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01-06-2001 | Artikelen

Neonatale behandeling met corticosteroïden en consequenties op de lange termijn

Auteurs: J. M. Bakker, C. J. Heijnen, F. van Bel

Gepubliceerd in: Tijdschrift voor Kindergeneeskunde | Uitgave 3/2001

Samenvatting

Corticosteroïden worden toegediend aan premature kinderen ter voorkoming van chronische longschade. Naast allerlei neveneffecten is vooral grote bezorgdheid ontstaan over de effecten op de lange termijn van behandeling met corticosteroïden. Over deze langetermijneffecten bij de mens is nog niet veel bekend. Experimenteel onderzoek met dieren geeft echter voldoende aanwijzingen dat neonatale behandeling met corticosteroïden permanente veranderingen induceert in hersenontwikkeling en gedrag. De laatste jaren wordt duidelijk dat ook de ziektegevoeligheid toeneemt na neonatale behandeling met corticosteroïden. Ratten lijken een pro-inflammatoir fenotype te krijgen na blootstelling aan corticosteroïden in de neonatale periode. Dit fenotype kan direct zijn ontstaan door effecten van corticosteroïden op bijvoorbeeld T-cellen en indirect via veranderingen in het functioneren van het neuro-endocriene systeem. In elk geval doet dit onderzoek sterk vermoeden dat toediening van corticosteroïden niet zonder risico is voor veranderingen in de ontwikkeling van het kind op de lange termijn.

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Titel: Neonatale behandeling met corticosteroïden en consequenties op de lange termijn
Auteurs: J. M. Bakker
C. J. Heijnen
F. van Bel
Publicatiedatum: 01-06-2001
Uitgeverij: Bohn Stafleu van Loghum
Gepubliceerd in: Tijdschrift voor Kindergeneeskunde / Uitgave 3/2001
Print ISSN: 0376-7442
Elektronisch ISSN: 1875-6840
DOI: https://doi.org/10.1007/BF03061344

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