Gepubliceerd in:
01-11-2011 | Letter to the Editor
c-Kit+ Cells Transplantation as a New Treatment for Autism, a Novel Hypothesis with Important Research and Clinical Implication
Auteur:
Ahmad Ghanizadeh
Gepubliceerd in:
Journal of Autism and Developmental Disorders
|
Uitgave 11/2011
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Excerpt
The excitatory amino acid neurotransmitter of Glutamate has a major role in the brain. However, it has a balance. Excess glutamate is neurotoxic. Glutamate transporters control the level of glutamate in synaptic space. There are different types of glutamate transporters. One of the transporters is GLT-1, which is distributed throughout different brain regions and spinal cord, and which is not present in the white matter (Maragakis and Rothstein
2001). GLT-1 has an important role for removal of glutamate (Danbolt
2001; Robinson
1998). In order to prevent excitotoxicity, these transporters keep glutamate synaptic concentrations low. …