Top

Gepubliceerd in:

2014 | OriginalPaper | Hoofdstuk

11. Colorectaal carcinoom

Auteur : Miriam Koopman

Gepubliceerd in: Ontwikkelingen in de oncologie

Uitgeverij: Bohn Stafleu van Loghum

Inleiding

Het colorectaal carcinoom (CRC) is één van de meest voorkomende vormen van kanker in Nederland, met bijna 12.000 nieuwe patiënten (meer dan 90% ouder dan 50 jaar) en bijna 5000 sterfgevallen in 2007.1 Een huisarts met een gemiddelde praktijk van 2350 patiënten ziet dus per jaar iets minder dan 2 nieuwe patiënten met een CRC, maar dat worden er meer want de laatste tijd neemt het aantal patiënten fors toe, met name bij mannen. In het jaar 2015 zal het aantal nieuwe patiënten naar verwachting 14.000 zijn, van wie 8000 ouder dan 65 jaar. Naast leeftijd zijn weinig lichaamsbeweging, ongezonde voeding en overgewicht belangrijke risicofactoren.

vorige hoofdstuk Mammacarcinoom

volgende hoofdstuk Prostaatcarcinoom

Van Steenbergen LN. Zorg voor darmkankerpatiënten in Zuid-Nederland verder verbeterd. Ned Tijdschr Oncol 2010;7:310–3.

Food, nutrition, physical activity and the prevention of cancer: A global perspective. Washington (DC): World Cancer Research Fund, American Institute for Cancer Research (AIRC), 2007.

O’Connell MJ, Laurie JA, Kahn M, Fitzgibbons jr RJ, Erlichman C, Shepherd LE, et al. Prospectively randomized trial of postoperative adjuvant chemotherapy in patiënts with high-risk colon cancer. J Clin Oncol 1998;16:295–300.PubMed

Punt CJA. Medicamenteuze behandeling van patiënten met colorectumcarcinoom. Ned Tijdschr Geneeskd 2005;149:1441–7.PubMed

Gray RG, Barnwell J, Hills R, McConkey C, Willimas N, Kerr D. QUASAR: Adjuvant chemotherapy vs observation in patiënts with colorectal cancer; a randomised study. Lancet 2007;370:2020–9.PubMedCrossRef

André T, Boni C, Navarro M, Tabernero J, Hickish T, Topham C, et al. Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial. J Clin Oncol 2009;27:3109–16.PubMedCrossRef

Twelves C, Wong A, Nowacki MP, Abt M, Burris H 3rd, Carrato A, et al. Capecitabine as adjuvant treatment of stage III colon cancer. N Engl J Med 2005;352:2696–704.PubMedCrossRef

Schmoll HJ, Cartwright T, Tabernero J, Nowacki MP, Figer A, Maroun J, et al. Phase III trial of capecitabine and oxaliplatin as adjuvant therapy for stage III colon cancer: A planned safety analysis in 1,864 patiënts. J Clin Oncol 2007;25:102–9.PubMedCrossRef

Wolmark N, Yothers G, O’Connell MJ, Sharif S, Atkins JN, Seay TE, et al. A phase III trial comparing mFOLFOX6 to mFOLFOX6 plus bevacizumab in stage II or III carcinoma of the olon: Results of NSABP Protocol C-08. J Clin Oncol 2009;27:18s (abstr. LBA4).

10.

Goldberg RM, Sargent DJ, Thibodeau SN, Mahoney MR, Shields AF, Chan E, et al. Adjuvant mFOLFOX6 plus or minus cetuximab (Cmab) in patiënts (pts) with KRAS mutant (m) resected stage III colon cancer (CC): NCCTG Intergroup Phase III Trial N0147. J Clin Oncol 2010;28:15s (abstr. 3508).

11.

Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350:2335–42.PubMedCrossRef

12.

Kopetz S, Chang GJ, Overman MJ, Eng C, Sargent DJ, Larson DW, et al. Improved survival in metastatic colorectal cancer is associated with adoption of hepatic resection and improved chemotherapy. J Clin Oncol 2009;27:3677–83.PubMedCentralPubMedCrossRef

13.

Modulation of fluorouracil by leucovorin in patiënts with advanced colorectal cancer: evidence in terms of response rate. Advanced Colorectal Cancer Meta-Analysis Project. J Clin Oncol 1992;10:896–903.

14.

Hoff PM, Ansari R, Batist G, Cox J, Kocha W, Kuperminc M, et al. Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patiënts with metastatic colorectal cancer: Results of a randomized phase III study. J Clin Oncol 2001;19:2282–92.PubMed

15.

Van Cutsem E, Twelves C, Cassidy J, Allman D, Bajetta E, Boyer M, et al. Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patiënts with metastatic colorectal cancer: results of a large phase III study. J Clin Oncol 2001;19:4097–106.PubMed

16.

Douillard JY, Hoff PM, Skillings JR, Eisenberg P, Davidson N, Harper P, et al. Multicenter phase III study of uracil/tegafur and oral leucovorin versus fluorouracil and leucovorin in patiënts with previously untreated metastatic colorectal cancer. J Clin Oncol 2002;20:3605–16.PubMedCrossRef

17.

Carmichael J, Popiela T, Radstone D, Falk S, Borner M, Oza A, et al. Randomized comparative study of tegafur/uracil and oral leucovorin versus parenteral fluorouracil and leucovorin in patiënts with previously untreated metastatic colorectal cancer. J Clin Oncol 2002;20:3617–27.PubMedCrossRef

18.

Cassidy J, Twelves C, Van Cutsem E, Hoff P, Bajetta E, Boyer M, et al. First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin. Ann Oncol 2002;13:566–75.PubMedCrossRef

19.

Van Cutsem E, Hoff PM, Harper P, Bukowski RM, Cunningham D, Dufour P, et al. Oral capecitabine vs intravenous 5-fluorouracil and leucovorin: integrated efficacy data and novel analyses from two large, randomised, phase III trials. Br J Cancer 2004;90:1190–1197.PubMedCrossRef

20.

Koopman M, Antonini NF, Douma J, Wals J, Honkoop AH, Erdkamp FL, et al. Sequential versus combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (CAIRO): A phase III randomised controlled trial. Lancet 2007;370:135–42.PubMedCrossRef

21.

Seymour MT, Maughan TS, Ledermann JA, Topham C, James R, Gwyther SJ, et al. Different strategies of sequential and combination chemotherapy for patiënts with poor prognosis advanced colorectal cancer (MRC FOCUS): A randomised controlled trial. Lancet 2007;370:143–52.PubMedCrossRef

22.

Grothey A, Sargent D, Goldberg RM, Schmoll HJ. Survival of patiënts with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment. J Clin Oncol 2004;22:1209–14.PubMedCrossRef

23.

Saltz LB, Clarke S, Díaz-Rubio E, Scheithauer W, Figer A, Wong R, et al. Bevacizumab in combination with oxaliplatin- based chemotherapy as first- line therapy in metastatic colorectal cancer: A randomized phase III study. J Clin Oncol 2008;26:2013–9.PubMedCrossRef

24.

Lièvre A, Bachet JB, Boige V, Cayre A, Le Corre D, Buc E, et al. KRAS mutations as an independent prognostic factor in patiënts with advanced colorectal cancer treated with cetuximab. J Clin Oncol 2008;26:374–9.PubMedCrossRef

25.

Koopman M, Muller EW, Punt CJA. Reversible posterior leukoencephalopathy syndrome due to bevacizumab. Dis Colon Rectum 2008;51:1425–6.PubMedCrossRef

26.

Jonker DJ, O’Callaghan CJ, Karapetis CS, Zalcberg JR, Tu D, Au HJ, et al. Cetuximab for the treatment of colorectal cancer. N Engl J Med 2007;357:2040–8.PubMedCrossRef

27.

Cunningham D, Humblet Y, Siena S, Khayat D, Bleiberg H, Santoro A, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan refractory metastatic colorectal cancer. N Engl J Med 2004;351:337–45.PubMedCrossRef

28.

Van Cutsem E, Köhne CH, Hitre E, Zaluski J, Chang Chien CR, Makhson A, et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 2009;360:1408–17.PubMedCrossRef

Titel: Colorectaal carcinoom
Auteur: Miriam Koopman
Uitgeverij: Bohn Stafleu van Loghum
Boek: Ontwikkelingen in de oncologie
Print ISBN: 978-90-368-0435-6

Elektronisch ISBN: 978-90-368-0436-3

Copyright: 2014
DOI: https://doi.org/10.1007/978-90-368-0436-3_11

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Inleiding

Log in om toegang te krijgen