Skip to main content
Top
Gepubliceerd in: Journal of Foot and Ankle Research 1/2011

Open Access 01-12-2011 | Poster presentation

Predictors of successful treatment in patients receiving intra-articular injections of hylan G-F 20 or saline for painful first MTPJ OA

Auteurs: Shannon Munteanu, Gerard V Zammit, Hylton B Menz

Gepubliceerd in: Journal of Foot and Ankle Research | bijlage 1/2011

share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail
insite
ZOEKEN

Background

We recently conducted a placebo controlled clinical trial investigating the efficacy of Synvisc® (hylan G-F 20) for first metatarsophalangeal joint (MTPJ) osteoarthritis (OA). The aim of the current study was to devise a clinical prediction rule to identify those people with first MTPJ OA that are more likely to benefit from intra-articular injections (of hylan G-F 20 or saline).

Methods

One hundred and fifty one participants with first MTPJ OA received an intra-articular injection of 1ml hylan G-F 20 or saline. Potential predictors included intervention group, demographics, height weight, BMI, symptom duration and severity, the Foot Health Status Questionnaire (FHSQ), first MTPJ dorsiflexion range of motion and radiographic OA severity (osteophytes and joint space narrowing as individual features in either the dorsal and lateral view, or as a combination, where scores of 2 for any feature in any view was considered ‘definite’ OA). The primary measure was a 15-point change in symptoms scale (range -7- ‘a very great deal worse’ to +7 – ‘a very great deal better’) at 12-weeks, dichotomised with scores of 3 defined as treatment success. Predictor variables were initially analysed with univariate analyses. Significant variables were than entered into a backward stepwise multivariate logistic regression.

Results

At 12-weeks, 63 (42%) participants reported treatment success. Predictors of treatment success identified by univariate analyses were increased FHSQ foot function (mean difference 7.23, p=0.027), absence of definite radiographic OA (OR=2.49, p=0.017) and a score of 1 or less for osteophytes on the lateral radiographic view (OR=2.10, p=0.028). After multivariate logistic regression analysis, only FHSQ foot function (B=0.02, p=0.027, OR=1.02) and the absence of definite radiographic OA at the first MTPJ (B=0.906, p=0.017, OR=2.47) remained significant. The pre-test success rate of 42% increased to 57% at 12-weeks if the participant did not exhibit definite radiographic first MTPJ OA (positive likelihood ratio 1.86 (95% CI 1.11 to 3.13).

Conclusions

This study identified few factors that could predict treatment success of intra-articular injections of hylan G-F 20 or saline for first MTPJ OA. Patients that do not display definite radiographic first MTPJ OA are more likely to report success of this treatment.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://​creativecommons.​org/​licenses/​by/​2.​0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Onze productaanbevelingen

BSL Podotherapeut Totaal

Binnen de bundel kunt u gebruik maken van boeken, tijdschriften, e-learnings, web-tv's en uitlegvideo's. BSL Podotherapeut Totaal is overal toegankelijk; via uw PC, tablet of smartphone.

Metagegevens
Titel
Predictors of successful treatment in patients receiving intra-articular injections of hylan G-F 20 or saline for painful first MTPJ OA
Auteurs
Shannon Munteanu
Gerard V Zammit
Hylton B Menz
Publicatiedatum
01-12-2011
Uitgeverij
BioMed Central
Gepubliceerd in
Journal of Foot and Ankle Research / Uitgave bijlage 1/2011
Elektronisch ISSN: 1757-1146
DOI
https://doi.org/10.1186/1757-1146-4-S1-P42

Andere artikelen bijlage 1/2011

Journal of Foot and Ankle Research 1/2011 Naar de uitgave

Invited speaker presentation

The challenges of contemporary wound care