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Gepubliceerd in: Huisarts en wetenschap 1/2008

01-01-2008 | Onderzoek

Helpen huisstofmijtwerende hoezen?

Auteurs: dr. Marjolein de Vries, Karen Aretz, dr. Bart Thoonen, dr. Jean Muris, dr. Arnold Kester, dr. Sonja Cloosterman, prof.dr. Onno van Schayck

Gepubliceerd in: Huisarts en wetenschap | Uitgave 1/2008

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Samenvatting

De Vries MP, Van den Bemt L, Aretz K, Thoonen BPA, Muris JWM, Kester A, Cloosterman S, Van Schayck CP. Helpen huisstofmijtwerende hoezen? Huisarts Wet 2008;51(1):12-7.
Achtergrond De effectiviteit van huisstofmijt (HSM) werende hoezen is nog steeds onderwerp van discussie.
Doel Onderzoeken of de combinatie van HSM-werende hoezen en zelfbehandeling, gebaseerd op piekstroomwaarden en symptomen, leidt tot gebruik van minder inhalatiecorticosteroïden (ICS) in vergelijking met zelfbehandeling alleen.
Opzet Prospectief, gerandomiseerd, dubbelblind, placebogecontroleerd onderzoek.
Methoden We includeerden astmapatiënten van zestien tot zestig jaar, die een een allergie hadden voor HSM, en ICS gebruikten. We legden ze uit hoe ze het zelfbehandelplan moesten gebruiken op basis van piekstroomwaarden en symptomen. Na een oefenperiode van drie maanden startte de interventieperiode van twee jaar met HSM-ondoorlaatbare of placebo hoezen. De primaire uitkomstmaat was gebruik van ICS, daarnaast keken we ook naar piekstroomparameters, astmacontrole en symptomen.
Resultaten Er begonnen 126 patiënten aan de interventieperiode met de hoezen. Na een en twee jaar was er een significant verschil in blootstelling aan allergenen tussen de groep met HSM-werende hoezen en de placebogroep (p < 0,001). We vonden geen significant verschil tussen de groepen in gebruik van ICS (p = 0,08), ochtend piekstroomwaarde (p = 0,52), piekstroomvariabiliteit (p = 0,36), dyspnoe (p = 0,46), piepen (p = 0,77) en hoesten (p = 0,41). Er was ook geen verschil in astmacontrole tussen de interventie- en controlegroep.
Conclusie HSM-werende hoezen in combinatie met zelfbehandeling leiden niet tot minder gebruik van ICS dan zelfbehandeling alleen.
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Metagegevens
Titel
Helpen huisstofmijtwerende hoezen?
Auteurs
dr. Marjolein de Vries
Karen Aretz
dr. Bart Thoonen
dr. Jean Muris
dr. Arnold Kester
dr. Sonja Cloosterman
prof.dr. Onno van Schayck
Publicatiedatum
01-01-2008
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Huisarts en wetenschap / Uitgave 1/2008
Print ISSN: 0018-7070
Elektronisch ISSN: 1876-5912
DOI
https://doi.org/10.1007/BF03086629

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