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01-11-2007 | Original article

Inhibition of platelet function by abciximab or high-dose tirofiban in patients with STEMI undergoing primary PCI: a randomised trial

Auteurs: J. W. van Werkum, W. B. M. Gerritsen, J. C. Kelder, C. M. Hackeng, S. M. Ernst, V. H. M. Deneer, M. J. Suttorp, B. J. W. M. Rensing, H. W. M. Plokker, J. M. ten Berg

Gepubliceerd in: Netherlands Heart Journal | Uitgave 11/2007

Extract

Platelet activation is pivotal in the pathogenesis of acute myocardial infarction (AMI) and in the occurrence of complications after percutaneous coronary interventions (PCI).1 In the Netherlands, primary PCI is the preferred reperfusion strategy in the treatment of ST-segment elevation myocardial infarction (STEMI) and recent studies in advancing the treatment of STEMI include the use of GP IIb/IIIa receptor inhibitors.2-5 Most data relate to abciximab, which has been registered for this indication. Specifically, the ADMIRAL (Abciximab before Direct angioplasty and stenting in Myocardial Infarction Regarding Acute and Long-term followup) trial showed that early administration of abciximab in patients with STEMI improves coronary patency, left ventricular function and clinical outcomes.4 However, data about the use of tirofiban in the setting of STEMI are limited. In the On-Time (ONgoing Tirofiban In Myocardial infarction Evaluation) study, tirofiban started before hospitalisation did not improve TIMI III flow compared with tirofiban started after angiography.5 …

vorige artikel Long-term prognostic value of CFVR and FFR versus perfusion scintigraphy in patients with multivessel disease

volgende artikel Stent thrombosis in real-world patients: a comparison of drug-eluting with bare metal stents

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Titel: Inhibition of platelet function by abciximab or high-dose tirofiban in patients with STEMI undergoing primary PCI: a randomised trial
Auteurs: J. W. van Werkum
W. B. M. Gerritsen
J. C. Kelder
C. M. Hackeng
S. M. Ernst
V. H. M. Deneer
M. J. Suttorp
B. J. W. M. Rensing
H. W. M. Plokker
J. M. ten Berg
Publicatiedatum: 01-11-2007
Uitgeverij: Bohn Stafleu van Loghum
Gepubliceerd in: Netherlands Heart Journal / Uitgave 11/2007
Print ISSN: 1568-5888
Elektronisch ISSN: 1876-6250
DOI: https://doi.org/10.1007/BF03086018

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Original article

Long-term prognostic value of CFVR and FFR versus perfusion scintigraphy in patients with multivessel disease

Original article