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CC BY-NC-ND 4.0 · Int Arch Otorhinolaryngol 2020; 24(03): e299-e307
DOI: 10.1055/s-0039-3399539
Original Research
Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

Normal Hearing Function in Children Prenatally Exposed to Zika Virus

Maria Helena Magalhães Barbosa 
1   Department of Otorhinolaryngology, Universidade Federal do Rio de Janeiro, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, RJ, Brazil
2   Department of Pediatrics, Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro, RJ, Brazil
,
Cristiane Fregonesi Dutra Garcia
3   Department of Phonoaudiology, Universidade Federal do Rio de Janeiro Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, RJ, Brazil
,
Maria Clara de Magalhães Barbosa
2   Department of Pediatrics, Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro, RJ, Brazil
,
Jaqueline Rodrigues Robaina
4   Department of Epidemiology, Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro, RJ, Brazil
,
Arnaldo Prata-Barbosa
2   Department of Pediatrics, Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro, RJ, Brazil
5   Department of Pediatrics, Universidade Federal do Rio de Janeiro Maternidade Escola, Rio de Janeiro, RJ, Brazil
,
Marco Antonio de Melo Tavares de Lima
1   Department of Otorhinolaryngology, Universidade Federal do Rio de Janeiro, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, RJ, Brazil
,
Antonio José Ledo Alves da Cunha
5   Department of Pediatrics, Universidade Federal do Rio de Janeiro Maternidade Escola, Rio de Janeiro, RJ, Brazil
6   Department of Pediatrics, Universidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagão Gesteira, Rio de Janeiro, RJ, Brazil
› Author Affiliations
Further Information

Publication History

16 April 2019

27 September 2019

Publication Date:
13 December 2019 (online)

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Abstract

Introduction The association between prenatal Zika virus infection and hearing alterations in offspring has been the object of some studies, although few have assessed children without microcephaly. However, a current trend to include prenatal Zika virus exposure in the group of risk indicators for hearing loss is noted.

Objective To present a series of 27 children prenatally exposed to the Zika virus submitted to multiple hearing assessments over time.

Methods A cohort of children born to symptomatic mothers with laboratorial Zika virus infection confirmation during pregnancy was submitted to an otoacoustic emission test, auditory brainstem response test (automated, neurodiagnostic and frequency-specific), audiometry, and imitanciometry over a period of 36 months since birth. The hearing assessment was performed independently of the presence of microcephaly or other apparent signs of congenital Zika syndrome.

Results The hearing tests presented predominantly normal results. Some children had signs of middle ear pathology. The only microcephalic child had normal electrophysiological tests, as well as preserved audiometric thresholds, but presented altered motor responses to sound.

Conclusion Prenatal exposure to Zika virus does not always determine hearing impairment. This risk seems to be more associated to the severity of the central nervous system damage. Hearing screening and follow-ups of the affected children are important, as well as further research in this area.

Keywords

zika virus - hearing - prenatal injuries
 

  • References

  • 1 Leal Mde C, Muniz LF. Caldas Neto S da S, van der Linden V, Ramos RCF. Sensorineural hearing loss in a case of congenital Zika virus. Rev Bras Otorrinolaringol (Engl Ed) 2016; (xx): 1-3 Available at http://www.ncbi.nlm.nih.gov/pubmed/27444419 . Accessed Apr 17, 2018 [Internet]
    Google Scholar
  • 2 Leal MC, Muniz LF, Ferreira TSA. , et al. Hearing loss in infants with microcephaly and evidence of congenital Zika virus infection - Brazil, November 2015-May 2016. MMWR Morb Mortal Wkly Rep 2016; 65 (34) 917-919
    CrossrefPubMedGoogle Scholar
  • 3 Cohen BE, Durstenfeld A, Roehm PC. Viral causes of hearing loss: a review for hearing health professionals. Trends Hear 2014; 18: 1-17
    CrossrefPubMedGoogle Scholar
  • 4 Chau J, Atashband S, Chang E, Westerberg BD, Kozak FK. A systematic review of pediatric sensorineural hearing loss in congenital syphilis. Int J Pediatr Otorhinolaryngol 2009; 73 (06) 787-792
    CrossrefPubMedGoogle Scholar
  • 5 Brown ED, Chau JK, Atashband S, Westerberg BD, Kozak FK. A systematic review of neonatal toxoplasmosis exposure and sensorineural hearing loss. Int J Pediatr Otorhinolaryngol 2009; 73 (05) 707-711
    CrossrefPubMedGoogle Scholar
  • 6 Nogueira ML, Nery Júnior NRR, Estofolete CF. , et al. Adverse birth outcomes associated with Zika virus exposure during pregnancy in São José do Rio Preto, Brazil. Clin Microbiol Infect 2018; 24 (06) 646-652
    CrossrefPubMedGoogle Scholar
  • 7 Barbosa MHM, Magalhães-Barbosa MC, Robaina JR, Prata-Barbosa A, Lima MAMT, Cunha AJLA. Auditory findings associated with Zika virus infection: an integrative revie w. Braz J Otorhinolaryngol [Internet]. 2019 ;S1808–8694(19). Available at: https://linkinghub.elsevier.com/retrieve/pii/S1808869419300540 . Accessed Jun 1, 2019.
    Google Scholar
  • 8 Ventura CV, Maia M, Dias N, Ventura LO, Belfort Jr R. Zika: neurological and ocular findings in infant without microcephaly. Lancet 2016; 387 (10037): 2502
    CrossrefPubMedGoogle Scholar
  • 9 American Academy of Pediatrics, Joint Committee on Infant Hearing. Year 2007 position statement: Principles and guidelines for early hearing detection and intervention programs. Pediatrics 2007; 120 (04) 898-921
    CrossrefPubMedGoogle Scholar
  • 10 Harlor Jr ADB, Bower C. ; Committee on Practice and Ambulatory Medicine; Section on Otolaryngology-Head and Neck Surgery. Hearing assessment in infants and children: recommendations beyond neonatal screening. Pediatrics 2009; 124 (04) 1252-1263
    CrossrefPubMedGoogle Scholar
  • 11 de Carvalho Leal M, Ramos DS, Caldas Neto SS. Hearing Loss From Congenital Zika Virus Infection. Top Magn Reson Imaging 2019; 28 (01) 19-22
    CrossrefPubMedGoogle Scholar
  • 12 Adebanjo T, Godfred-Cato S, Viens L. , et al; Contributors. Update: interim guidance for the diagnosis, evaluation, and management of infants with possible congenital Zika virus infection - United States, October 2017. MMWR Morb Mortal Wkly Rep 2017; 66 (41) 1089-1099
    CrossrefPubMedGoogle Scholar
  • 13 Borja A, de Araújo RPC. Hearing screening in children exposed to zika virus during pregnancy. Rev Ciênc Méd Biol 2017; 16 (03) 271
    Google Scholar
  • 14 Fandiño-Cárdenas M, Molina-Franky J, Velandia R. , et al. Zika virus infection during pregnancy and sensorineural hearing loss among children at 3 and 24 months post-partum. J Trop Pediatr 2018; •••: 1-8
    Google Scholar
  • 15 Heidari S, Manesh AO, Rajabi F. The Sensitivity and Specificity of Automated Auditory Brainstem Response and Otoacoustic Emission in Neonatal Hearing Screening: a Systematic Review. Audit Vestib Res 2015; 24 (03) 32-42
    Google Scholar
  • 16 Farinetti A, Raji A, Wu H, Wanna B, Vincent C. International consensus (ICON) on audiological assessment of hearing loss in children. Eur Ann Otorhinolaryngol Head Neck Dis 2018; 135 (1S): S41-S48
    CrossrefPubMedGoogle Scholar
  • 17 Stapells DR. Threshold Estimation by the Tone-Evoked Auditory Brainstem Response: A Literature Meta-Analysis. J Speech Lang Pathol Audiol 2000; 24 (02) 74-83
    Google Scholar
  • 18 Shetty HN, Kooknoor V, Rajalakshmi G. Sensitivity and Specificity of Combined Physiological Tests in Newborn Hearing Screening. J Phonetics Audiol 2016 2(02):
    Google Scholar
  • 19 Ministério da Saúde. Diretrizes de Atenção da Triagem Auditiva Neonatal [Internet]. Ministério da Saúde 2012 p. 32. Available at: http://bvsms.saude.gov.br/bvs/publicacoes/diretrizes_atencao_triagem_auditiva_neonatal.pdf . Accessed May 22, 2018.
  • 20 British Columbia Children's Hospital, Provincial Health Service Authority. BC Early Hearing Program [Internet]. BC Early Hearing Program. 2012 . p. 118. Available at: http://www.phsa.ca/Documents/bcehpaudiologyassessmentprotocol.pdf . Accessed Aug 03, 2019.
    Google Scholar
  • 21 Otodynamics. Otoport Lite DP [Internet]. Available at: https://www.otodynamics.info/product/otoport-lite-dp/ . Accessed Jul 28, 2019.
  • 22 IHS. Intelligent Hearing Systems [Internet]. Available at: http://www.ihsys.com/site/SmartEP.asp?tab=1 . Accessed Jul 28, 2019.
    Google Scholar
  • 23 Interacoustics. Interacoustics [Internet]. Available at: https://www.interacoustics.com . Accessed Jul 28, 2019.
  • 24 World Health Organization. Pregnancy management in the context of Zika virus Interim guidance 2 March 2016 [Internet]. 2016 p. 1–14. Available at: http://apps.who.int/iris/bitstream/10665/204520/1/WHO_ZIKV_MOC_16.2_eng.pdf?ua=1 . Accessed Aug 3, 2019.
    Google Scholar
  • 25 Klase ZA, Khakhina S, Schneider AdeB, Callahan MV, Glasspool-Malone J, Malone R. Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome. PLoS Negl Trop Dis 2016; 10 (08) e0004877
    CrossrefPubMedGoogle Scholar
  • 26 Microcephaly Epidemic Research Group. Microcephaly in Infants, Pernambuco State, Brazil, 2015. Emerg Infect Dis 2016; 22 (06) 1090-1093
    CrossrefPubMedGoogle Scholar
  • 27 Satterfield-Nash A, Kotzky K, Allen J. , et al. Health and Development at Age 19-24 Months of 19 Children Who Were Born with Microcephaly and Laboratory Evidence of Congenital Zika Virus Infection During the 2015 Zika Virus Outbreak - Brazil, 2017. MMWR Morb Mortal Wkly Rep 2017; 66 (49) 1347-1351
    CrossrefPubMedGoogle Scholar
  • 28 Silva Mde A. Mendonça de Araújo FC. Hearing screening in children exposed to Zika virus. In: II Congresso Brasileiro de Ciências da Saúde. Campina Grande - Paraíba; 2018
    Google Scholar
  • 29 Leite RFP, Santos MSA, Ribeiro EM. , et al. Hearing Screening in children with Congenital Zika Virus Syndrome in Fortaleza, Ceará, Brazil, 2016. Epidemiol Serv Saude 2018; 27 (04) e2017553
    PubMedGoogle Scholar
  • 30 Marques Abramov D, Saad T, Gomes-Junior S-C. , et al. Auditory brainstem function in microcephaly related to Zika virus infection. Neurology 2018; 90 (07) e606-e614
    CrossrefPubMedGoogle Scholar
  • 31 Chen J, Hu L, Wu M, Zhong T, Zhou YH, Hu Y. Kinetics of IgG antibody to cytomegalovirus (CMV) after birth and seroprevalence of anti-CMV IgG in Chinese children. Virol J 2012; 9 (01) 304
    CrossrefPubMedGoogle Scholar
  • 32 Palmeira P, Quinello C, Silveira-Lessa AL, Zago CA, Carneiro-Sampaio M. IgG placental transfer in healthy and pathological pregnancies. Clin Dev Immunol. [Internet] 2012 ; Published online 2011 Oct 1. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251916/ . Accessed Apr 14 2019.
    Google Scholar
  • 33 De Santis M, Cavaliere AF, Straface G, Caruso A. Rubella infection in pregnancy. Reprod Toxicol 2006; 21 (04) 390-398
    CrossrefPubMedGoogle Scholar