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Gepubliceerd in: Quality of Life Research 10/2012

01-12-2012

The effect of weight loss on changes in health-related quality of life among overweight and obese women with urinary incontinence

Auteurs: Angela Marinilli Pinto, Leslee L. Subak, Sanae Nakagawa, Eric Vittinghoff, Rena R. Wing, John W. Kusek, William H. Herman, Delia Smith West, Miriam Kuppermann

Gepubliceerd in: Quality of Life Research | Uitgave 10/2012

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Abstract

Objective

To estimate the effect of change in weight and change in urinary incontinence (UI) frequency on changes in preference-based measures of health-related quality of life (HRQL) among overweight and obese women with UI participating in a weight loss trial.

Methods

We conducted a longitudinal cohort analysis of 338 overweight and obese women with UI enrolled in a randomized clinical trial comparing a behavioral weight loss intervention to an educational control condition. At baseline, 6, and 18 months, health utilities were estimated using the Health Utilities Index Mark 3 (HUI3), a transformation of the SF-36 to the preference-based SF-6D, and the estimated Quality of Well-Being (eQWB) score (a summary calculated from the SF-36 physical functioning, mental health, bodily pain, general health perceptions, and role limitations–physical subscale scores). Potential predictors of changes in these outcomes were examined using generalized estimating equations.

Results

In adjusted multivariable models, weight loss was associated with improvement in HUI3, SF-6D, and eQWB at 6 and 18 months (P < 0.05). Increases in physical activity also were independently associated with improvement in HUI3 (P = 0.01) and SF-6D (P = 0.006) scores at 18 months. In contrast, reduction in UI frequency did not predict improvements in HRQL at 6 or 18 months.

Conclusion

Weight loss and increased physical activity, but not reduction in UI frequency, were strongly associated with improvements in health utilities measured by the HUI3, SF-6D, and eQWB. These findings provide important information that can be used to inform cost–utility analyses of weight loss interventions.
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Metagegevens
Titel
The effect of weight loss on changes in health-related quality of life among overweight and obese women with urinary incontinence
Auteurs
Angela Marinilli Pinto
Leslee L. Subak
Sanae Nakagawa
Eric Vittinghoff
Rena R. Wing
John W. Kusek
William H. Herman
Delia Smith West
Miriam Kuppermann
Publicatiedatum
01-12-2012
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 10/2012
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-011-0086-2

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