Skip to main content
Top

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in: Journal of Abnormal Child Psychology 5/2018

13-11-2017

Callous-Unemotional Traits Modulate Brain Drug Craving Response in High-Risk Young Offenders

Auteurs: Gina M. Vincent, Lora M. Cope, Jean King, Prashanth Nyalakanti, Kent A. Kiehl

Gepubliceerd in: Research on Child and Adolescent Psychopathology | Uitgave 5/2018

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Adults with psychopathy have a high propensity for substance abuse, generally starting from a young age. This investigation tested hypotheses about differences in the neural responses associated with drug craving among high-risk young offenders with histories of abuse of stimulants and other drugs as a function of psychopathic traits. Fifty-four male adolescents (44 with a history of stimulant abuse and 10 controls) incarcerated at a maximum-security facility (M age = 17.08 years) completed a drug-cue exposure task while brain hemodynamic activity was monitored using functional magnetic resonance imaging (fMRI) with a mobile MRI scanner stationed at the facility. Psychopathic traits were assessed using the Hare Psychopathy Checklist: Youth Version (PCL:YV). In the stimulant abuser group, drug cues elicited activity in classic reward circuitry. Consistent with studies of adult psychopathic traits and substance abuse, there was a negative association between PCL-YV scores and hemodynamic response related to drug craving in the amygdala and ACC in youth with a history of stimulant abuse. However, there were considerably more negative associations between the PCL:YV and hemodynamic response among youth than adults and this was primarily due to callous-unemotional traits rather than interpersonal or behavioral traits. The implications for how personality traits modulate motivations for drug-seeking behavior among adolescent offenders are discussed.
Bijlagen
Alleen toegankelijk voor geautoriseerde gebruikers
Literatuur
go back to reference Blair, R. J. R. (2015). Psychopathic traits from an RDoC perspective. Current Opinion in Neurobiology, 30, 79–84. CrossRefPubMed Blair, R. J. R. (2015). Psychopathic traits from an RDoC perspective. Current Opinion in Neurobiology, 30, 79–84. CrossRefPubMed
go back to reference Carter, C. S., Braver, T. S., Barch, D. M., Botvinick, M. M., Noll, D., & Cohen, J. D. (1998). Anterior cingulate cortex, error detection, and the online monitoring of performance. Science, 280, 747–749. Carter, C. S., Braver, T. S., Barch, D. M., Botvinick, M. M., Noll, D., & Cohen, J. D. (1998). Anterior cingulate cortex, error detection, and the online monitoring of performance. Science, 280, 747–749.
go back to reference Castellanos-Ryan, N., & Conrod, P. J. (2012). Personality and substance misuse: Evidence for a four-factor model of vulnerability. In J. B. K. Verster, K. Brady, M. Galanter, & P. J. Conrod (Eds.), Drug abuse and addiction in medical illness: Causes, consequences, and treatment (pp. 47–62). New York: Humana/Spring Press. CrossRef Castellanos-Ryan, N., & Conrod, P. J. (2012). Personality and substance misuse: Evidence for a four-factor model of vulnerability. In J. B. K. Verster, K. Brady, M. Galanter, & P. J. Conrod (Eds.), Drug abuse and addiction in medical illness: Causes, consequences, and treatment (pp. 47–62). New York: Humana/Spring Press. CrossRef
go back to reference Cleckley, H. (1976). The mask of sanity (5th ed.). St. Louis: Mosby. Cleckley, H. (1976). The mask of sanity (5th ed.). St. Louis: Mosby.
go back to reference Conrod, P. J., Pihl, R. O., Stewart, S. H., & Dongier, M. (2000). Validation of a system of classifying female substance abusers on the basis of personality and motivational risk factors for substance abuse. Psychology & Addiction Behavior, 14, 243–256. CrossRef Conrod, P. J., Pihl, R. O., Stewart, S. H., & Dongier, M. (2000). Validation of a system of classifying female substance abusers on the basis of personality and motivational risk factors for substance abuse. Psychology & Addiction Behavior, 14, 243–256. CrossRef
go back to reference Conrod, P. J., O’Leary-Barrett, M., Newton, N., Topper, L., Castellanos-Ryan, N., Mackie, C., et al. (2013). Effectiveness of a selective, personality-targeted prevention program for adolescent alcohol use and misuse. JAMA Psychiatry, 70(3), 334–342. Conrod, P. J., O’Leary-Barrett, M., Newton, N., Topper, L., Castellanos-Ryan, N., Mackie, C., et al. (2013). Effectiveness of a selective, personality-targeted prevention program for adolescent alcohol use and misuse. JAMA Psychiatry, 70(3), 334–342.
go back to reference Cohn, M. D., Pape, L. E., Schmaal, L., van den Brink, W., van Wingen, G., Vermeiren, R. R. J. M., et al. (2015). Differential relations between juvenile psychopathic traits and resting state network connectivity. Human Brain Mapping, 36, 2396–2405. Cohn, M. D., Pape, L. E., Schmaal, L., van den Brink, W., van Wingen, G., Vermeiren, R. R. J. M., et al. (2015). Differential relations between juvenile psychopathic traits and resting state network connectivity. Human Brain Mapping, 36, 2396–2405.
go back to reference Decety, J., Skelly, L. R., & Kiehl, K. K. (2013). Brain response to empathy- eliciting scenarios involving pain in incarcerated individuals with psychopathy. JAMA Psychiatry, 70, 638–645. CrossRefPubMedPubMedCentral Decety, J., Skelly, L. R., & Kiehl, K. K. (2013). Brain response to empathy- eliciting scenarios involving pain in incarcerated individuals with psychopathy. JAMA Psychiatry, 70, 638–645. CrossRefPubMedPubMedCentral
go back to reference Finger, E. C., Marsh, A. A., Blair, K. S., Reid, M. E., Sims, C., Ng, P., et al. (2011). Disrupted reinforcement signaling in the orbitofrontal cortex and caudate in youths with conduct disorder or oppositional defiant disorder and a high level of psychopathic traits. American Journal of Psychiatry, 168, 152–162. CrossRefPubMed Finger, E. C., Marsh, A. A., Blair, K. S., Reid, M. E., Sims, C., Ng, P., et al. (2011). Disrupted reinforcement signaling in the orbitofrontal cortex and caudate in youths with conduct disorder or oppositional defiant disorder and a high level of psychopathic traits. American Journal of Psychiatry, 168, 152–162. CrossRefPubMed
go back to reference Fink, B. C., Tant, A. S., Tremba, K., & Kiehl, K. A. (2012). Assessment of psychopathic traits in an incarcerated adolescent sample: A methodological comparison. Journal of Abnormal Child Psychology, 40(6), 971–986. CrossRefPubMedPubMedCentral Fink, B. C., Tant, A. S., Tremba, K., & Kiehl, K. A. (2012). Assessment of psychopathic traits in an incarcerated adolescent sample: A methodological comparison. Journal of Abnormal Child Psychology, 40(6), 971–986. CrossRefPubMedPubMedCentral
go back to reference Forth, A., Kosson, D., & Hare, R. (2003). The psychopathy checklist: Youth version. Toronto: Multi-Health Systems. Forth, A., Kosson, D., & Hare, R. (2003). The psychopathy checklist: Youth version. Toronto: Multi-Health Systems.
go back to reference Grant, S., London, E. D., Newlin, D. B., Villemagne, V. L., Liu, X., Contoreggi, C., et al. (1996). Activation of memory circuits during cue-elicited cocaine craving. Proceedings of the National Academy of Sciences USA, 93, 12040–12045. CrossRef Grant, S., London, E. D., Newlin, D. B., Villemagne, V. L., Liu, X., Contoreggi, C., et al. (1996). Activation of memory circuits during cue-elicited cocaine craving. Proceedings of the National Academy of Sciences USA, 93, 12040–12045. CrossRef
go back to reference Hare, R. (1991). The hare psychopathy checklist. Toronto, Ontario: Multi-Health Systems. Hare, R. (1991). The hare psychopathy checklist. Toronto, Ontario: Multi-Health Systems.
go back to reference Hare, R. (2003). The hare psychopathy checklist-revised. Toronto, Ontario: Multi-Health Systems. Hare, R. (2003). The hare psychopathy checklist-revised. Toronto, Ontario: Multi-Health Systems.
go back to reference Hemphill, J. F., Hart, S. D., & Hare, R. D. (1994). Psychopathy and substance use. Journal of Personality Disorders, 8, 169–180. CrossRef Hemphill, J. F., Hart, S. D., & Hare, R. D. (1994). Psychopathy and substance use. Journal of Personality Disorders, 8, 169–180. CrossRef
go back to reference Kaufman, J., Birmaher, B., Brent, D., Rao, U., & Ryan, N. D. (1996). Diagnostic interview: Kiddie-Sads-Present and Lifetime (K-SADS-PL) version 1.0. Pittsburgh: University of Pittsburgh. Kaufman, J., Birmaher, B., Brent, D., Rao, U., & Ryan, N. D. (1996). Diagnostic interview: Kiddie-Sads-Present and Lifetime (K-SADS-PL) version 1.0. Pittsburgh: University of Pittsburgh.
go back to reference Khurana, A., Romer, D., Betancourt, L. M., Brodsky, N. L., Giannetta, J. M., & Hurt, H. (2015). Experimentation versus progression in adolescent drug use: A test of an emerging neurobehavioral imbalance model. Development and Psychopathology, 27, 901–913 PMCID: PMC4890960. CrossRefPubMed Khurana, A., Romer, D., Betancourt, L. M., Brodsky, N. L., Giannetta, J. M., & Hurt, H. (2015). Experimentation versus progression in adolescent drug use: A test of an emerging neurobehavioral imbalance model. Development and Psychopathology, 27, 901–913 PMCID: PMC4890960. CrossRefPubMed
go back to reference Kiehl, K. A., & Hoffman, M. B. (2011). The criminal psychopath: History, neuroscience, treatment, and economics. Jurimetrics, 51, 355–397. PubMedPubMedCentral Kiehl, K. A., & Hoffman, M. B. (2011). The criminal psychopath: History, neuroscience, treatment, and economics. Jurimetrics, 51, 355–397. PubMedPubMedCentral
go back to reference Koob, G. F., & Volkow, N. D. (2010). Neurocircuitry of addiction. Neuropsychopharmacology, 35, 217–238. CrossRefPubMed Koob, G. F., & Volkow, N. D. (2010). Neurocircuitry of addiction. Neuropsychopharmacology, 35, 217–238. CrossRefPubMed
go back to reference Mailloux, D., Forth, A., & Kroner, D. (1997). Psychopathy and substance abuse in adolescent male offenders. Psychological Reports, 80, 529–530. CrossRef Mailloux, D., Forth, A., & Kroner, D. (1997). Psychopathy and substance abuse in adolescent male offenders. Psychological Reports, 80, 529–530. CrossRef
go back to reference Marsh, A. A., Finger, E. C., Fowler, K. A., Adalio, C. J., Jurkowitz, I. T. N., Schechter, J. C., et al. (2013). Empathic responsiveness in amygdala and anterior cingulate cortex in youths with psychopathic traits. Journal of Child Psychology & Psychiatry, 54, 900–910. CrossRef Marsh, A. A., Finger, E. C., Fowler, K. A., Adalio, C. J., Jurkowitz, I. T. N., Schechter, J. C., et al. (2013). Empathic responsiveness in amygdala and anterior cingulate cortex in youths with psychopathic traits. Journal of Child Psychology & Psychiatry, 54, 900–910. CrossRef
go back to reference Mazaika, P., Hoeft, F., Glover, G. H., & Reiss, A. L. (2009). Methods and software for fMRI analysis for clinical subjects. Poster presented at the annual meeting of the Organization for Human Brain Mapping, San Francisco, CA. Mazaika, P., Hoeft, F., Glover, G. H., & Reiss, A. L. (2009). Methods and software for fMRI analysis for clinical subjects. Poster presented at the annual meeting of the Organization for Human Brain Mapping, San Francisco, CA.
go back to reference Neumann, C. S., Kosson, D. S., Forth, A. E., & Hare, R. D. (2006). Factor structure of the hare psychopathy checklist: Youth version (PCL: YV) in incarcerated adolescents. Psychological Assessment, 18, 142–154. CrossRefPubMed Neumann, C. S., Kosson, D. S., Forth, A. E., & Hare, R. D. (2006). Factor structure of the hare psychopathy checklist: Youth version (PCL: YV) in incarcerated adolescents. Psychological Assessment, 18, 142–154. CrossRefPubMed
go back to reference Prisciandaro, J. J., Korte, J. E., McRae-Clark, A. L., & Brady, K. T. (2012). Associations between behavioral disinhibition and cocaine use history in individuals with cocaine dependence. Addictive Behaviors, 37, 1185–1188 PMCID: PMC3626086. CrossRefPubMedPubMedCentral Prisciandaro, J. J., Korte, J. E., McRae-Clark, A. L., & Brady, K. T. (2012). Associations between behavioral disinhibition and cocaine use history in individuals with cocaine dependence. Addictive Behaviors, 37, 1185–1188 PMCID: PMC3626086. CrossRefPubMedPubMedCentral
go back to reference Robins, L. N. (1978). Etiological implications in studies of childhood histories relating to antisocial personality. In R. D. Hare & D. Schalling (Eds.), Psychopathic behavior: Approaches to research (pp. 255–271). Chichester, England: Wiley. Robins, L. N. (1978). Etiological implications in studies of childhood histories relating to antisocial personality. In R. D. Hare & D. Schalling (Eds.), Psychopathic behavior: Approaches to research (pp. 255–271). Chichester, England: Wiley.
go back to reference Rutherford, M. J., Alterman, A. I., Cacciola, J. S., & McKay, J. R. (1997). Validity of the psychopathy checklist-revised in male methadone patients. Drug and Alcohol Dependence, 44, 143–149. CrossRefPubMed Rutherford, M. J., Alterman, A. I., Cacciola, J. S., & McKay, J. R. (1997). Validity of the psychopathy checklist-revised in male methadone patients. Drug and Alcohol Dependence, 44, 143–149. CrossRefPubMed
go back to reference Viding, E., Sebastian, C. L., Dadds, M. R., Lockwood, P. L., Cecil, C. A. M., DeBrito, S. A., et al. (2012). Amygdala response to preattentive masked fear in children with conduct problems: The role of callous– Unemotional traits. American Journal of Psychiatry, 169, 1109–1116. CrossRefPubMed Viding, E., Sebastian, C. L., Dadds, M. R., Lockwood, P. L., Cecil, C. A. M., DeBrito, S. A., et al. (2012). Amygdala response to preattentive masked fear in children with conduct problems: The role of callous– Unemotional traits. American Journal of Psychiatry, 169, 1109–1116. CrossRefPubMed
go back to reference Vincent, G. M. (2002). The Legitimacy of Psychopathy Assessments in Young Offenders: Contributions of Item Response Theory (unpublished doctoral dissertation). Burnaby: Simon Fraser University. Vincent, G. M. (2002). The Legitimacy of Psychopathy Assessments in Young Offenders: Contributions of Item Response Theory (unpublished doctoral dissertation). Burnaby: Simon Fraser University.
go back to reference Vincent, G. M., Kimonis, E., & Clark, A. (2015). Juvenile psychopathy: Appropriate and inappropriate uses in legal proceedings. In K. Heilbrun, D. DeMatteo, & N. Goldstein (Eds.), APA handbook of psychology and juvenile justice (pp. 197–232). Washington: APA Books. https://​doi.​org/​10.​1037/​14643-010. Vincent, G. M., Kimonis, E., & Clark, A. (2015). Juvenile psychopathy: Appropriate and inappropriate uses in legal proceedings. In K. Heilbrun, D. DeMatteo, & N. Goldstein (Eds.), APA handbook of psychology and juvenile justice (pp. 197–232). Washington: APA Books. https://​doi.​org/​10.​1037/​14643-010.
go back to reference Volkow, N. D., Wang, G. J., Fowler, J. S., Gatley, S. J., Ding, Y. S., Logan, J., et al. (1996). Relationship between psychostimulant induced “high” and dopamine transporter occupancy. Proceedings of the National Academy of Sciences USA, 93, 10388–10392. CrossRef Volkow, N. D., Wang, G. J., Fowler, J. S., Gatley, S. J., Ding, Y. S., Logan, J., et al. (1996). Relationship between psychostimulant induced “high” and dopamine transporter occupancy. Proceedings of the National Academy of Sciences USA, 93, 10388–10392. CrossRef
go back to reference White, S. F., Fowler, K. A., Sinclair, S., Schechter, J. C., Majestic, C. M., Pine, D. S., et al. (2014). Disrupted expected value signaling in youth with disruptive behavior disorders to environmental reinforcers. Journal of the American Academy of Child & Adolescent Psychiatry, 53, 579–588.e9. CrossRef White, S. F., Fowler, K. A., Sinclair, S., Schechter, J. C., Majestic, C. M., Pine, D. S., et al. (2014). Disrupted expected value signaling in youth with disruptive behavior disorders to environmental reinforcers. Journal of the American Academy of Child & Adolescent Psychiatry, 53, 579–588.e9. CrossRef
go back to reference Wilkinson, G. S. (1993). WRAT: Wide Range Achievement Test Administration Manual. Wilmington: Wide Range, Inc. Wilkinson, G. S. (1993). WRAT: Wide Range Achievement Test Administration Manual. Wilmington: Wide Range, Inc.
Metagegevens
Titel
Callous-Unemotional Traits Modulate Brain Drug Craving Response in High-Risk Young Offenders
Auteurs
Gina M. Vincent
Lora M. Cope
Jean King
Prashanth Nyalakanti
Kent A. Kiehl
Publicatiedatum
13-11-2017
Uitgeverij
Springer US
Gepubliceerd in
Research on Child and Adolescent Psychopathology / Uitgave 5/2018
Print ISSN: 2730-7166
Elektronisch ISSN: 2730-7174
DOI
https://doi.org/10.1007/s10802-017-0364-8

Andere artikelen Uitgave 5/2018

Journal of Abnormal Child Psychology 5/2018 Naar de uitgave