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HEAL = Health, Eating, Activity and Lifestyle (HEAL) Study.
Purpose The purpose of this study was to estimate prevalence of fatigue, identify correlates of fatigue and evaluate the relationship between fatigue and health-related quality of life (HRQOL) in a large cohort of disease-free breast cancer survivors.
Methods Participants are enrolled in the HEAL Study, a multi-center prospective study of women diagnosed with in-situ to Stage IIIA breast cancer. HEAL participants (n = 1183) completed a baseline and a 24-month follow-up interview. Women in this report (n = 800) also completed a quality of life questionnaire that included the Piper Fatigue Scale and the RAND SF-36 two to five years after diagnosis. Multivariate regression methods were used to identify significant factors associated with fatigue. SF-36 scores for fatigued survivors were compared to non-fatigued survivor scores and population norms.
Results Forty-one percent of the breast cancer survivors were fatigued. Significant correlates of fatigue included pain, cognitive problems, physical inactivity, weight gain/personal appearance and antidepressant use. Fatigue was associated with poorer HRQOL, most notably in areas of role and social functioning.
Conclusion This study provides further support for the conclusion that a significant proportion of breast cancer survivors experience fatigue that compromises HRQOL two to five years post-diagnosis.
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Cancer facts and figures. (2003). Atlanta, GA: American Cancer Society.
Goodwin, P. J., Ennis, M., Pritchard, K. I., Trudeau, M., & Hood, N. (1999). Risk of menopause during the first year after breast cancer diagnosis. Journal of Clinical Oncology, 17, 2365–2370. PubMed
Goodwin, P. J., Ennis, M., & Pritchard, K. I. et al. (1999). Adjuvant treatment and onset of menopause predict weight gain after breast cancer diagnosis. Journal of Clinical Oncology, 17, 120–129. PubMed
Shapiro, C. L., Hardenbergh, P. H., & Gelman, R. et al. (1998). Cardiac effects of adjuvant doxorubicin and radiation therapy in breast cancer patients. Journal of Clinical Oncology, 16, 3493–3501. PubMed
Macdonald, L., Bruce, J., Scott, N. W., Smith, W. C. S., & Chambers, W. A. (2005). Long-term follow-up of breast cancer survivors with post-mastectomy pain syndrome. British Journal of Cancer, 92, 225–230. PubMed
Curt, G. A., Breitbart, W., Cella, D., Groopman, J. E., Horning, S. J., Itri, L. M., Johnson, D. H., Miaskowski, C., Scherr, S. L., Portenoy, R. K., & Volgelzang, N. J. (2000). Impact of cancer-related fatigue on the lives of patients: New findings from the fatigue coalition. Oncologist, 4, 353–360. CrossRef
Bower, J. E., Ganz, P. A., Desmond, K. A., Rowland, J. H., Meyerowitz, B. E., & Belin, R. R. (2000). Fatigue in breast cancer survivors: Occurrence, correlates and impact on quality of life. Journal of Clinical Oncology, 18, 743–753. PubMed
Piper, B. F., Lindsey, A. M., & Dodd, M. J. (1987). Fatigue mechanisms in cancer patients: Developing nursing theory. Oncology Nursing Forum, 14, 17–23. PubMed
Woo, B., Dibble, S. L., Piper, B. F., Keating, S. B., & Weiss, M. C. (1998). Differences in fatigue by treatment methods in women with breast cancer. Oncology Nursing Forum, 25, 915–920. PubMed
Broeckel, J. A., Jacobson, P. B., Horton, J., Balducci, L., & Lymman, G. H. (1998). Characteristics and correlates of fatigue after adjuvant chemotherapy for breast cancer. Journal of Clinical Oncology, 16, 1689–1696. PubMed
Okuyama, R., Akechi, T., & Kugaya, A. et al. (2000). Factors correlated with fatigue in disease-free breast cancer patients: Application of the Cancer Fatigue Scale. Supportive Care Cancer, 8, 215–222. CrossRef
Jacobsen, P. B., Donovan, K. A., & Weitzner, M. A. (2003). Distinguishing fatigue and depression in patients with cancer. Seminars in Clinical Neuropsychiatry, 8, 229–240. PubMed
Bower, J. E., Ganz, P. A., Kaziz, N., & Fahey, J. L. (2002). Fatigue and proinflammatory cytokine activity in breast cancer survivors. Psychosomatic Medicine, 64, 604–611. PubMed
Meeske, K., Press, M., Patel, A., & Bernstein, L. (2004). Impact of reproductive factors and lactation on breast carcinoma in situ risk. International Journal of Cancer, 110, 102–109. CrossRef
Piper, B. F., Dibble, S. L., Dodd, M. J., Weiss, M. C., Slaughter, R. E., & Paul, S. M. (1998). The revised piper fatigue scale: Psychometric evaluation in women with breast cancer. Oncology Nursing Forum, 25, 677–684. PubMed
Berger, A. M. (1998). Patterns of fatigue and activity and rest during adjuvant breast cancer chemotherapy. Oncology Nursing Forum, 25, 51–62. PubMed
Woo, B., Dibble, S. L., Piper, B. F., Keating, S. B., & Weiss, M. C. (1998). Difference in fatigue by treatment methods in women with breast cancer. Oncology Nursing Forum, 25, 915–920. PubMed
Wu, H. S., & McSweeney M. (2001). Measurement of fatigue in people with cancer. Oncology Nursing Forum, 28, 1371–1464. PubMed
Kriska, A. (1997). Modifiable activity questionnaire. Medicine and Science in Sports and Exercise, 29, S73–78.
Irwin, M. L., McTiernan, A., & Bernstein, L. et al. (2004). Physical activity levels among breast cancer survivors. Medicine and Science in Sports and Exercise, 36, 1484–1491. PubMed
Ware, J. E. Jr., Snow, K. K., & Kosinski, M. (2000). SF-36 health survey: Manual and interpretation guide. Lincoln, RI: Quality Metric Inc.
Kleinbaum, K. D., Kupper, L. L., Muller, K. E., & Nizam, A. (1998). Applied regression analysis and other multivariable methods, (3rd ed.). Pacific Grove, CA: Duxbury Press.
Breslow, N. E. & Day, N. E. (1980). Statistical methods in cancer research. vol I. The analysis of case–control studies. International Agency for Research on Cancer (IARC) Scientific Publications, vol. 32, pp. 5–338.
Ware, J. E. Jr., & Kosinski, M. (2001). SF-36 physical & mental health summary scales: A manual for users of version 1 (2nd ed.). Lincoln, RI: Quality Metric Inc.
Bosompra, K., Ashikaga, T., O’Brien, P. J., Nelson, L., & Skelly, J. (2002). Swelling, numbness, pain and their relationship to arm function among breast cancer survivors: A disablement process model perspective. The Breast Journal, 8, 238–248. CrossRef
Cull, A., Hay, C., Love, S. B., Mackie, M., Smets, E., & Stewart, M. (1996). What do cancer patients mean when they complain of concentration and memory problems? British Journal of Cancer, 74, 1674–1679. PubMed
Wagner, L. I., & Cella, D. (2004). Fatigue and cancer: Causes, prevalence and treatment approaches. British Journal of Cancer, 91, 822–828. PubMed
Anonymous. (2002). NIH State-of-the-Science Statement on symptom management in cancer: Pain, depression and fatigue. NIH Consensus & State-of-the-Science Statements (Vol. 19, pp. 1–29).
Kohrt, W. M., Bloomfield, S. A., Little, K. D., Nelson, M. E., & Yingling, V. R. (2004). Physical activity and bone health. Medicine and Science in Sports and Exercise, 36, 1955–1996.
- Fatigue in breast cancer survivors two to five years post diagnosis: a HEAL Study report
Ashley Wilder Smith
Catherine M. Alfano
Bonnie A. McGregor
Kathy B. Baumgartner
Kathleen E. Malone
Bryce B. Reeve
- Springer Netherlands