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Gepubliceerd in: Huisarts en wetenschap 8/2007

01-08-2007 | Kleine kwalen

Herpes labialis

Auteurs: W Opstelten, dr. A Knuistingh Neven, dr. JAH Eekhof

Gepubliceerd in: Huisarts en wetenschap | Uitgave 8/2007

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Samenvatting

Herpes labialis, ook wel koortslip of koortsuitslag genoemd, is een veelvoorkomende aandoening. De aan de huisarts gepresenteerde incidentie bedraagt ongeveer 1,6 en de prevalentie 2,5 per 1000 patiënten per jaar.1 Bij naar schatting eenderde van de patiënten treden recidieven op. Voor patiënten met een goed functionerend immuunsysteem is het een onschuldige, maar vaak hinderlijke aandoening die in ongeveer 10 dagen spontaan geneest. Herpes labialis is besmettelijk voor patiënten die niet eerder met het virus besmet zijn en voor patiënten met een verzwakt immuunsysteem – zoals bij hiv-besmetting of tijdens chemotherapie – en kan door orogenitaal contact leiden tot genitale herpes.
Literatuur
go back to reference Van der Linden MW, Westert GP, De Bakker DH, Schellevis FG. Tweede Nationale Studie naar ziekten en verrichtingen in de huisartspraktijk. Utrecht, Bilthoven: NIVEL, RIVM, 2004. Van der Linden MW, Westert GP, De Bakker DH, Schellevis FG. Tweede Nationale Studie naar ziekten en verrichtingen in de huisartspraktijk. Utrecht, Bilthoven: NIVEL, RIVM, 2004.
go back to reference Esmann J. The many challenges of facial herpes simplex virus infection. J Antimicrob Chemother 2001;47 Suppl T1:17-27.CrossRefPubMed Esmann J. The many challenges of facial herpes simplex virus infection. J Antimicrob Chemother 2001;47 Suppl T1:17-27.CrossRefPubMed
go back to reference Straus SE, Rooney JF, Sever JL, Seidlin M, Nusinoff-Lehrman S, Cremer K. NIH Conference. Herpes simplex virus infection: biology, treatment, and prevention. Ann Intern Med 1985;103:404-19.PubMed Straus SE, Rooney JF, Sever JL, Seidlin M, Nusinoff-Lehrman S, Cremer K. NIH Conference. Herpes simplex virus infection: biology, treatment, and prevention. Ann Intern Med 1985;103:404-19.PubMed
go back to reference Opstelten W. Stomatitis herpetica. In: Eekhof JAH, Knuistingh Neven A, Verheij TJM, redactie. Kleine kwalen bij kinderen. Maarssen: Elsevier, 2005. Opstelten W. Stomatitis herpetica. In: Eekhof JAH, Knuistingh Neven A, Verheij TJM, redactie. Kleine kwalen bij kinderen. Maarssen: Elsevier, 2005.
go back to reference Godfrey HR, Godfrey NJ, Godfrey JC, Riley D. A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine. Altern Ther Health Med 2001;7:49-56.PubMed Godfrey HR, Godfrey NJ, Godfrey JC, Riley D. A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine. Altern Ther Health Med 2001;7:49-56.PubMed
go back to reference Kneist W, Hempel B, Borelli S. Klinische Doppelblindprüfung mit Zinksulfat topisch bei Herpes labialis recidivans [Clinical double-blind trial of topical zinc sulfate for herpes labialis recidivans]. Arzneimittelforschung 1995;45:624-6.PubMed Kneist W, Hempel B, Borelli S. Klinische Doppelblindprüfung mit Zinksulfat topisch bei Herpes labialis recidivans [Clinical double-blind trial of topical zinc sulfate for herpes labialis recidivans]. Arzneimittelforschung 1995;45:624-6.PubMed
go back to reference Van Vloten WA, Swart RN, Pot F. Topical acyclovir therapy in patients with recurrent orofacial herpes simplex infections. J Antimicrob Chemother 1983;12 Suppl B:89-93.PubMed Van Vloten WA, Swart RN, Pot F. Topical acyclovir therapy in patients with recurrent orofacial herpes simplex infections. J Antimicrob Chemother 1983;12 Suppl B:89-93.PubMed
go back to reference Spruance SL, Nett R, Marbury T, Wolff R, Johnson J, Spaulding T. Acyclovir cream for treatment of herpes simplex labialis: results of two randomized, double-blind, vehicle-controlled, multicenter clinical trials. Antimicrob Agents Chemother 2002;46:2238-43.CrossRefPubMed Spruance SL, Nett R, Marbury T, Wolff R, Johnson J, Spaulding T. Acyclovir cream for treatment of herpes simplex labialis: results of two randomized, double-blind, vehicle-controlled, multicenter clinical trials. Antimicrob Agents Chemother 2002;46:2238-43.CrossRefPubMed
go back to reference Spruance SL, Schnipper LE, Overall JC Jr, Kern ER, Wester B, Modlin J, et al. Treatment of herpes simplex labialis with topical acyclovir in polyethylene glycol. J Infect Dis 1982;146:85-90.PubMed Spruance SL, Schnipper LE, Overall JC Jr, Kern ER, Wester B, Modlin J, et al. Treatment of herpes simplex labialis with topical acyclovir in polyethylene glycol. J Infect Dis 1982;146:85-90.PubMed
go back to reference Fiddian AP, Yeo JM, Stubbings R, Dean D. Successful treatment of herpes labialis with topical acyclovir. Br Med J (Clin Res Ed) 1983;286:1699-701.CrossRef Fiddian AP, Yeo JM, Stubbings R, Dean D. Successful treatment of herpes labialis with topical acyclovir. Br Med J (Clin Res Ed) 1983;286:1699-701.CrossRef
go back to reference Fiddian AP, Ivanyi L. Topical acyclovir in the management of recurrent herpes labialis. Br J Dermatol 1983;109:321-6.CrossRefPubMed Fiddian AP, Ivanyi L. Topical acyclovir in the management of recurrent herpes labialis. Br J Dermatol 1983;109:321-6.CrossRefPubMed
go back to reference Shaw M, King M, Best JM, Banatvala JE, Gibson JR, Klaber MR. Failure of acyclovir cream in treatment of recurrent herpes labialis. Br Med J (Clin Res Ed) 1985;291:7-9.CrossRef Shaw M, King M, Best JM, Banatvala JE, Gibson JR, Klaber MR. Failure of acyclovir cream in treatment of recurrent herpes labialis. Br Med J (Clin Res Ed) 1985;291:7-9.CrossRef
go back to reference Raborn GW, McGaw WT, Grace M, Percy J, Samuels S. Herpes labialis treatment with acyclovir 5% modified aqueous cream: a double-blind randomized trial. Oral Surg Oral Med Oral Pathol 1989;67:676-9.CrossRefPubMed Raborn GW, McGaw WT, Grace M, Percy J, Samuels S. Herpes labialis treatment with acyclovir 5% modified aqueous cream: a double-blind randomized trial. Oral Surg Oral Med Oral Pathol 1989;67:676-9.CrossRefPubMed
go back to reference Raborn GW, McGaw WT, Grace M, Houle L. Herpes labialis treatment with acyclovir 5 per cent ointment. J Can Dent Assoc 1989;55:135-7.PubMed Raborn GW, McGaw WT, Grace M, Houle L. Herpes labialis treatment with acyclovir 5 per cent ointment. J Can Dent Assoc 1989;55:135-7.PubMed
go back to reference Evans TG, Bernstein DI, Raborn GW, Harmenberg J, Kowalski J, Spruance SL. Double-blind, randomized, placebo-controlled study of topical 5% acyclovir-1% hydrocortisone cream (ME-609) for treatment of UV radiation-induced herpes labialis. Antimicrob Agents Chemother 2002;46:1870-4.CrossRefPubMed Evans TG, Bernstein DI, Raborn GW, Harmenberg J, Kowalski J, Spruance SL. Double-blind, randomized, placebo-controlled study of topical 5% acyclovir-1% hydrocortisone cream (ME-609) for treatment of UV radiation-induced herpes labialis. Antimicrob Agents Chemother 2002;46:1870-4.CrossRefPubMed
go back to reference Horwitz E, Pisanty S, Czerninski R, Helser M, Eliav E, Touitou E. A clinical evaluation of a novel liposomal carrier for acyclovir in the topical treatment of recurrent herpes labialis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;87:700-5.CrossRefPubMed Horwitz E, Pisanty S, Czerninski R, Helser M, Eliav E, Touitou E. A clinical evaluation of a novel liposomal carrier for acyclovir in the topical treatment of recurrent herpes labialis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;87:700-5.CrossRefPubMed
go back to reference Boon R, Goodman JJ, Martinez J, Marks GL, Gamble M, Welch C. Penciclovir cream for the treatment of sunlight-induced herpes simplex labialis: a randomized, double-blind, placebo-controlled trial. Penciclovir Cream Herpes Labialis Study Group. Clin Ther 2000;22:76-90.CrossRefPubMed Boon R, Goodman JJ, Martinez J, Marks GL, Gamble M, Welch C. Penciclovir cream for the treatment of sunlight-induced herpes simplex labialis: a randomized, double-blind, placebo-controlled trial. Penciclovir Cream Herpes Labialis Study Group. Clin Ther 2000;22:76-90.CrossRefPubMed
go back to reference Spruance SL, Rea TL, Thoming C, Tucker R, Saltzman R, Boon R. Penciclovir cream for the treatment of herpes simplex labialis. A randomized, multicenter, double-blind, placebo-controlled trial. Topical Penciclovir Collaborative Study Group. JAMA 1997;277:1374-9.CrossRefPubMed Spruance SL, Rea TL, Thoming C, Tucker R, Saltzman R, Boon R. Penciclovir cream for the treatment of herpes simplex labialis. A randomized, multicenter, double-blind, placebo-controlled trial. Topical Penciclovir Collaborative Study Group. JAMA 1997;277:1374-9.CrossRefPubMed
go back to reference Raborn GW, McGaw WT, Grace M, Tyrrell LD, Samuels SM. Oral acyclovir and herpes labialis: a randomized, double-blind, placebo-controlled study. J Am Dent Assoc 1987;115:38-42.PubMed Raborn GW, McGaw WT, Grace M, Tyrrell LD, Samuels SM. Oral acyclovir and herpes labialis: a randomized, double-blind, placebo-controlled study. J Am Dent Assoc 1987;115:38-42.PubMed
go back to reference Spruance SL, Stewart JC, Rowe NH, McKeough MB, Wenerstrom G, Freeman DJ. Treatment of recurrent herpes simplex labialis with oral acyclovir. J Infect Dis 1990;161:185-90.PubMed Spruance SL, Stewart JC, Rowe NH, McKeough MB, Wenerstrom G, Freeman DJ. Treatment of recurrent herpes simplex labialis with oral acyclovir. J Infect Dis 1990;161:185-90.PubMed
go back to reference Spruance SL, Jones TM, Blatter MM, Vargas-Cortes M, Barber J, Hill J, et al. High-dose, short-duration, early valacyclovir therapy for episodic treatment of cold sores: results of two randomized, placebo-controlled, multicenter studies. Antimicrob Agents Chemother 2003;47:1072-80.CrossRefPubMed Spruance SL, Jones TM, Blatter MM, Vargas-Cortes M, Barber J, Hill J, et al. High-dose, short-duration, early valacyclovir therapy for episodic treatment of cold sores: results of two randomized, placebo-controlled, multicenter studies. Antimicrob Agents Chemother 2003;47:1072-80.CrossRefPubMed
go back to reference Spruance SL, Bodsworth N, Resnick H, Conant M, Oeuvray C, Gao J, et al. Single-dose, patient-initiated famciclovir: a randomized, double-blind, placebo-controlled trial for episodic treatment of herpes labialis. J Am Acad Dermatol 2006;55:47-53.CrossRefPubMed Spruance SL, Bodsworth N, Resnick H, Conant M, Oeuvray C, Gao J, et al. Single-dose, patient-initiated famciclovir: a randomized, double-blind, placebo-controlled trial for episodic treatment of herpes labialis. J Am Acad Dermatol 2006;55:47-53.CrossRefPubMed
go back to reference Rooney JF, Bryson Y, Mannix ML, Dillon M, Wohlenberg CR, Banks S, et al. Prevention of ultraviolet-light-induced herpes labialis by sunscreen. Lancet 1991;338:1419-22.CrossRefPubMed Rooney JF, Bryson Y, Mannix ML, Dillon M, Wohlenberg CR, Banks S, et al. Prevention of ultraviolet-light-induced herpes labialis by sunscreen. Lancet 1991;338:1419-22.CrossRefPubMed
go back to reference Mills J, Hauer L, Gottlieb A, Dromgoole S, Spruance S. Recurrent herpes labialis in skiers. Clinical observations and effect of sunscreen. Am J Sports Med 1987;15:76-8.CrossRefPubMed Mills J, Hauer L, Gottlieb A, Dromgoole S, Spruance S. Recurrent herpes labialis in skiers. Clinical observations and effect of sunscreen. Am J Sports Med 1987;15:76-8.CrossRefPubMed
go back to reference Spruance SL, Freeman DJ, Stewart JC, McKeough MB, Wenerstrom LG, Krueger GG, et al. The natural history of ultraviolet radiation-induced herpes simplex labialis and response to therapy with peroral and topical formulations of acyclovir. J Infect Dis 1991;163:728-34.PubMed Spruance SL, Freeman DJ, Stewart JC, McKeough MB, Wenerstrom LG, Krueger GG, et al. The natural history of ultraviolet radiation-induced herpes simplex labialis and response to therapy with peroral and topical formulations of acyclovir. J Infect Dis 1991;163:728-34.PubMed
go back to reference Raborn GW, Martel AY, Grace MG, McGaw WT. Herpes labialis in skiers: randomized clinical trial of acyclovir cream versus placebo. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997;84:641-5.CrossRefPubMed Raborn GW, Martel AY, Grace MG, McGaw WT. Herpes labialis in skiers: randomized clinical trial of acyclovir cream versus placebo. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997;84:641-5.CrossRefPubMed
go back to reference Spruance SL, Kriesel JD. Treatment of herpes simplex labialis. Herpes 2002;9:64-9.PubMed Spruance SL, Kriesel JD. Treatment of herpes simplex labialis. Herpes 2002;9:64-9.PubMed
go back to reference Spruance SL, Hamill ML, Hoge WS, Davis LG, Mills J. Acyclovir prevents reactivation of herpes simplex labialis in skiers. JAMA 1988;260:1597-9.CrossRefPubMed Spruance SL, Hamill ML, Hoge WS, Davis LG, Mills J. Acyclovir prevents reactivation of herpes simplex labialis in skiers. JAMA 1988;260:1597-9.CrossRefPubMed
go back to reference Raborn GW, Martel AY, Grace MG, McGaw WT. Oral acyclovir in prevention of herpes labialis. A randomized, double-blind, multi-centered clinical trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;85:55-9.CrossRefPubMed Raborn GW, Martel AY, Grace MG, McGaw WT. Oral acyclovir in prevention of herpes labialis. A randomized, double-blind, multi-centered clinical trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;85:55-9.CrossRefPubMed
go back to reference Fawcett HA, Wansbrough-Jones MH, Clark AE, Leigh IM. Prophylactic topical acyclovir for frequent recurrent herpes simplex infection with and without erythema multiforme. Br Med J (Clin Res Ed) 1983;287:798-9.CrossRef Fawcett HA, Wansbrough-Jones MH, Clark AE, Leigh IM. Prophylactic topical acyclovir for frequent recurrent herpes simplex infection with and without erythema multiforme. Br Med J (Clin Res Ed) 1983;287:798-9.CrossRef
go back to reference Gibson JR, Klaber MR, Harvey SG, Tosti A, Jones D, Yeo JM. Prophylaxis against herpes labialis with acyclovir cream--a placebo-controlled study. Dermatologica 1986;172:104-7.CrossRefPubMed Gibson JR, Klaber MR, Harvey SG, Tosti A, Jones D, Yeo JM. Prophylaxis against herpes labialis with acyclovir cream--a placebo-controlled study. Dermatologica 1986;172:104-7.CrossRefPubMed
go back to reference Meyrick Thomas RH, Dodd HJ, Yeo JM, Kirby JD. Oral acyclovir in the suppression of recurrent non-genital herpes simplex virus infection. Br J Dermatol 1985;113:731-5.CrossRefPubMed Meyrick Thomas RH, Dodd HJ, Yeo JM, Kirby JD. Oral acyclovir in the suppression of recurrent non-genital herpes simplex virus infection. Br J Dermatol 1985;113:731-5.CrossRefPubMed
go back to reference Rooney JF, Straus SE, Mannix ML, Wohlenberg CR, Alling DW, Dumois JA, et al. Oral acyclovir to suppress frequently recurrent herpes labialis. A double-blind, placebo-controlled trial. Ann Intern Med 1993;118:268-72.PubMed Rooney JF, Straus SE, Mannix ML, Wohlenberg CR, Alling DW, Dumois JA, et al. Oral acyclovir to suppress frequently recurrent herpes labialis. A double-blind, placebo-controlled trial. Ann Intern Med 1993;118:268-72.PubMed
go back to reference Baker D, Eisen D. Valacyclovir for prevention of recurrent herpes labialis: 2 double-blind, placebo-controlled studies. Cutis 2003;71:239-42.PubMed Baker D, Eisen D. Valacyclovir for prevention of recurrent herpes labialis: 2 double-blind, placebo-controlled studies. Cutis 2003;71:239-42.PubMed
Metagegevens
Titel
Herpes labialis
Auteurs
W Opstelten
dr. A Knuistingh Neven
dr. JAH Eekhof
Publicatiedatum
01-08-2007
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Huisarts en wetenschap / Uitgave 8/2007
Print ISSN: 0018-7070
Elektronisch ISSN: 1876-5912
DOI
https://doi.org/10.1007/BF03085265

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