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2009 | OriginalPaper | Hoofdstuk

7 Leverfalen

Auteurs : Prof.dr. H.J. Metselaar, Dr. B. van Hoek

Gepubliceerd in: Leverziekten

Uitgeverij: Bohn Stafleu van Loghum

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Samenvatting

De lever vervult tal van essentiële functies in het menselijk lichaam, waaronder ontgifting van het bloed en aanmaak van diverse eiwitten en hormonen. Tevens speelt de lever een rol in het afweersysteem. Leverfalen kan omschreven worden als een situatie van onvoldoende werking van de lever bij deze processen. Dit beeld ontstaat wanneer door het verlies van functionele cellen het totale effectieve levervolume beneden een kritische grens komt. In dit hoofdstuk wordt ingegaan op diverse vormen van leverfalen en twee specifieke bij leverfalen voorkomende problemen, namelijk hepatische encefalopathie en verhoogde bloedingsneiging.
Literatuur
3.
go back to reference O’Grady JG, Schalm SW, Williams R. Acute liver failure: redefining the syndromes. Lancet 1993;342:273–275.PubMedCrossRef O’Grady JG, Schalm SW, Williams R. Acute liver failure: redefining the syndromes. Lancet 1993;342:273–275.PubMedCrossRef
4.
go back to reference O’Grady JG. Paracetamol-induced acute liver failure: prevention and management. J Hepatol 1997;26(Suppl 1):41–46.PubMedCrossRef O’Grady JG. Paracetamol-induced acute liver failure: prevention and management. J Hepatol 1997;26(Suppl 1):41–46.PubMedCrossRef
6.
go back to reference Korman JD, Volenberg I, Balko J, Webster J, Schiodt FV, Squires RH Jr, Fontana RJ, Lee WM, Schilsky ML. Screening for Wilson disease in acute liver failure: a comparison of currently available diagnostic tests. Hepatology 2008;48:1167–1174.PubMedCrossRef Korman JD, Volenberg I, Balko J, Webster J, Schiodt FV, Squires RH Jr, Fontana RJ, Lee WM, Schilsky ML. Screening for Wilson disease in acute liver failure: a comparison of currently available diagnostic tests. Hepatology 2008;48:1167–1174.PubMedCrossRef
7.
go back to reference Brouwer RE, Manten A, Leeuwen AM van, Veenendaal RA, Ringers J, Hoek B van. [Een adolescent met hemolytische anemie en stollingsstoornissen als uiting van de ziekte van Wilson, behandeld met levertransplantatie.] Ned Tijdschr Geneeskd 2001;145:316–322.PubMed Brouwer RE, Manten A, Leeuwen AM van, Veenendaal RA, Ringers J, Hoek B van. [Een adolescent met hemolytische anemie en stollingsstoornissen als uiting van de ziekte van Wilson, behandeld met levertransplantatie.] Ned Tijdschr Geneeskd 2001;145:316–322.PubMed
9.
go back to reference Lisman T, Leebeek FW. Hemostatic alterations in liver disease: a review on pathophysiology, clinical consequences, and treatment. Dig Surg 2007;24:250–258.PubMedCrossRef Lisman T, Leebeek FW. Hemostatic alterations in liver disease: a review on pathophysiology, clinical consequences, and treatment. Dig Surg 2007;24:250–258.PubMedCrossRef
10.
go back to reference Caldwell SH, Hoffman M, Lisman T, Macik BG, Northup PG, Reddy KR, Tripodi A, Sanyal AJ. Coagulation disorders and hemostasis in liver disease: pathophysiology and critical assessment of current management. Hepatology 2006;44:1039–1046.PubMedCrossRef Caldwell SH, Hoffman M, Lisman T, Macik BG, Northup PG, Reddy KR, Tripodi A, Sanyal AJ. Coagulation disorders and hemostasis in liver disease: pathophysiology and critical assessment of current management. Hepatology 2006;44:1039–1046.PubMedCrossRef
11.
go back to reference Bernal W, Auzinger G, Sizer E, Wendon J. Intensive care management of acute liver failure. Semin Liver Dis 2008;28:188–200.PubMedCrossRef Bernal W, Auzinger G, Sizer E, Wendon J. Intensive care management of acute liver failure. Semin Liver Dis 2008;28:188–200.PubMedCrossRef
12.
go back to reference Wendon J, Lee W. Encephalopathy and cerebral edema in the setting of acute liver failure: pathogenesis and management. Neurocrit Care 2008;9:97–102.PubMedCrossRef Wendon J, Lee W. Encephalopathy and cerebral edema in the setting of acute liver failure: pathogenesis and management. Neurocrit Care 2008;9:97–102.PubMedCrossRef
13.
go back to reference Larsen FS, Wendon J. Prevention and management of brain edema in patients with acute liver failure. Liver Transpl 2008;14:S 90–96.CrossRef Larsen FS, Wendon J. Prevention and management of brain edema in patients with acute liver failure. Liver Transpl 2008;14:S 90–96.CrossRef
14.
go back to reference Jalan R, Olde Damink SW, Deutz NE, Hayes PC, Lee A. Moderate hypothermia in patients with acute liver failure and uncontrolled intracranial hypertension. Gastroenterology 2004;127:1338–1346.PubMedCrossRef Jalan R, Olde Damink SW, Deutz NE, Hayes PC, Lee A. Moderate hypothermia in patients with acute liver failure and uncontrolled intracranial hypertension. Gastroenterology 2004;127:1338–1346.PubMedCrossRef
15.
go back to reference Raschke RA, Curry SC, Rempe S, Gerkin R, Little E, Manch R, Wong M, Ramos A, Leibowitz AI. Results of a protocol for the management of patients with fulminant liver failure. Crit Care Med 2008;36:2244–2248.PubMedCrossRef Raschke RA, Curry SC, Rempe S, Gerkin R, Little E, Manch R, Wong M, Ramos A, Leibowitz AI. Results of a protocol for the management of patients with fulminant liver failure. Crit Care Med 2008;36:2244–2248.PubMedCrossRef
16.
go back to reference Rabadan AT, Spaho N, Hernandez D, Gadano A, de Santibanes SE. Intraparenchymal intracranial pressure monitoring in patients with acute liver failure. Arq Neuropsiquiatr 2008;66:374–377.PubMedCrossRef Rabadan AT, Spaho N, Hernandez D, Gadano A, de Santibanes SE. Intraparenchymal intracranial pressure monitoring in patients with acute liver failure. Arq Neuropsiquiatr 2008;66:374–377.PubMedCrossRef
17.
go back to reference Aggarwal S, Brooks DM, Kang Y, Linden PK, Patzer JF. Noninvasive monitoring of cerebral perfusion pressure in patients with acute liver failure using transcranial doppler ultrasonography. Liver Transpl 2008;14:1048–1057.PubMedCrossRef Aggarwal S, Brooks DM, Kang Y, Linden PK, Patzer JF. Noninvasive monitoring of cerebral perfusion pressure in patients with acute liver failure using transcranial doppler ultrasonography. Liver Transpl 2008;14:1048–1057.PubMedCrossRef
18.
go back to reference Macquillan GC, Seyam MS, Nightingale P, Neuberger JM, Murphy N. Blood lactate but not serum phosphate levels can predict patient outcome in fulminant hepatic failure. Liver Transpl 2005;11:1073–1079.PubMedCrossRef Macquillan GC, Seyam MS, Nightingale P, Neuberger JM, Murphy N. Blood lactate but not serum phosphate levels can predict patient outcome in fulminant hepatic failure. Liver Transpl 2005;11:1073–1079.PubMedCrossRef
19.
go back to reference Schmidt LE, Larsen FS. Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure. Crit Care Med 2006;34:337–343.PubMedCrossRef Schmidt LE, Larsen FS. Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure. Crit Care Med 2006;34:337–343.PubMedCrossRef
20.
go back to reference Cholongitas E, O’Beirne J, Betrossian A, Senzolo M, Shaw S, Patch D, Burroughs AK. Prognostic impact of lactate in acute liver failure. Liver Transpl 2008;14:121–122.PubMedCrossRef Cholongitas E, O’Beirne J, Betrossian A, Senzolo M, Shaw S, Patch D, Burroughs AK. Prognostic impact of lactate in acute liver failure. Liver Transpl 2008;14:121–122.PubMedCrossRef
21.
go back to reference Kotoh K, Enjoji M, Kato M, Kohjima M, Nakamuta M, Takayanagi R. A new parameter using serum lactate dehydrogenase and alanine aminotransferase level is useful for predicting the prognosis of patients at an early stage of acute liver injury: A retrospective study. Comp Hepatol 2008;7:6.PubMedCentralPubMedCrossRef Kotoh K, Enjoji M, Kato M, Kohjima M, Nakamuta M, Takayanagi R. A new parameter using serum lactate dehydrogenase and alanine aminotransferase level is useful for predicting the prognosis of patients at an early stage of acute liver injury: A retrospective study. Comp Hepatol 2008;7:6.PubMedCentralPubMedCrossRef
22.
go back to reference Jalan R. Pathophysiological basis of therapy of raised intracranial pressure in acute liver failure. Neurochem Int 2005;47:78–83.PubMedCrossRef Jalan R. Pathophysiological basis of therapy of raised intracranial pressure in acute liver failure. Neurochem Int 2005;47:78–83.PubMedCrossRef
23.
go back to reference Fontana RJ. Acute liver failure including acetaminophen overdose. Med Clin North Am 2008;92:761–794, viii. Fontana RJ. Acute liver failure including acetaminophen overdose. Med Clin North Am 2008;92:761–794, viii.
25.
go back to reference Kortsalioudaki C, Taylor RM, Cheeseman P, Bansal S, Mieli-Vergani G, Dhawan A. Safety and efficacy of N-acetylcysteine in children with non-acetaminopheninduced acute liver failure. Liver Transpl 2008;14:25–30.PubMedCrossRef Kortsalioudaki C, Taylor RM, Cheeseman P, Bansal S, Mieli-Vergani G, Dhawan A. Safety and efficacy of N-acetylcysteine in children with non-acetaminopheninduced acute liver failure. Liver Transpl 2008;14:25–30.PubMedCrossRef
26.
go back to reference Leonis MA, Balistreri WF. Is there a ‘NAC’ to treating acute liver failure in children? Liver Transpl 2008;14:7–8.PubMedCrossRef Leonis MA, Balistreri WF. Is there a ‘NAC’ to treating acute liver failure in children? Liver Transpl 2008;14:7–8.PubMedCrossRef
27.
go back to reference San-Miguel B, Alvarez M, Culebras JM, Gonzalez-Gallego J, Tunon MJ. N-acetyl-cysteine protects liver from apoptotic death in an animal model of fulminant hepatic failure. Apoptosis 2006;11:1945–1957.PubMedCrossRef San-Miguel B, Alvarez M, Culebras JM, Gonzalez-Gallego J, Tunon MJ. N-acetyl-cysteine protects liver from apoptotic death in an animal model of fulminant hepatic failure. Apoptosis 2006;11:1945–1957.PubMedCrossRef
28.
go back to reference Sklar GE, Subramaniam M. Acetylcysteine treatment for non-acetaminophen-induced acute liver failure. Ann Pharmacother 2004;38:498–500.PubMedCrossRef Sklar GE, Subramaniam M. Acetylcysteine treatment for non-acetaminophen-induced acute liver failure. Ann Pharmacother 2004;38:498–500.PubMedCrossRef
29.
go back to reference Raghavan M, Marik PE. Therapy of intracranial hypertension in patients with fulminant hepatic failure. Neurocrit Care 2006;4:179–189.PubMedCrossRef Raghavan M, Marik PE. Therapy of intracranial hypertension in patients with fulminant hepatic failure. Neurocrit Care 2006;4:179–189.PubMedCrossRef
31.
32.
go back to reference Blonski W, Siropaides T, Reddy KR. Coagulopathy in liver disease. Curr Treat Options Gastroenterol 2007; 10:464–473.PubMedCrossRef Blonski W, Siropaides T, Reddy KR. Coagulopathy in liver disease. Curr Treat Options Gastroenterol 2007; 10:464–473.PubMedCrossRef
33.
go back to reference Li M, Zhang LF, Yang L. Fluids administration and coagulation characteristics in patients with different model for end-stage liver disease scores undergoing orthotopic liver transplantation. Chin Med J (Engl) 2007;120:1963–1968. Li M, Zhang LF, Yang L. Fluids administration and coagulation characteristics in patients with different model for end-stage liver disease scores undergoing orthotopic liver transplantation. Chin Med J (Engl) 2007;120:1963–1968.
34.
go back to reference Miyake Y, Iwasaki Y, Takaki A, Fujioka S, Takaguchi K, Ikeda H, Kobashi H, Sakaguchi K, Shiratori Y. Lamivudine treatment improves the prognosis of fulminant hepatitis B. Intern Med 2008;47:1293–1299.PubMedCrossRef Miyake Y, Iwasaki Y, Takaki A, Fujioka S, Takaguchi K, Ikeda H, Kobashi H, Sakaguchi K, Shiratori Y. Lamivudine treatment improves the prognosis of fulminant hepatitis B. Intern Med 2008;47:1293–1299.PubMedCrossRef
35.
go back to reference Kumar M, Satapathy S, Monga R, Das K, Hissar S, Pande C, Sharma BC, Sarin SK. A randomized controlled trial of lamivudine to treat acute hepatitis B. Hepatology 2007;45:97–101.PubMedCrossRef Kumar M, Satapathy S, Monga R, Das K, Hissar S, Pande C, Sharma BC, Sarin SK. A randomized controlled trial of lamivudine to treat acute hepatitis B. Hepatology 2007;45:97–101.PubMedCrossRef
36.
go back to reference Tillmann HL, Hadem J, Leifeld L, Zachou K, Canbay A, Eisenbach C, Graziadei I, Encke J, Schmidt H, Vogel W, Schneider A, Spengler U, Gerken G, Dalekos GN, Wedemeyer H, Manns MP. Safety and efficacy of lamivudine in patients with severe acute or fulminant hepatitis B, a multicenter experience. J Viral Hepat 2006;13:256–263.PubMedCrossRef Tillmann HL, Hadem J, Leifeld L, Zachou K, Canbay A, Eisenbach C, Graziadei I, Encke J, Schmidt H, Vogel W, Schneider A, Spengler U, Gerken G, Dalekos GN, Wedemeyer H, Manns MP. Safety and efficacy of lamivudine in patients with severe acute or fulminant hepatitis B, a multicenter experience. J Viral Hepat 2006;13:256–263.PubMedCrossRef
37.
go back to reference Kramer DJ, Canabal JM, Arasi LC. Application of intensive care medicine principles in the management of the acute liver failure patient. Liver Transpl 2008;14: S85–S89.PubMedCrossRef Kramer DJ, Canabal JM, Arasi LC. Application of intensive care medicine principles in the management of the acute liver failure patient. Liver Transpl 2008;14: S85–S89.PubMedCrossRef
38.
go back to reference Canabal JM, Kramer DJ. Management of sepsis in patients with liver failure. Curr Opin Crit Care 2008; 14:189–197.PubMedCrossRef Canabal JM, Kramer DJ. Management of sepsis in patients with liver failure. Curr Opin Crit Care 2008; 14:189–197.PubMedCrossRef
39.
go back to reference Wu VC, Ko WJ, Chang HW, Chen YS, Chen YW, Chen YM, Hu FC, Lin YH, Tsai PR, Wu KD. Early renal replacement therapy in patients with postoperative acute liver failure associated with acute renal failure: effect on postoperative outcomes. J Am Coll Surg 2007; 205:266–276.PubMedCrossRef Wu VC, Ko WJ, Chang HW, Chen YS, Chen YW, Chen YM, Hu FC, Lin YH, Tsai PR, Wu KD. Early renal replacement therapy in patients with postoperative acute liver failure associated with acute renal failure: effect on postoperative outcomes. J Am Coll Surg 2007; 205:266–276.PubMedCrossRef
40.
41.
go back to reference Pugliese F, Ruberto F, Perrella SM, Cappannoli A, Bruno K, Martelli S, Celli P, Summonti D, D’Alio A, Tosi A, Novelli G, Morabito V, Poli L, Rossi M, Berloco PB, Pietropaoli P. Modifications of intracranial pressure after molecular adsorbent recirculating system treatment in patients with acute liver failure: case reports. Transplant Proc 2007;39:2042–2044.PubMedCrossRef Pugliese F, Ruberto F, Perrella SM, Cappannoli A, Bruno K, Martelli S, Celli P, Summonti D, D’Alio A, Tosi A, Novelli G, Morabito V, Poli L, Rossi M, Berloco PB, Pietropaoli P. Modifications of intracranial pressure after molecular adsorbent recirculating system treatment in patients with acute liver failure: case reports. Transplant Proc 2007;39:2042–2044.PubMedCrossRef
42.
go back to reference Markiewicz-Kijewska M, Szymczak M, Ismail H, Prokurat S, Teisseyre J, Socha P, Jankowska I, Chyzynska A, Kalicinski P, Migdal M. Liver transplantation for fulminant Wilson’s disease in children. Ann Transplant 2008;13:28–31.PubMed Markiewicz-Kijewska M, Szymczak M, Ismail H, Prokurat S, Teisseyre J, Socha P, Jankowska I, Chyzynska A, Kalicinski P, Migdal M. Liver transplantation for fulminant Wilson’s disease in children. Ann Transplant 2008;13:28–31.PubMed
43.
go back to reference Faenza S, Baraldi O, Bernardi M, Bolondi L, Coli L, Cucchetti A, Donati G, Gozzetti F, Lauro A, Mancini E, Pinna AD, Piscaglia F, Rasciti L, Ravaioli M, Ruggeri G, Santoro A, Stefoni S. Mars and Prometheus: our clinical experience in acute chronic liver failure. Transplant Proc 2008;40:1169–1171.PubMedCrossRef Faenza S, Baraldi O, Bernardi M, Bolondi L, Coli L, Cucchetti A, Donati G, Gozzetti F, Lauro A, Mancini E, Pinna AD, Piscaglia F, Rasciti L, Ravaioli M, Ruggeri G, Santoro A, Stefoni S. Mars and Prometheus: our clinical experience in acute chronic liver failure. Transplant Proc 2008;40:1169–1171.PubMedCrossRef
44.
go back to reference Koivusalo AM, Teikari T, Hockerstedt K, Isoniemi H. Albumin dialysis has a favorable effect on amino acid profile in hepatic encephalopathy. Metab Brain Dis 2008;23(4):387–398.PubMedCrossRef Koivusalo AM, Teikari T, Hockerstedt K, Isoniemi H. Albumin dialysis has a favorable effect on amino acid profile in hepatic encephalopathy. Metab Brain Dis 2008;23(4):387–398.PubMedCrossRef
45.
go back to reference Klammt S, Mitzner SR, Stange J, Loock J, Heemann U, Emmrich J, Reisinger EC, Schmidt R. Improvement of impaired albumin binding capacity in acute-on-chronic liver failure by albumin dialysis. Liver Transpl 2008;14:1333–1339.PubMedCrossRef Klammt S, Mitzner SR, Stange J, Loock J, Heemann U, Emmrich J, Reisinger EC, Schmidt R. Improvement of impaired albumin binding capacity in acute-on-chronic liver failure by albumin dialysis. Liver Transpl 2008;14:1333–1339.PubMedCrossRef
46.
go back to reference Ronco C, Tetta C. Extracorporal blood purification: more than diffusion and convection. Does this help? Curr Opin Crit Care 2007;13:662–667.PubMedCrossRef Ronco C, Tetta C. Extracorporal blood purification: more than diffusion and convection. Does this help? Curr Opin Crit Care 2007;13:662–667.PubMedCrossRef
47.
go back to reference Karvellas C, Wendon J. MARS in acute-on-chronic liver failure. Indian J Gastroenterol 2007;26:109.PubMed Karvellas C, Wendon J. MARS in acute-on-chronic liver failure. Indian J Gastroenterol 2007;26:109.PubMed
48.
go back to reference O’Grady JG. Postoperative issues and outcome for acute liver failure. Liver Transpl 2008;14:S97–S101.PubMedCrossRef O’Grady JG. Postoperative issues and outcome for acute liver failure. Liver Transpl 2008;14:S97–S101.PubMedCrossRef
49.
go back to reference Quaglia A, Portmann BC, Knisely AS, Srinivasan P, Muiesan P, Wendon J, Heneghan MA, O’Grady JG, Samyn M, Hadzic D, Dhawan A, Mieli-Vergani G, Heaton N, Rela M. Auxiliary transplantation for acute liver failure: Histopathological study of native liver regeneration. Liver Transpl 2008;14:1437–1448.PubMedCrossRef Quaglia A, Portmann BC, Knisely AS, Srinivasan P, Muiesan P, Wendon J, Heneghan MA, O’Grady JG, Samyn M, Hadzic D, Dhawan A, Mieli-Vergani G, Heaton N, Rela M. Auxiliary transplantation for acute liver failure: Histopathological study of native liver regeneration. Liver Transpl 2008;14:1437–1448.PubMedCrossRef
Metagegevens
Titel
7 Leverfalen
Auteurs
Prof.dr. H.J. Metselaar
Dr. B. van Hoek
Copyright
2009
Uitgeverij
Bohn Stafleu van Loghum
DOI
https://doi.org/10.1007/978-90-313-7437-3_7