Top

Quality of Life Research

Gepubliceerd in:

01-04-2015

The relationship between economic characteristics and health-related quality of life in newly diagnosed cancer patients in Southeast Asia: results from an observational study

Auteurs: Merel Kimman, Stephen Jan, Helen Monaghan, Mark Woodward

Gepubliceerd in: Quality of Life Research | Uitgave 4/2015

Abstract

Purpose

We investigate whether cancer patients’ economic characteristics are independent determinants of health-related quality of life (HRQoL) in low- and middle-income settings to identify priorities for health policy and research.

Methods

A cross-sectional survey of 9,513 cancer patients from Southeast Asia provided data on demographics, economic status and HRQoL. HRQoL was measured using the EORTC QLQ-C30 and EQ-5D. Information on cancer site and stage was collected using the patients’ medical records. Multiple linear regression analysis estimated the relative impact of economic characteristics (i.e. health insurance, employment status, household income and economic hardship) on HRQoL.

Results

All economic characteristics were significant independent determinants of HRQoL, when we controlled for demographic and clinical characteristics. Economic hardship was found to be most important. The adjusted mean differences in HRQoL scores between patients who had experienced economic hardship in the year before diagnosis compared to patients who did not were −5.6, −6.7, −7.3 and −0.06, respectively, for global health, physical function, emotional function and the EQ-5D index (all p values <0.001). Subgroup analyses showed that this significant result for economic hardship as a predictor of poor HRQoL was consistent across all age groups, for males and females, and across all levels of education.

Conclusions

Living in poor economic circumstances before a cancer diagnosis is associated with greatly impaired HRQoL after diagnosis. There is wide scope for research on innovative interventions that provide low-cost and targeted support aimed to improve health outcomes of disadvantaged cancer patients in low- and middle-income settings.

vorige artikel Living with orofacial conditions: psychological distress and quality of life in adults affected with Treacher Collins syndrome, cherubism, or oligodontia/ectodermal dysplasia—a comparative study

volgende artikel Glycaemic control and quality of life among ethnically diverse Malaysian diabetic patients

Alleen toegankelijk voor geautoriseerde gebruikers

Stewart, B. W., & Wild, C. P. (2014). World Cancer Report 2014. Lyon: International Agency for Research on Cancer.

Lancet, T. (2010). Moving cancer up the global health agenda. Lancet, 375(9731), 2051. doi:10.1016/s0140-6736(10)60942-7.CrossRef

Kimman, M., Norman, R., Jan, S., Kingston, D., & Woodward, M. (2012). The Burden of Cancer in Member Countries of the Association of Southeast Asian Nations (ASEAN). Asian Pacific Journal of Cancer Prevention, 13(2), 411–420.CrossRefPubMed

Guyatt, G. H., Feeny, D. H., & Patrick, D. L. (1993). Measuring health-related quality of life. Annals of Internal Medicine, 118(8), 622–629. doi:10.7326/0003-4819-118-8-199304150-00009.CrossRefPubMed

Farmer, P., Frenk, J., Knaul, F. M., Shulman, L. N., Alleyne, G., Armstrong, L., et al. (2010). Expansion of cancer care and control in countries of low and middle income: A call to action. Lancet, 376(9747), 1186–1193. doi:10.1016/S0140-6736(10)61152-X.CrossRefPubMed

Farkkila, N., Torvinen, S., Roine, R. P., Sintonen, H., Hanninen, J., Taari, K., et al. (2013). Health-related quality of life among breast, prostate, and colorectal cancer patients with end-stage disease. Quality of Life Research,. doi:10.1007/s11136-013-0562-y.PubMed

Farooqui, M., Hassali, M. A., Knight, A., Shafie, A. A., Farooqui, M. A., Saleem, F., et al. (2013). Cross Sectional Assessment of Health Related Quality of Life (HRQoL) among patients with cancer in Malaysia. Asian Pacific Journal of Cancer Prevention, 14(5), 3017–3021.CrossRefPubMed

Jordan, K., Proskorovsky, I., Lewis, P., Ishak, J., Payne, K., Lordan, N., et al. (2013). Effect of general symptom level, specific adverse events, treatment patterns, and patient characteristics on health-related quality of life in patients with multiple myeloma: Results of a European, multicenter cohort study. Supportive Care in Cancer,. doi:10.1007/s00520-013-1991-4.PubMedCentral

Jordhoy, M. S., Fayers, P., Loge, J. H., Saltnes, T., Ahlner-Elmqvist, M., & Kaasa, S. (2001). Quality of life in advanced cancer patients: The impact of sociodemographic and medical characteristics. British Journal of Cancer, 85(10), 1478–1485.CrossRefPubMedCentralPubMed

10.

Lehto, U.-S., Ojanen, M., & Kellokumpu-Lehtinen, P. (2005). Predictors of quality of life in newly diagnosed melanoma and breast cancer patients. Annals of Oncology, 16(5), 805–816. doi:10.1093/annonc/mdi146.CrossRefPubMed

11.

Lundh, M. H., Lampic, C., Nordin, K., Ahlgren, J., Bergkvist, L., Lambe, M., et al. (2013). Changes in health-related quality of life by occupational status among women diagnosed with breast cancer-a population-based cohort study. Psychooncology,. doi:10.1002/pon.3285.PubMed

12.

Parker, P. A., Baile, W. F., Moor, C. D., & Cohen, L. (2003). Psychosocial and demographic predictors of quality of life in a large sample of cancer patients. Psycho-Oncology, 12(2), 183–193. doi:10.1002/pon.635.CrossRefPubMed

13.

Shen, F. R., Liu, M., Zhang, X., Feng, Y. H., Zhou, L. S., & Chen, Y. G. (2012). Health-related quality of life among breast cancer patients and its influencing factor in a Chinese population. Asian Pacific Journal of Cancer Prevention, 13(8), 3747–3750.CrossRefPubMed

14.

Vissers, P. A., Thong, M. S., Pouwer, F., Zanders, M. M., Coebergh, J. W., & van de Poll-Franse, L. V. (2013). The impact of comorbidity on Health-Related Quality of Life among cancer survivors: Analyses of data from the PROFILES registry. Journal of Cancer Survivorship, 7(4), 602–613. doi:10.1007/s11764-013-0299-1.CrossRefPubMed

15.

Wong, C. K., Lam, C. L., Poon, J. T., & Kwong, D. L. (2013). Clinical correlates of health preference and generic health-related quality of life in patients with colorectal neoplasms. PLoS ONE, 8(3), e58341. doi:10.1371/journal.pone.0058341.CrossRefPubMedCentralPubMed

16.

Hoyer, M., Johansson, B., Nordin, K., Bergkvist, L., Ahlgren, J., Lidin-Lindqvist, A., et al. (2011). Health-related quality of life among women with breast cancer: A population-based study. Acta Oncologica, 50(7), 1015–1026. doi:10.3109/0284186x.2011.577446.CrossRefPubMed

17.

Kimman, M., Jan, S., Kingston, D., Monaghan, H., Sokha, E., Thabrany, H., et al. (2012). Socioeconomic Impact of Cancer in Member Countries of the Association of Southeast Asian Nations (ASEAN): The ACTION study protocol. Asian Pacific Journal of Cancer Prevention, 13(2), 421–425.CrossRefPubMed

18.

Tangcharoensathien, V., Patcharanarumol, W., Ir, P., Aljunid, S. M., Mukti, A. G., Akkhavong, K., et al. (2011). Health-financing reforms in southeast Asia: Challenges in achieving universal coverage. Lancet, 377(9768), 863–873. doi:10.1016/s0140-6736(10)61890-9.CrossRefPubMed

19.

Saw, Y. M., Win, K. L., Shiao, L. W., Thandar, M. M., Amiya, R. M., Shibanuma, A., et al. (2013). Taking stock of Myanmar’s progress toward the health-related Millennium Development Goals: Current roadblocks, paths ahead. International Journal for Equity in Health, 12, 78. doi:10.1186/1475-9276-12-78.CrossRefPubMedCentralPubMed

20.

Aaronson, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Duez, N. J., et al. (1993). The European Organization for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology. Journal of the National Cancer Institute, 85(5), 365–376.CrossRefPubMed

21.

Fayers, P., Aaronson, N., Bjordal, K., & Sullivan, M. (1995). EORTC QLQ-C30 Scoring Manual. EORTC Study Group on Quality of Life.

22.

Duijts, S. F. A., van Egmond, M. P., Spelten, E., van Muijen, P., Anema, J. R., & van der Beek, A. J. (2014). Physical and psychosocial problems in cancer survivors beyond return to work: A systematic review. Psycho-Oncology, 23(5), 481–492. doi:10.1002/pon.3467.CrossRefPubMed

23.

Cocks, K., King, M. T., Velikova, G., Martyn St-James, M., Fayers, P. M., & Brown, J. M. (2011). Evidence-based guidelines for determination of sample size and interpretation of the European organisation for the research and treatment of cancer quality of life questionnaire core 30. Journal of Clinical Oncology, 29(1), 89–96. doi:10.1200/jco.2010.28.0107.CrossRefPubMed

24.

EuroQoL Group. (1990). EuroQol–a new facility for the measurement of health-related quality of life. The EuroQol Group. Health Policy, 16(3), 199–208.CrossRef

25.

Tongsiri, S., & Cairns, J. (2011). Estimating population-based values for EQ-5D health states in Thailand. Value Health, 14(8), 1142–1145. doi:10.1016/j.jval.2011.06.005.CrossRefPubMed

26.

Pickard, A. S., Neary, M. P., & Cella, D. (2007). Estimation of minimally important differences in EQ-5D utility and VAS scores in cancer. Health Qual Life Outcomes, 5, 70. doi:10.1186/1477-7525-5-70.CrossRefPubMedCentralPubMed

27.

Galobardes, B., Lynch, J., & Smith, G. D. (2007). Measuring socioeconomic position in health research. British Medical Bulletin, 81–82(1), 21–37. doi:10.1093/bmb/ldm001.CrossRefPubMed

28.

Heeley, E., Anderson, C. S., Huang, Y., Jan, S., Li, Y., Liu, M., et al. (2009). Role of health insurance in averting economic hardship in families after acute stroke in China. Stroke, 40(6), 2149–2156. doi:10.1161/strokeaha.108.540054.CrossRefPubMed

29.

Ferlay, J., Soerjomataram, I., Ervik, M., Dikshit, R., Eser, S., Mathers, C., et al. (2013). GLOBOCAN 2012 v1.0, cancer incidence and mortality worldwide. IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer.

30.

Coates, A., Porzsolt, F., & Osoba, D. (1997). Quality of life in oncology practice: Prognostic value of EORTC QLQ-C30 scores in patients with advanced malignancy. European Journal of Cancer, 33(7), 1025–1030. doi:10.1016/S0959-8049(97)00049-X.CrossRefPubMed

31.

Quinten, C., Martinelli, F., Coens, C., Sprangers, M. A. G., Ringash, J., Gotay, C., et al. (2014). A global analysis of multitrial data investigating quality of life and symptoms as prognostic factors for survival in different tumor sites. Cancer, 120(2), 302–311. doi:10.1002/cncr.28382.CrossRefPubMed

32.

Dowie, J. (2002). Decision validity should determine whether a generic or condition-specific HRQOL measure is used in health care decisions. Health Economics, 11(1), 1–8. doi:10.1002/hec.667.CrossRefPubMed

33.

Link, B. G., & Phelan, J. C. (1996). Understanding sociodemographic differences in health–the role of fundamental social causes. American Journal of Public Health, 86(4), 471–473.CrossRefPubMedCentralPubMed

34.

McIntyre, D., Thiede, M., Dahlgren, G., & Whitehead, M. (2006). What are the economic consequences for households of illness and of paying for health care in low- and middle-income country contexts? Social Science and Medicine, 62(4), 858–865. doi:10.1016/j.socscimed.2005.07.001.CrossRefPubMed

35.

Xu, K., Evans, D. B., Kawabata, K., Zeramdini, R., Klavus, J., & Murray, C. J. (2003). Household catastrophic health expenditure: A multicountry analysis. Lancet, 362(9378), 111–117. doi:10.1016/s0140-6736(03)13861-5.CrossRefPubMed

36.

Cleary, J., Ddungu, H., Distelhorst, S. R., Ripamonti, C., Rodin, G. M., & Bushnaq, M. A., et al. (2013). Supportive and palliative care for metastatic breast cancer: Resource allocations in low- and middle-income countries. A Breast Health Global Initiative 2013 consensus statement. The Breast, 22(5), 616–627, doi:10.1016/j.breast.2013.07.052.

37.

Ganz, P. A., Yip, C. H., Gralow, J. R., Distelhorst, S. R., Albain, K. S., & Andersen, B. L., et al. (2013). Supportive care after curative treatment for breast cancer (survivorship care): Resource allocations in low- and middle-income countries. A Breast Health Global Initiative 2013 consensus statement. The Breast, 22(5), 606–615, doi:10.1016/j.breast.2013.07.049.

Titel: The relationship between economic characteristics and health-related quality of life in newly diagnosed cancer patients in Southeast Asia: results from an observational study
Auteurs: Merel Kimman
Stephen Jan
Helen Monaghan
Mark Woodward
Publicatiedatum: 01-04-2015
Uitgeverij: Springer International Publishing
Gepubliceerd in: Quality of Life Research / Uitgave 4/2015
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-014-0828-z

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Purpose

Methods

Results

Conclusions

Log in om toegang te krijgen

Andere artikelen Uitgave 4/2015

Quality of life domains important and relevant to family caregivers of advanced cancer patients in an Asian population: a qualitative study

Validity of EQ-5D-5L in stroke

Validation of clinical symptom IRT scores for diagnosis and severity assessment of common mental disorders

Measuring changes in health over time using the EQ-5D 3L and 5L: a head-to-head comparison of measurement properties and sensitivity to change in a German inpatient rehabilitation sample

Common patterns of morbidity and multi-morbidity and their impact on health-related quality of life: evidence from a national survey

Construct validity of SF-6D health state utility values in an employed population