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Quality of Life Research

Gepubliceerd in:

01-03-2015

Contribution of symptom clusters to multiple sclerosis consequences

Auteurs: Shahnaz Shahrbanian, Pierre Duquette, Ayse Kuspinar, Nancy E. Mayo

Gepubliceerd in: Quality of Life Research | Uitgave 3/2015

Abstract

Purpose

There were two objectives in this study: (1) to identify, among women and men with MS, the extent to which different MS-related symptoms, including fatigue, pain, sleep disturbance, depression, anxiety, irritability, cognitive impairment, spasticity, and poor balance, cluster and (2) to compare the contribution of generated symptom clusters to MS consequences including functional walking capacity, perceived health, illness intrusiveness, and quality of life (QOL).

Methods

This was a cross-sectional study. A center-stratified random sample comprising 139 women and 49 men was recruited from three major MS clinics in Montreal. Subjects completed several self-report and performance-based measures that assessed symptoms and downstream MS consequences. Hierarchical and K-means cluster analyses were used to create clusters.

Results

Three symptom clusters were identified. Cluster 1, labeled the “emotional/cognitive symptom cluster,” comprised of depression, anxiety, cognitive impairments, and irritability. The second cluster, labeled the “physical symptom cluster,” included pain, fatigue, and sleep disorders. Cluster 3, labeled the “motor symptom cluster,” included spasticity and poor balance. Furthermore, the motor symptom cluster had a strong effect on functional walking capacity, while it did not affect significantly illness intrusiveness and QOL. On the other hand, the physical symptom clusters and emotional/cognitive symptom clusters showed a significant contribution to prediction of illness intrusiveness and QOL. All symptom clusters showed a significant effect in predicting the overall variability of perceived health status.

Conclusions

The findings of this study provide useful information to help healthcare professionals, clinicians, and researchers to target symptoms that are often in the same cluster when one or two of them are present. Identification of the strength of the contributions of each symptom clusters to the targeted MS consequences would further help to prioritize treatment approaches for the MS population.

vorige artikel Individual patient monitoring in daily clinical practice: a critical evaluation of minimal important change

volgende artikel A qualitative study of the impact of severe asthma and its treatment showing that treatment burden is neglected in existing asthma assessment scales

Noseworthy, J. H., Lucchinetti, C., Rodriguez, M., & Weinshenker, B. G. (2000). Multiple sclerosis. New England Journal of Medicine, 343, 938–952.PubMedCrossRef

O’Connor, P. (2002). Key issues in the diagnosis and treatment of multiple sclerosis: An overview. Neurology, 59(6 Suppl. 3), S1–S33.PubMedCrossRef

Lublin, F. D., & Reingold, S. C. (1996). Defining the clinical course of multiple sclerosis: results of an international survey. national multiple sclerosis society (USA) advisory committee on clinical trials of new agents in multiple sclerosis. Neurology, 46(4), 907–911.PubMedCrossRef

Fisk, J. D., Pontefract, A., Ritvo, P. G., Archibald, C. J., & Murray, T. J. (1994). The impact of fatigue on patients with multiple sclerosis. Canadian Journal of Neurological Sciences, 21, 9–14.PubMed

Ford, H., Trigwell, P., & Johnson, M. (1998). The nature of fatigue in multiple sclerosis. Journal of Psychosomatic Research, 45, 33–38.PubMedCrossRef

Archibald, C. J., McGrath, P. J., & Ritvo, P. G. (1994). Pain prevalence, severity and impact in a clinic sample of multiple sclerosis patients. Pain, 58, 89–93.PubMedCrossRef

Ehde, D. M., Gibbons, L. E., Chwastiak, L., Bombardier, C. H., Sullivan, M. D., & Kraft, G. H. (2003). Chronic pain in a large community sample of persons with multiple sclerosis. Multiple Sclerosis, 9, 605–611.PubMedCrossRef

Kalia, L. V., & O’Connor, P. W. (2005). Severity of chronic pain and its relationship to quality of life in multiple sclerosis. Multiple Sclerosis, 11, 322–327.PubMedCrossRef

Svendsen, K. B., Jensen, T. S., Overvad, K., Hansen, H. J., KochHenriksen, N., & Bach, F. W. (2003). Pain in patients with multiple sclerosis. Archives of Neurology, 60, 1089–1094.PubMedCrossRef

10.

Svendsen, K. B., Jensen, T. S., Hansen, H. J., & Bach, F. W. (2005). Sensory function and quality of life in patients with multiple sclerosis and pain. Pain, 114, 473–478.PubMedCrossRef

11.

Bamer, A. M., Johnson, K. L., Amtmann, D., & Kraft, G. H. (2008). Prevalence of sleep problems in individuals with multiple sclerosis. Multiple Sclerosis, 14(8), 1127–1130.PubMedCentralPubMedCrossRef

12.

Brass, S. D., Duquette, P., Proulx-Therrien, J., & Auerbach, S. (2010). Sleep disorders in patients with multiple sclerosis. Sleep Medicine Reviews, 14, 121–129.PubMedCrossRef

13.

Stanton, B. R., Barnes, F., & Silber, E. (2006). Sleep and fatigue in multiple sclerosis. Multiple Sclerosis, 12(4), 481–486.PubMedCrossRef

14.

Tachibana, N., Howard, R. S., Hirsch, N. P., Miller, D. H., Moseley, I. F., & Fish, D. (1994). Sleep problems in multiple sclerosis. European Neurology, 34(6), 320–323.PubMedCrossRef

15.

Grytten, N., & Maseide, P. (2006). ‘When I am together with them I feel more ill’. The stigma of multiple sclerosis experienced in social relationships. Chronic Illness, 2, 195–208.PubMed

16.

Leussink, V. I., Husseini, L., Warnke, C., Broussalis, E., Hartung, H. P., & Kieseier, B. C. (2012). Symptomatic therapy in multiple sclerosis: the role of cannabinoids in treating spasticity. Therapeutic Advances in Neurological Disorders, 5(5), 255–266.PubMedCentralPubMedCrossRef

17.

Rao, S. M., Leo, G. J., Bernardin, L., & Unverzagt, F. (1991). Cognitive dysfunction in multiple sclerosis. Frequency, patterns, and prediction. Neurology, 41(5), 685–691.PubMedCrossRef

18.

Teng, S.Y., Bartlett, S., Koski, L., Chamelian, L., Duquette, P., Grand’Maison, F., Lapierre, Y., Mayo, N.E. (2009). Self-perceived and tested cognition in multiple sclerosis: Differences across gender. Journal of Multiple Sclerosis Clinical and Laboratory research, 15 (2).

19.

Feinstein, A. (2002). An examination of suicidal intent in patients with multiple sclerosis. Neurology, 59, 674–678.PubMedCrossRef

20.

Mohr, D. C. (2007). Stress and multiple sclerosis. Journal of Neurology, 254(2), II65–II68.PubMed

21.

Newland, P. K., Fearing, A., Riley, M., & Neath, A. (2012). Symptom clusters in women with relapsing-remitting multiple sclerosis. Journal of Neuroscience Nursing, 44(2), 66–71.PubMedCrossRef

22.

D’Alisa, S., Miscio, G., Baudo, S., Simone, A., Tesio, L., & Mauro, A. (2006). Depression is the main determinant of quality of life in multiple sclerosis: A classification-regression (CART) study. Disability and Rehabilitation, 28(5), 307–314.PubMedCrossRef

23.

Lovera, J., Bagert, B., Smoot, K. H., Wild, K., Frank, R., Bogardus, K., et al. (2006). Correlations of perceived deficits questionnaire of multiple sclerosis quality of life inventory with beck depression inventory and neuropsychological tests. Journal of Rehabilitation Research and Development, 43(1), 73–82.PubMedCrossRef

24.

DeLuca, J. (2006). What we know about cognitive changes in multiple sclerosis. In N. L. LaRocca & R. Kalb (Eds.), Multiple sclerosis: Understanding the cognitive changes (pp. 17–39). New York: Demos Medical Publishing.

25.

Krupp, L. B. (2004). Fatigue in multiple sclerosis: A guide to diagnosis and management. New York, NY: Demos Medical Publishing.

26.

Motl, R. W., Weikert, M., Suh, Y., & Dlugonski, D. (2010). Symptom cluster and physical activity in relapsing-remitting multiple sclerosis. Research in Nursing & Health, 33, 398–412.CrossRef

27.

Kim, H. J., & Abraham, A. L. (2008). Statistical approaches to modeling symptom clusters in cancer patients. Cancer Nursing, 31, 162–220.CrossRef

28.

Dodd, M. J., Miaskowski, C., & Paul, S. M. (2001). Symptom clusters and their effect on the functional status of patients with cancer. Oncology Nursing Forum, 28, 465–470.PubMed

29.

McSweeney, J. C., Cleves, M. A., Lefler, L., & Yang, S. (2010). Cluster analysis of women’s prodromal and acute myocardial infarction symptoms by race and other characteristics. Journal of Cardiovascular Nursing, 25(4), 311–322.PubMedCentralPubMedCrossRef

30.

Miaskowski, C., Dodd, M., & Lee, K. (2004). Symptom clusters: The new frontier in symptom management research. Journal of National Cancer Institute Monographs, 32, 17–21.CrossRef

31.

Miaskowski, C. (2006). Symptom clusters: establishing the link between clinical practice and symptom management research. Supportive Care in Cancer, 14, 792–794.PubMedCrossRef

32.

Motl, R. W., & McAuley, E. (2009). Symptom cluster as a predictor of physical activity in multiple sclerosis: Preliminary evidence. Journal of Pain and Symptom Management, 38, 270–280.PubMedCrossRef

33.

Motl, R. W., & McAuley, E. (2009). Pathways between physical activity and quality of life in adults with multiple sclerosis. Health Psychology, 28, 682–689.PubMedCrossRef

34.

Lenz, E. R., Pugh, L. C., Milligan, R. A., Gift, A., & Suppe, F. (1997). The middle-range theory of unpleasant symptoms: An update. Advances in Nursing Science, 19(3), 14–27.PubMedCrossRef

35.

Lenz, E. R., & Pugh, L. C. (2003). The theory of unpleasant symptoms. In M. J. Smith & P. R. Liehr (Eds.), Middle range theory for nursing (pp. 69–90). New York: Springer.

36.

Given, C. W., Given, B., Azzouz, F., Kozachik, S., & Stommel, M. (2001). Predictors of pain and fatigue in the year following diagnosis among elderly cancer persons. Journal of Pain and Symptom Management, 6, 456–466.CrossRef

37.

Given, B., Given, C. W., & McCorkle, R. (2002). Pain and fatigue management: results of a nursing randomized clinical trial. Oncology Nursing Forum, 29, 949–956.PubMedCrossRef

38.

Pearson, O. R., Busse, M. E., Van Deursen, R. W. M., & Wiles, C. M. (2004). Quantification of walking mobility in neurological disorders. Quarterly Journal of Medicine, 97(8), 463–475.CrossRef

39.

Motl, R. W., Snook, E. M., McAuley, E., & Gliottoni, R. (2006). Symptoms, self-efficacy, and physical activity among individuals with multiple sclerosis. Research in Nursing & Health, 29, 597–606.CrossRef

40.

Motl, R. W., Arnett, P. A., & Smith, M. M. (2008). Worsening of symptoms is associated with lower physical activity levels in individuals with multiple sclerosis. Multiple Sclerosis, 14, 140–142.PubMedCrossRef

41.

Motl, R. W., Snook, E. M., & Schapiro, R. T. (2008). Symptoms and physical activity behavior in individuals with multiple sclerosis. Research in Nursing & Health, 31, 466–475.CrossRef

42.

Snook, E. M., & Motl, R. W. (2008). Physical activity behaviors in individuals with multiple sclerosis: Roles of overall and specific symptoms, and self-efficacy. Journal of Pain and Symptom Management, 36, 46–53.PubMedCrossRef

43.

Parkin, D., Rice, N., Jacoby, A., & Doughty, J. (2004). Use of a visual analogue scale in a daily person diary: Modelling cross-sectional time-series data on health-related quality of life. Social Science and Medicine, 59(2), 351–360.PubMedCrossRef

44.

Devins, G. M., Edworthy, S. M., Paul, L. C., Mandin, H., Seland, T. P., Klein, G., et al. (1993). Restless sleep, illness intrusiveness, and depressive symptoms in three chronic illness conditions: rheumatoid arthritis, end-stage renal disease, and multiple sclerosis. Journal of Psychosomatic Research, 37(2), 163–170.PubMedCrossRef

45.

Devins, G. M., Edworthy, S. M., Seland, T. P., Klein, G. M., Paul, L. C., & Mandin, H. (1993). Differences in illness intrusiveness across rheumatoid arthritis, end-stage renal disease, and multiple sclerosis. The Journal of Nervous Mental Disease, 181(6), 377–381.PubMedCrossRef

46.

Devins, G. M. (1994). Illness intrusiveness and the psychosocial impact of lifestyle disruptions in chronic life-threatening disease. Advanced Renal Replacement Therapy, 1, 251–263.

47.

Devins, G. M., Styra, R., O’Connor, P., Gray, T., Seland, T. P., & Klein, G. M. (1996). Psychosocial impact of illness intrusiveness moderated by age in multiple sclerosis. Psychology, Health & Medicine, 1, 179–191.CrossRef

48.

Devins, G. M., Dion, R., Pelletier, L. G., Shapiro, C. M., Abbey, S., Raiz, L. R., et al. (2001). Structure of lifestyle disruptions in chronic disease: a confirmatory factor analysis of the illness intrusiveness ratings scale. Medical Care, 39(10), 1097–1104.PubMedCrossRef

49.

Mullins, L. L., Cote, M. P., Fuemmeler, B. F., Jean, V. M., Beatty, W. W., & Paul, R. H. (2001). Illness intrusiveness, uncertainty, and distress in individuals with multiple sclerosis. Rehabilitation Psychology, 46(2), 139–153.CrossRef

50.

Culp, D. (2010). Illness intrusiveness and sexual satisfaction among women with multiple sclerosis. Master of Arts Thesis in Psychology, Ryerson University.

51.

Turpin, K. V., Carroll, L. J., Cassidy, J. D., & Hader, W. J. (2007). Deterioration in the health-related quality of life of persons with multiple sclerosis: the possible warning signs. Multiple Sclerosis, 13(8), 1038–1045.PubMedCrossRef

52.

Amato, M., Battaglia, M., & Caputo, D. (2002). The costs of multiple sclerosis: A cross-sectional, multicenter cost-of-illness study in Italy. Journal of Neurology, 249, 152–163.PubMedCrossRef

53.

Benedict, R., Wahlig, E., Bakshi, R., Fishman, I., Munschauer, F., & Weinstock-Guttman, B. (2005). Predicting quality of life in multiple sclerosis: Accounting for physical disability, fatigue, cognition, mood disorder, personality, and behavior change. Journal of the Neurological Sciences, 231(1, 2), 29–34.PubMedCrossRef

54.

Benito-Leon, J., Morales, J. M., & Rivera-Navarro, J. (2002). Health-related quality of life and its relationship to cognitive and emotional functioning in multiple sclerosis persons. European Journal of Neurology, 9, 497–502.PubMedCrossRef

55.

Egner, A., Phillips, V. L., Vora, R., & Wiggers, E. (2003). Depression, fatigue, and health-related quality of life among people with advanced multiple sclerosis: results from an exploratory telerehabilitation study. Neurorehabilitation, 18, 125–133.PubMed

56.

Janssens, A. C., Doorn, P. A., de Boer, J. B., Kalkers, N. F., Meche, F. G., & Passchier, J. (2003). Anxiety and depression influence the relation between disability status and quality of life in multiple sclerosis. Multiple Sclerosis, 9, 397–403.PubMedCrossRef

57.

Miller, D. M., Rudick, R. A., Baier, M., Cutter, G., Doughtery, D. S., & Weinstock-Guttman, B. (2003). Factors that predict health-related quality of life in persons with relapsing–remitting multiple sclerosis. Multiple Sclerosis, 9, 1–5.PubMedCrossRef

58.

O’Connor, P., Lee, L., Ng, P. T., Narayana, P., & Wolinsky, J. S. (2001). Determinants of overall quality of life in secondary progressive MS: A longitudinal study. Neurology, 57, 889–891.PubMedCrossRef

59.

Esper, P., & Heidrich, D. (2005). Symptom clusters in advanced illness. Seminars in Oncology Nursing, 21, 20–28.PubMedCrossRef

60.

Wilmoth, M. C., Coleman, E. A., Smith, S. C., & Davis, C. (2004). Fatigue, weight gain, and altered sexuality in persons with breast cancer: Exploration of a symptom cluster. Oncology Nursing Forum, 31, 1069–1075.PubMedCrossRef

61.

Armstrong, T. S., Cohen, M. Z., Eriksen, L. R., & Hickey, J. V. (2004). Symptom clusters in oncology persons and implications for symptom research in people with primary brain tumors. Journal of Nursing Scholarship, 36, 197–206.PubMedCrossRef

62.

Gift, A. G., Stommel, M., Jablonski, A., & Given, W. (2003). A cluster of symptoms over time in patients with lung cancer. Nursing Research, 52, 393–400.PubMedCrossRef

63.

Gift, A. G., Jablonski, A., Stommel, M., & Given, C. W. (2004). Symptom clusters in elderly patients with lung cancer. Oncology Nursing Forum, 31, 202–212.PubMedCrossRef

64.

Drew, M., Tippett, L. J., Starkey, N. J., & Isler, R. B. (2008). Executive dysfunction and cognitive impairment in a large community-based sample with Multiple Sclerosis from New Zealand: A descriptive study. Archives of Clinical Neuropsychology, 23, 1–19.PubMedCrossRef

65.

Motl, R. W., Suh, Y., & Weikert, M. (2010). Symptom cluster and quality of life in multiple sclerosis. Journal of Pain and Symptom Management, 39(6), 1025–1032.PubMedCrossRef

66.

Nocentini, U., Pasqualetti, P., Bonavita, S., Buccafusca, M., De Caro, M. F., Farina, D., et al. (2006). Cognitive dysfunction in patients with relapsing-remitting multiple sclerosis. Multiple Sclerosis, 12, 77.PubMedCrossRef

67.

Kurtzke, J. F. (1983). Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS). Neurology, 33(11), 1444–1452.PubMedCrossRef

68.

Hays, R. D., & Morales, L. S. (2001). The RAND-36 measure of health- related quality of life. Annals of Medicine, 33, 350–357.PubMedCrossRef

69.

Brunet, D. G., Hopman, W. M., Singer, M. A., Edgar, C. M., & MacKenzie, T. A. (1996). Measurement of health-related quality of life in multiple sclerosis patients. The Canadian Journal of Neurological Sciences, 23(2), 99–103.PubMed

70.

Freeman, J. A., Hobart, J. C., Langdon, D. W., & Thompson, A. J. (2000). Clinical appropriateness: A key factor in outcome measure selection: The 36 item short form health survey in multiple sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 68, 150–156.PubMedCentralPubMedCrossRef

71.

McHorney, C. A., Ware, J. E., & Raczek, A. E. (1993). The MOS 36-item short-form health survey (SF-36): II. A psychometric and clinical test of validity in measuring physical and mental health constructs. Medical Care, 31, 247–263.PubMedCrossRef

72.

McHorney, C. A., Ware, J. E., & Sherbourne, C. D. (1994). The MOS 36-item short-form health survey (SF-36): III. Tests of data quality, scaling assumptions, and reliability across diverse patient groups. Medical Care, 32, 40–66.PubMedCrossRef

73.

Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989). The pittsburgh sleep quality index: A new instrument for psychiatric practice and research. Psychiatry Research, 28(2), 193–213.PubMedCrossRef

74.

Zigmond, A. S., & Snaith, R. P. (1983). The hospital anxiety and depression scale. Acta Psychiatrica Scandinavica, 67, 361–370.PubMedCrossRef

75.

Herrmann, C. (1997). International experiences with the hospital anxiety and depression scale-a review of validation data and clinical results. Journal of Psychosomatic Research, 42(1), 17–41.PubMedCrossRef

76.

Bjelland, I., Dahl, A. A., Haug, T. T., & Neckelmann, D. (2002). The validity of the hospital anxiety and depression scale; an updated review. Journal of Psychosomatic Research, 52(2), 69–77.PubMedCrossRef

77.

da Silva, A. M., Vilhena, E., Lopes, A., & Santos, E. (2011). Depression and anxiety in a Portuguese MS population: Associations with physical disability and severity of disease. Journal of the Neurological Sciences, 306(15), 66–70.PubMedCrossRef

78.

Honarmand, K., & Feinstein, A. (2009). Validation of the hospital anxiety and depression scale for use with multiple sclerosis patients. Multiple Sclerosis, 15(12), 1518–1524.PubMedCrossRef

79.

Ilfeld, F. W, Jr. (1976). Further validation of a psychiatric symptom index in a normal population. Psychological Reports, 39, 1215–1228.CrossRef

80.

Sullivan, M. J. L., Edgley, K., & Mikail, S. (1993). Psychological correlates of health care utilization in chronic illness. Canadian Journal of Rehabilitation, 6, 13–21.

81.

Shevil, E., & Finlayson, M. (2006). Perceptions of persons with multiple sclerosis on cognitive changes and their impact on daily life. Disability and Rehabilitation, 28(12), 779–788.PubMedCrossRef

82.

Marrie, R. A., Miller, D. M., Chelune, G. J., & Cohen, J. A. (2003). Validity and reliability of the MSQLI in cognitively impaired patients with multiple sclerosis. Multiple Sclerosis, 9(6), 621–626.PubMedCrossRef

83.

Bohannon, R., & Smith, M. (1987). Interrater reliability of a modified Ashworth scale of muscle spasticity. Physical Therapy, 67(2), 206–207.PubMed

84.

Ashworth, B. (1964). Preliminary trial of carisoprodal in multiple sclerosis. The Practitioner, 192, 540–542.PubMed

85.

Leslie, G. C., Muir, C., Part, N. J., & Roberts, R. C. (1992). A comparison of the assessment of spasticity by the Wartenberg pendulum test and the Ashworth grading scale in patients with multiple sclerosis. Clinical Rehabilitation, 6, 41–48.CrossRef

86.

Nuyens, G., De Weerdt, W., Ketelaer, P., Feys, H., De Wolf, L., Hantson, L., Nieuboer, A., Spaepen, A., & Carton, H. (1994). Inter-rater reliability of the Ashworth scale in multiple Sclerosis. Clinical Rehabilitation, 8, 286–292.

87.

Pandyan, A. D., Price, C. I. M., & Curless, R. H. (1999). A review of the properties and limitations of the Ashworth & modified Ashworth Scales. Clinical Rehabilitation, 13(5), 373–383.PubMedCrossRef

88.

Pandyan, A. D., Price, C. I. M., & Rodgers, H. (2001). Biomechanical examination of a commonly used measure of spasticity. Clinical Biomechanics, 16, 859–865.PubMedCrossRef

89.

Tesio, L., Perucca, L., Franchignoni, F. P., & Battaglia, M. A. (1997). A short measure of balance in multiple sclerosis: validation through Rasch analysis. Functional Neurology, 12(5), 255–265.PubMed

90.

Butland, R. J. A., Pang, J., Gross, E. R., Woodcock, A. A., & Geddes, D. M. (1982). Two-, six- and 12-minute walking tests in respiratory disease. British Medical Journal, 284, 1607–1608.PubMedCentralPubMedCrossRef

91.

Savci, S., InalInce, D., & Arikan, H. (2005). Six-minute walk distance as a measure of functional exercise capacity in multiple sclerosis. Disability and Rehabilitation, 27(22), 1365–1371.PubMedCrossRef

92.

Goldman, M., Marrie, R. A., & Cohen, J. A. (2007). Evaluation of six minutes walk test in MS and healthy population. Multiple Sclerosis, 14, 383–390.PubMedCrossRef

93.

Morales, F. J., Martinez, A., Mendez, M., Agarrado, A., Ortega, F., & Fernandez-Guerra, J. (1999). A shuttle walk test for assessment of functional capacity in chronic heart failure. Americal Heart Journal, 138(2), 291–298.

94.

Paltamaa, J., West, H., Sarasoja, T., Wikstrom, J., & Malkia, E. (2005). Reliability of physical functioning measures in ambulatory subjects with MS. Physiotherapy Research International, 10(2), 93–109.PubMedCrossRef

95.

EuroQol Group. (1990). EuroQol-a new facility for the measurement of health-related quality of life. The EuroQol Group. Health Policy, 16(3), 199–208.CrossRef

96.

Nortvedt, M., Riise, T., & Myhr, K. (1999). Quality of life in multiple sclerosis: measuring the disease effects more. Neurology, 53, 1098–1103.PubMedCrossRef

97.

Devins, G. M., Binik, Y. M., Hutchinson, T. A., Hollomby, D. J., Barré, P. E., & Guttmann, R. D. (1983). The emotional impact of end-stage renal disease: Importance of persons’ perceptions of intrusiveness and control. The International Journal of Psychiatry in Medicine, 13(4), 1983–1984.CrossRef

98.

Devins, G. M. (2010). Using the illness intrusiveness ratings scale to understand health-related quality of life in chronic disease. Journal of Psychosomatic Research, 68(6), 591–602.PubMedCrossRef

99.

Ruta, D. A., Garratt, A. M., Leng, M., Russell, I. T., & MacDonald, L. M. (1994). A new approach to the measurement of quality of life. the person-generated index. Medical Care, 32, 1109–1126.PubMedCrossRef

100.

Ruta, D. A., Garratt, A. M., & Russell, I. T. (1999). Person centred assessment of quality of life for persons with four common conditions. Qualitative Health Care, 8, 22–29.CrossRef

101.

Lintern, T. C., Beaumont, J. G., Kenealy, P. M., & Murrell, R. C. (2001). Quality of life (HRQL) in severely disabled multiple sclerosis persons: Comparison of three HRQL measures using multidimensional scaling. Quality of Life Research, 10, 371–378.PubMedCrossRef

102.

Garratt, A. M., & Ruta, D. A. (1999). The person generated index. In C. R. B. Joyce, C. A. O’Boyle, & H. McGee (Eds.), Individual quality of life: Approaches to conceptualization and assessment (pp. 105–118). Amsterdam: Harwood Academic Publishers.

103.

Anderberg, M. R. (1973). Cluster Analysis for Applications. New York: Academic Press Inc.

104.

Everitt, B. S., Landau, S., & Leese, M. (2001). Cluster analysis. New York: Oxford University Press.

105.

Hopman, W. M., Towheed, T., Anastassiades, T., Tenenhouse, A., Poliquin, S., Berger, C., et al. (2000). Canadian normative data for the SF-36 health survey. Canadian Medical Association Journal, 163(3), 265–271.PubMedCentralPubMed

106.

Enright, P. (2003). The six-minute walk test. Respiratory care, 48(8), 783–785.PubMed

107.

Mayo, N., Goldberg, M.S., Kind, P. (1997). Calibrating the EQ-5D for a Canadian Population. In: Proceedings from EuroQol Plenary Meeting, Center for Health Policy and Law, Erasmus University, Rotterdam, The Netherlands. pp. 25–40.

108.

Redelmeier, D., Bayoumi, A., Goldstein, R., & Guyatt, G. (1997). Interpreting small differences in functional status: the six minute walk test in chronic lung disease persons. American Journal of Respiratory and Critical Care Medicine, 155, 1278–1282.PubMedCrossRef

109.

Fox, S. W., & Lyon, D. E. (2006). Symptom clusters and quality of life in survivors of lung cancer. Oncology Nursing Forum, 33, 931–936.PubMedCrossRef

110.

Kelley, K. W., Bluthé, R. M., Dantzer, R., Zhou, J. H., Shen, W. H., Johnson, R. W., et al. (2003). Cytokine-induced sickness behavior. Brain, Behavior, and Immunity, 17(Suppl 1), S112–S118.PubMedCrossRef

111.

Mayo, N. (2008). Setting the agenda for multiple sclerosis rehabilitation research. Multiple Sclerosis, 14(9), 1154–1156.PubMedCrossRef

112.

Kirkova, J. K., Aktas, A., Walsh, D., & Davis, M. P. (2011). Cancer symptom clusters: Clinical and research methodology. Journal of Palliative Medicine, 14(10), 1149–1166.PubMedCrossRef

Titel: Contribution of symptom clusters to multiple sclerosis consequences
Auteurs: Shahnaz Shahrbanian
Pierre Duquette
Ayse Kuspinar
Nancy E. Mayo
Publicatiedatum: 01-03-2015
Uitgeverij: Springer International Publishing
Gepubliceerd in: Quality of Life Research / Uitgave 3/2015
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-014-0804-7

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