Top

Gepubliceerd in:

07-07-2015

Long-term health-related quality of life of living kidney donors: a single-center experience

Auteurs: Christian Benzing, Hans-Michael Hau, Greta Kurtz, Moritz Schmelzle, Hans-Michael Tautenhahn, Mehmet Haluk Morgül, Georg Wiltberger, Johannes Broschewitz, Georgi Atanasov, Anette Bachmann, Michael Bartels

Gepubliceerd in: Quality of Life Research | Uitgave 12/2015

Abstract

Purpose

Over the last few years, the evaluation of the health-related quality of life (HRQoL) of living kidney donors (LKD) has become of particular interest. The present study sought to evaluate the physical and mental HRQoL after kidney removal. The clinical and paraclinical course of these patients was examined, and the impact of preoperative donor evaluation, donor nephrectomy, and surgical recovery was evaluated. These data were compared with reference data of the general population.

Methods

Between 1998 and 2010, 72 living kidney donations were performed at our institution. To assess the HRQoL, two questionnaires—the Short Form 36 (SF-36) and a special LKD questionnaire—were sent to all 72 living donors. The records of the follow-up examinations of all 72 donors were retrospectively analyzed in order to assess the clinical and paraclinical data after kidney donation.

Results

Out of 72 donors, 55 (76.4 %) responded to the questionnaires. There was no change in systolic and diastolic blood pressure during the 7-year follow-up (p > 0.05). Mild proteinuria (>150 mg/l) was observed in six cases. Kidney donors had a higher HRQoL compared to the general population with mean values of the physical and mental summation scale (PCS and MCS, respectively) being 51.3 (SD = 7.6) and 50.6 (SD = 8.1). Peri- or postoperative complications were associated with lower values for physical function and physical component summary (PCS) (p < 0.05).

Discussion

Living donor kidney transplantation appears to be safe for donors. The HRQoL is excellent. To ensure a positive outcome for donors, a good clinical evaluation of potential donors is essential.

vorige artikel Examining the relationship between health-related quality of life and increasing numbers of diagnoses

volgende artikel Caring for relatives with lung cancer in Europe: an evaluation of caregivers’ experience

Wolfe, R. A., Ashby, V. B., Milford, E. L., Ojo, A. O., Ettenger, R. E., Agodoa, L. Y., et al. (1999). Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. New England Journal of Medicine, 341(23), 1725–1730. doi:10.1056/NEJM199912023412303.CrossRefPubMed

Mihovilović, K., Maksimović, B., Kocman, B., Guštin, D., Vidas, Z., Bulimbašić, S., et al. (2014). Effect of mycophenolate mofetil on progression of interstitial fibrosis and tubular atrophy after kidney transplantation: A retrospective study. BMJ Open, 4(7), e005005. doi:10.1136/bmjopen-2014-005005.PubMedCentralCrossRefPubMed

Pan, X. M., Xiang, H. L., Ding, C. G., Luo, Z. Z., Tian, P. X., & Xue, W. J. (2014). Comparative study of one-stitch versus Lich-Gregoir ureterovesical implantation for kidney transplants. World Journal of Urology, 32(5), 1355–1361. doi:10.1007/s00345-013-1217-x.CrossRefPubMed

Brusich, K. T., Acan, I., Filipcic, N. V., & Gustin, D. (2013). Anaesthesia for renal transplant surgery. European Journal of Anaesthesiology, 30(11), 715–716. doi:10.1097/EJA.0b013e328362a708.CrossRefPubMed

Eurotransplant. (2014). Statistics report library. http://statistics.eurotransplant.org/index.php?search_type=donors+deceased&search_organ=kidney&search_region=All+ET&search_period=by+year&search_characteristic=&search_text=. Accessed 05 Oct 2014.

Tellioglu, G., Berber, I., Yatkin, I., Yigit, B., Ozgezer, T., Gulle, S., et al. (2008). Quality of life analysis of renal donors. Transplantation Proceedings, 40(1), 50–52. doi:10.1016/j.transproceed.2007.11.030.CrossRefPubMed

Toyoda, M., Yamanaga, S., Kawabata, C., Hidaka, Y., Inadome, A., Arakane, F., et al. (2014). Long-term safety of living kidney donors aged 60 and older. Transplantation Proceedings, 46(2), 318–320. doi:10.1016/j.transproceed.2013.11.019.CrossRefPubMed

Johnson, S. R., Khwaja, K., Pavlakis, M., Monaco, A. P., & Hanto, D. W. (2005). Older living donors provide excellent quality kidneys: A single center experience (older living donors). Clinical Transplantation, 19(5), 600–606. doi:10.1111/j.1399-0012.2004.00328.x.CrossRefPubMed

Kamran, T., Zaheer, K., Hussain, S. W., Zahid, K. H., & Akhtar, M. S. (2003). Are live kidney donors at risk? Journal of the College of Physicians and Surgeons—Pakistan: JCPSP, 13(3), 153–156.PubMed

10.

Kasiske, B. L., Anderson-Haag, T., Ibrahim, H. N., Pesavento, T. E., Weir, M. R., Nogueira, J. M., et al. (2013). A prospective controlled study of kidney donors: Baseline and 6-month follow-up. American Journal of Kidney Diseases, 62(3), 577–586. doi:10.1053/j.ajkd.2013.01.027.PubMedCentralCrossRefPubMed

11.

Patel, N., Mason, P., Rushton, S., Hudson, A., Ploeg, R., Friend, P., et al. (2013). Renal function and cardiovascular outcomes after living donor nephrectomy in the UK: Quality and safety revisited. BJU International, 112(2), E134–E142. doi:10.1111/bju.12213.CrossRefPubMed

12.

Bieniasz, M., Domagala, P., Kwiatkowski, A., Gozdowska, J., Krzysztof, O., Kieszek, R. A., et al. (2009). The assessment of residual kidney function after living donor nephrectomy. Transplantation Proceedings, 41(1), 91–92. doi:10.1016/j.transproceed.2008.08.160.CrossRefPubMed

13.

Ellison, M. D., McBride, M. A., Taranto, S. E., Delmonico, F. L., & Kauffman, H. M. (2002). Living kidney donors in need of kidney transplants: A report from the organ procurement and transplantation network. Transplantation, 74(9), 1349–1351. doi:10.1097/01.TP.0000034031.95427.2A.CrossRefPubMed

14.

Mjøen, G., Hallan, S., Hartmann, A., Foss, A., Midtvedt, K., Øyen, O., et al. (2014). Long-term risks for kidney donors. Kidney International, 86(1), 162–167. doi:10.1038/ki.2013.460.CrossRefPubMed

15.

Muzaale, A. D., Massie, A. B., Wang, M. C., Montgomery, R. A., McBride, M. A., Wainright, J. L., et al. (2014). Risk of end-stage renal disease following live kidney donation. JAMA, 311(6), 579–586. doi:10.1001/jama.2013.285141.PubMedCentralCrossRefPubMed

16.

Mjøen, G., Oyen, O., Midtvedt, K., Dahle, D. O., Norby, G., & Holdaas, H. (2011). Age, gender, and body mass index are associated with renal function after kidney donation. Clinical Transplantation, 25(6), E579–E583. doi:10.1111/j.1399-0012.2011.01503.x.CrossRefPubMed

17.

de Groot, I. B., Stiggelbout, A. M., van der Boog, P. J., Baranski, A. G., Marang-van de Mheen, P. J., & PARTNER-study group. (2012). Reduced quality of life in living kidney donors: Association with fatigue, societal participation and pre-donation variables. Transplant International, 25(9), 967–975. doi:10.1111/j.1432-2277.2012.01524.x.CrossRefPubMed

18.

Ethics Committee of the Transplantation Society. (2004). The consensus statement of the Amsterdam Forum on the Care of the Live Kidney Donor. Transplantation, 78(4), 491–492.CrossRef

19.

Virzì, A., Signorelli, M. S., Veroux, M., Giammarresi, G., Maugeri, S., Nicoletti, A., et al. (2007). Depression and quality of life in living related renal transplantation. Transplantation Proceedings, 39(6), 1791–1793. doi:10.1016/j.transproceed.2007.05.011.CrossRefPubMed

20.

Giessing, M. (2012). Living donor nephrectomy—quantifying the risk for the donor. Transplantation Proceedings, 44(6), 1786–1789. doi:10.1016/j.transproceed.2012.06.006.CrossRefPubMed

21.

Sener, A., & Cooper, M. (2008). Live donor nephrectomy for kidney transplantation. Nature Clinical Practice Urology, 5(4), 203–210. doi:10.1038/ncpuro1047.PubMed

22.

Glotzer, O. S., Singh, T. P., Gallichio, M. H., Conti, D. J., & Siparsky, N. F. (2013). Long-term quality of life after living kidney donation. Transplantation Proceedings, 45(9), 3225–3228. doi:10.1016/j.transproceed.2013.05.006.CrossRefPubMed

23.

Giessing, M., Reuter, S., Schönberger, B., Deger, S., Tuerk, I., Hirte, I., et al. (2004). Quality of life of living kidney donors in Germany: A survey with the Validated Short Form-36 and Giessen Subjective Complaints List-24 questionnaires. Transplantation, 78(6), 864–872.CrossRefPubMed

24.

Lopes, A., Frade, I. C., Teixeira, L., Almeida, M., Dias, L., & Henriques, A. C. (2013). Quality of life assessment in a living donor kidney transplantation program: Evaluation of recipients and donors. Transplantation Proceedings, 45(3), 1106–1109. doi:10.1016/j.transproceed.2013.02.100.CrossRefPubMed

25.

Gross, C. R., Messersmith, E. E., Hong, B. A., Jowsey, S. G., Jacobs, C., Gillespie, B. W., et al. (2013). Health-related quality of life in kidney donors from the last five decades: Results from the RELIVE study. American Journal of Transplantation, 13(11), 2924–2934. doi:10.1111/ajt.12434.PubMedCentralCrossRefPubMed

26.

Garcia, M. F., Andrade, L. G., & Carvalho, M. F. (2013). Living kidney donors: A prospective study of quality of life before and after kidney donation. Clinical Transplantation, 27(1), 9–14. doi:10.1111/j.1399-0012.2012.01687.x.CrossRefPubMed

27.

Lima, D. X., Petroianu, A., & Hauter, H. L. (2006). Quality of life and surgical complications of kidney donors in the late post-operative period in Brazil. Nephrology, Dialysis, Transplantation, 21(11), 3238–3242. doi:10.1093/ndt/gfl433.CrossRefPubMed

28.

Ibrahim, H. N., Foley, R., Tan, L., Rogers, T., Bailey, R. F., Guo, H., et al. (2009). Long-term consequences of kidney donation. New England Journal of Medicine, 360(5), 459–469. doi:10.1056/NEJMoa0804883.PubMedCentralCrossRefPubMed

29.

Feltrin, A., Pegoraro, R., Rago, C., Benciolini, P., Pasquato, S., Frasson, P., et al. (2008). Experience of donation and quality of life in living kidney and liver donors. Transplant International, 21(5), 466–472. doi:10.1111/j.1432-2277.2007.00632.x.CrossRefPubMed

30.

Isotani, S., Fujisawa, M., Ichikawa, Y., Ishimura, T., Matsumoto, O., Hamami, G., et al. (2002). Quality of life of living kidney donors: The short-form 36-item health questionnaire survey. Urology, 60(4), 588–592. discussion 592.CrossRefPubMed

31.

Jackobs, S., Becker, T., Lück, R., Jäger, M. D., Nashan, B., Gwinner, W., et al. (2005). Quality of life following living donor nephrectomy comparing classical flank incision and anterior vertical mini-incision. World Journal of Urology, 23(5), 343–348. doi:10.1007/s00345-005-0008-4.CrossRefPubMed

32.

Reimer, J., Rensing, A., Haasen, C., Philipp, T., Pietruck, F., & Franke, G. H. (2006). The impact of living-related kidney transplantation on the donor’s life. Transplantation, 81(9), 1268–1273. doi:10.1097/01.tp.0000210009.96816.db.CrossRefPubMed

33.

Langenbach, M., Stippel, A., & Stippel, D. (2009). Kidney donors’ quality of life and subjective evaluation at 2 years after donation. Transplantation Proceedings, 41(6), 2512–2514. doi:10.1016/j.transproceed.2009.06.122.CrossRefPubMed

34.

Ware, J. E., & Sherbourne, C. D. (1992). The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Medical Care, 30(6), 473–483.CrossRefPubMed

35.

von Zerssen, D., & Petermann, F. (2011). Bf-SR-Die Befindlichkeits-Skala-Revidierte Fassung. Göttingen: Hogrefe.

36.

Mandelbrot, D. A., Pavlakis, M., Danovitch, G. M., Johnson, S. R., Karp, S. J., Khwaja, K., et al. (2007). The medical evaluation of living kidney donors: A survey of US transplant centers. American Journal of Transplantation, 7(10), 2333–2343. doi:10.1111/j.1600-6143.2007.01932.x.CrossRefPubMed

37.

Morfeld, M., Kirchberger, I., & Bullinger, M. (2011). SF 36-Fragebogen zum Gesundheitszustand. Göttingen: Hogrefe.

38.

Shrestha, A., Vallance, C., McKane, W. S., Shrestha, B. M., & Raftery, A. T. (2008). Quality of life of living kidney donors: A single-center experience. Transplantation Proceedings, 40(5), 1375–1377. doi:10.1016/j.transproceed.2008.03.132.CrossRefPubMed

39.

Pugh, D. (2012). Time to encourage patients to take more exercise. Practitioner, 256(1754), 25–28.PubMed

40.

Sprangers, M. A., & Schwartz, C. E. (1999). Integrating response shift into health-related quality of life research: A theoretical model. Social Science and Medicine, 48(11), 1507–1515.CrossRefPubMed

41.

Rapkin, B. D., & Schwartz, C. E. (2004). Toward a theoretical model of quality-of-life appraisal: Implications of findings from studies of response shift. Health and Quality of Life Outcomes, 2, 14. doi:10.1186/1477-7525-2-14.PubMedCentralCrossRefPubMed

42.

Buer, L. C., & Hofmann, B. M. (2012). How does kidney transplantation affect the relationship between donor and recipient? Tidsskrift for den Norske Laegeforening, 132(1), 41–43. doi:10.4045/tidsskr.10.1403.CrossRefPubMed

43.

Levidiotis, V. (2009). Live kidney donors: Assessment and follow up. Australian Family Physician, 38(5), 316–320.PubMed

44.

Gaston, R. S., Kumar, V., & Matas, A. J. (2014). Reassessing medical risk in living kidney donors. Journal of the American Society of Nephrology,. doi:10.1681/ASN.2014030227.

45.

Dindo, D., Demartines, N., & Clavien, P. A. (2004). Classification of surgical complications: A new proposal with evaluation in a cohort of 6336 patients and results of a survey. Annals of Surgery, 240(2), 205–213.PubMedCentralCrossRefPubMed

46.

Sterner, K., Zelikovsky, N., Green, C., & Kaplan, B. S. (2006). Psychosocial evaluation of candidates for living related kidney donation. Pediatric Nephrology(Berlin, Germany), 21(10), 1357–1363. doi:10.1007/s00467-006-0177-4.CrossRef

47.

Frade, I. C., Fonseca, I., Dias, L., Henriques, A. C., Martins, L. S., Santos, J., et al. (2008). Impact assessment in living kidney donation: Psychosocial aspects in the donor. Transplantation Proceedings, 40(3), 677–681. doi:10.1016/j.transproceed.2008.02.036.CrossRefPubMed

48.

Fehrman-Ekholm, I., Brink, B., Ericsson, C., Elinder, C. G., Dunér, F., & Lundgren, G. (2000). Kidney donors don’t regret: Follow-up of 370 donors in Stockholm since 1964. Transplantation, 69(10), 2067–2071.CrossRefPubMed

49.

Klop, K. W., Dols, L. F., Weimar, W., Dooper, I. M., IJzermans, J. N., & Kok, N. F. (2013). Quality of life of elderly live kidney donors. Transplantation, 96(7), 644–648. doi:10.1097/TP.0b013e31829e6d9b.CrossRefPubMed

50.

Aull, M. J., Afaneh, C., Charlton, M., Serur, D., Douglas, M., Christos, P. J., et al. (2014). A randomized, prospective, parallel group study of laparoscopic versus laparoendoscopic single site donor nephrectomy for kidney donation. American Journal of Transplantation, 14(7), 1630–1637. doi:10.1111/ajt.12735.PubMedCentralCrossRefPubMed

51.

Giacomoni, A., Di Sandro, S., Lauterio, A., Concone, G., Mangoni, I., Mihaylov, P., et al. (2014). Evolution of robotic nephrectomy for living donation: From hand-assisted to totally robotic technique. Journal of Medical Robotics and Computer Assisted Surgery, 10(3), 286–293. doi:10.1002/rcs.1576.CrossRef

52.

Ahearn, A. J., Posselt, A. M., Kang, S. M., Roberts, J. P., & Freise, C. E. (2011). Experience with laparoscopic donor nephrectomy among more than 1000 cases: Low complication rates, despite more challenging cases. Archives of Surgery, 146(7), 859–864. doi:10.1001/archsurg.2011.156.CrossRefPubMed

53.

Giessing, M., Reuter, S., Deger, S., Tüllmann, M., Hirte, I., Budde, K., et al. (2005). Laparoscopic versus open donor nephrectomy in Germany: Impact on donor health-related quality of life and willingness to donate. Transplantation proceedings, 37(5), 2011–2015. doi:10.1016/j.transproceed.2005.03.007.CrossRefPubMed

54.

Schnitzbauer, A. A., Hornung, M., Seidel, U., Krüger, B., Krämer, B. K., Schlitt, H. J., et al. (2007). Does mini-incision donor nephrectomy improve quality of life in living kidney donors? Clinical Transplantation, 21(2), 235–240. doi:10.1111/j.1399-0012.2006.00631.x.CrossRefPubMed

55.

Andersen, M. H., Mathisen, L., Veenstra, M., Oyen, O., Edwin, B., Digernes, R., et al. (2007). Quality of life after randomization to laparoscopic versus open living donor nephrectomy: Long-term follow-up. Transplantation, 84(1), 64–69. doi:10.1097/01.tp.0000268071.63977.42.CrossRefPubMed

56.

Krosnick, J. A. (1999). Survey research. Annual Review of Psychology, 50, 537–567. doi:10.1146/annurev.psych.50.1.537.CrossRefPubMed

Titel: Long-term health-related quality of life of living kidney donors: a single-center experience
Auteurs: Christian Benzing
Hans-Michael Hau
Greta Kurtz
Moritz Schmelzle
Hans-Michael Tautenhahn
Mehmet Haluk Morgül
Georg Wiltberger
Johannes Broschewitz
Georgi Atanasov
Anette Bachmann
Michael Bartels
Publicatiedatum: 07-07-2015
Uitgeverij: Springer International Publishing
Gepubliceerd in: Quality of Life Research / Uitgave 12/2015
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-015-1027-2

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Purpose

Methods

Results

Discussion

Log in om toegang te krijgen

Andere artikelen Uitgave 12/2015

Dynamic weight-bearing assessment of pain in knee osteoarthritis: a reliability and agreement study

Development and validation of the Diabetic Peripheral Neuropathic Pain Impact (DPNPI) measure, a patient-reported outcome measure

Psychometric properties of the EQ-5D-5L in Thai patients with chronic diseases

Long-term health and quality of life experiences of Vietnam veterans with combat-related limb loss

Proposing a re-adapted successful aging model addressing chronic diseases in low- and middle-income countries

Watchful waiting for subthreshold depression and anxiety in visually impaired older adults