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22-06-2021

Health-related quality of life and associated factors in HIV-positive transplant candidates and recipients from a HIV-positive donor

Auteurs: Claire Juliet Martin, Elmi Muller, Demetre Labadarios, Frederick Johannes Veldman, Susanna Maria Kassier

Gepubliceerd in: Quality of Life Research | Uitgave 1/2022

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Abstract

Introduction

HRQOL in transplant candidates and recipients who are also infected with HIV and are awaiting a kidney, or have received one from a HIV-positive donor, has not been previously investigated.

Methods

The HRQOL of 47 HIV-positive kidney transplant candidates and 21 recipients from HIV-positive donors was evaluated using the Short Form-36 (SF-36) and face to face interviews at baseline and at 6 months. The correlation between SF-36 scores and sociodemographic, clinical and nutritional factors was determined.

Results

68 patients completed the SF-36 at baseline and 6 months. Transplant candidates: transplant candidates had lower HRQOL than recipients. The main mental stressors were income, employment and waiting for a donor. Physical health complaints were body pain (BP) and fatigue. Pre-albumin and BMI was positively correlated with general health at baseline (r = 0.401, p = 0.031 and r = 0.338, p = 0.025). Besides a positive association with role physical (RP) and BP, albumin was associated with overall physical composite score (PCS) (r = 0.329, p = 0.024) at 6 months. Transplant recipients: Transplant recipients had high HRQOL scores in all domains. PCS was 53.8 ± 10.0 and 56.6 ± 6.5 at baseline and 6 months respectively. MCS was 51.3 ± 11.5 and 54.2 ± 8.5 at baseline and 6 months respectively. Albumin correlated positively with PCS (r = 0.464, p = 0.034) at 6 months and role emotional (RE) (r = 0.492, p = 0.024). Higher pre-albumin was associated with better RE and RP abilities and MCS (r = 0.495, p = 0.034). MAMC was associated with four domains of physical health and strongly correlated with PCS (r = 0.821, p = 0.000).

Conclusion

Strategies to improve HRQOL include ongoing social support, assistance with employment issues and optimising nutritional status.
Literatuur
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Metagegevens
Titel
Health-related quality of life and associated factors in HIV-positive transplant candidates and recipients from a HIV-positive donor
Auteurs
Claire Juliet Martin
Elmi Muller
Demetre Labadarios
Frederick Johannes Veldman
Susanna Maria Kassier
Publicatiedatum
22-06-2021
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 1/2022
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-021-02898-y