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2009 | OriginalPaper | Hoofdstuk

4 Functies van de lever

Auteurs : Prof.dr. R.P. Oude Elferink, Dr. J. Kwekkeboom

Gepubliceerd in: Leverziekten

Uitgeverij: Bohn Stafleu van Loghum

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Samenvatting

De lever vervult een centrale rol in de metabole functies en energiehuishouding van het gehele lichaam. In de eerste plaats is het orgaan zodanig geplaatst in de bloedsomloop dat al het bloed afkomstig van het maag-darmkanaal eerst door de lever gaat. Dit stelt de lever in staat om voedingsstoffen afkomstig uit de darm op te nemen en vervolgens te verdelen over de andere organen.
Literatuur
2.
go back to reference Hachem SB, Mooradian AD. Familial dyslipidaemias: an overview of genetics, pathophysiology and management. Drugs 2006;66:1949–1969.PubMedCrossRef Hachem SB, Mooradian AD. Familial dyslipidaemias: an overview of genetics, pathophysiology and management. Drugs 2006;66:1949–1969.PubMedCrossRef
3.
go back to reference Olde Damink SW, Deutz NE, DeJong CH, Soeters PB, Jalan R. Interorgan ammonia metabolism in liver failure. Neurochem Int 2002;41:177–188.PubMedCrossRef Olde Damink SW, Deutz NE, DeJong CH, Soeters PB, Jalan R. Interorgan ammonia metabolism in liver failure. Neurochem Int 2002;41:177–188.PubMedCrossRef
4.
go back to reference Zamek-Gliszczynski MJ, Hoffmaster KA, Nezasa K, Tallman MN, Brouwer KL. Integration of hepatic drug transporters and phase II metabolizing enzymes: mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites. Eur J Pharm Sci 2006;27:447–486.PubMedCrossRef Zamek-Gliszczynski MJ, Hoffmaster KA, Nezasa K, Tallman MN, Brouwer KL. Integration of hepatic drug transporters and phase II metabolizing enzymes: mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites. Eur J Pharm Sci 2006;27:447–486.PubMedCrossRef
5.
go back to reference Grunhage F, Lammert F. Gallstone disease. Pathogenesis of gallstones: A genetic perspective. Best Pract Res Clin Gastroenterol 2006;20:997–1015.PubMedCrossRef Grunhage F, Lammert F. Gallstone disease. Pathogenesis of gallstones: A genetic perspective. Best Pract Res Clin Gastroenterol 2006;20:997–1015.PubMedCrossRef
6.
go back to reference Oude Elferink RP, Paulusma CC, Groen AK. Hepatocanalicular transport defects: pathophysiologic mechanisms of rare diseases. Gastroenterology 2006; 130:908–925.PubMedCrossRef Oude Elferink RP, Paulusma CC, Groen AK. Hepatocanalicular transport defects: pathophysiologic mechanisms of rare diseases. Gastroenterology 2006; 130:908–925.PubMedCrossRef
7.
go back to reference Pauli-Magnus C, Meier PJ. Hepatobiliary transporters and drug-induced cholestasis. Hepatology 2006;44: 778–787.PubMedCrossRef Pauli-Magnus C, Meier PJ. Hepatobiliary transporters and drug-induced cholestasis. Hepatology 2006;44: 778–787.PubMedCrossRef
8.
9.
10.
go back to reference Peck-Radosavljevic M. Review article: coagulation disorders in chronic liver disease. Aliment Pharmacol Ther 2007;26(Suppl 1):21–28.PubMedCrossRef Peck-Radosavljevic M. Review article: coagulation disorders in chronic liver disease. Aliment Pharmacol Ther 2007;26(Suppl 1):21–28.PubMedCrossRef
11.
12.
go back to reference Knolle PA, Gerken G. Local control of the immune response in the liver. Immunol Rev 2000;174:21–34.PubMedCrossRef Knolle PA, Gerken G. Local control of the immune response in the liver. Immunol Rev 2000;174:21–34.PubMedCrossRef
14.
go back to reference Wisse E, Luo D, Vermijlen D, Kanellopoulou C, Zanger R de, Braet F. On the function of pit cells, the liverspecific natural killer cells. Seminars in Liver Disease 1997;17:265–286.PubMedCrossRef Wisse E, Luo D, Vermijlen D, Kanellopoulou C, Zanger R de, Braet F. On the function of pit cells, the liverspecific natural killer cells. Seminars in Liver Disease 1997;17:265–286.PubMedCrossRef
15.
go back to reference Exley MA, Koziel MJ. To be or not to be NKT: natural killer T cells in the liver. Hepatology 2004;40:1033–1040.PubMedCrossRef Exley MA, Koziel MJ. To be or not to be NKT: natural killer T cells in the liver. Hepatology 2004;40:1033–1040.PubMedCrossRef
16.
go back to reference Pillarisetty VG, Shah AB, Miller G, Bleier JI, De Matteo RP. Liver dendritic cells are less immunogenic than spleen dendritic cells because of differences in subtype composition. J Immunol 2004;172:1009–1017.PubMedCrossRef Pillarisetty VG, Shah AB, Miller G, Bleier JI, De Matteo RP. Liver dendritic cells are less immunogenic than spleen dendritic cells because of differences in subtype composition. J Immunol 2004;172:1009–1017.PubMedCrossRef
Metagegevens
Titel
4 Functies van de lever
Auteurs
Prof.dr. R.P. Oude Elferink
Dr. J. Kwekkeboom
Copyright
2009
Uitgeverij
Bohn Stafleu van Loghum
DOI
https://doi.org/10.1007/978-90-313-7437-3_4