Childhood cancer survivors are at increased risk for adverse late effects due to the tumour itself or secondary to treatment with chemotherapy and/or radiotherapy. In the Netherlands paediatric oncology centres have established dedicated late effects clinics. Here specialised care is offered to the survivors, who are also screened for unknown late effects. If necessary, survivors are referred for further diagnostic work-up and treatment. Furthermore the paediatric oncology centres are exploring ways to provide adequate care for adult survivors. Finally, the centres are initiating research in the field of late treatment effects. Two representative case histories are presented.