement.
Australian Bureau of Statistics. (2012). Australian health survey. First results, 2011–12—Table 3.3 long-term conditions, proportion of persons, children aged 0–14 yrs. Excel spreadsheet, cat. no. 4364.0.55.001. Retrieved from http://www.abs.gov.au/ausstats/subscriber.nsf/log?openagent&43640do003_20112012v2.xls&4364.0.55.001&Data%20Cubes&C6D4971625F0E865CA257B820017A54F&0&2011-12&07.06.2013&Previous.
Osman, L. M., Baxter-Jones, A. D. G., & Helms, P. J. (2001). Parents’ quality of life and respiratory symptoms in young children with mild wheeze. European Respiratory Journal, 17(2), 254–258. https://doi.org/10.1183/09031936.01.17202540. PubMed
Cutler, D. M., & Lleras-Muney, A. (2010). Understanding differences in health behaviors by education. Journal of Health Economics, 29(1), 1–28. https://doi.org/10.1016/j.jhealeco.2009.10.003. PubMed
Bont, L., Steijn, M., van Aalderen, W. M. C., & Kimpen, J. L. L. (2004). Impact of wheezing after respiratory syncytial virus infection on health-related quality of life. The Pediatric Infectious Disease Journal, 23(5), 414–417. https://doi.org/10.1097/01.inf.0000122604.32137.29. PubMed
Desager, K. N., Nelen, V., Weyler, J. J. J., & De Backer, W. A. (2005). Sleep disturbance and daytime symptoms in wheezing school-aged children. Journal of Sleep Research, 14(1), 77–82. https://doi.org/10.1111/j.1365-2869.2004.00432.x. PubMed
Mistry, R. D., Stevens, M. W., & Gorelick, M. H. (2009). Health-related quality of life for pediatric emergency department febrile illnesses: An evaluation of the pediatric quality of life inventory 4.0 generic core scales. Health and Quality of Life Outcomes, 7(1), 5–13. https://doi.org/10.1186/1477-7525-7-5. PubMed
Wiebe, S., Guyatt, G., Weaver, B., Matijevic, S., & Sidwell, C. (2003). Comparative responsiveness of generic and specific quality-of-life instruments. Journal of Clinical Epidemiology, 56(1), 52–60. https://doi.org/10.1016/s0895-4356(02)00537-1. PubMed
- Longitudinal study of quality of life among children with acute respiratory infection and cough
Yolanda G. Lovie-Toon
Anne B. Chang
Peter A. Newcombe
Benjamin J. Drescher
Michael E. Otim
Kerry-Ann F. O’Grady
- Springer International Publishing