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07-02-2020 | ORIGINAL PAPER

Increased Salivary Oxytocin and Empathy in Students of Clinical and Health Psychology After a Mindfulness and Compassion-Based Intervention

Auteurs: Miguel Bellosta-Batalla, M. Carmen Blanco-Gandía, Marta Rodríguez-Arias, Ausiàs Cebolla, Josefa Pérez-Blasco, Luis Moya-Albiol

Gepubliceerd in: Mindfulness | Uitgave 4/2020

Abstract

Objectives

Mindfulness and compassion-based interventions (MCBI) have shown to be effective in increasing self-reported empathy in healthcare professionals. However, no studies described a beneficial effect of MCBI on biological variables related to empathy. In this study, we analyze the effects of an MCBI on the basal levels of salivary oxytocin (sOXT), empathic accuracy, and self-reported empathy in students of clinical and health psychology (N = 90).

Methods

In the experimental group (n = 37), an MCBI was applied. In the active control group (n = 27), students participated in basic psychotherapeutic skills training. In the waiting list group (n = 26), students did not participate in any intervention. A repeated-measures analysis of variance was performed, including pre- and post-intervention evaluations and the follow-up evaluation.

Results

Results indicate a significant interaction between the groups on the basal levels of sOXT (p = .045, η_p² = .05) and perspective taking (p = .040, η_p² = .06), so that the experimental group showed increased sOXT at the end of the MCBI (p = .009, d = .66) and in perspective taking on the follow-up evaluation (p = .001, d = .52).

Conclusions

Introducing MCBI in the university education of clinical and health psychologists can help to improve their empathy skills, which would ultimately have a beneficial influence on the health of the users of their services. Furthermore, sOXT could be used as a valid biomarker in the study of the effects of MCBI on biological variables associated with empathy and affective bonds in different settings.

vorige artikel The Impact of a Mindfulness Intervention on Elementary Classroom Climate and Student and Teacher Mindfulness: a Pilot Study

volgende artikel Testing the Role of State Mindfulness in Facilitating Autonomous Physical Activity Motivation

Bachner-Melman, R., & Ebstein, R. P. (2014). The role of oxytocin and vasopressin in emotional and social behaviors. Handbook of Clinical Neurology, 124, 53–68.PubMed

Baron-Cohen, S., Wheelwright, S., Hill, J., Raste, Y., & Plumb, I. (2001). The "Reading the mind in the eyes" test revised version: A study with normal adults, and adults with Asperger syndrome or high-functioning autism. Journal of Child Psychology and Psychiatry, 42(2), 241–251.PubMed

Bartz, J. A., Zaki, J., Bolger, N., Hollander, E., Ludwig, N. N., Kolevzon, A., & Ochsner, K. N. (2010). Oxytocin selectively improves empathic accuracy. Psychological Science, 21(10), 1426–1428.PubMedPubMedCentral

Batt-Rawden, S. A., Chisolm, M. S., Anton, B., & Flickinger, T. E. (2013). Teaching empathy to medical students: An updated, systematic review. Academic Medicine, 88(8), 1171–1177.PubMed

Bellosta-Batalla, M., Ruiz-Robledillo, N., Sariñana-González, P., Capella-Solano, T., Vitoria-Estruch, S., Hidalgo-Moreno, G., et al. (2018). Increased salivary IgA response as an indicator of immunocompetence after a mindfulness and self-compassion-based intervention. Mindfulness, 9(3), 905–913.

Bellosta-Batalla, M., Cebolla, A., Pérez-Blasco, J., & Moya-Albiol, L. (2019a). La empatía en el ejercicio y formación de los psicólogos clínicos y sanitaristas, y su relación con mindfulness y compasión. Revista Argentina de Clínica Psicológica, 28(2), 210–220.

Bellosta-Batalla, M., Garrote-Caparrós, E., Pérez-Blasco, J., Moya-Albiol, L., & Cebolla, A. (2019b). Mindfulness, empatía y compasión: Evolución de la empatía a la compasión en el ámbito sanitario. Revista de Investigación y Educación en Ciencias de la Salud, 4(1), 47–57.

Bibeau, M., Dionne, F., & Leblanc, J. (2016). Can compassion meditation contribute to the development of psychotherapists’ empathy? A review. Mindfulness, 7(1), 255–263.

Bishop, S. R., Lau, M., Shapiro, S. L., Carlson, L., Anderson, N. D., Carmody, J., et al. (2004). Mindfulness: A proposed operational definition. Clinical Psychology: Science and Practice, 11(3), 230–241.

Black, D. S., & Slavich, G. M. (2016). Mindfulness meditation and the immune system: A systematic review of randomized controlled trials. Annals of the New York Academy of Sciences, 1373(1), 13–24.PubMedPubMedCentral

Blagrove, M., Fouquet, N. C., Baird, A. L., Pace-Schott, E. F., Davies, A. C., Neuschaffer, J. L., et al. (2012). Association of salivary-assessed oxytocin and cortisol levels with time of night and sleep stage. Journal of Neural Transmission, 119(10), 1223–1232.PubMed

Boellinghaus, I., Jones, F. W., & Hutton, J. (2014). The role of mindfulness and loving-kindness meditation in cultivating self-compassion and other-focused concern in health care professionals. Mindfulness, 5(2), 129–138.

Bohart, A. C., & Greenberg, L. S. (1997). Empathy reconsidered: New directions in psychotherapy. Washington, DC: American Psychological Association.

Brito, G. (2014). Rethinking mindfulness in the therapeutic relationship. Mindfulness, 5(4), 351–359.

Brito, G., Campos, D., & Cebolla, A. (2018). Implicit or explicit compassion? Effects of compassion cultivation training and comparison with mindfulness-based stress reduction. Mindfulness, 9(5), 1494–1508.

Bruce, N., Shapiro, S. L., Constantino, M. J., & Manber, R. (2010). Psychotherapist mindfulness and the psychotherapy process. Psychotherapy, 47(1), 83–97.PubMed

Carter, C. S., Pournajafi-Nazarloo, H., Kramer, K. M., Ziegler, T. E., White-Traut, R., Bello, D., & Schwertz, D. (2007). Oxytocin: Behavioral associations and potential as a salivary biomarker. Annals of the New York Academy of Sciences, 1098(1), 312–322.PubMed

Cebolla, A., Galiana, L., Campos, D., Oliver, A., Soler, J., Demarzo, M., et al. (2018). How does mindfulness work? Exploring a theoretical model using samples of meditators and non-meditators. Mindfulness, 9(3), 860–870.

Christensen, J. C., Shiyanov, P. A., Estepp, J. R., & Schlager, J. J. (2014). Lack of association between human plasma oxytocin and interpersonal trust in a Prisoner’s dilemma paradigm. PLoS One, 9(12), e116172.PubMedPubMedCentral

Coutinho, J. F., Silva, P. O., & Decety, J. (2014). Neurosciences, empathy, and healthy interpersonal relationships: Recent findings and implications for counseling psychology. Journal of Counseling Psychology, 61(4), 541–548.PubMed

Crockford, C., Deschner, T., Ziegler, T. E., & Wittig, R. M. (2014). Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: A review. Frontiers in Behavioral Neuroscience, 8, 68.PubMedPubMedCentral

Daughters, K., Manstead, A. S., Hubble, K., Rees, A., Thapar, A., & van Goozen, S. H. (2015). Salivary oxytocin concentrations in males following intranasal administration of oxytocin: A double-blind, cross-over study. PLoS One, 10(12), e0145104.PubMedPubMedCentral

Davis, M. H. (1980). A multidimensional approach to individual differences in empathy. JSAS Catalog of Selected Documents in Psychology, 10, 85.

Davis, D. M., & Hayes, J. A. (2011). What are the benefits of mindfulness? A practice review of psychotherapy-related research. Psychotherapy, 48(2), 198–208.PubMed

Decety, J., & Lamm, C. (2009). Empathy versus personal distress. Recent evidence from social neuroscience. In J. Decety & W. Ickes (Eds.), The social neuroscience of empathy (pp. 199–213). Cambridge: MIT Press.

Ebert, A., & Brüne, M. (2018). Oxytocin and social cognition. Current Topics in Behavioral Neurosciences, 35, 375–388.PubMed

Elices, M., Carmona, C., Pascual, J. C., Feliu-Soler, A., Martin-Blanco, A., & Soler, J. (2017). Compassion and self-compassion: Construct and measurement. Mindfulness & Compassion, 2(1), 34–40.

Elliott, R., Bohart, A. C., Watson, J. C., & Greenberg, L. S. (2011). Empathy. Psychotherapy, 48(1), 43–49.PubMed

Eyal, T., Steffel, M., & Epley, N. (2018). Perspective mistaking: Accurately understanding the mind of another requires getting perspective, not taking perspective. Journal of Personality and Social Psychology, 114(4), 547–571.PubMed

Feeser, M., Fan, Y., Weigand, A., Hahn, A., Gärtner, M., Böker, H., et al. (2015). Oxytocin improves mentalizing – pronounced effects for individuals with attenuated ability to empathize. Psychoneuroendocrinology, 53, 223–232.PubMed

Feldman, R. (2012). Oxytocin and social affiliation in humans. Hormones and Behavior, 61(3), 380–391.PubMed

Feldman, R., Gordon, I., & Zagoory-Sharon, O. (2010). The cross-generation transmission of oxytocin in humans. Hormones and Behavior, 58(4), 669–676.PubMed

Galante, J., Galante, I., Bekkers, M. -J., & Gallacher, J. (2014). Effect of kindness-based meditation on health and well-being: A systematic review and meta-analysis. Journal of Consulting and Clinical Psychology, 82(6), 1101–1114.

Gilbert, P. (Ed.). (2005). Compassion: Conceptualisations, research and use in psychotherapy. New York, NY: Routledge.

Gonzalez-Liencres, C., Shamay-Tsoory, S. G., & Brüne, M. (2013). Towards a neuroscience of empathy: Ontogeny, phylogeny, brain mechanisms, context and psychopathology. Neuroscience & Biobehavioral Reviews, 37(8), 1537–1548.

Grepmair, L., Mitterlehner, F., Loew, T., Bachler, E., Rother, W., & Nickel, M. (2007). Promoting mindfulness in psychotherapists in training influences the treatment results of their patients: A randomized, double-blind, controlled study. Psychotherapy and Psychosomatics, 76(7), 332–338.PubMed

Gröschl, M. (2009). The physiological role of hormones in saliva. Bioessays, 31(8), 843–852.PubMed

Holt-Lunstad, J., Birmingham, W. A., & Light, K. C. (2008). Influence of a "warm touch" support enhancement intervention among married couples on ambulatory blood pressure, oxytocin, alpha amylase, and cortisol. Psychosomatic Medicine, 70(9), 976–985.PubMed

Hölzel, B. K., Lazar, S. W., Gard, T., Schuman-Olivier, Z., Vago, D. R., & Ott, U. (2011). How does mindfulness meditation work? Proposing mechanisms of action from a conceptual and neural perspective. Perspectives on Psychological Science, 6(6), 537–559.PubMed

Horvat-Gordon, M., Granger, D. A., Schwartz, E. B., Nelson, V. J., & Kivlighan, K. T. (2005). Oxytocin is not a valid biomarker when measured in saliva by immunoassay. Physiology & Behavior, 84(3), 445–448.

Hubble, K., Daughters, K., Manstead, A. S. R., Rees, A., Thapar, A., & van Goozen, S. H. M. (2017). Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear. Neuropsychologia, 106, 350–357.PubMed

Hurlemann, R., Patin, A., Onur, O. A., Cohen, M. X., Baumgartner, T., Metzler, S., et al. (2010). Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans. Journal of Neuroscience, 30(14), 4999–5007.PubMed

Isgett, S. F., Algoe, S. B., Boulton, A. J., Way, B. M., & Fredrickson, B. L. (2016). Common variant in OXTR predicts growth in positive emotions from loving-kindness training. Psychoneuroendocrinology, 73, 244–251.PubMedPubMedCentral

Kabat-Zinn, J. (1990). Full catastrophe living: Using the wisdom of your body and mind to face stress, pain, and illness. New York, NY: Dell Publishing.

Keijsers, G. P. J., Schaap, C. P. D. R., & Hoogduin, C. A. L. (2000). The impact of interpersonal patient and therapist behavior on outcome in cognitive-behavior therapy. Behavior Modification, 24(2), 264–297.PubMed

Kendrick, K. M. (2000). Oxytocin, motherhood and bonding. Experimental Physiology, 85, 111–124.

Khoury, B., Sharma, M., Rush, S. E., & Fournier, C. (2015). Mindfulness-based stress reduction for healthy individuals: A meta-analysis. Journal of Psychosomatic Research, 78(6), 519–528.PubMed

Kiken, L. G., Garland, E. L., Bluth, K., Palsson, O. S., & Gaylord, S. A. (2015). From a state to a trait: Trajectories of state mindfulness in meditation during intervention predict changes in trait mindfulness. Personality and Individual Differences, 81, 41–46.PubMedPubMedCentral

Kivlighan, K. T., Granger, D. A., Schwartz, E. B., Nelson, V., Curran, M., & Shirtcliff, E. A. (2004). Quantifying blood leakage into the oral mucosa and its effects on the measurement of cortisol, dehydroepiandrosterone, and testosterone in saliva. Hormones and Behavior, 46(1), 39–46.PubMed

Klimecki, O., & Singer, T. (2012). Empathic distress fatigue rather than compassion fatigue? Integrating findings from empathy research in psychology and social neuroscience. In B. Oakley, A. Knafo, G. Madhavan, & D. S. Wilson (Eds.), Pathological altruism (pp. 368–383). New York, NY: Oxford University Press.

Kreplin, U., Farias, M., & Brazil, I. A. (2018). The limited prosocial effects of meditation: A systematic review and meta-analysis. Scientific Reports, 8, 2403.PubMedPubMedCentral

Lambert, M. J., & Barley, D. E. (2001). Research summary on the therapeutic relationship and psychotherapy outcome. Psychotherapy, 38(4), 357–361.

Lamothe, M., Rondeau, É., Malboeuf-Hurtubise, C., Duval, M., & Sultan, S. (2016). Outcomes of MBSR or MBSR-based interventions in health care providers: A systematic review with a focus on empathy and emotional competencies. Complementary Therapies in Medicine, 24, 19–28.PubMed

Lebowitz, E. R., Leckman, J. F., Feldman, R., Zagoory-Sharon, O., McDonald, N., & Silverman, W. K. (2016). Salivary oxytocin in clinically anxious youth: Associations with separation anxiety and family accommodation. Psychoneuroendocrinology, 65, 35–43.PubMed

Leng, G., & Ludwig, M. (2016). Intranasal oxytocin: Myths and delusions. Biological Psychiatry, 79(3), 243–250.PubMed

Leonard, H. D., Campbell, K., & Gonzalez, V. M. (2018). The relationships among clinician self-report of empathy, mindfulness, and therapeutic alliance. Mindfulness, 9(6), 1837–1844.

Lipschitz, D. L., Kuhn, R., Kinney, A. Y., Grewen, K., Donaldson, G. W., & Nakamura, Y. (2015). An exploratory study of the effects of mind-body interventions targeting sleep on salivary oxytocin levels in cancer survivors. Integrative Cancer Therapies, 14(4), 366–380.PubMed

Loseth, G. E., Ellingsen, D. -M., & Leknes, S. (2014). State-dependent μ-opioid modulation of social motivation. Frontiers in Behavioral Neuroscience, 8, 430.

Luberto, C. M., Shinday, N., Song, R., Philpotts, L. L., Park, E. R., Fricchione, G. L., & Yeh, G. Y. (2018). A systematic review and meta-analysis of the effects of meditation on empathy, compassion, and prosocial behaviors. Mindfulness, 9(3), 708–724.PubMed

MacLean, E. L., Gesquiere, L. R., Gee, N., Levy, K., Martin, W. L., & Carter, C. S. (2018). Validation of salivary oxytocin and vasopressin as biomarkers in domestic dogs. Journal of Neuroscience Methods, 293, 67–76.PubMed

Mascaro, J. S., Rilling, J. K., Tenzin Negi, L., & Raison, C. L. (2013). Compassion meditation enhances empathic accuracy and related neural activity. Social Cognitive and Affective Neuroscience, 8(1), 48–55.PubMed

McCullough, M. E., Churchland, P. S., & Mendez, A. J. (2013). Problems with measuring peripheral oxytocin: Can the data on oxytocin and human behavior be trusted? Neuroscience & Biobehavioral Reviews, 37(8), 1485–1492.

Mestre, V., Frías, M. D., & Samper, P. (2004). La medida de la empatía: Análisis del Interpersonal Reactivity Index. Psicothema, 16(2), 255–260.

Murphy, B. A., Costello, T. H., Watts, A. L., Cheong, Y. F., Berg, J. M., & Lilienfeld, S. O. (2018). Strengths and weaknesses of two empathy measures: A comparison of the measurement precision, construct validity, and incremental validity of two multidimensional indices. Assessment. https://doi.org/10.1177/1073191118777636.PubMed

Neumann, I. D., & Landgraf, R. (2012). Balance of brain oxytocin and vasopressin: Implications for anxiety, depression, and social behaviors. Trends in Neuroscience, 35(11), 649–659.

Nilsson, U. (2009). Soothing music can increase oxytocin levels during bed rest after open-heart surgery: A randomised control trial. Journal of Clinical Nursing, 18(15), 2153–2161.PubMed

Nishizato, M., Fujisawa, T. X., Kosaka, H., & Tomoda, A. (2017). Developmental changes in social attention and oxytocin levels in infants and children. Scientific Reports, 7, 2540.PubMedPubMedCentral

Norcross, J. C. (Ed.). (2011). Psychotherapy relationships that work (2nd ed.). New York, NY: Oxford University Press.

Norcross, J. C., & Wampold, B. E. (2011). Evidence-based therapy relationships: Research conclusions and clinical practices. Psychotherapy, 48(1), 98–102.PubMed

Patin, A., Scheele, D., & Hurlemann, R. (2018). Oxytocin and interpersonal relationships. Current Topics in Behavioral Neurosciences, 35, 389–420.PubMed

Proctor, G. B., & Carpenter, G. H. (2014). Salivary secretion: Mechanism and neural regulation. Monographs in Oral Science, 24, 14–29.PubMed

Robinson, K. J., Hazon, N., Lonergan, M., & Pomeroy, P. P. (2014). Validation of an enzyme-linked immunoassay (ELISA) for plasma oxytocin in a novel mammal species reveals potential errors induced by sampling procedure. Journal of Neuroscience Methods, 226, 73–79.PubMed

Sanada, K., Montero-Marin, J., Alda-Díez, M., Salas-Valero, M., Pérez-Yus, M. C., Morillo, H., et al. (2016). Effects of mindfulness-based interventions on salivary cortisol in healthy adults: A meta-analytical review. Frontiers in Physiology, 7, 471.PubMedPubMedCentral

Saxbe, D., & Mendez, A. J. (2019). Maternal prenatal plasma oxytocin is positively associated with prenatal psychological symptoms, but method of immunoassay extraction may affect results. Biological Psychology, 147, 107718.PubMed

Schulze, L., Lischke, A., Greif, J., Herpertz, S. C., Heinrichs, M., & Domes, G. (2011). Oxytocin increases recognition of masked emotional faces. Psychoneuroendocrinology, 36(9), 1378–1382.PubMed

Shamay-Tsoory, S. G., & Abu-Akel, A. (2016). The social salience hypothesis of oxytocin. Biological Psychiatry, 79(3), 194–202.PubMed

Siegel, D. J. (2007). The mindful brain: Reflection and attunement in the cultivation of well-being. New York, NY: W.W. Norton & Company.

Siegel, R. D., & Germer, C. K. (2012). Wisdom and compassion in psychotherapy: Deepening mindfulness in clinical practice. New York, NY: Guilford Press.

Singer, T., & Lamm, C. (2009). The social neuroscience of empathy. Annals of the New York Academy of Science, 1156(1), 81–96.

Szeto, A., McCabe, P. M., Nation, D. A., Tabak, B. A., Rossetti, M. A., McCullough, M. E., et al. (2011). Evaluation of enzyme immunoassay and radioimmunoassay methods for the measurement of plasma oxytocin. Psychosomatic Medicine, 73(5), 393–400.PubMedPubMedCentral

Teding van Berkhout, E., & Malouff, J. M. (2016). The efficacy of empathy training: A meta-analysis of randomized controlled trials. Journal of Counseling Psychology, 63(1), 32–41.PubMed

Vachon, D. D., & Lynam, D. R. (2016). Fixing the problem with empathy: Development and validation of the affective and cognitive measure of empathy. Assessment, 23(2), 135–149.PubMed

Valstad, M., Alvares, G. A., Egknud, M., Matziorinis, A. M., Andreassen, O. A., Westlye, L. T., & Quintana, D. S. (2017). The correlation between central and peripheral oxytocin concentrations: A systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews, 78, 117–124.

Van Cappellen, P., Way, B. M., Isgett, S. F., & Fredrickson, B. L. (2016). Effects of oxytocin administration on spirituality and emotional responses to meditation. Social Cognitive and Affective Neuroscience, 11(10), 1579–1587.PubMedPubMedCentral

Vittner, D., McGrath, J., Robinson, J., Lawhon, G., Cusson, R., Eisenfeld, L., et al. (2018). Increase in oxytocin from skin-to-skin contact enhances development of parent-infant relationship. Biological Research for Nursing, 20(1), 54–62.PubMed

Vivino, B. L., Thompson, B. J., Hill, C. E., & Ladany, N. (2009). Compassion in psychotherapy: The perspective of therapists nominated as compassionate. Psychotherapy Research, 19(2), 157–171.PubMed

World Medical Association. (2013). WMA Declaration of Helsinki - Ethical principles for medical research involving human subjects. https://www.wma.net/policies-post/wma-declaration-of-helsinki-ethical-principles-for-medical-research-involving-human-subjects/. Accessed 9 September 2018.

Zilcha-Mano, S., Porat, Y., Dolev, T., & Shamay-Tsoory, S. (2018). Oxytocin as a neurobiological marker of ruptures in the working alliance. Psychotherapy and Psychosomatics, 87(2), 126–127.PubMed

Titel: Increased Salivary Oxytocin and Empathy in Students of Clinical and Health Psychology After a Mindfulness and Compassion-Based Intervention
Auteurs: Miguel Bellosta-Batalla
M. Carmen Blanco-Gandía
Marta Rodríguez-Arias
Ausiàs Cebolla
Josefa Pérez-Blasco
Luis Moya-Albiol
Publicatiedatum: 07-02-2020
Uitgeverij: Springer US
Gepubliceerd in: Mindfulness / Uitgave 4/2020
Print ISSN: 1868-8527
Elektronisch ISSN: 1868-8535
DOI: https://doi.org/10.1007/s12671-020-01316-7

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