Gepubliceerd in:
01-02-2013
Convection Enhanced Delivery of carmustine in diffuse intrinsic pontine glioma
Auteurs:
S.E.M. Veldhuijzen van Zanten, M.H.A. Jansen, D.G. van Vuurden, E. Hulleman, T. Lagerweij, S. Idema, D. P. Noske, N.I. Wolf, N.H. Hendrikse, W.P. Vandertop, G.J.L. Kaspers
Gepubliceerd in:
Tijdschrift voor Kindergeneeskunde
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bijlage 1/2013
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Extract
DIPG patients have a dismal prognosis with a median overall survival of nine months. Typically, surgical resection is not possible, radiotherapy has only temporary effect and systemic chemotherapeutics fail. Convection Enhanced Delivery (CED) provides high local drug concentrations and equal drug distribution directly at the tumor site through micro-catheters via a pressure gradient. In a murine CED-model, we injected DIPG with carmustine, a highly-active nitrosourea compound, and found a significantly prolonged survival with no severe toxicity. Based on these preclinical data, and on studies in adults showing the safety of the procedure, we developed a clinical study in children with DIPG. …