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Endosc Int Open 2014; 02(03): E191-E192
DOI: 10.1055/s-0034-1377175
Case report
© Georg Thieme Verlag KG Stuttgart · New York

Pseudomelanosis of the stomach and duodenum: an uncommon endoscopic finding

M. Thure Caire
1   University of South Florida Health, Morsani College of Medicine, Department of Gastroenterology
,
Shivam Kalan
2   University of South Florida Health, Morsani College of Medicine, Department of Internal Medicine
,
Patrick Brady
1   University of South Florida Health, Morsani College of Medicine, Department of Gastroenterology
,
Jeffrey Gill
3   James A. Haley Veterans Hospital, Department of Gastroenterology
› Author Affiliations
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Publication History

submitted04 April 2014

accepted after revision23 April 2014

Publication Date:
23 June 2014 (online)

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Pseudomelanosis of the stomach and duodenum: an uncommon endoscopic findingEndosc Int Open 2014; 02(03): C1-C1
DOI: 10.1055/s-0034-1367651

A woman (70-years) with a history of iron deficiency anemia and chronic kidney disease presented with two weeks of abdominal pain. Upper endoscopy demonstrated the gastric and duodenal mucosa was black and speckled consistent with diagnosis of pseudomelanosis. Biopsies showed pigment-laden macrophages in the lamina propria, which stained positive for iron and Masson-Fontana trichrome stain consistent with a “melanin-like” pigment. Although an uncommon endoscopic finding, this pigment has been associated with the use of certain medications, antihypertensives and iron supplements, and systemic illnesses, including hypertension, chronic kidney disease, gastric hemorrhage, and diabetes mellitus.

 

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