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28-05-2016

Explaining fatigue in multiple sclerosis: cross-validation of a biopsychosocial model

Auteurs: Melloney L. M. Wijenberg, Sven Z. Stapert, Sebastian Köhler, Yvonne Bol

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 5/2016

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Abstract

Fatigue is a common and disabling symptom in patients with multiple sclerosis (MS), but its pathogenesis is still poorly understood and consequently evidence-based treatment options are limited. Bol et al. (J Behav Med 33(5):355–363, 2010) suggested a new model, which explains fatigue in MS from a biopsychosocial perspective, including cognitive-behavioral factors. For purposes of generalization to clinical practice, cross-validation of this model in another sample of 218 patients with MS was performed using structural equation modeling. Path analysis indicated a close and adequate global fit (RMSEA = 0.053 and CFI = 0.992). The cross-validated model indicates a significant role for disease severity, depression and a fear-avoidance cycle in explaining MS-related fatigue. Modifiable factors, such as depression and catastrophizing thoughts, propose targets for treatment options. Our findings are in line with recent evidence for the effectiveness of a new generation of cognitive behavioral therapy, including acceptance and mindfulness-based interventions, and provide a theoretical framework for treating fatigue in MS.
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Metagegevens
Titel
Explaining fatigue in multiple sclerosis: cross-validation of a biopsychosocial model
Auteurs
Melloney L. M. Wijenberg
Sven Z. Stapert
Sebastian Köhler
Yvonne Bol
Publicatiedatum
28-05-2016
Uitgeverij
Springer US
Gepubliceerd in
Journal of Behavioral Medicine / Uitgave 5/2016
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI
https://doi.org/10.1007/s10865-016-9749-3