Skip to main content


Swipe om te navigeren naar een ander artikel

01-12-2008 | Research | Uitgave 1/2008 Open Access

Journal of Foot and Ankle Research 1/2008

Threshold for detection of diabetic peripheral sensory neuropathy using a range of research grade monofilaments in persons with Type 2 diabetes mellitus

Journal of Foot and Ankle Research > Uitgave 1/2008
Mary P Thomson, Julia Potter, Paul M Finch, Richard B Paisey
Belangrijke opmerkingen

Electronic supplementary material

The online version of this article (doi:10.​1186/​1757-1146-1-9) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

MT conceived and designed the study, undertook all data collection and analysis and wrote the paper. JP supervised the study at all levels from the design stages, interpretation of data through to completion of the paper to which she has given permission for publication. PF has been involved in intellectual discussions with regard to the study throughout, revising the manuscript for important intellectual content and has given approval for the final version to be published. RP has actively participated and supported the conception and design of the study, supervising all the recruitment of the participants actively discussed the interpretation and implications of results and proof read the final paper and given approval for the final version to be published.



To identify the threshold of reduced sensory perception in Type 2 diabetes mellitus (Type 2 DM) using a range of research grade monofilaments.


Three groups of participants were recruited into a between subject, cross-sectional study. Group 1(NEW), persons with Type 2 DM diagnosed for less than 2 years (n = 80); Group 2 (EST) persons with Type 2 DM diagnosed for more than 2 years (n = 91), and Group 3, a Comparison group without Type 2 DM (n = 73), resulted in a total study population, n = 244. Research grade monofilaments (2, 4, 6, 8 and 10-gram) were employed using standardised protocol, at 6 sites on the plantar aspect of both feet. The demographic and anthropometric measures of gender, age, height, weight, body mass index (BMI), blood pressure and duration of Type 2 DM since diagnosis (if applicable) of the participants were analysed.


Perception of the research grade monofilaments differed significantly between the 3 groups (p < 0.05). The 6-gram monofilament was found to be the threshold of normal perception, based on 90% of the Comparison group perceiving the 6-gram monofilament at all sites in contrast to 64% of NEW and 48% of EST groups.


The 6-gram monofilament was identified as the threshold of normal sensory perception. Inability to perceive the 6-gram monofilament indicates, when using the method described in this study, that diminution of sensory perception is evident. Employing a range of monofilaments, 6, 8 and 10-grams in Type 2 DM foot screening would allow the clinical detection of deteriorating sensory perception and enable implementation of foot protection strategies at an earlier stage than is currently practised.

Onze productaanbevelingen

BSL Podotherapeut Totaal

Binnen de bundel kunt u gebruik maken van boeken, tijdschriften, e-learnings, web-tv's en uitlegvideo's. BSL Podotherapeut Totaal is overal toegankelijk; via uw PC, tablet of smartphone.

Extra materiaal
Over dit artikel

Andere artikelen Uitgave 1/2008

Journal of Foot and Ankle Research 1/2008 Naar de uitgave