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Journal of Autism and Developmental Disorders

Gepubliceerd in:

29-03-2022 | Original Paper

Corpus Callosum Volumes in Children with Autism Spectrum Disorders: Sex-Associated Differences

Auteurs: Yun Zhang, Bin Qin, Longlun Wang, Ke Zhang, Cui Song, Jie Chen, Jinhua Cai, Tingyu Li

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2023

Abstract

This study aimed to analyze the relationship between sex and corpus callosum (CC) volume in children with autism spectrum disorders (ASD) aged 2–4 years. This prospective study included 50 children with ASD and 50 typically developing (TD) children aged 2–4 years. Midsagittal slices of the CCs of the participants were divided into five subregions using FreeSurfer software. The PMCC, AMCC and TCC volumes were significantly higher in ASD participants than in TD participants, and results were significant in females with ASD rather than in males with ASD (all P < 0.05). In toddlers with ASD, the CC volumes were increased and more pronounced in females than in males. This could be due to overgrowth of axons or/and axonal pruning disorders.

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Titel: Corpus Callosum Volumes in Children with Autism Spectrum Disorders: Sex-Associated Differences
Auteurs: Yun Zhang
Bin Qin
Longlun Wang
Ke Zhang
Cui Song
Jie Chen
Jinhua Cai
Tingyu Li
Publicatiedatum: 29-03-2022
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 6/2023
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-022-05538-7

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