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Gepubliceerd in: Neuropraxis 1/2007

01-02-2007 | Artikelen

Op zoek naar de biologische basis van adhd: aanwijzingen vanuit cognitie, neuro-imaging, psychofarmacologie en genetica-onderzoek

Auteur: Sarah Durston

Gepubliceerd in: Neuropraxis | Uitgave 1/2007

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Abstract

Attention Deficit Hyperactivity Disorder (adhd) is een neuropsychiatrische aandoening die relatief veel voorkomt bij kinderen in de schoolgaande leeftijd. De prevalentie is 3 tot 5 procent. Zoals de naam al zegt, wordt deze aandoening gekenmerkt door hyperactief, impulsief, gedesorganiseerd en aandachtsgestoord gedrag, dat niet bij de leeftijd past (Kaplan et al., 1994). Neuropsychologisch wordt deze aandoening in verband gebracht met problemen met gedragsregulatie, ofwel cognitieve controle, het vermogen om ongepast gedrag tegen te houden en gedrag aan te passen naar aanleiding van prikkels uit de omgeving. Dit komt tot uitdrukking in de diagnostische criteria die omschreven staan in dsm-iv (apa, 1994), waarin dat gedrag wordt gepreciseerd: het maken van ongepaste opmerkingen, storend gedrag in de klas, en zelfs potentieel gevaarlijk gedrag, zoals de straat oversteken zonder te kijken.
Literatuur
go back to reference American Psychiatric Association (1994). Diagnostic and Statistical Manual of Mental Disorders, 4th edition (dsm-iv). Washington DC: American Psychiatric Association. American Psychiatric Association (1994). Diagnostic and Statistical Manual of Mental Disorders, 4th edition (dsm-iv). Washington DC: American Psychiatric Association.
go back to reference Arnsten, A.F. (2000). Genetics of childhood disorders: XVIII. adhd, Part. 2: Norepinephrine has a critical modulatory influence on prefrontal cortical function. J Am Acad Child Adolesc Psychiatry, 39,1201-1203. Arnsten, A.F. (2000). Genetics of childhood disorders: XVIII. adhd, Part. 2: Norepinephrine has a critical modulatory influence on prefrontal cortical function. J Am Acad Child Adolesc Psychiatry, 39,1201-1203.
go back to reference Barkley, R.A. (1997). Behavioral inhibition, sustained attention and executive functions: constructing a unifying theory of adhd. Psychol Bull, 21, 65–94. Barkley, R.A. (1997). Behavioral inhibition, sustained attention and executive functions: constructing a unifying theory of adhd. Psychol Bull, 21, 65–94.
go back to reference Durston, S. (2003). A Review of the Biological Bases of adhd: What have we learned from imaging studies? Ment Retard Dev Disabil Res Rev, 9(3),184–195. Durston, S. (2003). A Review of the Biological Bases of adhd: What have we learned from imaging studies? Ment Retard Dev Disabil Res Rev, 9(3),184–195.
go back to reference Durston, S., Fossella, J.A., Casey, B.J., Hulshoff Pol, H.E., Galvan, A., Schnack, H.G., Steenhuis, M.P., Minderaa, R.B., Buitelaar, J.K., Kahn, R.S. & Engeland, H. van (2005). Differential effects of drd4 and dat1 genotype on fronto-striatal gray matter volumes in a sample of subjects with Attention Deficit Hyperactivity Disorder, their unaffected siblings and controls. Mol Psychiatry, 10(7), 678–685. Durston, S., Fossella, J.A., Casey, B.J., Hulshoff Pol, H.E., Galvan, A., Schnack, H.G., Steenhuis, M.P., Minderaa, R.B., Buitelaar, J.K., Kahn, R.S. & Engeland, H. van (2005). Differential effects of drd4 and dat1 genotype on fronto-striatal gray matter volumes in a sample of subjects with Attention Deficit Hyperactivity Disorder, their unaffected siblings and controls. Mol Psychiatry, 10(7), 678–685.
go back to reference Durston S., Fossella, J.A., Mulder, M.J., Casey, B.J., Ziermans, T.B., Vessaz, M.N. & Engeland, H. van (aangeboden). Dopamine-transporter genotype conveys familial risk for Attention-Deficit/Hyperactivity Disorder through striatal activation. Durston S., Fossella, J.A., Mulder, M.J., Casey, B.J., Ziermans, T.B., Vessaz, M.N. & Engeland, H. van (aangeboden). Dopamine-transporter genotype conveys familial risk for Attention-Deficit/Hyperactivity Disorder through striatal activation.
go back to reference Durston, S., Hulshoff Pol, H.E., Schnack, H.G., Buitelaar, J.K., Steenhuis, M.P., Minderaa, R.B., Kahn, R.S. & Engeland, H. van (2004). Magnetic Resonance Imaging of boys with Attention Deficit Hyperactivity Disorder and their unaffected siblings. J Am Acad Child Adolesc Psychiatry, 43(3), 332–340. Durston, S., Hulshoff Pol, H.E., Schnack, H.G., Buitelaar, J.K., Steenhuis, M.P., Minderaa, R.B., Kahn, R.S. & Engeland, H. van (2004). Magnetic Resonance Imaging of boys with Attention Deficit Hyperactivity Disorder and their unaffected siblings. J Am Acad Child Adolesc Psychiatry, 43(3), 332–340.
go back to reference Durston, S., Mulder, M., Casey, B.J., Ziermans, T. & Engeland, H. van (in druk). Activation in ventral prefrontal cortex is sensitive to genetic vulnerability for Attention Deficit Hyperactivity Disorder. Biol Psychiatry. Durston, S., Mulder, M., Casey, B.J., Ziermans, T. & Engeland, H. van (in druk). Activation in ventral prefrontal cortex is sensitive to genetic vulnerability for Attention Deficit Hyperactivity Disorder. Biol Psychiatry.
go back to reference Durston, S., Tottenham, N.T., Thomas, K.M., Davidson, M.C., Eigsti, I.M., Yang, Y., Ulug, A.M. & Casey, B.J. (2003). Differential patterns of striatal activation young children with and without adhd. Biol Psychiatry, 53, 871–878. Durston, S., Tottenham, N.T., Thomas, K.M., Davidson, M.C., Eigsti, I.M., Yang, Y., Ulug, A.M. & Casey, B.J. (2003). Differential patterns of striatal activation young children with and without adhd. Biol Psychiatry, 53, 871–878.
go back to reference Faraone, S.V., Perlis, R.H., Doyle, A.E., Smoller, J.W., Goralnick, J.J., Holmgren, M.A. & Sklar, P. (2005). Molecular Genetics of Attention-Deficit/Hyperactivity Disorder. Biol Psychiatry, 57(11), 1313–1323. Faraone, S.V., Perlis, R.H., Doyle, A.E., Smoller, J.W., Goralnick, J.J., Holmgren, M.A. & Sklar, P. (2005). Molecular Genetics of Attention-Deficit/Hyperactivity Disorder. Biol Psychiatry, 57(11), 1313–1323.
go back to reference Goldman-Rakic, P.S., Mully, E.C. & Williams, G.V. (2000). D1 receptors in prefrontal cell and circuits. Brain Res Brain Res Rev, 31, 295–301. Goldman-Rakic, P.S., Mully, E.C. & Williams, G.V. (2000). D1 receptors in prefrontal cell and circuits. Brain Res Brain Res Rev, 31, 295–301.
go back to reference Kaplan, H.I., Sadock, B.J. & Grebb, J.A. (1994). Attention-deficit disorders. In: Kaplan and Sadock's synopsis of psychiatry. Williams & Wilkins, Baltimore, USA, pp 1063–1068. Kaplan, H.I., Sadock, B.J. & Grebb, J.A. (1994). Attention-deficit disorders. In: Kaplan and Sadock's synopsis of psychiatry. Williams & Wilkins, Baltimore, USA, pp 1063–1068.
go back to reference Krause, K.H., Dresel, S.H., Krause, J., Kung, H.F. & Tatsch K (2000). Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: effects of methylphenidate as measured by single photon emission computed tomography. Neurosci Lett, 285, 107–110. Krause, K.H., Dresel, S.H., Krause, J., Kung, H.F. & Tatsch K (2000). Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: effects of methylphenidate as measured by single photon emission computed tomography. Neurosci Lett, 285, 107–110.
go back to reference Pliszka, S.R., McCracken, J.T. & Maas, J.W. (1996). Catecholamines in attention-deficit hyperactivity disorder: current perspectives. J Am Acad Child Adolec Psychiatry, 35, 264–272. Pliszka, S.R., McCracken, J.T. & Maas, J.W. (1996). Catecholamines in attention-deficit hyperactivity disorder: current perspectives. J Am Acad Child Adolec Psychiatry, 35, 264–272.
go back to reference Solanto, M.V. (2002). Dopamine dysfunction in ad/hd: integrating clinical and basic neuroscience research. Behav Brain Res, 130, 65–71. Solanto, M.V. (2002). Dopamine dysfunction in ad/hd: integrating clinical and basic neuroscience research. Behav Brain Res, 130, 65–71.
go back to reference Swanson, J.M., Sergeant, J.A., Taylor, E., Sonuga-Barke, E.J.S., Jensen, P.S. & Cantwell, D.P. (1998). Attention-deficit hyperactivity disorder and hyperkinetic disorder. Lancet, 351, 429–433. Swanson, J.M., Sergeant, J.A., Taylor, E., Sonuga-Barke, E.J.S., Jensen, P.S. & Cantwell, D.P. (1998). Attention-deficit hyperactivity disorder and hyperkinetic disorder. Lancet, 351, 429–433.
go back to reference Thapar, A., Holmes, J., Poulton, K. & Harrington, R. (1999). Genetic basis of attention deficit and hyperactivity. Br J Psychiatry, 174, 105–111. Thapar, A., Holmes, J., Poulton, K. & Harrington, R. (1999). Genetic basis of attention deficit and hyperactivity. Br J Psychiatry, 174, 105–111.
go back to reference Vaidya, C.J., Austin, G., Kirkorian, G., Ridlehuber, H.W., Desmond, J.E., Glover, G.H. & Gabrieli, J.D. (1998). Selective effects of methylphenidate in attention deficit hyperactivity disorder: a functional magnetic resonance study. Proc Natl Acad Sci USA, 95, 14494–14499. Vaidya, C.J., Austin, G., Kirkorian, G., Ridlehuber, H.W., Desmond, J.E., Glover, G.H. & Gabrieli, J.D. (1998). Selective effects of methylphenidate in attention deficit hyperactivity disorder: a functional magnetic resonance study. Proc Natl Acad Sci USA, 95, 14494–14499.
go back to reference Volkow, N.D., Wang, G.J., Fowler, J.S., Gatley, S.J., Logan, J., Ding, Y.S., Hitzemann, R, & Pappas, N. (1998). Dopamine transporters occupancies in the human brain induced by therapeutic dosis of oral methylphenidate. Am J Psychiatry, 155, 1325–1331. Volkow, N.D., Wang, G.J., Fowler, J.S., Gatley, S.J., Logan, J., Ding, Y.S., Hitzemann, R, & Pappas, N. (1998). Dopamine transporters occupancies in the human brain induced by therapeutic dosis of oral methylphenidate. Am J Psychiatry, 155, 1325–1331.
go back to reference Volkow, N.D., Wang, G.J., Fowler, J.S., Logan, J., Gerasimov, M., Maynard, L., Ding, Y.S., Gatley, S.J., Gifford, A. & Franceschi, D. (2001). Therapeutic doses of oral methylphenidate significantly increase extracellular dopamine in the human brain. J Neurosci, 21, RC121. Volkow, N.D., Wang, G.J., Fowler, J.S., Logan, J., Gerasimov, M., Maynard, L., Ding, Y.S., Gatley, S.J., Gifford, A. & Franceschi, D. (2001). Therapeutic doses of oral methylphenidate significantly increase extracellular dopamine in the human brain. J Neurosci, 21, RC121.
Metagegevens
Titel
Op zoek naar de biologische basis van adhd: aanwijzingen vanuit cognitie, neuro-imaging, psychofarmacologie en genetica-onderzoek
Auteur
Sarah Durston
Publicatiedatum
01-02-2007
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Neuropraxis / Uitgave 1/2007
Print ISSN: 1387-5817
Elektronisch ISSN: 1876-5785
DOI
https://doi.org/10.1007/BF03079116

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