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Research on Child and Adolescent Psychopathology

Gepubliceerd in:

13-10-2022

Maternal Adversity and Epigenetic Age Acceleration Predict Heightened Emotional Reactivity in Offspring: Implications for Intergenerational Transmission of Risk

Auteurs: Brooke G. McKenna, Joanne Choi, Patricia A. Brennan, Anna K. Knight, Alicia K. Smith, Stefanie R. Pilkay, Elizabeth J. Corwin, Anne L. Dunlop

Gepubliceerd in: Research on Child and Adolescent Psychopathology | Uitgave 12/2023

Abstract

Black American women are disproportionately exposed to adversities that may have an intergenerational impact on mental health. The present study examined whether maternal exposure to adversity and epigenetic age acceleration (EAA; a biomarker of stress exposure) predicts the socioemotional health of her offspring. During pregnancy, 180 Black American women self-reported experiences of childhood adversity and marginalization-related adversity (i.e., racial discrimination and gendered racial stress) and provided a blood sample for epigenetic assessment. At a three-year follow-up visit, women reported their offspring’s emotional reactivity (an early indicator of psychopathology) via the CBCL/1.5–5. After adjusting for maternal education and offspring sex, results indicated that greater maternal experiences of childhood trauma (β = 0.21, SE(β) = 0.01; p = 0.01) and racial discrimination (β = 0.14, SE(β) = 0.07; p = 0.049) predicted greater offspring emotional reactivity, as did maternal EAA (β = 0.17, SE(β) = 0.09, p = 0.046). Our findings suggest that maternal EAA could serve as an early biomarker for intergenerational risk conferred by maternal adversity, and that ‘maternal adversity’ must be defined more broadly to include social marginalization, particularly for Black Americans.

vorige artikel Individual and Social Risk and Protective Factors as Predictors of Trajectories of Post-traumatic Stress Symptoms in Adolescents

volgende artikel Networks of Adversity in Childhood and Adolescence and Their Relationship to Adult Mental Health

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Titel: Maternal Adversity and Epigenetic Age Acceleration Predict Heightened Emotional Reactivity in Offspring: Implications for Intergenerational Transmission of Risk
Auteurs: Brooke G. McKenna
Joanne Choi
Patricia A. Brennan
Anna K. Knight
Alicia K. Smith
Stefanie R. Pilkay
Elizabeth J. Corwin
Anne L. Dunlop
Publicatiedatum: 13-10-2022
Uitgeverij: Springer US
Gepubliceerd in: Research on Child and Adolescent Psychopathology / Uitgave 12/2023
Print ISSN: 2730-7166
Elektronisch ISSN: 2730-7174
DOI: https://doi.org/10.1007/s10802-022-00981-7

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