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Quality of Life Research

Gepubliceerd in:

28-10-2023 | Review

Associations of frailty with symptoms, and HRQOL in older cancer survivors after cancer treatments: a systematic review and meta-analyses

Auteurs: Claire J. Han, Ashley E. Rosko, Daniel J. Spakowicz, Marilyn J. Hammer, Diane Von Ah

Gepubliceerd in: Quality of Life Research | Uitgave 3/2024

Abstract

Purpose

Frailty in older adult cancer survivors after cancer treatments is associated with various health outcomes. However, there is less agreement on how frailty affects symptoms and health-related quality of life (HRQOL). This systematic review and meta-analysis aimed to evaluate the current literature on frailty, symptoms, and HRQOL, as well as the associations of frailty with these factors in older adult cancer survivors with chemotherapy.

Methods

A review was conducted on peer-reviewed publications from 2008 to 2023, using seven electronic databases. Meta-analyses were performed using random effects models to determine pooled effect estimates for frailty prevalence, symptom severity, and HRQOL scores.

Results

A total of 26 studies involving older cancer survivors were included in the analysis. Most of these studies were conducted in Western countries and focused on White survivors, particularly those with breast cancer. The mean pooled prevalence of frailty was 43.5%. Among frail survivors, the most common symptoms reported after cancer treatments were pain (36.4%), neuropathy (34.1%), and fatigue (21.3%). Frailty was associated with higher pooled mean symptom severity (B = 1.23, p = 0.046) and lower functional HRQOL (B = − 0.31, p = 0.051, with marginal significance) after cancer treatments.

Conclusion

Frail older cancer survivors are at high risk of adverse symptoms and poor HRQOL after cancer treatment. Further research on screening for frailty is needed to prevent older adults from developing worse symptoms burden and maintain HRQOL. It is also essential to understand the mechanisms of the associations between frailty, symptoms and HRQOL in this population.

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United Nations, Department of Economic and Social Affairs, Population Division. World Population Prospects 2019: Highlights 2019. Accessed 2 Apr 2023. https://www.un.org/development/desa/publications/world-population-prospects-2019-highlights.html

Handforth, C., Clegg, A., Young, C., Simpkins, S., Seymour, M. T., Selby, P. J., & Young, J. (2015). The prevalence and outcomes of frailty in older cancer patients: A systematic review. Annals of Oncology., 26(6), 1091–1101. https://doi.org/10.1093/annonc/mdu540CrossRefPubMed

Pilleron, S., Soto-Perez-de-Celis, E., Vignat, J., Ferlay, J., Soerjomataram, I., Bray, F., & Sarfat, D. (2021). Estimated global cancer incidence in the oldest adults in 2018 and projections to 2050. International Journal of Cancer., 148(3), 601–608. https://doi.org/10.1002/ijc.33232CrossRefPubMed

Rønning, B., Wyller, T. B., Jordhøy, M. S., Nesbakken, A., Bakka, A., Seljeflot, I., & Kristjansson, S. R. (2014). Frailty indicators and functional status in older patients after colorectal cancer surgery. Journal of Geriatric Oncology., 5(1), 26–32. https://doi.org/10.1016/j.jgo.2013.08.001CrossRefPubMed

Ruiz, J., Miller, A. A., Tooze, J. A., Crane, S., Petty, W. J., Gajra, A., & Klepin, H. D. (2019). Frailty assessment predicts toxicity during first cycle chemotherapy for advanced lung cancer regardless of chronologic age. Journal of Geriatric Oncology., 10(1), 48–54. https://doi.org/10.1016/j.jgo.2018.06.007CrossRefPubMed

Rosko, A. E., Huang, Y., Benson, D. M., Efebera, Y. A., Hofmeister, C., Jaglowski, S., Devine, S., Bhatt, G., Wildes, T. M., Dyko, A., & Jones, D. (2019). Use of a comprehensive frailty assessment to predict morbidity in patients with multiple myeloma undergoing transplant. Journal of Geriatric Oncology., 10(3), 479–485. https://doi.org/10.1016/j.jgo.2018.05.015CrossRefPubMed

Long-Term Side Effects of Cancer Treatment. Cancer.Net. Sept 11, 2022. Accessed 15 Feb 2023. https://www.cancer.net/survivorship/long-term-side-effects-cancer-treatment

Su, M., Yao, N., Shang, M., Shen, Y., Qin, T., Wang, J., & Sun, X. (2022). Frailty and its association with health-related quality of life among older cancer patients: an evidence-based study from China. Health and Qual Life Outcomes., 20(1), 124. https://doi.org/10.1186/s12955-022-02032-7. Published 2022 Aug 19.CrossRef

Huang, I. C., Hudson, M. M., Robison, L. L., & Krull, K. R. (2017). Differential impact of symptom prevalence and chronic conditions on quality of life in cancer survivors and non-cancer individuals: A Population Study. Cancer Epidemiology, Biomarkers & Prevention., 26(7), 1124–1132. https://doi.org/10.1158/1055-9965.EPI-16-1007CrossRef

10.

Rao, A., & Cohen, H. J. (2004). Symptom management in the elderly cancer patient: Fatigue, pain, and depression. Journal of National Cancer Institute., 32, 150–157. https://doi.org/10.1093/jncimonographs/lgh031CrossRef

11.

Yates, P., Miaskowski, C., Cataldo, J. K., Paul, S. M., Cooper, B. A., Alexander, K., Aouizerat, B., Dunn, L., Ritchie, C., McCarthy, A., & Skerman, H. (2015). Differences in the composition of symptom clusters between older and younger oncology patients. Journal of Pain Symptom Management., 49(6), 1025–1034. https://doi.org/10.1016/j.jpainsymman.2014.11.296CrossRefPubMed

12.

Wenkstetten-Holub, A., Fangmeyer-Binder, M., & Fasching, P. (2021). Prevalence of comorbidities in elderly cancer patients. MEMO, 14(1), 15–19. https://doi.org/10.1007/s12254-020-00657-2CrossRef

13.

Sulicka, J., Pac, A., Puzianowska-Kuźnicka, M., Zdrojewski, T., Chudek, J., Tobiasz-Adamczyk, B., Mossakowska, M., Skalska, A., Więcek, A., & Grodzicki, T. (2018). Health status of older cancer survivors-results of the PolSenior study. Journal of Cancer Survivorship., 12(3), 326–333. https://doi.org/10.1007/s11764-017-0672-6CrossRefPubMedPubMedCentral

14.

Mohile, S. G., Heckler, C., Fan, L., Mustian, K., Jean-Pierre, P., Usuki, K., Sprod, L., Janelsins, M., Purnell, J., Peppone, L., & Palesh, O. (2011). Age-related differences in symptoms and their interference with quality of life in 903 cancer patients undergoing radiation therapy. Journal of Geriatric Oncology., 2(4), 225–232. https://doi.org/10.1016/j.jgo.2011.08.002CrossRefPubMedPubMedCentral

15.

Talarico, L., Chen, G., & Pazdur, R. (2004). Enrollment of elderly patients in clinical trials for cancer drug registration: A 7-year experience by the US Food and Drug Administration. Journal of Clinical Oncology., 22(22), 4626–4631. https://doi.org/10.1200/JCO.2004.02.175CrossRefPubMed

16.

Quaglia, A., Tavilla, A., Shack, L., Brenner, H., Janssen-Heijnen, M., Allemani, C., Colonna, M., Grande, E., Grosclaude, P., Vercelli, M., EUROCARE Working Group. (2009). The cancer survival gap between elderly and middle-aged patients in Europe is widening. European Journal of Cancer., 45(6), 1006–1016. https://doi.org/10.1016/j.ejca.2008.11.028CrossRefPubMed

17.

Mian, H., McCurdy, A., Giri, S., Grant, S., Rochwerg, B., Winks, E., Rosko, A. E., Engelhardt, M., Pawlyn, C., Cook, G., & Jackson, G. I. (2023). The prevalence and outcomes of frail older adults in clinical trials in multiple myeloma: A systematic review. Blood Cancer Journal., 13(1), 6. https://doi.org/10.1038/s41408-022-00779-2. Published 2023 Jan 5.CrossRefPubMedPubMedCentral

18.

Fletcher, J. A., Fox, S. T., Reid, N., Hubbard, R. E., & Ladwa, R. (2022). The impact of frailty on health outcomes in older adults with lung cancer: A systematic review. Cancer Treatment Research and Communication, 33, 100652.CrossRef

19.

Dotan, E., Walter, L. C., Browner, I. S., Clifton, K., Cohen, H. J., Extermann, M., Gross, C., Gupta, S., Hollis, G., Hubbard, J., & Jagsi, R. (2021). NCCN guidelines® insights: older adult oncology, version 1.2021: featured updates to the NCCN guidelines. Journal of the National Comprehensive Cancer Network., 19(9), 1006–1019. https://doi.org/10.6004/jnccn.2021.0043. Published 2021 Sep 20.CrossRefPubMed

20.

Gobbens, R. J. J., van Assen, M. A. L. M., Luijkx, K. G., & Schols, J. M. (2012). Testing an integral conceptual model of frailty. Journal of Advanced Nursing., 68(9), 2047–2060. https://doi.org/10.1111/j.1365-2648.2011.05896.xCrossRefPubMed

21.

Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., & Chou, R. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. British Medical Journal., 372, n71. https://doi.org/10.1136/bmj.n71. Published 2021 Mar 29.CrossRefPubMedPubMedCentral

22.

Critical Appraisal Skills Programme. CASP Checklist. May 6, 2019. Accessed 12 Aug 2022. https://casp-uk.net/casp-tools-checklists/

23.

Singh, J. (2013). Critical appraisal skills programme. Journal of Pharmacology and Pharmacotherapeutics., 4(1), 76–76. https://doi.org/10.4103/0976-500X.107697CrossRef

24.

Barendregt, J. J., Doi, S. A., Lee, Y. Y., Norman, R. E., & Vos, T. (2013). Meta-analysis of prevalence. Journal of Epidemiology and Community Health., 67(11), 974–978. https://doi.org/10.1136/jech-2013-203104CrossRefPubMed

25.

Hackett, M. L., & Pickles, K. (2014). Part I: Frequency of depression after stroke: An updated systematic review and meta-analysis of observational studies. International Journal of Stroke., 9(8), 1017–1025. https://doi.org/10.1111/ijs.12357CrossRefPubMed

26.

Shi, X., Nie, C., Shi, S., et al. (2017). Effect comparison between Egger’s test and Begg’s test in publication bias diagnosis in meta-analyses: Evidence from a pilot survey. International Journal of Research., 5, 14–20. https://doi.org/10.20431/2349-0365.0505003CrossRef

27.

Higgins, J. P., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003). Measuring inconsistency in meta-analyses. British Medical Journal., 327(7414), 557–560. https://doi.org/10.1136/bmj.327.7414.557CrossRefPubMedPubMedCentral

28.

Biesma, B., Wymenga, A. N. M., Vincent, A., Dalesio, O., Smit, H. J., Stigt, J. A., Smit, E. F., van Felius, C. L., van Putten, J. W., Slaets, J. P., & Groen, H. J. (2011). Quality of life, geriatric assessment and survival in elderly patients with non-small-cell lung cancer treated with carboplatin–gemcitabine or carboplatin–paclitaxel: NVALT-3 a phase III study. Annals of Oncology., 22(7), 1520–1527. https://doi.org/10.1093/annonc/mdq637CrossRefPubMed

29.

Clough-Gorr, K. M., Stuck, A. E., Thwin, S. S., & Silliman, R. A. (2010). Older breast cancer survivors: Geriatric assessment domains are associated with poor tolerance of treatment adverse effects and predict mortality over 7 years of follow-up. Journal of Clinical Oncology., 28(3), 380–386.CrossRefPubMed

30.

Corre, R., Greillier, L., Caër, H. L., Audigier-Valette, C., Baize, N., Bérard, H., Falchero, L., Monnet, I., Dansin, E., Vergnenègre, A., & Marcq, M. (2016). Use of a comprehensive geriatric assessment for the management of elderly patients with advanced non–small-cell lung Cancer: The phase III randomized ESOGIA-GFPC-GECP 08–02 Study. Journal of Clinical Oncology., 34(13), 1476–1483. https://doi.org/10.1200/JCO.2015.63.5839CrossRefPubMed

31.

Cummings, A., Foster, R., Calman, L., Permyakova, N. V., Bridges, J., Wiseman, T., Corbett, T., Smith, P. W., & Foster, C. (2022). Quality of life and health status in older adults (≥65 years) up to five years following colorectal cancer treatment: Findings from the ColoREctal Wellbeing (CREW) cohort study. PLoS One., 17(7), e0270033. https://doi.org/10.1371/journal.pone.0270033. Published 2022 Jul 14.CrossRefPubMedPubMedCentral

32.

de Vries, J., Bras, L., Sidorenkov, G., Festen, S., Steenbakkers, R. J., Langendijk, J. A., Witjes, M. J., van der Laan, B. F., de Bock, G. H., & Halmos, G. B. (2020). Frailty is associated with decline in health-related quality of life of patients treated for head and neck cancer. Oral Oncology., 111, 105020. https://doi.org/10.1016/j.oraloncology.2020.105020CrossRefPubMed

33.

Duan, L., Cui, H., Zhang, W., & Wu, S. (2022). Symptoms and experiences of frailty in lung cancer patients with chemotherapy: A mixed-method approach. Frontiers in Oncology., 12, 1019006. https://doi.org/10.3389/fonc.2022.1019006. Published 2022 Oct 6.CrossRefPubMedPubMedCentral

34.

Gharagozlian, S., Mala, T., Brekke, H. K., Kolbjørnsen, L. C., Ullerud, Å. A., & Johnson, E. (2020). Nutritional status, sarcopenia, gastrointestinal symptoms and quality of life after gastrectomy for cancer—a cross-sectional pilot study. Clinical Nutrition., 37, 195–201. https://doi.org/10.1016/j.clnesp.2020.03.001CrossRef

35.

Gilmore, N., Kehoe, L., Bauer, J., Xu, H., Hall, B., Wells, M., Lei, L., Culakova, E., Flannery, M., Grossman, V. A., & Sardari, R. A. (2021). The relationship between frailty and emotional health in older patients with advanced cancer. Oncologist., 26(12), e2181–e2191. https://doi.org/10.1002/onco.13975CrossRefPubMedPubMedCentral

36.

Hamaker, M. E., Seynaeve, C., Wymenga, A. N., Xu, H., Hall, B., Wells, M., Lei, L., Culakova, E., Flannery, M., Grossman, V. A., & Sardari, R. A. (2014). Baseline comprehensive geriatric assessment is associated with toxicity and survival in elderly metastatic breast cancer patients receiving single-agent chemotherapy: Results from the OMEGA study of the Dutch breast cancer trialists’ group. Breast., 23(1), 81–87. https://doi.org/10.1016/j.breast.2013.11.004CrossRefPubMed

37.

Hamaya, T., Hatakeyama, S., Momota, M., Narita, T., Iwamura, H., Kojima, Y., Hamano, I., Fujita, N., Okamoto, T., Togashi, K., & Yoneyama, T. (2021). Association between the baseline frailty and quality of life in patients with prostate cancer (FRAQ-PC study). International Journal of Clinical Oncology., 26(1), 199–206. https://doi.org/10.1007/s10147-020-01798-4CrossRefPubMed

38.

Hurria, A., Togawa, K., Mohile, S. G., Klepin, H. D., Gross, C. P., Lichtman, S. M., Gajra, A., Bhatia, S., Katheria, V., & Klapper, S. (2011). Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. Journal of Clinical Oncology., 29(25), 3457–3465. https://doi.org/10.1200/JCO.2011.34.7625CrossRefPubMedPubMedCentral

39.

Kim, Y. J., Kim, J. H., Park, M.-S., Lee, K. W., Kim, K. I., Bang, S. M., Lee, J. S., & Kim, C. H. (2011). Comprehensive geriatric assessment in Korean elderly cancer patients receiving chemotherapy. Journal of Cancer Research and Clinical Oncology., 137(5), 839–847. https://doi.org/10.1007/s00432-010-0945-1CrossRefPubMed

40.

Kirkhus, L., Šaltytė Benth, J., Grønberg, B. H., et al. (2019). Frailty identified by geriatric assessment is associated with poor functioning, high symptom burden and increased risk of physical decline in older cancer patients: Prospective observational study. Palliative Medicine., 33(3), 312–322. https://doi.org/10.1177/0269216319825972CrossRefPubMed

41.

Klepin, H. D., Tooze, J. A., Pardee, T. S., et al. (2016). Effect of intensive chemotherapy on the physical, cognitive, and emotional health of older adults with acute myeloid leukemia. Journal of the American Geriatrics Society., 64(10), 1988–1995. https://doi.org/10.1111/jgs.14301CrossRefPubMedPubMedCentral

42.

Magnuson, A., Lei, L., Gilmore, N., et al. (2019). Longitudinal relationship between frailty and cognition in patients 50 years and older with breast cancer. Journal of the American Geriatrics Society., 67(5), 928–936. https://doi.org/10.1111/jgs.15934CrossRefPubMedPubMedCentral

43.

Mandelblatt, J. S., Clapp, J. D., Luta, G., et al. (2016). Long-term trajectories of self-reported cognitive function in a cohort of older survivors of breast cancer: CALGB 369901 (Alliance). Cancer, 122(22), 3555–3563. https://doi.org/10.1002/cncr.30208CrossRefPubMed

44.

Mandelblatt, J. S., Zhou, X., Small, B. J., et al. (2021). Deficit accumulation frailty trajectories of older breast cancer survivors and non-cancer controls: The thinking and living with cancer study. Journal of the National Cancer Institute., 113(8), 1053–1064. https://doi.org/10.1093/jnci/djab003CrossRefPubMedPubMedCentral

45.

Mohile, S. G., Mohamed, M. R., Xu, H., Culakova, E., Loh, K. P., Magnuson, A., Flannery, M. A., Obrecht, S., Gilmore, N., Ramsdale, E., & Dunne, R. F. (2021). Evaluation of geriatric assessment and management on the toxic effects of cancer treatment (GAP70+): A cluster-randomised study. Lancet., 398(10314), 1894–1904. https://doi.org/10.1016/S0140-6736(21)01789-XCrossRefPubMedPubMedCentral

46.

Pandya, C., Magnuson, A., Flannery, M., Zittel, J., Duberstein, P., Loh, K. P., Ramsdale, E., Gilmore, N., Dale, W., & Mohile, S. G. (2019). Association between symptom burden and physical function in older patients with cancer. Journal of the American Geriatrics Society., 67(5), 998–1004. https://doi.org/10.1111/jgs.15864CrossRefPubMedPubMedCentral

47.

Pottel, L., Lycke, M., Boterberg, T., Pottel, H., Goethals, L., Duprez, F., Van Den Noortgate, N., De Neve, W., Rottey, S., Geldhof, K., & Buyse, V. (2014). Serial comprehensive geriatric assessment in elderly head and neck cancer patients undergoing curative radiotherapy identifies evolution of multidimensional health problems and is indicative of quality of life. European Journal of Cancer Care (Engl)., 23(3), 401–412. https://doi.org/10.1111/ecc.12179CrossRef

48.

Puts, M. T. E., Monette, J., Girre, V., Pepe, C., Monette, M., Assouline, S., Panasci, L., Basik, M., Miller, W. H., Jr., Batist, G., & Wolfson, C. (2011). Are frailty markers useful for predicting treatment toxicity and mortality in older newly diagnosed cancer patients? Results from a prospective pilot study. Critical Review in Oncology/Hematology., 78(2), 138–149. https://doi.org/10.1016/j.critrevonc.2010.04.003CrossRef

49.

Quinten, C., Kenis, C., Decoster, L., Debruyne, P. R., De Groof, I., Focan, C., Cornélis, F., Verschaeve, V., Bachmann, C., Bron, D., & Luce, S. (2019). Determining clinically important differences in health-related quality of life in older patients with cancer undergoing chemotherapy or surgery. Quality of Life Research., 28(3), 663–676. https://doi.org/10.1007/s11136-018-2062-6CrossRefPubMed

50.

Rønning, B., Wyller, T. B., Nesbakken, A., Skovlund, E., Jordhøy, M. S., Bakka, A., & Rostoft, S. (2016). Quality of life in older and frail patients after surgery for colorectal cancer—a follow-up study. Journal of Geriatric Oncology., 7(3), 195–200. https://doi.org/10.1016/j.jgo.2016.03.002CrossRefPubMed

51.

Shehu, E., Roggendorf, S., Golla, A., Koenig, A., Stangl, G. I., Diestelhorst, A., Medenwald, D., Vordermark, D., Steckelberg, A., & Schmidt, H. (2022). Development and evaluation of a multimodal supportive intervention for promoting physical function in older patients with cancer. Cancers (Basel)., 14(11), 2599. https://doi.org/10.3390/cancers14112599. Published 2022 May 24.CrossRefPubMedPubMedCentral

52.

Williams, G. R., Deal, A. M., Sanoff, H. K., Nyrop, K. A., Guerard, E. J., Pergolotti, M., Shachar, S. S., Reeve, B. B., Bensen, J. T., Choi, S. K., & Muss, H. B. (2019). Frailty and health-related quality of life in older women with breast cancer. Supportive Care in Cancer, 27(7), 2693–2698. https://doi.org/10.1007/s00520-018-4558-6CrossRefPubMed

53.

Cooley, M. E., & Siefert, M. L. (2016). Assessment of multiple co-occurring cancer symptoms in the clinical setting. Seminars in Oncology Nursing., 32(4), 361–372. https://doi.org/10.1016/j.soncn.2016.08.003CrossRefPubMed

54.

Atkinson, T. M., Ryan, S. J., Bennett, A. V., Stover, A. M., Saracino, R. M., Rogak, L. J., Jewell, S. T., Matsoukas, K., Li, Y., & Basch, E. (2016). The association between clinician-based common terminology criteria for adverse events (CTCAE) and patient-reported outcomes (PRO): A systematic review. Supportive Care in Cancer, 24(8), 3669–3676. https://doi.org/10.1007/s00520-016-3297-9CrossRefPubMedPubMedCentral

55.

Kenzik, K. M., Martin, M. Y., Fouad, M. N., & Pisu, M. (2015). Health-related quality of life in lung cancer survivors: Latent class and latent transition analysis. Cancer, 121(9), 1520–1528. https://doi.org/10.1002/cncr.29232CrossRefPubMed

56.

Lee, L., Ross, A., Griffith, K., Jensen, R. E., & Wallen, G. R. (2020). Symptom clusters in breast cancer survivors: A latent class profile analysis. Oncology Nursing Forum., 47(1), 89–100. https://doi.org/10.1188/20.ONF.89-100CrossRefPubMedPubMedCentral

57.

Park, H., Lim, J., Baek, J. Y., Lee, E., Jung, H.-W., & Jang, I.-Y. (2021). Status of constipation and its association with sarcopenia in older adults: A population-based cohort study. International Journal of Environmental Research and Health., 18(21), 11083. https://doi.org/10.3390/ijerph182111083. Published 2021 Oct 21.CrossRef

58.

Gao, K., Ma, W. Z., Huck, S., Li, B.-L., Zhang, L., Zhu, J., Li, T., & Zhou, D. (2021). Association between sarcopenia and depressive symptoms in Chinese older adults: Evidence from the china health and retirement longitudinal study. Frontiers in Medicine., 8, 755705. https://doi.org/10.3389/fmed.2021.755705. Published 2021 Nov 17.CrossRefPubMedPubMedCentral

59.

Bai, A., Xu, W., Sun, J., Liu, J., Deng, X., Wu, L., Zou, X., Zuo, J., Zou, L., Liu, Y., & Xie, H. (2021). Associations of sarcopenia and its defining components with cognitive function in community-dwelling oldest old. British Medical Center Geriatrics., 21(1), 292. https://doi.org/10.1186/s12877-021-02190-1CrossRef

60.

Syrjala, K. L., Stover, A. C., Yi, J. C., Artherholt, S. B., & Abrams, J. R. (2010). Measuring social activities and social function in long-term cancer survivors who received hematopoietic stem cell transplantation. Psycho-Oncology, 19(5), 462–471. https://doi.org/10.1002/pon.1572CrossRefPubMedPubMedCentral

61.

King, M. T. (1996). The interpretation of scores from the EORTC quality of life questionnaire QLQ-C30. Quality of Life Research., 5(6), 555–567. https://doi.org/10.1007/BF00439229CrossRefPubMed

62.

Torta, R., Ieraci, V., & Zizzi, F. (2017). A review of the emotional aspects of neuropathic pain: From comorbidity to co-pathogenesis. Pain and Therapy, 6(Suppl 1), 11–17. https://doi.org/10.1007/s40122-017-0088-zCrossRefPubMedPubMedCentral

63.

de Sousa, D. E., de Carli, M. N., Fernandes, R. C., Trindade, D. B., Laviano, A., Pichard, C., & Pimentel, G. D. (2020). Are depression and anxiety disorders associated with adductor pollicis muscle thickness, sleep duration, and protein intake in cancer patients? Experimental Gerontology., 130, 110803. https://doi.org/10.1016/j.exger.2019.110803CrossRefPubMed

64.

Fu, P., Zhou, C., & Meng, Q. (2020). Associations of sleep quality and frailty among the older adults with chronic disease in China: The mediation effect of psychological distress. International Journal of Environmental Research and Public Health., 17(14), 5240. https://doi.org/10.3390/ijerph17145240. Published 2020 Jul 20.CrossRefPubMedPubMedCentral

65.

Gobbens, R. J., Schols, J. M., & van Assen, M. A. (2017). Exploring the efficiency of the Tilburg frailty indicator: a review. Clinical Interventions in Aging, 12, 1739–1752. https://doi.org/10.2147/CIA.S13068665. Published 2017 Oct 19.CrossRefPubMedPubMedCentral

66.

Zhou, S., & Shen, C. (2022). Avoiding definitive conclusions in meta-analysis of heterogeneous studies with small sample sizes. JAMA otolaryngology—Head & Neck Surgery, 148(11), 1003–1004. https://doi.org/10.1001/jamaoto.2022.2847CrossRef

Titel: Associations of frailty with symptoms, and HRQOL in older cancer survivors after cancer treatments: a systematic review and meta-analyses
Auteurs: Claire J. Han
Ashley E. Rosko
Daniel J. Spakowicz
Marilyn J. Hammer
Diane Von Ah
Publicatiedatum: 28-10-2023
Uitgeverij: Springer International Publishing
Gepubliceerd in: Quality of Life Research / Uitgave 3/2024
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-023-03537-4

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