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Quality of Life Research
Gepubliceerd in: Quality of Life Research 2/2015

01-02-2015

Health-related quality of life and cost comparison of adjuvant capecitabine versus 5-fluorouracil/leucovorin in stage III colorectal cancer patients

Auteurs: Hong-Hwa Chen, William Tzu-Liang Chen, Hsin-Chung Lee, Jen-Kou Lin, Chuan-Yin Fang, Yenn-Hwei Chou, Peng-Chan Lin, Bo-Wen Lin, Chi-Chou Huang, Chung-Hung Yeh, Hsi-Hsien Hsu, Hung-Chang Chen, Wen-Chien Ting, Ming-Chin Yang, Elise Chia-Hui Tan

Gepubliceerd in: Quality of Life Research | Uitgave 2/2015

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Abstract

Purpose

The purpose of this study was to compare health-related quality of life (HRQoL) and costs associated with 2 adjuvant chemotherapy regimens [capecitabine-based therapy versus 5-fluorouracil/leucovorin (5-FU/LV)-based therapy] in stage III colorectal cancer patients.

Methods

We conducted a prospective, open-label, observational, multicenter study from July 2008 to July 2011. The European Organization for Research and Treatment of Cancer QLQ-C30 and QLQ-CR38 questionnaires was used to assess HRQoL before, during, and after treatment. The direct and indirect costs of adjuvant treatment were estimated from a specially prepared questionnaire, the National Health Insurance Research Database, and other published sources. We used propensity scoring to match samples between groups and performed multivariate analyses to adjust for differences in patient demographics and clinical characteristics.

Results

A total of 497 patients were enrolled, and 356 completed the surveys. Following propensity score matching, 239 patients were included in the analysis (122 in the capecitabine-based group, 117 in the 5-FU/LV-based group). Global HRQoL scores did not differ significantly between the two groups. However, compared to patients in the 5-FU/LV-based group, patients in the capecitabine-based group had less nausea and vomiting (mid-term, P = 0.024; final, P = 0.013), appetite loss (mid-term, P < 0.0001; final, P = 0.001), and fewer side effects from chemotherapy (mid-term, P = 0.017). In addition, the monthly cost of capecitabine-based therapy was lower than those of 5-FU/LV-based therapy [NT$31,895.46 (US$1063.18) vs. NT$79,159.24 (US$2638.64) per patient].

Conclusions

Capecitabine is a reasonable alternative and cost-effective treatment option under current conditions for patients with stage III colorectal cancer.
vorige artikel Intimate partner violence and health-related quality of life in European men and women: findings from the DOVE study
volgende artikel Longitudinal analysis of relationships between social support and general health in an Australian population cohort of young women
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Metagegevens
Titel
Health-related quality of life and cost comparison of adjuvant capecitabine versus 5-fluorouracil/leucovorin in stage III colorectal cancer patients
Auteurs
Hong-Hwa Chen
William Tzu-Liang Chen
Hsin-Chung Lee
Jen-Kou Lin
Chuan-Yin Fang
Yenn-Hwei Chou
Peng-Chan Lin
Bo-Wen Lin
Chi-Chou Huang
Chung-Hung Yeh
Hsi-Hsien Hsu
Hung-Chang Chen
Wen-Chien Ting
Ming-Chin Yang
Elise Chia-Hui Tan
Publicatiedatum
01-02-2015
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 2/2015
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-014-0773-x

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